Search Results - "Williamson, Elizabeth"

Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals by Williamson, Elizabeth M., Liu, Xinmin, Izzo, Angelo A.

“…The nutraceuticals market is vast, encompassing many different products with inconsistent levels of evidence available to support their use. This overview…”
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A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies by Izzo, Angelo A., Hoon-Kim, Sung, Radhakrishnan, Rajan, Williamson, Elizabeth M.

“…Systematic reviews and meta‐analyses represent the uppermost ladders in the hierarchy of evidence. Systematic reviews/meta‐analyses suggest preliminary or…”
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Introduction to propensity scores by Williamson, Elizabeth J., Forbes, Andrew

“…Although randomization provides a gold‐standard method of assessing causal relationships, it is not always possible to randomly allocate exposures. Where…”
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Drugging the Cancers Addicted to DNA Repair by Nickoloff, Jac A, Jones, Dennie, Lee, Suk-Hee, Williamson, Elizabeth A, Hromas, Robert

“…Defects in DNA repair can result in oncogenic genomic instability. Cancers occurring from DNA repair defects were once thought to be limited to rare inherited…”
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Variance reduction in randomised trials by inverse probability weighting using the propensity score by Williamson, Elizabeth J., Forbes, Andrew, White, Ian R.

“…In individually randomised controlled trials, adjustment for baseline characteristics is often undertaken to increase precision of the treatment effect…”
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Factors associated with COVID-19-related death using OpenSAFELY by Williamson, Elizabeth J., Walker, Alex J., Bhaskaran, Krishnan, Bacon, Seb, Bates, Chris, Morton, Caroline E., Curtis, Helen J., Mehrkar, Amir, Evans, David, Inglesby, Peter, Cockburn, Jonathan, McDonald, Helen I., MacKenna, Brian, Tomlinson, Laurie, Douglas, Ian J., Rentsch, Christopher T., Mathur, Rohini, Wong, Angel Y. S., Grieve, Richard, Harrison, David, Forbes, Harriet, Schultze, Anna, Croker, Richard, Parry, John, Hester, Frank, Harper, Sam, Perera, Rafael, Evans, Stephen J. W., Smeeth, Liam, Goldacre, Ben

“…Coronavirus disease 2019 (COVID-19) has rapidly affected mortality worldwide 1 . There is unprecedented urgency to understand who is most at risk of severe…”
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Resistance to the BCL-XL degrader DT2216 in T-cell acute lymphoblastic leukemia is rare and correlates with decreased BCL-XL proteolysis by Jaiswal, Arunima, Jaiswal, Aruna, Williamson, Elizabeth A., Gelfond, Jonathon, Zheng, Guangrong, Zhou, Daohong, Hromas, Robert

“…Purpose The BCL-2 family of anti-apoptotic proteins, BCL-2, BCL-XL and MCL-1, can mediate survival of some types of cancer. DT2216 is a PROteolysis-TArgeting…”
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Common Methods for Handling Missing Data in Marginal Structural Models: What Works and Why by Leyrat, Clémence, Carpenter, James R, Bailly, Sébastien, Williamson, Elizabeth J

“…Abstract Marginal structural models (MSMs) are commonly used to estimate causal intervention effects in longitudinal nonrandomized studies. A common challenge…”
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Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study by Clift, Ash K, Coupland, Carol A C, Keogh, Ruth H, Diaz-Ordaz, Karla, Williamson, Elizabeth, Harrison, Ewen M, Hayward, Andrew, Hemingway, Harry, Horby, Peter, Mehta, Nisha, Benger, Jonathan, Khunti, Kamlesh, Spiegelhalter, David, Sheikh, Aziz, Valabhji, Jonathan, Lyons, Ronan A, Robson, John, Semple, Malcolm G, Kee, Frank, Johnson, Peter, Jebb, Susan, Williams, Tony, Hippisley-Cox, Julia

“…AbstractObjectiveTo derive and validate a risk prediction algorithm to estimate hospital admission and mortality outcomes from coronavirus disease 2019…”
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Ethnic differences in SARS-CoV-2 infection and COVID-19-related hospitalisation, intensive care unit admission, and death in 17 million adults in England: an observational cohort study using the OpenSAFELY platform by Mathur, Rohini, Rentsch, Christopher T, Morton, Caroline E, Hulme, William J, Schultze, Anna, MacKenna, Brian, Eggo, Rosalind M, Bhaskaran, Krishnan, Wong, Angel Y S, Williamson, Elizabeth J, Forbes, Harriet, Wing, Kevin, McDonald, Helen I, Bates, Chris, Bacon, Seb, Walker, Alex J, Evans, David, Inglesby, Peter, Mehrkar, Amir, Curtis, Helen J, DeVito, Nicholas J, Croker, Richard, Drysdale, Henry, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, Douglas, Ian J, Tomlinson, Laurie, Evans, Stephen J W, Grieve, Richard, Harrison, David, Rowan, Kathy, Khunti, Kamlesh, Chaturvedi, Nishi, Smeeth, Liam, Goldacre, Ben

“…COVID-19 has disproportionately affected minority ethnic populations in the UK. Our aim was to quantify ethnic differences in SARS-CoV-2 infection and COVID-19…”
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Annual High-Dose Oral Vitamin D and Falls and Fractures in Older Women: A Randomized Controlled Trial by Sanders, Kerrie M, Stuart, Amanda L, Williamson, Elizabeth J, Simpson, Julie A, Kotowicz, Mark A, Young, Doris, Nicholson, Geoffrey C

“…CONTEXT Improving vitamin D status may be an important modifiable risk factor to reduce falls and fractures; however, adherence to daily supplementation is…”
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Propensity scores: From naïve enthusiasm to intuitive understanding by Williamson, Elizabeth, Morley, Ruth, Lucas, Alan, Carpenter, James

“…Estimation of the effect of a binary exposure on an outcome in the presence of confounding is often carried out via outcome regression modelling. An…”
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An evaluation of inverse probability weighting using the propensity score for baseline covariate adjustment in smaller population randomised controlled trials with a continuous outcome by Raad, Hanaya, Cornelius, Victoria, Chan, Susan, Williamson, Elizabeth, Cro, Suzie

“…It is important to estimate the treatment effect of interest accurately and precisely within the analysis of randomised controlled trials. One way to increase…”
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Tuberculosis in migrants moving from high-incidence to low-incidence countries: a population-based cohort study of 519 955 migrants screened before entry to England, Wales, and Northern Ireland by Aldridge, Robert W, Dr, Zenner, Dominik, MD, White, Peter J, PhD, Williamson, Elizabeth J, PhD, Muzyamba, Morris C, PhD, Dhavan, Poonam, MPH, Mosca, Davide, MD, Thomas, H Lucy, MFPH, Lalor, Maeve K, PhD, Abubakar, Ibrahim, Prof, Hayward, Andrew C, Prof

“…Summary Background Tuberculosis elimination in countries with a low incidence of the disease necessitates multiple interventions, including innovations in…”
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Astaxanthin: How much is too much? A safety review by Brendler, Thomas, Williamson, Elizabeth Mary

“…Astaxanthin (AX)‐containing preparations are increasingly popular as health food supplements. Evaluating the maximum safe daily intake of AX is important when…”
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Catastrophic Decline of World's Largest Primate: 80% Loss of Grauer's Gorilla (Gorilla beringei graueri) Population Justifies Critically Endangered Status by Plumptre, Andrew J, Nixon, Stuart, Kujirakwinja, Deo K, Vieilledent, Ghislain, Critchlow, Rob, Williamson, Elizabeth A, Nishuli, Radar, Kirkby, Andrew E, Hall, Jefferson S

“…Grauer's gorilla (Gorilla beringei graueri), the World's largest primate, is confined to eastern Democratic Republic of Congo (DRC) and is threatened by civil…”
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Experience in optimizing fertility outcomes in men with congenital adrenal hyperplasia due to 21 hydroxylase deficiency by King, Thomas F.J., Lee, Marilyn Cheng, Williamson, Elizabeth E.J., Conway, Gerard S.

“…Summary Objective Men with congenital adrenal hyperplasia (CAH) have impaired fertility. We aimed to assess fertility outcomes and the importance of…”
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The rise of traditional Chinese medicine and its materia medica: A comparison of the frequency and safety of materials and species used in Europe and China by Williamson, Elizabeth M., Lorenc, Ava, Booker, Anthony, Robinson, Nicola

“…Due to the global rise in the use of traditional Chinese medicine (TCM), Chinese materia medica (medicinal materials, or CMM) are giving cause for concern over…”
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The use of phylogeny to interpret cross-cultural patterns in plant use and guide medicinal plant discovery: an example from Pterocarpus (Leguminosae) by Saslis-Lagoudakis, C Haris, Klitgaard, Bente B, Forest, Félix, Francis, Louise, Savolainen, Vincent, Williamson, Elizabeth M, Hawkins, Julie A

“…The study of traditional knowledge of medicinal plants has led to discoveries that have helped combat diseases and improve healthcare. However, the development…”
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Planning a method for covariate adjustment in individually randomised trials: a practical guide by Morris, Tim P, Walker, A Sarah, Williamson, Elizabeth J, White, Ian R

“…It has long been advised to account for baseline covariates in the analysis of confirmatory randomised trials, with the main statistical justifications being…”
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