Search Results - "Willies, Simon C"

Engineering an Enantioselective Amine Oxidase for the Synthesis of Pharmaceutical Building Blocks and Alkaloid Natural Products by Ghislieri, Diego, Green, Anthony P, Pontini, Marta, Willies, Simon C, Rowles, Ian, Frank, Annika, Grogan, Gideon, Turner, Nicholas J

“…The development of cost-effective and sustainable catalytic methods for the production of enantiomerically pure chiral amines is a key challenge facing the…”
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Monoamine Oxidase (MAO-N) Catalyzed Deracemization of Tetrahydro-β-carbolines: Substrate Dependent Switch in Enantioselectivity by Ghislieri, Diego, Houghton, Deborah, Green, Anthony P, Willies, Simon C, Turner, Nicholas J

“…The tetrahydro-β-carboline (THBC) ring system is an important structural motif found in a large number of bioactive alkaloid natural products. Herein we report…”
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Engineering of phenylalanine ammonia lyase from Rhodotorula graminis for the enhanced synthesis of unnatural l-amino acids by Rowles, Ian, Groenendaal, Bas, Binay, Baris, Malone, Kirk J., Willies, Simon C., Turner, Nicholas J.

“…Phenylalanine ammonia lyase (PAL) catalyses the reversible non-oxidative deamination of phenylalanine to trans-cinnamic acid and ammonia. Analogues of…”
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Glycoprotein Labeling Using Engineered Variants of Galactose Oxidase Obtained by Directed Evolution by Rannes, Julie B, Ioannou, Avgousta, Willies, Simon C, Grogan, Gideon, Behrens, Carsten, Flitsch, Sabine L, Turner, Nicholas J

“…A directed evolution approach has been used for the generation of variants of galactose oxidase (GOase) that can selectively oxidize glycans on glycoproteins…”
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Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers by Staniland, Samantha, Yuan, Bo, Giménez-Agulló, Nelson, Marcelli, Tommaso, Willies, Simon C., Grainger, Damian M., Turner, Nicholas J., Clayden, Jonathan

“…Atropisomeric biaryls carrying ortho‐hydroxymethyl and formyl groups were made enantioselectively by desymmetrisation of dialdehyde or diol substrates. The…”
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A stereospecific solid-phase screening assay for colonies expressing both (R)- and (S)-selective ω-aminotransferases by Willies, Simon C., Galman, James L., Slabu, Iustina, Turner, Nicholas J.

“…A novel solid-phase screening assay was developed for colonies expressing both (R)- and (S)-selective ω-aminotransferases. This high-throughput assay can be…”
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Biocatalytic Desymmetrization of an Atropisomer with both an Enantioselective Oxidase and Ketoreductases by Yuan, Bo, Page, Abigail, Worrall, Christopher P, Escalettes, Franck, Willies, Simon C, McDouall, Joseph J.W, Turner, Nicholas J, Clayden, Jonathan

“…All roads lead to …︁ atropisomeric diaryl ethers containing a benzylic hydroxy group and an aldehyde unit. The isomers were synthesized in enantiomerically…”
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Directed Evolution of the Enzyme Monoamine Oxidase (MAO-N): Highly Efficient Chemo-enzymatic Deracemisation of the Alkaloid (±)-CrispineA by Rowles, Ian, Malone, Kirk J, Etchells, Laura L, Willies, Simon C, Turner, Nicholas J

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Development of a high-throughput screening method for racemase activity and its application to the identification of alanine racemase variants with activity towards l-arginine by Willies, Simon C., White, Jemma L., Turner, Nicholas J.

“…A high-throughput solid phase screening method has been developed for alanine racemase. Conversion of an l-amino acid to the d-amino acid is detected by a…”
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binding of haem and zinc in the 1.9 Å X-ray structure of Escherichia coli bacterioferritin by Willies, Simon C, Isupov, Michail N, Garman, Elspeth F, Littlechild, Jennifer A

“…The crystal structure of Escherichia coli bacterioferritin has been solved to 1.9 Å, and shows the symmetrical binding of a haem molecule on the local twofold…”
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Directed Evolution of the Enzyme Monoamine Oxidase (MAO-N): Highly Efficient Chemo-enzymatic Deracemisation of the Alkaloid (±)-Crispine A by Rowles, Ian, Malone, Kirk J., Etchells, Laura L., Willies, Simon C., Turner, Nicholas J.

“…Crispine, at the double! Modification of the active site of the enzyme monoamine oxidase (MAO‐N) allows the efficient deracemisation of the alkaloid crispine…”
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A stereospecific solid-phase screening assay for colonies expressing both (R)- and (S)-selective ω-aminotransferases by Willies, Simon C., Galman, James L., Slabu, Iustina, Turner, Nicholas J.

“…A novel solid-phase screening assay was developed for colonies expressing both (R)- and (S)-selective ω-aminotransferases. This high-throughput assay can be…”
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Biocatalytic Desymmetrization of an Atropisomer with both an Enantioselective Oxidase and Ketoreductases by Yuan, Bo, Page, Abigail, Worrall, Christopher P., Escalettes, Franck, Willies, Simon C., McDouall, Joseph J. W., Turner, Nicholas J., Clayden, Jonathan

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Biocatalytic Desymmetrization of an Atropisomer with both an Enantioselective Oxidase and Ketoreductases by Yuan, Bo, Page, Abigail, Worrall, Christopher P., Escalettes, Franck, Willies, Simon C., McDouall, Joseph J. W., Turner, Nicholas J., Clayden, Jonathan

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Biocatalytic Desymmetrization of an Atropisomer with both an Enantioselective Oxidase and Ketoreductases by Yuan, Bo, Page, Abigail, Worrall, Christopher P., Escalettes, Franck, Willies, Simon C., McDouall, Joseph J. W., Turner, Nicholas J., Clayden, Jonathan

“…Alle Wege führen zu …︁ atropisomeren Diarylethern mit einer benzylischen Hydroxygruppe und einer Aldehydeinheit. Die Isomere wurden enantiomerenangereichert…”
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