Search Results - "Williams, Simon A."

Multiple genetic loci affect place learning and memory performance in Drosophila melanogaster by Williams‐Simon, Patricka A., Posey, Christopher, Mitchell, Samuel, Ng'oma, Enoch, Mrkvicka, James A., Zars, Troy, King, Elizabeth G.

“…Learning and memory are critical functions for all animals, giving individuals the ability to respond to changes in their environment. Within populations,…”
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Diverse biological processes coordinate the transcriptional response to nutritional changes in a Drosophila melanogaster multiparent population by Ng'oma, E, Williams-Simon, P A, Rahman, A, King, E G

“…Environmental variation in the amount of resources available to populations challenge individuals to optimize the allocation of those resources to key fitness…”
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Bortezomib abolishes tumor necrosis factor-related apoptosis- inducing ligand resistance via a p21-dependent mechanism in human bladder and prostate cancer cells by LASHINGER, Laura M, KEYI ZHU, WILLIAMS, Simon A, SHRADER, Marissa, DINNEY, Colin P. N, MCCONKEY, David J

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor family of cytokines that induces apoptosis in some…”
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Prostate-specific antigen (PSA) is activated by KLK2 in prostate cancer ex vivo models and in prostate-targeted PSA/KLK2 double transgenic mice by Williams, Simon A., Xu, Yi, De Marzo, Angelo M., Isaacs, John T., Denmeade, Samuel R.

“…BACKGROUND Prostate‐specific antigen (PSA) is a serine protease secreted as a zymogen. Previously, cell‐free biochemical studies have identified various…”
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Bortezomib inhibits docetaxel-induced apoptosis via a p21-dependent mechanism in human prostate cancer cells by Canfield, Steven E, Zhu, Keyi, Williams, Simon A, McConkey, David J

“…Bortezomib (PS-341, Velcade) is a peptide boronate inhibitor of the 20S proteasome that is currently being combined with taxanes in several clinical trials in…”
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Inhibitory control and the speech patterns of second language users by Korko, Malgorzata, Williams, Simon A.

“…Inhibitory control (IC), an ability to suppress irrelevant and/or conflicting information, has been found to underlie performance on a variety of cognitive…”
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Ecological monitoring to support Water Sharing Plan evaluation and protect wetlands of inland New South Wales, Australia by Driver, Patrick D., Raine, Allan, Foster, Neal D., Williams, Simon A.

“…Summary Government‐funded flow response monitoring and modelling programmes (flow science) provided by the New South Wales Office of Water (NOW) have supported…”
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The appearance of voice: EAP and academic literacies approaches to teaching reflective writing by Williams, Simon A.

“…The increasingly common requirement for higher education courses to include reflective writing as part of assessment practices places additional demands on…”
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Flexible surgical training in Australasia by Williams, Simon A

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Response of a barrier estuary to climate change and river regulation using attractor analysis: Snowy River estuary, Australia by McLean, Errol J., Hinwood, Jon B., Williams, Simon A.

“…The evolution of the entrance channel of the Snowy River estuary in response to river regulation and climate change is predicted. The predictions are made in…”
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Does PSA play a role as a promoting agent during the initiation and/or progression of prostate cancer? by Williams, Simon A., Singh, Pratap, Isaacs, John T., Denmeade, Samuel R.

“…Prostate cancer cells, like normal prostate epithelial cells, produce high levels of the differentiation marker and serine protease prostate‐specific antigen…”
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Proteolysis of complement factors iC3b and C5 by the serine protease prostate-specific antigen in prostatic fluid and seminal plasma by Manning, Michael L, Williams, Simon A, Jelinek, Christine A, Kostova, Maya B, Denmeade, Samuel R

“…Prostate-specific Ag (PSA) is a serine protease that is expressed exclusively by normal and malignant prostate epithelial cells. The continued high-level…”
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Enzymatically active prostate-specific antigen promotes growth of human prostate cancers by Williams, Simon A., Jelinek, Christine A., Litvinov, Ivan, Cotter, Robert J., Isaacs, John T., Denmeade, Samuel R.

“…BACKGROUND Prostate specific antigen (PSA) is the best‐known member of the kallikrein‐related peptidase family, with an established role as a prostatic disease…”
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Mutational Analysis of Prostate-Specific Antigen Defines the Intrinsic Proteolytic Activity of the proPSA Zymogen by Sangster-Guity, Niquiche, Tu-Sekine, Becky, Raben, Daniel M., Denmeade, Samuel R., Williams, Simon A.

“…BACKGROUND Prostate‐specific antigen (PSA) is an important prostate cancer biomarker. It is also a protease expressed at high concentrations by the normal and…”
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The proteasome inhibitor bortezomib stabilizes a novel active form of p53 in human LNCaP-Pro5 prostate cancer cells by WILLIAMS, Simon A, MCCONKEY, David J

“…Advanced prostate cancer is resistant to current therapeutic strategies. Bortezomib (Velcade; previously called PS-341) is a potent and specific inhibitor of…”
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A Prostate-Specific Antigen–Activated Channel-Forming Toxin as Therapy for Prostatic Disease by Williams, Simon A., Merchant, Rosemina F., Garrett-Mayer, Elizabeth, Isaacs, John T., Buckley, J. Thomas, Denmeade, Samuel R.

“…Background Most men will develop prostatic abnormalities, such as benign prostatic hyperplasia (BPH) or prostate cancer, as they age. Prostate-specific antigen…”
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Trypsin-like proteolytic contamination of commercially available psa purified from human seminal fluid by Manning, Michael L., Kostova, Maya, Williams, Simon A., Denmeade, Samuel R.

“…BACKGROUND Prostate‐Specific Antigen (PSA) is a serine protease whose expression is maintained in all stages of prostate cancer. A role for PSA in the…”
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Naturally segregating genetic variants contribute to thermal tolerance in a Drosophila melanogaster model system by Williams-Simon, Patricka A, Oster, Camille, Moaton, Jordyn A, Ghidey, Ronel, Ng'oma, Enoch, Middleton, Kevin M, King, Elizabeth G

“…Thermal tolerance is a fundamental physiological complex trait for survival in many species. For example, everyday tasks such as foraging, finding a mate, and…”
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Comparative study of PSMA expression in the prostate of mouse, dog, monkey, and human by Aggarwal, Saurabh, Ricklis, Rebecca M., Williams, Simon A., Denmeade, Samuel R.

“…BACKGROUND Intraprostatic PSMA targeted prodrugs/protoxins are under development in our laboratory. Future toxicologic studies of these therapies require…”
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Modulating paclitaxel bioavailability for targeting prostate cancer by Kumar, Srinivas K., Williams, Simon A., Isaacs, John T., Denmeade, Samuel R., Khan, Saeed R.

“…Four novel water-soluble peptide-paclitaxel conjugates were designed and synthesized as prostate-specific antigen (PSA)-activated prodrugs for prostate cancer…”
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