Search Results - "Williamson, Anthony"

Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies by Jones, Harrison G, Ritschel, Tina, Pascual, Gabriel, Brakenhoff, Just P J, Keogh, Elissa, Furmanova-Hollenstein, Polina, Lanckacker, Ellen, Wadia, Jehangir S, Gilman, Morgan S A, Williamson, R Anthony, Roymans, Dirk, van 't Wout, Angélique B, Langedijk, Johannes P, McLellan, Jason S

“…Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections in infants and the elderly, and yet there remains no effective…”
Get full text

A Broadly Neutralizing Human Monoclonal Antibody Exhibits In Vivo Efficacy Against Both Human Metapneumovirus and Respiratory Syncytial Virus by Schuster, Jennifer E., Cox, Reagan G., Hastings, Andrew K., Boyd, Kelli L., Wadia, Jay, Chen, Zhifeng, Burton, Dennis R., Williamson, R. Anthony, Williams, John V.

“…Background. Human metapneumovirus (HMPV) is a leading cause of acute respiratory tract infection, with significant morbidity and mortality. No licensed…”
Get full text

Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity by Zhang, Xue-Song, Li, Jackie, Krautkramer, Kimberly A, Badri, Michelle, Battaglia, Thomas, Borbet, Timothy C, Koh, Hyunwook, Ng, Sandy, Sibley, Rachel A, Li, Yuanyuan, Pathmasiri, Wimal, Jindal, Shawn, Shields-Cutler, Robin R, Hillmann, Ben, Al-Ghalith, Gabriel A, Ruiz, Victoria E, Livanos, Alexandra, van 't Wout, Angélique B, Nagalingam, Nabeetha, Rogers, Arlin B, Sumner, Susan Jenkins, Knights, Dan, Denu, John M, Li, Huilin, Ruggles, Kelly V, Bonneau, Richard, Williamson, R Anthony, Rauch, Marcus, Blaser, Martin J

“…The early-life intestinal microbiota plays a key role in shaping host immune system development. We found that a single early-life antibiotic course (1PAT)…”
Get full text

Selective Incorporation of Polyanionic Molecules into Hamster Prions by Geoghegan, James C., Valdes, Pablo A., Orem, Nicholas R., Deleault, Nathan R., Williamson, R. Anthony, Harris, Brent T., Supattapone, Surachai

“…The central pathogenic event of prion disease is the conformational conversion of a host protein, PrPC, into a pathogenic isoform, PrPSc. We previously showed…”
Get full text

Immunological memory to hyperphosphorylated tau in asymptomatic individuals by Pascual, Gabriel, Wadia, Jehangir S., Zhu, Xueyong, Keogh, Elissa, Kükrer, Başak, van Ameijde, Jeroen, Inganäs, Hanna, Siregar, Berdien, Perdok, Gerrard, Diefenbach, Otto, Nahar, Tariq, Sprengers, Imke, Koldijk, Martin H., der Linden, Els C. Brinkman-van, Peferoen, Laura A., Zhang, Heng, Yu, Wenli, Li, Xinyi, Wagner, Michelle, Moreno, Veronica, Kim, Julie, Costa, Martha, West, Kiana, Fulton, Zara, Chammas, Lucy, Luckashenak, Nancy, Fletcher, Lauren, Holland, Trevin, Arnold, Carrie, Anthony Williamson, R., Hoozemans, Jeroen J., Apetri, Adrian, Bard, Frederique, Wilson, Ian A., Koudstaal, Wouter, Goudsmit, Jaap

“…Several reports have described the presence of antibodies against Alzheimer’s disease-associated hyperphosphorylated forms of tau in serum of healthy…”
Get full text

Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid by Owens, Gregory P., Bennett, Jeffrey L., Lassmann, Hans, O'Connor, Kevin C., Ritchie, Alanna M., Shearer, Andrew, Lam, Chiwah, Yu, Xiaoli, Birlea, Marius, DuPree, Cecily, Williamson, R. Anthony, Hafler, David A., Burgoon, Mark P., Gilden, Don

“…Objective Intrathecal IgG synthesis, persistence of bands of oligoclonal IgG, and memory B‐cell clonal expansion are well‐characterized features of the humoral…”
Get full text

High Titers of Transmissible Spongiform Encephalopathy Infectivity Associated with Extremely Low Levels of PrPSc in Vivo by Barron, Rona M, Campbell, Susan L, King, Declan, Bellon, Anne, Chapman, Karen E, Williamson, R. Anthony, Manson, Jean C

“…Diagnosis of transmissible spongiform encephalopathy (TSE) disease in humans and ruminants relies on the detection in post-mortem brain tissue of the…”
Get full text

Pathologic prion protein infects cells by lipid-raft dependent macropinocytosis by Wadia, Jehangir S, Schaller, Monica, Williamson, R Anthony, Dowdy, Steven F

“…Transmissible spongiform encephalopathies, including variant-Creutzfeldt-Jakob disease (vCJD) in humans and bovine spongiform encephalopathies in cattle, are…”
Get full text

Protease-resistant Prion Protein Amplification Reconstituted with Partially Purified Substrates and Synthetic Polyanions by Deleault, Nathan R., Geoghegan, James C., Nishina, Koren, Kascsak, Richard, Williamson, R. Anthony, Supattapone, Surachai

“…Little is currently known about the biochemical mechanism by which induced prion protein (PrP) conformational change occurs during mammalian prion propagation…”
Get full text

Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis In vivo by Solforosi, Laura, Criado, Jose R., McGavern, Dorian B., Wirz, Sebastian, Sánchez-Alavez, Manuel, Sugama, Shuei, DeGiorgio, Lorraine A., Volpe, Bruce T., Wiseman, Erika, Abalos, Gil, Masliah, Eliezer, Gilden, Donald, Oldstone, Michael B., Conti, Bruno, Williamson, R. Anthony

“…Neuronal death is a prominent, but poorly understood, pathological hallmark of prion disease. Notably, in the absence of the cellular prion protein PrPC), the…”
Get full text

Toward Molecular Dissection of PrPC-PrPSc Interactions by Solforosi, Laura, Bellon, Anne, Schaller, Monica, Cruite, Justin T., Abalos, Gil C., Williamson, R. Anthony

“…Direct interaction between endogenous cellular prion protein (PrPC) and misfolded, disease-associated (PrPSc) conformers is a key event in prion propagation,…”
Get full text

Antibodies inhibit prion propagation and clear cell cultures of prion infectivity by Williamson, R. Anthony, Peretz, David, Kaneko, Kiotoshi, Vergara, Julie, Leclerc, Estelle, Schmitt-Ulms, Gerold, Mehlhorn, Ingrid R, Legname, Giuseppe, Wormald, Mark R, Rudd, Pauline M, Dwek, Raymond A, Burton, Dennis R, Prusiner, Stanley B

“…Prions are the transmissible pathogenic agents responsible for diseases such as scrapie and bovine spongiform encephalopathy. In the favoured model of prion…”
Get full text

Trafficking of Prion Proteins through a Caveolae-Mediated Endosomal Pathway by Peters, Peter J., Mironov, Alexander, Peretz, David, van Donselaar, Elly, Leclerc, Estelle, Erpel, Susanne, DeArmond, Stephen J., Burton, Dennis R., Williamson, R. Anthony, Vey, Martin, Prusiner, Stanley B.

“…To understand the posttranslational conversion of the cellular prion protein (PrPC) to its pathologic conformation, it is important to define the intracellular…”
Get full text

Directed Evolution of an Anti-prion Protein scFv Fragment to an Affinity of 1 pM and its Structural Interpretation by Luginbühl, Béatrice, Kanyo, Zoltan, Jones, R. Mark, Fletterick, Robert J., Prusiner, Stanley B., Cohen, Fred E., Williamson, R. Anthony, Burton, Dennis R., Plückthun, Andreas

“…Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative prion disease affecting cattle that is transmissible to humans, manifesting as a variant of…”
Get full text

Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice by Burton, Dennis R, Prusiner, Stanley B, Safar, Jiri G, Scott, Michael, Monaghan, Jeff, Deering, Camille, Didorenko, Svetlana, Vergara, Julie, Ball, Haydn, Legname, Giuseppe, Leclerc, Estelle, Solforosi, Laura, Serban, Hana, Groth, Darlene, Williamson, R. Anthony

“…There is increasing concern over the extent to which bovine spongiform encephalopathy (BSE) prions have been transmitted to humans, as a result of the rising…”
Get full text

A Recombinant Human Monoclonal Antibody to Human Metapneumovirus Fusion Protein That Neutralizes Virus In Vitro and Is Effective Therapeutically In Vivo by WILLIAMS, John V, ZHIFENG CHEN, BURTON, Dennis R, CROWE, James E, WILLIAMSON, R. Anthony, CSEKE, Gabriella, WRIGHT, David W, KEEFER, Christopher J, TOLLEFSON, Sharon J, HESSELL, Ann, PODSIAD, Amy, SHEPHERD, Bryan E, PAOLO SANNA, Pietro

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Calpain-dependent Endoproteolytic Cleavage of PrPSc Modulates Scrapie Prion Propagation by Yadavalli, Rajgopal, Guttmann, Rodney P, Seward, Tanya, Centers, Adrian P, Williamson, R Anthony, Telling, Glenn C

“…Previous studies using post-mortem human brain extracts demonstrated that PrP in Creutzfeldt-Jakob disease (CJD) brains is cleaved by a cellular protease to…”
Get full text

Probing the Conformation of the Prion Protein within a Single Amyloid Fibril Using a Novel Immunoconformational Assay by Novitskaya, Vera, Makarava, Natallia, Bellon, Anne, Bocharova, Olga V., Bronstein, Igor B., Williamson, R. Anthony, Baskakov, Ilia V.

“…The coexistence of multiple strains or subtypes of the disease-related isoform of prion protein (PrP) in natural isolates, together with the observed…”
Get full text

Lack of Prion Infectivity in Fixed Heart Tissue from Patients with Creutzfeldt-Jakob Disease or Amyloid Heart Disease by Priola, Suzette A, Ward, Anne E, McCall, Sherman A, Trifilo, Matthew, Choi, Young Pyo, Solforosi, Laura, Williamson, R Anthony, Cruite, Justin T, Oldstone, Michael B A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Motif-Grafted Antibodies Containing the Replicative Interface of Cellular PrP Are Specific for PrPSc by Moroncini, Gianluca, Kanu, Nnennaya, Solforosi, Laura, Abalos, Gil, Telling, Glenn C., Head, Mark, Ironside, James, Brockes, Jeremy P., Burton, Dennis R., Williamson, R. Anthony, Chanock, Robert M.

“…Prion diseases are closely associated with the conversion of the cellular prion protein ( PrPC) to an abnormal conformer ( PrPSc) [Prusiner, S. B. (1998) Proc…”
Get full text