Search Results - "Williamson, Anna‐Lise"
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Recent Developments in Human Papillomavirus (HPV) Vaccinology
Published in Viruses (26-06-2023)“…Human papillomavirus (HPV) is causally associated with 5% of cancers, including cancers of the cervix, penis, vulva, vagina, anus and oropharynx. The most…”
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Production of complex viral glycoproteins in plants as vaccine immunogens
Published in Plant biotechnology journal (01-09-2018)“…Summary Plant molecular farming offers a cost‐effective and scalable approach to the expression of recombinant proteins which has been proposed as an…”
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Co‐expression of human calreticulin significantly improves the production of HIV gp140 and other viral glycoproteins in plants
Published in Plant biotechnology journal (01-10-2020)“…Summary Plant molecular farming (PMF) is rapidly gaining traction as a viable alternative to the currently accepted paradigm of producing biologics. While the…”
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Comparative analysis of avian poxvirus genomes, including a novel poxvirus from lesser flamingos (Phoenicopterus minor), highlights the lack of conservation of the central region
Published in BMC genomics (06-12-2017)“…Avian poxviruses are important pathogens of both wild and domestic birds. To date, seven isolates from subclades A and B and one from proposed subclade E, have…”
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Augmenting glycosylation‐directed folding pathways enhances the fidelity of HIV Env immunogen production in plants
Published in Biotechnology and bioengineering (01-10-2022)“…Heterologous glycoprotein production relies on host glycosylation‐dependent folding. When the biosynthetic machinery differs from the usual expression host,…”
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Recombination Between High-Risk Human Papillomaviruses and Non-Human Primate Papillomaviruses: Evidence of Ancient Host Switching Among Alphapapillomaviruses
Published in Journal of molecular evolution (01-07-2020)“…We use all the currently known 405 Papillomavirus (PV) sequences, 343 curated PV sequences from both humans and animals from the PAVE data base, to analyse the…”
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Predictive functional analysis reveals inferred features unique to cervicovaginal microbiota of African women with bacterial vaginosis and high-risk human papillomavirus infection
Published in PloS one (18-06-2021)“…Mounting evidence suggests that Lactobacillus species may not necessarily be the sine qua non of healthy cervicovaginal microbiota (CVM), especially among…”
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High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa
Published in PloS one (18-06-2021)“…As part of the human papillomavirus (HPV) vaccination strategy in South Africa, it is essential to have information on HPV prevalence, and HPV types…”
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High human papillomavirus (HPV)-35 prevalence among South African women with cervical intraepithelial neoplasia warrants attention
Published in PloS one (09-03-2022)“…Human papillomavirus (HPV) prevalence and genotype distribution data is important for HPV vaccine monitoring. This study investigated the prevalence and…”
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Lumpy Skin Disease-An Emerging Cattle Disease in Europe and Asia
Published in Vaccines (Basel) (01-03-2023)“…Lumpy skin disease virus (LSDV) is a member of the Capripoxvirus genus, mainly infecting cattle and buffalo, which until relatively recently was only endemic…”
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South African bovine ephemeral fever virus glycoprotein sequences are phylogenetically distinct from those from the rest of the world
Published in Archives of virology (01-05-2020)“…Bovine ephemeral fever virus (BEFV) is an economically important arbovirus affecting cattle and water buffalo. Currently, isolates can be separated into three…”
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The Brighton Collaboration standardized template for collection of key information for risk/benefit assessment of a Modified Vaccinia Ankara (MVA) vaccine platform
Published in Vaccine (21-05-2021)“…The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) was formed to evaluate the safety and characteristics of live, recombinant viral…”
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Genital inflammatory status and the innate immune response to contraceptive initiation
Published in American journal of reproductive immunology (1989) (01-08-2022)“…Problem Data on the effects of contraceptives on female genital tract (FGT) immune mediators are inconsistent, possibly in part due to pre‐existing conditions…”
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Heterologous prime-boost vaccination with DNA and MVA vaccines, expressing HIV-1 subtype C mosaic Gag virus-like particles, is highly immunogenic in mice
Published in PloS one (09-03-2017)“…In an effort to make affordable vaccines suitable for the regions most affected by HIV-1, we have constructed stable vaccines that express an HIV-1 subtype C…”
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The penile microbiota of Black South African men: relationship with human papillomavirus and HIV infection
Published in BMC microbiology (06-04-2020)“…To date, the microbiota of the human penis has been studied mostly in connection with circumcision, HIV risk and female partner bacterial vaginosis (BV). These…”
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Human papillomavirus prevalence and risk factors among HIV-negative and HIV-positive women residing in rural Eastern Cape, South Africa
Published in International journal of infectious diseases (01-06-2020)“…•The burden of cervical cancer is high among South African women of rural Eastern Cape Province.•Among women visiting the community health clinic for any…”
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Development of a dual vaccine against East Coast fever and lumpy skin disease
Published in Frontiers in immunology (30-03-2023)“…East Coast fever is an acute bovine disease caused by the apicomplexan parasite and is regarded as one of the most important tick-vectored diseases in Africa…”
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High human papillomavirus (HPV) prevalence in South African adolescents and young women encourages expanded HPV vaccination campaigns
Published in PloS one (01-01-2018)“…The objectives of the study were to investigate prevalence of cervical human papillomavirus (HPV) genotypes to inform HPV vaccination strategy in South Africa…”
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Investigating Constraints Along the Plant Secretory Pathway to Improve Production of a SARS-CoV-2 Spike Vaccine Candidate
Published in Frontiers in plant science (04-01-2022)“…Given the complex maturation requirements of viral glycoproteins and the challenge they often pose for expression in plants, the identification of host…”
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Acceptability of self- collection for human papillomavirus detection in the Eastern Cape, South Africa
Published in PloS one (10-11-2020)“…Human papillomavirus (HPV) testing on vaginal self-collected and cervical clinician-collected specimens shows comparable performance. Self-sampling on FTA…”
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