Search Results - "Williams, S. B"
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Developing a Tanshinone IIA Memetic by Targeting MIOS to Regulate mTORC1 and Autophagy in Glioblastoma
Published in International journal of molecular sciences (14-06-2024)“…Tanshinone IIA (T2A) is a bioactive compound that provides promise in the treatment of glioblastoma multiforme (GBM), with a range of molecular mechanisms…”
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Magnetic-field-assisted terahertz quantum cascade laser operating up to 225 K
Published in Nature photonics (01-01-2009)“…Advances in semiconductor bandgap engineering have resulted in the recent development of the terahertz quantum cascade laser 1 . These compact optoelectronic…”
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3
Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders
Published in Lancet neurology (01-01-2018)“…High-fat, low-carbohydrate diets, known as ketogenic diets, have been used as a non-pharmacological treatment for refractory epilepsy. A key mechanism of this…”
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Topography, substratum and benthic macrofaunal relationships on a tropical mesophotic shelf margin, central Great Barrier Reef, Australia
Published in Coral reefs (01-03-2011)“…Habitats and ecological communities occurring in the mesophotic region of the central Great Barrier Reef (GBR), Australia, were investigated using autonomous…”
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Mitochondrial calcium uptake
Published in Proceedings of the National Academy of Sciences - PNAS (25-06-2013)“…Calcium (Ca²⁺) uptake into the mitochondrial matrix is critically important to cellular function. As a regulator of matrix Ca²⁺ levels, this flux influences…”
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A common mechanism of action for three mood-stabilizing drugs
Published in Nature (London) (16-05-2002)“…Lithium, carbamazepine and valproic acid are effective mood-stabilizing treatments for bipolar affective disorder. The molecular mechanisms underlying the…”
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Environment-wide association study to comprehensively test and validate associations between nutrition and lifestyle factors and testosterone deficiency: NHANES 1988–1994 and 1999–2004
Published in Hormones (Athens, Greece) (01-06-2020)“…Purpose Testosterone (T) plays an important role in men’s health and its deficiency is linked with poorer health. However, the role of nutritional and…”
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Stereo-imaging AUV detects trends in sea urchin abundance on deep overgrazed reefs
Published in Limnology and oceanography, methods (01-05-2016)“…Remote underwater vehicles are cutting‐edge tools for mapping benthic habitats, yet their reliability for detecting patterns in abundance of benthic species…”
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Enhanced Sestrin expression through Tanshinone 2A treatment improves PI3K-dependent inhibition of glioma growth
Published in Cell death discovery (19-05-2023)“…Glioblastomas are a highly aggressive cancer type which respond poorly to current pharmaceutical treatments, thus novel therapeutic approaches need to be…”
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Functional anatomy and muscle moment arms of the pelvic limb of an elite sprinting athlete: the racing greyhound (Canis familiaris)
Published in Journal of anatomy (01-10-2008)“…We provide quantitative anatomical data on the muscle–tendon architecture and geometry of the pelvic limb of an elite sprint athlete, the racing greyhound…”
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Functional anatomy and muscle moment arms of the thoracic limb of an elite sprinting athlete: the racing greyhound (Canis familiaris)
Published in Journal of anatomy (01-10-2008)“…We provide quantitative muscle–tendon architecture and geometry data for the racing greyhound thoracic limb. Muscle mass, belly length, fascicle lengths,…”
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Exploring the mechanical basis for acceleration: pelvic limb locomotor function during accelerations in racing greyhounds (Canis familiaris)
Published in Journal of experimental biology (15-02-2009)“…Animals in their natural environments are confronted with a regular need to perform rapid accelerations (for example when escaping from predators or chasing…”
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13
CikA, a Bacteriophytochrome That Resets the Cyanobacterial Circadian Clock
Published in Science (American Association for the Advancement of Science) (04-08-2000)“…The circadian oscillator of the cyanobacterium Synechococcus elongatus, like those in eukaryotes, is entrained by environmental cues. Inactivation of the gene…”
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RpkA, a highly conserved GPCR with a lipid kinase domain, has a role in phagocytosis and anti-bacterial defense
Published in PloS one (02-11-2011)“…RpkA (Receptor phosphatidylinositol kinase A) is an unusual seven-helix transmembrane protein of Dictyostelium discoideum with a G protein coupled receptor…”
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Gamma secretase orthologs are required for lysosomal activity and autophagic degradation in Dictyostelium discoideum, independent of PSEN (presenilin) proteolytic function
Published in Autophagy (03-08-2019)“…Mutations in the γ-secretase complex are strongly associated with familial Alzheimer disease. Both proteolytic and non-proteolytic functions for the…”
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Genetic control of lithium sensitivity and regulation of inositol biosynthetic genes
Published in PloS one (17-06-2010)“…Lithium (Li(+)) is a common treatment for bipolar mood disorder, a major psychiatric illness with a lifetime prevalence of more than 1%. Risk of bipolar…”
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Antimicrobial activity of extracts from macroalgae Ulva lactuca against clinically important Staphylococci is impacted by lunar phase of macroalgae harvest
Published in Letters in applied microbiology (01-05-2016)“…Staphylococcus aureus is a common human bacterial pathogen that causes skin and soft tissue infections. Methicillin‐resistant Staph. aureus (MRSA) are…”
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Terahertz heterodyne receiver based on a quantum cascade laser and a superconducting bolometer
Published in Applied physics letters (13-06-2005)“…We report the first demonstration of an all solid-state heterodyne receiver that can be used for high-resolution spectroscopy above 2 THz suitable for…”
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Effect of doping concentration on the performance of terahertz quantum-cascade lasers
Published in Applied physics letters (03-10-2005)“…We characterized a set of terahertz quantum-cascade lasers with identical device parameters except for the doping concentration. The δ-doping density was…”
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Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in Dictyostelium discoideum
Published in Disease models & mechanisms (01-09-2018)“…Valproic acid (VPA) provides a common treatment for both epilepsy and bipolar disorder; however, common cellular mechanisms relating to both disorders have yet…”
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