Search Results - "Willis, Christine"

ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease by Evans, Charles E., Miners, James S., Piva, Giulia, Willis, Christine L., Heard, David M., Kidd, Emma J., Good, Mark A., Kehoe, Patrick G.

“…Mid-life hypertension and cerebrovascular dysfunction are associated with increased risk of later life dementia, including Alzheimer’s disease (AD). The…”
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A Bioinspired Strategy for the Enantioselective Synthesis of Bicyclic Oxygen Heterocycles by Venegas, Edith Rodriguez, Willis, Christine L

“…A new strategy is described for the direct conversion of unsaturated 3,5-dihydroxy-diarylheptanoids to dimeric products assembled on…”
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Core Steps to the Azaphilone Family of Fungal Natural Products by Williams, Katherine, Greco, Claudio, Bailey, Andrew M., Willis, Christine L.

“…Azaphilones are a family of polyketide‐based fungal natural products that exhibit interesting and useful bioactivities. This minireview explores the literature…”
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Book Club: A Guide to Hosting by Willis, Christine A.

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Strobilurin biosynthesis in Basidiomycete fungi by Nofiani, Risa, de Mattos-Shipley, Kate, Lebe, Karen E., Han, Li-Chen, Iqbal, Zafar, Bailey, Andrew M., Willis, Christine L., Simpson, Thomas J., Cox, Russell J.

“…Strobilurins from fungi are the inspiration for the creation of the β-methoxyacrylate class of agricultural fungicides. However, molecular details of the…”
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The Catalytic Mechanism of a Natural Diels–Alderase Revealed in Molecular Detail by Byrne, Matthew J, Lees, Nicholas R, Han, Li-Chen, van der Kamp, Marc W, Mulholland, Adrian J, Stach, James E. M, Willis, Christine L, Race, Paul R

“…The Diels–Alder reaction, a [4 + 2] cycloaddition of a conjugated diene to a dienophile, is one of the most powerful reactions in synthetic chemistry…”
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Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives by Alberti, Fabrizio, Khairudin, Khairunisa, Venegas, Edith Rodriguez, Davies, Jonathan A., Hayes, Patrick M., Willis, Christine L., Bailey, Andy M., Foster, Gary D.

“…The rise in antibiotic resistance is a major threat for human health. Basidiomycete fungi represent an untapped source of underexploited antimicrobials, with…”
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Synthetic and biosynthetic methods for selective cyclisations of 4,5-epoxy alcohols to tetrahydropyrans by Bowen, James I, Wang, Luoyi, Crump, Matthew P, Willis, Christine L

“…Tetrahydropyrans (THPs) are common structural motifs found in natural products and synthetic therapeutic molecules. In Nature these 6-membered oxygen…”
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Combining total synthesis and genetic engineering to probe dihydropyran formation in ambruticin biosynthesis by Bowen, James I, Zhong, Xiaotong, Gao, Kaining, Reed, Benjamin, Crump, Matthew P, Wang, Luoyi, Willis, Christine L

“…The ambruticins are a family of potent antifungal polyketide derived natural products isolated from the myxobacterium Sorangium cellulosum . Their unusual…”
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Divergent Tandem Acyl Carrier Proteins Necessitate In-Series Polyketide Processing in the Leinamycin Family by Phillips, Annabel P, Winter, Ashley J, Hooper, Chloe M, Williams, Christopher, Crosby, John, Willis, Christine L, Crump, Matthew Philip

“…The leinamycin family of polyketides are promising antitumour antibiotics, yet several aspects of their biosynthesis remain elusive. All leinamycin family…”
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Hospital Accreditation: A Primer by Willis, Christine A.

“…This article will focus on the accreditation organizations and government compliance requirements that directly relate to hospitals…”
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Resistance to and synthesis of the antibiotic mupirocin by Thomas, Christopher M, Hothersall, Joanne, Willis, Christine L, Simpson, Thomas J

“…Key Points The spread of methicillin-resistant Staphylococcus aureus (MRSA) necessitates the development of new antibiotics. The control of mupirocin…”
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Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungi by Greco, Claudio, de Mattos-Shipley, Kate, Bailey, Andrew M, Mulholland, Nicholas P, Vincent, Jason L, Willis, Christine L, Cox, Russell J, Simpson, Thomas J

“…Three novel dimeric xanthones, cryptosporioptides A-C were isolated from Cryptosporiopsis sp. 8999 and their structures elucidated. Methylation of…”
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An Integrated Module Performs Selective ‘Online’ Epoxidation in the Biosynthesis of the Antibiotic Mupirocin by Winter, Ashley J., Courcy‐Ireland, Felix, Phillips, Annabel P., Barker, Joseph M., Bakar, Nurfarhanim A., Akter, Nahida, Wang, Luoyi, Song, Zhongshu, Crosby, John, Williams, Christopher, Willis, Christine L., Crump, Matthew P.

“…The delineation of the complex biosynthesis of the potent antibiotic mupirocin, which consists of a mixture of pseudomonic acids (PAs) isolated from…”
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Biosynthesis of pleuromutilin congeners using an Aspergillus oryzae expression platform by Alberti, Fabrizio, Khairudin, Khairunisa, Davies, Jonathan A, Sangmalee, Suphattra, Willis, Christine L, Foster, Gary D, Bailey, Andy M

“…Pleuromutilin is an antibiotic diterpenoid made by and related fungi, and it is the progenitor of a growing class of semi-synthetic antibiotics used in…”
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Identification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production by Bailey, Andy M., Alberti, Fabrizio, Kilaru, Sreedhar, Collins, Catherine M., de Mattos-Shipley, Kate, Hartley, Amanda J., Hayes, Patrick, Griffin, Alison, Lazarus, Colin M., Cox, Russell J., Willis, Christine L., O’Dwyer, Karen, Spence, David W., Foster, Gary D.

“…Semi-synthetic derivatives of the tricyclic diterpene antibiotic pleuromutilin from the basidiomycete Clitopilus passeckerianus are important in combatting…”
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Sequential Photochemical and Prins Reactions for the Diastereoselective Synthesis of Tricyclic Scaffolds by Donnelly, Bethan L., Elliott, Luke D., Willis, Christine L., Booker‐Milburn, Kevin I.

“…Cyclobutene alcohols undergo Prins cyclisations to generate single diastereomers of novel tricyclic heterocycles with five contiguous stereocentres. The…”
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Structure and Function of the α‐Hydroxylation Bimodule of the Mupirocin Polyketide Synthase by Winter, Ashley J., Khanizeman, R. Nisha, Barker‐Mountford, Abigail M. C., Devine, Andrew J., Wang, Luoyi, Song, Zhongshu, Davies, Jonathan A., Race, Paul R., Williams, Christopher, Simpson, Thomas J., Willis, Christine L., Crump, Matthew P.

“…Mupirocin is a clinically important antibiotic produced by a trans‐AT Type I polyketide synthase (PKS) in Pseudomonas fluorescens. The major bioactive…”
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Diastereodivergent Synthesis of Trisubstituted Alkenes through Protodeboronation of Allylic Boronic Esters: Application to the Synthesis of the Californian Red Scale Beetle Pheromone by Hesse, Matthew J., Butts, Craig P., Willis, Christine L., Aggarwal, Varinder K.

“…E‐allylic boronic esters undergo a highly diastereoselective protodeboronation with TBAF⋅3 H2O to give Z‐trisubstituted alkenes. The selectivity can be…”
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Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi by Szwalbe, Agnieszka J, Williams, Katherine, Song, Zhongshu, de Mattos-Shipley, Kate, Vincent, Jason L, Bailey, Andrew M, Willis, Christine L, Cox, Russell J, Simpson, Thomas J

“…Two new dihydroxy-xanthone metabolites, agnestins A and B, were isolated from along with a number of related benzophenones and xanthones including…”
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