Search Results - "Williard, Robin L"

THE ROLE OF THE POLYMORPHIC EFFLUX TRANSPORTER P-GLYCOPROTEIN ON THE BRAIN ACCUMULATION OF d-METHYLPHENIDATE AND d-AMPHETAMINE by ZHU, Hao-Jie, WANG, Jun-Sheng, LINDSAY DEVANE, C, WILLIARD, Robin L, DONOVAN, Jennifer L, MIDDAUGH, Lawrence D, GIBSON, Brian B, PATRICK, Kennerly S, MARKOWITZ, John S

“…The psychostimulant medications methylphenidate (MPH) and amphetamine (AMP), available in various ratios or enantiopure formulations of their respective active…”
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Methylphenidate and its ethanol transesterification metabolite ethylphenidate: brain disposition, monoamine transporters and motor activity by Williard, Robin L, Middaugh, Lawrence D, Zhu, Hao-Jie B, Patrick, Kennerly S

“…Ethylphenidate is formed by metabolic transesterification of methylphenidate and ethanol. Study objectives were to (a) establish that ethylphenidate is formed…”
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Synthesis and Pharmacology of Ethylphenidate Enantiomers:  The Human Transesterification Metabolite of Methylphenidate and Ethanol by Patrick, Kennerly S, Williard, Robin L, VanWert, Adam L, Dowd, Justin J, Oatis, John E, Middaugh, Lawrence D

“…Ethanol elevates methylphenidate (1) plasma concentrations and yields the metabolite ethylphenidate (2). The therapeutic implications are under investigation…”
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