Search Results - "Williams, Sybil B."

Evaluation of the Xylum Clot Signature Analyzer in Normal Subjects and Patients with the Hermansky–Pudlak Syndrome by Horne, McDonald K., Williams, Sybil B., Gahl, William A., Rick, Margaret E.

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GLYCOCALICIN DERIVED PEPTIDES INHIBIT von WILLEBRAND FACTOR BINDING TO PLATELETS by Williams, Sybil B, Krutzsch, Henry, McKeown, Laurie P, Gralnick, Harvey R

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Glycocalicin levels in the plasma of HIV+ patients: An indicator of platelet turnover by Williams, Sybil B., Sano, Masayuki, Smith, Nikisha, Horne, McDonald, Yarchoan, Robert, Wyvill, Kathleen, Zeichner, Steven, Taylor, Perdita, Knudson, Tena, Gralnick, Harvey R.

“…Glycocalicin (GC) is the carbohydrate-rich portion of platelet membrane glycoprotein Ibα that can be cleaved from circulating platelets by proteases. The…”
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Conformational Regulation of the Fibronectin Binding and α3β1 Integrin-mediated Adhesive Activities of Thrombospondin-1 by Rui G. Rodrigues, Neng-hua Guo, Longen Zhou, John M. Sipes, Sybil B. Williams, Nancy Smyth Templeton, Harvey R. Gralnick, David D. Roberts

“…The recognition of extracellular matrix components can be regulated by conformational changes that alter the activity of cell surface integrins. We now…”
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Conformational Regulation of the Fibronectin Binding and α3β1 Integrin-mediated Adhesive Activities of Thrombospondin-1 by Rodrigues, Rui G., Guo, Neng-hua, Zhou, Longen, Sipes, John M., Williams, Sybil B., Templeton, Nancy Smyth, Gralnick, Harvey R., Roberts, David D.

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Plasma and platelet von Willebrand factor defects in uremia by Gralnick, H R, McKeown, L P, Williams, S B, Shafer, B C, Pierce, L

“…Several mechanisms have been proposed to explain the prolonged bleeding times and clinical bleeding in chronic renal failure. Recent evidence has implicated an…”
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Purification and characterization of human platelet von Willebrand factor by Williams, S B, McKeown, L P, Krutzsch, H, Hansmann, K, Gralnick, H R

“…Platelet von Willebrand factor (vWf) was purified from human platelet concentrates. The multimeric structure of the purified platelet vWf was similar to that…”
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Platelet adhesion at high shear rates: The roles of von Willebrand factor/GPIb and the β1 integrin α2β1 by Gralnicks, Harvey R., Kramer, Wendy S., McKeown, Laurie P., Garfinkel, Leonard, Pinot, Amos, Williams, Sybil B., Krutzsch, Henry

“…We have previously described a monomeric rvWf fragment, Leu504-Lys728 that contains one disulfide bond linking Cys509-Cys695. This fragment, VCL, has…”
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Endogenous platelet fibrinogen: its modulation after surface expression is related to size-selective access to and conformational changes in the bound fibrinogen by Gralnick, H R, Williams, S B, McKeown, L, Shafer, B, Connaghan, G D, Hansmann, K, Vail, M, Magruder, L

“…Platelet stimulation results in the release of endogenous platelet fibrinogen which binds to the platelet surface. Previous studies have demonstrated that…”
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Platelet von Willebrand factor by Gralnick, H R, Williams, S B, McKeown, L P, Magruder, L, Hansmann, K, Vail, M, Parker, R I

“…von Willebrand factor (vWF) circulates in the blood in two distinct compartments. One, plasma vWF, is synthesized and released from endothelial cells; the…”
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Thrombocytopenia Associated With Pregnancy in a Patient With Type IIB von Willebrand’s Disease by Rick, Margaret E., Williams, Sybil B., Sacher, Ronald A., McKeown, Laurie P.

“…Thrombocytopenia may accompany variant (type IIB) von Willebrand's disease (vWD) and is thought to result from binding of the abnormal von Willebrand factor…”
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Structure-Function Studies on the Inhibition of Binding of α-Thrombin to Platelet GpIbα by the Peptide D-Y-Y-P-E and the Artifactual Inhibitory Activity of C-Terminal E in this Peptide by Krutzsch, Henry, Williams, Sybil B., McKeown, Laurie P., Gralnick, Harvey R.

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Fibrinogen Competes With von Willebrand Factor for Binding to the Glycoprotein IIb/IIIa Complex When Platelets Are Stimulated With Thrombin by Gralnick, Harvey R., Williams, Sybil B., Coller, Barry S.

“…Two monoclonal antibodies—one that blocks ristocetin-induced platelet binding of von Willebrand factor to glycoprotein Ib and one that blocks adenosine…”
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Arginine-glycine-aspartic acid- and fibrinogen γ-chain carboxyterminal peptides inhibit platelet adherence to arterial subendothelium at high wall shear rates : an effect dissociable from interference with adhesive protein binding by LAWRENCE, J. B, KRAMER, W. S, MCKEOWN, L. P, WILLIAMS, S. B, GRALNICK, H. R

“…Arg-Gly-Asp (RGD)- and fibrinogen gamma-chain carboxyterminal (GQQHHLGGAKQAGDV) peptides inhibit fibrinogen, fibronectin (Fn), vitronectin, and von Willebrand…”
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Effect of the Multimeric Structure of the Factor VIII/von Willebrand Factor Protein on Binding to Platelets by Gralnick, Harvey R., Williams, Sybil B., Morisato, Donald K.

“…The characteristics of the intact factor VIII/von Willebrand factor protein binding to human platelets was compared to 2-mercaptoethanol-treated factor…”
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Alpha granule proteins in type I von Willebrand's disease by McKeown, L P, Williams, S B, Shafer, B, Murray, N, Gralnick, H R

“…Platelet von Willebrand factor (vWf) is located in the alpha granules. Individuals with type I von Willebrand's disease (vWd) with prolonged bleeding times are…”
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In vitro Correction of the Abnormal Multimeric Structure of Von Willebrand Factor in Type IIa Von Willebrand's Disease by Gralnick, Harvey R., Williams, Sybil B., McKeown, Laurie P., Maisonneuve, Pascal, Jenneau, Christine, Sultan, Yvette, Rick, Margaret E.

“…Type IIa von Willebrand's disease (vWd) has been characterized by the absence of the largest and a reduction in the intermediate-sized multimers of the plasma…”
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Platelets adhere to sulfatides by von Willebrand factor dependent and independent mechanisms by Data, R E, Williams, S B, Roberts, D D, Gralnick, H R

“…Unstimulated human platelets from normal volunteers adhere to sulfatides (galactosylceramide-I3-sulfate) as single cells but do not adhere appreciably to other…”
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A variant of type II von Willebrand disease with an abnormal triplet structure and discordant effects of protease inhibitors on plasma and platelet von Willebrand factor structure by Gralnick, H R, Williams, S B, McKeown, L P, Maisonneuve, P, Jenneau, C, Sultan, Y

“…We have characterized the plasma and platelet von Willebrand factor (vWf) multimeric structure of a patient with von Willebrand disease (vWd) as having a long…”
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Platelet von Willebrand factor: comparison with plasma von Willebrand factor by Gralnick, H R, Williams, S B, McKeown, L P, Krizek, D M, Shafer, B C, Rick, M E

“…Platelet von Willebrand factor (vWf) was compared to its plasma counterpart. The platelet vWf was different from plasma vWf in that the multimeric organization…”
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