Search Results - "Willie, Chris K."
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UBC‐Nepal expedition: phenotypical evidence for evolutionary adaptation in the control of cerebral blood flow and oxygen delivery at high altitude
Published in The Journal of physiology (01-06-2019)“…Key points Sherpa have lived in the Nepal Himalaya for 25–40 thousand years and display positive physiological adaptations to hypoxia. Sherpa have previously…”
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Cerebrovascular Regulation During Transient Hypotension and Hypertension in Humans
Published in Hypertension (Dallas, Tex. 1979) (01-08-2010)“…The cerebrovasculature dilates or constricts in response to acute blood pressure changes to stabilize cerebral blood flow across a range of blood pressures. It…”
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Indomethacin‐induced impairment of regional cerebrovascular reactivity: implications for respiratory control
Published in The Journal of physiology (01-03-2015)“…Key points Anterior and posterior cerebral circulations have differential reactivity to changes in arterial blood gases, but the implications for the…”
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Fundamental relationships between arterial baroreflex sensitivity and dynamic cerebral autoregulation in humans
Published in Journal of applied physiology (1985) (01-05-2010)“…The functional relationship between dynamic cerebral autoregulation (CA) and arterial baroreflex sensitivity (BRS) in humans is unknown. Given that adequate…”
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The effect of α1‐adrenergic blockade on post‐exercise brachial artery flow‐mediated dilatation at sea level and high altitude
Published in The Journal of physiology (01-03-2017)“…Key points Our objective was to quantify endothelial function (via brachial artery flow‐mediated dilatation) at sea level (344 m) and high altitude (3800 m) at…”
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Initial orthostatic hypotension is unrelated to orthostatic tolerance in healthy young subjects
Published in Journal of applied physiology (1985) (01-08-2009)“…1 Department of Physiology, 2 School of Physical Education, and 3 Department of Medical and Surgical Sciences, University of Otago, Dunedin, New Zealand; and 4…”
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Chemoreceptor Responsiveness at Sea Level Does Not Predict the Pulmonary Pressure Response to High Altitude
Published in Chest (01-07-2015)“…BACKGROUND The hypoxic ventilatory response (HVR) at sea level (SL) is moderately predictive of the change in pulmonary artery systolic pressure (PASP) to…”
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Contribution of arterial Windkessel in low-frequency cerebral hemodynamics during transient changes in blood pressure
Published in Journal of applied physiology (1985) (01-04-2011)“…The Windkessel properties of the vasculature are known to play a significant role in buffering arterial pulsations, but their potential importance in dampening…”
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Interactions between heart rate variability and pulmonary gas exchange efficiency in humans
Published in Experimental physiology (01-07-2010)“…The respiratory component of heart rate variability (respiratory sinus arrhythmia, RSA) has been associated with improved pulmonary gas exchange efficiency in…”
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Role of cerebral blood flow in extreme breath holding
Published in Translational neuroscience (01-01-2016)“…The role of cerebral blood flow (CBF) on a maximal breath-hold (BH) in ultra-elite divers was examined. Divers (n = 7) performed one control BH, and one BH…”
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Appropriate within-subjects statistical models for the analysis of baroreflex sensitivity
Published in Clinical physiology and functional imaging (01-01-2011)“…Summary An individual’s baroreflex sensitivity is typically described by the relationship between serial manipulations in systolic blood pressure and the…”
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End tidal-to-arterial CO2 and O2 gas gradients at low- and high-altitude during dynamic end-tidal forcing
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01-06-2015)“…We sought to characterize and quantify the performance of a portable dynamic end-tidal forcing (DEF) system in controlling the partial pressure of arterial CO2…”
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Muscle sympathetic reactivity to apneic and exercise stress in high-altitude Sherpa
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01-03-2020)“…Lowland-dwelling populations exhibit persistent sympathetic hyperactivity at altitude that alters vascular function. High-altitude populations, such as Sherpa,…”
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The effect of α 1 -adrenergic blockade on post-exercise brachial artery flow-mediated dilatation at sea level and high altitude
Published in The Journal of physiology (01-03-2017)“…Our objective was to quantify endothelial function (via brachial artery flow-mediated dilatation) at sea level (344 m) and high altitude (3800 m) at rest and…”
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Baroreflex, cerebral perfusion, and stroke: integrative physiology at its best
Published in Stroke (1970) (01-05-2010)Get full text
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Influence of posture on the regulation of cerebral perfusion
Published in Aviation, space, and environmental medicine (01-08-2012)“…Posture has a major influence on cerebral blood flow (CBF). Unlike head-up tilt (HUT), less is known about how CBF is regulated during head-down tilt (HDT). We…”
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The effect of alpha sub(1)-adrenergic blockade on post-exercise brachial artery flow-mediated dilatation at sea level and high altitude
Published in The Journal of physiology (01-03-2017)“…Key points * Our objective was to quantify endothelial function (via brachial artery flow-mediated dilatation) at sea level (344 m) and high altitude (3800 m)…”
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The effect of [alpha]1-adrenergic blockade on post-exercise brachial artery flow-mediated dilatation at sea level and high altitude
Published in The Journal of physiology (01-03-2017)“…Key points Our objective was to quantify endothelial function (via brachial artery flow-mediated dilatation) at sea level (344 m) and high altitude (3800 m) at…”
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Cerebral blood flow velocity during passive heat stress in man: influence of stroke volume
Published in The FASEB journal (01-04-2011)“…Cerebral blood flow velocity is reduced during heat stress with 50% of this reduction due to hyperventilatory‐induced hypocapnia and subsequent cerebral…”
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