Search Results - "Willigen, Danny"

Size and affinity kinetics of nanobodies influence targeting and penetration of solid tumours by Debie, Pieterjan, Lafont, Chrystel, Defrise, Michel, Hansen, Inge, van Willigen, Danny M., van Leeuwen, Fijs W.B., Gijsbers, Rik, D'Huyvetter, Matthias, Devoogdt, Nick, Lahoutte, Tony, Mollard, Patrice, Hernot, Sophie

“…A compound's intratumoural distribution is an important determinant for the effectiveness of molecular therapy or imaging. Antibodies (Abs), though often used…”
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High-resolution imaging and single-cell analysis via laser ablation-inductively coupled plasma-mass spectrometry for the determination of membranous receptor expression levels in breast cancer cell lines using receptor-specific hybrid tracers by Van Acker, Thibaut, Buckle, Tessa, Van Malderen, Stijn J.M., van Willigen, Danny M., van Unen, Vincent, van Leeuwen, Fijs W.B., Vanhaecke, Frank

“…This work evaluates the possibility of placement of high-resolution imaging and single-cell analysis via laser ablation-inductively coupled plasma-mass…”
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In vivo stability of supramolecular host–guest complexes monitored by dual-isotope multiplexing in a pre-targeting model of experimental liver radioembolization by Welling, Mick M., Spa, Silvia J., van Willigen, Danny M., Rietbergen, Daphne D.D., Roestenberg, Meta, Buckle, Tessa, van Leeuwen, Fijs W.B.

“…Cyclodextrin (CD)-based supramolecular interactions have been proposed as nanocarriers for drug delivery. We previously explored the use of these…”
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Chemically Enhanced Immunogenicity of Bacteria by Supramolecular Functionalization with an Adjuvant by Duszenko, Nikolas, Willigen, Danny M., Bunschoten, Anton, Velders, Aldrik H., Roestenberg, Meta, Leeuwen, Fijs W. B.

“…Many pathogens blunt immune responses because they lack immunogenic structural features, which typically results in disease. Here, we show evidence suggesting…”
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Multi-Wavelength Fluorescence in Image-Guided Surgery, Clinical Feasibility and Future Perspectives by van Beurden, Florian, van Willigen, Danny M., Vojnovic, Borivoj, van Oosterom, Matthias N., Brouwer, Oscar R., der Poel, Henk G. van, Kobayashi, Hisataka, van Leeuwen, Fijs W.B., Buckle, Tessa

“…With the rise of fluorescence-guided surgery, it has become evident that different types of fluorescence signals can provide value in the surgical setting…”
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Hybrid Tracers Based on Cyanine Backbones Targeting Prostate-Specific Membrane Antigen: Tuning Pharmacokinetic Properties and Exploring Dye-Protein Interaction by Hensbergen, Albertus W, Buckle, Tessa, van Willigen, Danny M, Schottelius, Margret, Welling, Mick M, van der Wijk, Felicia A, Maurer, Tobias, van der Poel, Henk G, van der Pluijm, Gabri, van Weerden, Wytske M, Wester, Hans-Jürgen, van Leeuwen, Fijs W B

“…Prostate cancer surgery is currently being revolutionized by the use of prostate-specific membrane antigen (PSMA)-targeted radiotracers, for example,…”
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Image-Guided Surgery: Are We Getting the Most Out of Small-Molecule Prostate-Specific-Membrane-Antigen-Targeted Tracers? by Hensbergen, Albertus Wijnand, van Willigen, Danny M, van Beurden, Florian, van Leeuwen, Pim J, Buckle, Tessa, Schottelius, Margret, Maurer, Tobias, Wester, Hans-Jürgen, van Leeuwen, Fijs W. B

“…Expressed on virtually all prostate cancers and their metastases, the transmembrane protein prostate-specific membrane antigen (PSMA) provides a valuable…”
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The helminth glycoprotein omega‐1 improves metabolic homeostasis in obese mice through type 2 immunity‐independent inhibition of food intake by Zande, Hendrik J.P., Gonzalez, Michael A., Ruiter, Karin, Wilbers, Ruud H.P., García‐Tardón, Noemí, Huizen, Mariska, Noort, Kim, Pelgrom, Leonard R., Lambooij, Joost M., Zawistowska‐Deniziak, Anna, Otto, Frank, Ozir‐Fazalalikhan, Arifa, Willigen, Danny, Welling, Mick, Poles, Jordan, Leeuwen, Fijs, Hokke, Cornelis H., Schots, Arjen, Yazdanbakhsh, Maria, Loke, P'ng, Guigas, Bruno

“…Type 2 immunity plays an essential role in the maintenance of metabolic homeostasis and its disruption during obesity promotes meta‐inflammation and insulin…”
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Advancing intraoperative magnetic tracing using 3D freehand magnetic particle imaging by Azargoshasb, Samaneh, Molenaar, Lennert, Rosiello, Giuseppe, Buckle, Tessa, van Willigen, Danny M., van de Loosdrecht, Melissa M., Welling, Mick M., Alic, Lejla, van Leeuwen, Fijs W. B., Winter, Alexander, van Oosterom, Matthias N.

“…Purpose Sentinel lymph node biopsy is a routine procedure for nodal staging in penile cancer. Most commonly, this procedure is guided by radioactive tracers,…”
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Cyclodextrin/Adamantane-Mediated Targeting of Inoculated Bacteria in Mice by Welling, Mick M, Duszenko, Nikolas, van Willigen, Danny M, Smits, Wiep Klaas, Buckle, Tessa, Roestenberg, Meta, van Leeuwen, Fijs W. B

“…Cyclodextrin (CD)-based host–guest interactions with adamantane (Ad) have demonstrated use for functionalizing living cells in vitro. The next step in this…”
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Tracers for Fluorescence-Guided Surgery: How Elongation of the Polymethine Chain in Cyanine Dyes Alters the Pharmacokinetics of a Dual-Modality c[RGDyK] Tracer by Buckle, Tessa, van Willigen, Danny M, Spa, Silvia J, Hensbergen, Albertus W, van der Wal, Steffen, de Korne, Clarize M, Welling, Mick M, van der Poel, Henk G, Hardwick, James C H, van Leeuwen, Fijs W B

“…The potential of receptor-mediated fluorescence-based image-guided surgery tracers is generally linked to the near-infrared emission profile and…”
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Tailoring Fluorescent Dyes To Optimize a Hybrid RGD-Tracer by Bunschoten, Anton, van Willigen, Danny M, Buckle, Tessa, van den Berg, Nynke S, Welling, Mick M, Spa, Silvia J, Wester, Hans-Jürgen, van Leeuwen, Fijs W. B

“…Quantitative assessment of affinity and kinetics is a critical component in the development of (receptor-targeted) radiotracers. For fluorescent tracers, such…”
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Chemically augmented malaria sporozoites display an altered immunogenic profile by Duszenko, Nikolas, van Schuijlenburg, Roos, Chevalley-Maurel, Severine, van Willigen, Danny M., de Bes-Roeleveld, Laura, van der Wees, Stefanie, Naar, Chanel, Baalbergen, Els, Heieis, Graham, Bunschoten, Anton, Velders, Aldrik H., Franke-Fayard, Blandine, van Leeuwen, Fijs W. B., Roestenberg, Meta

“…Despite promising results in malaria-naïve individuals, whole sporozoite (SPZ) vaccine efficacy in malaria-endemic settings has been suboptimal. Vaccine…”
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Intraoperative visualization of nerves using a myelin protein-zero specific fluorescent tracer by Buckle, Tessa, Hensbergen, Albertus. W., van Willigen, Danny M., Bosse, Frank, Bauwens, Kevin, Pelger, Rob C. M., van Leeuwen, Fijs W. B.

“…Background Surgically induced nerve damage is a common but debilitating side effect in oncological surgery. With the aim to use fluorescence guidance to enable…”
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Bioorthogonally Applicable Fluorescence Deactivation Strategy for Receptor Kinetics Study and Theranostic Pretargeting Approaches by van der Wal, Steffen, de Korne, Clarize M., Sand, Laurens G. L., van Willigen, Danny M., Hogendoorn, Pancras C. W., Szuhai, Karoly, van Leeuwen, Fijs W. B., Buckle, Tessa

“…The availability of a receptor for theranostic pretargeting approaches was assessed by use of a new click‐chemistry‐based deactivatable fluorescence‐quenching…”
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Multispectral-Fluorescence Imaging as a Tool to Separate Healthy from Disease-Related Lymphatic Anatomy During Robot-Assisted Laparoscopy by Meershoek, Philippa, KleinJan, Gijs H, van Oosterom, Matthias N, Wit, Esther M K, van Willigen, Danny M, Bauwens, Kevin P, van Gennep, Erik J, Mottrie, Alexandre M, van der Poel, Henk G, van Leeuwen, Fijs W B

“…To reduce the invasive nature of extended pelvic lymph node (LN) dissections in prostate cancer, we have developed a multispectral-fluorescence guidance…”
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Fluorescence background quenching as a means to increase Signal to Background ratio - a proof of concept during Nerve Imaging by Buckle, Tessa, van der Wal, Steffen, van Willigen, Danny M., Aalderink, Germaine, KleinJan, Gijs H., van Leeuwen, Fijs W.B.

“…Introduction: Adequate signal to background ratios are critical for the implementation of fluorescence-guided surgery technologies. While local tracer…”
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Obtaining control of cell surface functionalizations via Pre-targeting and Supramolecular host guest interactions by Rood, Mark T. M., Spa, Silvia J., Welling, Mick M., ten Hove, Jan Bart, van Willigen, Danny M., Buckle, Tessa, Velders, Aldrik H., van Leeuwen, Fijs W. B.

“…The use of mammalian cells for therapeutic applications is finding its way into modern medicine. However, modification or “training” of cells to make them…”
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Multi-wavelength fluorescence imaging with a da Vinci Firefly—a technical look behind the scenes by Meershoek, Philippa, KleinJan, Gijs H., van Willigen, Danny M., Bauwens, Kevin P., Spa, Silvia J., van Beurden, Florian, van Gennep, Erik J., Mottrie, Alexandre M., van der Poel, Henk G., Buckle, T., van Leeuwen, Fijs W. B., van Oosterom, Matthias N.

“…The field of fluorescence-guided surgery builds on colored fluorescent tracers that have become available for different clinical applications. Combined use of…”
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A Truncated 14-Amino-Acid Myelin Protein-Zero-Targeting Peptide for Fluorescence-Guided Nerve-Preserving Surgery by Berehova, Nataliia, van Meerbeek, Maarten P, Azargoshasb, Samaneh, van Willigen, Danny M, Slof, Leon J, Navaei Lavasani, Saaedeh, van Oosterom, Matthias N, van Leeuwen, Fijs W B, Buckle, Tessa

“…The occurrence of accidental nerve damage during surgery and the increasing application of image guidance during head-and-neck surgery have highlighted the…”
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