Search Results - "Williams, Shirley"

What do people study when they study Twitter? Classifying Twitter related academic papers by Williams, Shirley A., Terras, Melissa M., Warwick, Claire

“…Purpose - Since its introduction in 2006, messages posted to the microblogging system Twitter have provided a rich dataset for researchers, leading to the…”
Get full text

Unaffected Li-Fraumeni Syndrome Carrier Parent Demonstrates Allele-Specific mRNA Stabilization of Wild-Type TP53 Compared to Affected Offspring by Buzby, Jeffrey S, Williams, Shirley A, Nugent, Diane J

“…Li-Fraumeni Syndrome (LFS) is an autosomal dominant disorder where an oncogenic germline mutation is inherited by offspring of a carrier parent. p53 is a key…”
Get full text

Genetic variants that affect platelet function by Kunicki, Thomas J, Williams, Shirley A, Nugent, Diane J

“…PURPOSE OF REVIEWThis review summarizes our current knowledge of common gene variants (polymorphisms) that have small individual effects on platelet function…”
Get full text

Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro by Chang, Mei, Nakagawa, Peggy A., Williams, Shirley A., Schwartz, Michael R., Imfeld, Karen L., Buzby, Jeffrey S., Nugent, Diane J.

“…To determine if megakaryocytes are targeted by immune thrombocytopenic purpura (ITP) autoantibodies, as are platelets, we have studied the effects of ITP…”
Get full text

Mean Platelet Volume and Integrin Alleles Correlate With Levels of Integrins αIIbβ3 and α2β1 in Acute Coronary Syndrome Patients and Normal Subjects by Kunicki, Thomas J, Williams, Shirley A, Nugent, Diane J, Yeager, Mark

“…OBJECTIVE—The interindividual variation in platelet α2β1 exceeds a 2-fold variance in platelet αIIbβ3 level. Our objective was to parse the contribution of…”
Get full text

Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease by Kunicki, Thomas J, Williams, Shirley A, Nugent, Diane J, Harrison, Paul, Segal, Helen C, Syed, Anila, Rothwell, Peter M

“…We studied the effect of prophylactic aspirin (ASA) ingestion on platelet function in 463 patients with stroke, transient ischemic attack (TIA) or acute…”
Get more information

International exchange programs and U.S. medical schools by McKinley, Danette W, Williams, Shirley R, Norcini, John J, Anderson, M Brownell

“…International health experiences have been shown to increase students' and residents' interest in public health, their likelihood of choosing a career in…”
Get full text

Enhanced binding of poly(ADP-ribose)polymerase-1 and Ku80/70 to the ITGA2 promoter via an extended cytosine-adenosine repeat by Cheli, Yann, Williams, Shirley A, Ballotti, Robert, Nugent, Diane J, Kunicki, Thomas J

“…We have identified a cytosine-adenosine (CA) repeat length polymorphism in the 5'-regulatory region of the human integrin alpha2 gene ITGA2 that begins at…”
Get full text

The low-frequency isoform of platelet glycoprotein VIb attenuates ligand-mediated signal transduction but not receptor expression or ligand binding by Trifiro, Elisabetta, Williams, Shirley A., Cheli, Yann, Furihata, Kenichi, Pulcinelli, Fabio M., Nugent, Diane J., Kunicki, Thomas J.

“…The 2 most common haplotypes of human GP6, GP6a and GP6b, generate the allelic isoforms glycoprotein VI (GPVI)a and GPVIb that differ by 5 amino acids: S219P,…”
Get full text

Developing government policies for distance education: Lessons learnt from two Sri Lankan case studies by Liyanagunawardena, Tharindu Rekha, Adams, Andrew A., Rassool, Naz, Williams, Shirley A.

“…Education, especially higher education, is considered vital for maintaining national and individual competitiveness in the global knowledge economy. Following…”
Get full text

Allele-Specific Wild-Type TP53 Expression in the Unaffected Carrier Parent of Children with Li-Fraumeni Syndrome by Buzby, Jeffrey S, Williams, Shirley A, Schaffer, Lana, Head, Steven R, Nugent, Diane J

“…Highlights • A heterozygous mutant TP53 carrier parent of children with Li-Fraumeni syndrome (LFS) remains unaffected in their fourth decade of life. • UV…”
Get full text

Platelet adhesion to decorin but not collagen I correlates with the integrin α2 dimorphism E534K, the basis of the human platelet alloantigen (HPA)-5 system by KUNICKI, Thomas J, WILLIAMS, Shirley A, DIAZ, Daniel, FARNDALE, Richard W, NUGENT, Diane J

“…A single nucleotide polymorphism in the integrin α2 gene ITGA2 (rs1801106; G1600A) creates the non-conservative amino acid substitution E534K, the basis of the…”
Get full text

MOOCs: A Systematic Study of the Published Literature 2008-2012 by Tharindu Rekha Liyanagunawardena, Andrew Alexandar Adams, Shirley Ann Williams

“…Massive open online courses (MOOCs) are a recent addition to the range of online learning options. Since 2008, MOOCs have been run by a variety of public and…”
Get full text

Biochemical characterization of desloratadine, a potent antagonist of the human histamine H1 receptor by ANTHES, John C, GILCHREST, Helen, EGAN, Robert W, RICHARD, Christian, ECKEL, Stephen, HESK, Dave, WEST, Robert E, WILLIAMS, Shirley M, GREENFEDER, Scott, BILLAH, Motasim, KREUTNER, William

Get full text

Tissue factor inflammatory response regulated by promoter genotype and p38 MAPK in neonatal vs. adult microvascular endothelial cells by Buzby, Jeffrey S., Williams, Shirley A., Imfeld, Karen L., Kunicki, Thomas J., Nugent, Diane J.

“…Objective and design Variable tissue factor (TF) expression by human microvascular endothelial cells (HMVEC) may be regulated by two promoter haplotypes,…”
Get full text

Synthesis and structure-activity relationships of 2-(1,4'-bipiperidin-1'-yl) thiazolopyridine as H3 receptor antagonists by RAO, Ashwin U, PALANI, Anandan, LACHOWICZ, Jean, XIAO CHEN, YING HUANG, ASLANIAN, Robert G, WEST, Robert E, WILLIAMS, Shirley M, WU, Ren-Long, HWA, Joyce, SONDEY, Christopher

“…A series of 2-(1,4'-bipiperidine-1'-yl)thiazolopyridines was synthesized and evaluated as a new lead of non-imidazole histamine H(3) receptor antagonists…”
Get full text

Synthesis and structure–activity relationship (SAR) study of 4-azabenzoxazole analogues as H3 antagonists by Shao, Ning, Aslanian, Robert, West, Robert E., Williams, Shirley M., Wu, Ren-Long, Hwa, Joyce, Sondey, Christopher, Lachowicz, Jean, Palani, Anandan

“…The synthesis and SAR of a novel series of 4-azabenzoxazole histamine H3 antagonists is described. Introduction of substituted phenyl, pyridyl and fused…”
Get full text

Fused bicycles as arylketone bioisosteres leading to potent, orally active thiadiazole H3 antagonists by Xiao, Dong, Palani, Anandan, Sofolarides, Michael, Aslanian, Robert, West, Robert E., Williams, Shirley M., Wu, Ren-Long, Hwa, Joyce, Sondey, Christopher, Lachowicz, Jean, Korfmacher, Walter A.

“…A structure–activity relationship study was undertaken to address the lack of oral exposure of the H3 antagonist 1, which incorporated an arylketone. Among a…”
Get full text

Benzimidazole-substituted (3-phenoxypropyl)amines as histamine H3 receptor ligands by Aslanian, Robert, Zhu, Xiaohong, Vaccaro, Henry A., Shih, Neng-Yang, Piwinski, John J., Williams, Shirley M., West, Robert E.

“…A series of non-imidazole histamine H 3 receptor antagonists based on the (3-phenoxypropyl)amine motif have been identified. Compound 8a displays a good…”
Get full text

Reduction of hERG inhibitory activity in the 4-piperidinyl urea series of H3 antagonists by Berlin, Michael, Lee, Yoon Joo, Boyce, Christopher W., Wang, Yi, Aslanian, Robert, McCormick, Kevin D., Sorota, Steve, Williams, Shirley M., West, Robert E., Korfmacher, Walter

“…Structural features of the substituted 4-piperidinyl urea analogs 1, responsible for the H3 antagonist activity, have been identified. Structure–activity…”
Get full text