Search Results - "Williams, Phillip E"

Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery by Flynn, Charles Robb, Albaugh, Vance L., Cai, Steven, Cheung-Flynn, Joyce, Williams, Phillip E., Brucker, Robert M., Bordenstein, Seth R., Guo, Yan, Wasserman, David H., Abumrad, Naji N.

“…Roux-en-Y gastric bypass (RYGB) is highly effective in reversing obesity and associated diabetes. Recent observations in humans suggest a contributing role of…”
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Pharmacokinetics, Tissue Localization, Toxicity, and Treatment Efficacy in the First Small Animal (Rabbit) Model of Intra-Arterial Chemotherapy for Retinoblastoma by Daniels, Anthony B, Froehler, Michael T, Pierce, Janene M, Nunnally, Amy H, Calcutt, M Wade, Bridges, Thomas M, LaNeve, David C, Williams, Phillip E, Boyd, Kelli L, Reyzer, Michelle L, Lindsley, Craig W, Friedman, Debra L, Richmond, Ann

“…Current intra-arterial chemotherapy (IAC) drug regimens for retinoblastoma have ocular and vascular toxicities. No small-animal model of IAC exists to test…”
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Glucagon's effect on liver protein metabolism in vivo by Kraft, Guillaume, Coate, Katie C, Winnick, Jason J, Dardevet, Dominique, Donahue, E Patrick, Cherrington, Alan D, Williams, Phillip E, Moore, Mary Courtney

“…The postprandial state is characterized by a storage of nutrients in the liver, muscle, and adipose tissue for later utilization. In the case of a protein-rich…”
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Interaction Between the Central and Peripheral Effects of Insulin in Controlling Hepatic Glucose Metabolism in the Conscious Dog by RAMNANAN, Christopher J, KRAFT, Guillaume, EDGERTON, Dale S, SMITH, Marta S, FARMER, Ben, NEAL, Doss, WILLIAMS, Phillip E, LAUTZ, Margaret, FARMER, Tiffany, PATRICK DONAHUE, E, CHERRINGTON, Alan D

“…The importance of hypothalamic insulin action to the regulation of hepatic glucose metabolism in the presence of a normal liver/brain insulin ratio (3:1) is…”
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Effects of Insulin on the Metabolic Control of Hepatic Gluconeogenesis In Vivo by EDGERTON, Dale S, RAMNANAN, Christopher J, GRUETER, Carrie A, JOHNSON, Kathryn M. S, LAUTZ, Margaret, NEAL, Doss W, WILLIAMS, Phillip E, CHERRINGTON, Alan D

“…Effects of Insulin on the Metabolic Control of Hepatic Gluconeogenesis In Vivo Dale S. Edgerton , Christopher J. Ramnanan , Carrie A. Grueter , Kathryn M.S…”
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Canine body composition quantification using 3 tesla fat-water MRI by Gifford, Aliya, Kullberg, Joel, Berglund, Johan, Malmberg, Filip, Coate, Katie C., Williams, Phillip E., Cherrington, Alan D., Avison, Malcolm J., Welch, E. Brian

“…Purpose To test the hypothesis that a whole‐body fat–water MRI (FWMRI) protocol acquired at 3 Tesla combined with semi‐automated image analysis techniques…”
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Liver, but not muscle, has an entrainable metabolic memory by Chen, Sheng-Song, Otero, Yolanda F, Mulligan, Kimberly X, Lundblad, Tammy M, Williams, Phillip E, McGuinness, Owen P

“…Hyperglycemia in the hospitalized setting is common, especially in patients that receive nutritional support either continuously or intermittently. As the…”
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The kinetics of glucagon action on the liver during insulin-induced hypoglycemia by Pedersen, Christina, Kraft, Guillaume, Edgerton, Dale S, Scott, Melanie, Farmer, Ben, Smith, Marta, Laneve, David C, Williams, Phillip E, Moore, L Merkle, Cherrington, Alan D

“…Glucagon's effect on hepatic glucose production (HGP), under hyperglycemic conditions, is time dependent such that after an initial burst of HGP, it slowly…”
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Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day by Moore, Mary Courtney, Smith, Marta S, Farmer, Ben, Coate, Katie C, Kraft, Guillaume, Shiota, Masakazu, Williams, Phillip E, Cherrington, Alan D

“…We observed that a 4-h morning (AM) duodenal infusion of glucose versus saline doubled hepatic glucose uptake (HGU) and storage during a…”
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1849-P: Importance of Insulin’s Direct and Indirect Effects on Postprandial Hepatic Glucose Uptake by EDGERTON, DALE S., KRAFT, GUILLAUME, FARMER, BEN, SMITH, MARTA S., WILLIAMS, PHILLIP E., CHERRINGTON, ALAN D.

“…In heathy individuals the liver is a primary site of glucose disposal, it is in a state of glucose uptake most of the day, and this process is impaired in…”
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Hepatic and muscle insulin action during late pregnancy in the dog by Connolly, Cynthia C, Papa, Tracy, Smith, Marta S, Lacy, D Brooks, Williams, Phillip E, Moore, Mary Courtney

“…We evaluated the effects of physiologic increases in insulin on hepatic and peripheral glucose metabolism in nonpregnant (NP) and pregnant (P; 3rd trimester)…”
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Enterically delivered insulin tregopil exhibits rapid absorption characteristics and a pharmacodynamic effect similar to human insulin in conscious dogs by Gregory, Justin M., Lautz, Margaret, Moore, Lindsey M., Williams, Phillip E., Reddy, Praveen, Cherrington, Alan D.

“…Aims Current therapy fails to emulate rapid (first‐phase) insulin release in relation to a meal, a key defect in types 1 and 2 diabetes. We aimed to quantify…”
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Priming Effect of a Morning Meal on Hepatic Glucose Disposition Later in the Day by Moore, Mary Courtney, Smith, Marta S, Farmer, Ben, Kraft, Guillaume, Shiota, Masakazu, Williams, Phillip E, Cherrington, Alan D

“…We used hepatic balance and tracer ([ H]glucose) techniques to examine the impact of "breakfast" on hepatic glucose metabolism later in the same day. From…”
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1801-P: Common Hepatic Artery Denervation Does Not Alter the Counterregulatory Response to Hypoglycemia in an Insulin Resistant Canine Model by KRAFT, GUILLAUME, MOORE, L. MERKLE, FARMER, BEN, SCOTT, MELANIE F., EDGERTON, DALE S., WILLIAMS, PHILLIP E., AZAMIAN, BOBAK, CHERRINGTON, ALAN D.

“…With the recent interest in sympathetic modulation as a way to improve insulin sensitivity and insulin secretion, it is important to assess the safety of the…”
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Targeting insulin to the liver corrects defects in glucose metabolism caused by peripheral insulin delivery by Edgerton, Dale S, Scott, Melanie, Farmer, Ben, Williams, Phillip E, Madsen, Peter, Kjeldsen, Thomas, Brand, Christian L, Fledelius, Christian, Nishimura, Erica, Cherrington, Alan D

“…Peripheral hyperinsulinemia resulting from subcutaneous insulin injection is associated with metabolic defects which include abnormal glucose metabolism. The…”
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Insulin's direct hepatic effect explains the inhibition of glucose production caused by insulin secretion by Edgerton, Dale S, Kraft, Guillaume, Smith, Marta, Farmer, Ben, Williams, Phillip E, Coate, Katie C, Printz, Richard L, O'Brien, Richard M, Cherrington, Alan D

“…Insulin can inhibit hepatic glucose production (HGP) by acting directly on the liver as well as indirectly through effects on adipose tissue, pancreas, and…”
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Interaction of Insulin and Prior Exercise in Control of Hepatic Metabolism of a Glucose Load by PENCEK, R. Richard, JAMES, Freyja, LACY, D. Brooks, JABBOUR, Kareem, WILLIAMS, Phillip E, FUEGER, Patrick T, WASSERMAN, David H

“…Interaction of Insulin and Prior Exercise in Control of Hepatic Metabolism of a Glucose Load R. Richard Pencek 1 , Freyja James 1 , D. Brooks Lacy 1 , Kareem…”
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Glucose autoregulation is the dominant component of the hormone-independent counterregulatory response to hypoglycemia in the conscious dog by Gregory, Justin M, Rivera, Noelia, Kraft, Guillaume, Winnick, Jason J, Farmer, Ben, Allen, Eric J, Donahue, E Patrick, Smith, Marta S, Edgerton, Dale S, Williams, Phillip E, Cherrington, Alan D

“…The contribution of hormone-independent counterregulatory signals in defense of insulin-induced hypoglycemia was determined in adrenalectomized,…”
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Assessment of Different Bariatric Surgeries in the Treatment of Obesity and Insulin Resistance in Mice by DENG PING YIN, QIANG GAO, LIAN LI MA, WENWEI YAN, WILLIAMS, Phillip E, MCGUINNESS, Owen P, WASSERMAN, David H, ABUMRAD, Naji N

“…To assess the effects of different bariatric surgical procedures on the treatment of obesity and insulin resistance in high fat diet-induced obese (DIO) mice…”
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Portal vein caffeine infusion enhances net hepatic glucose uptake during a glucose load in conscious dogs by Pencek, R Richard, Battram, Danielle, Shearer, Jane, James, Freyja D, Lacy, D Brooks, Jabbour, Kareem, Williams, Phillip E, Graham, Terry E, Wasserman, David H

“…We determined whether intraportal caffeine infusion, at rates designed to create concentrations similar to that seen with normal dietary intake, would enhance…”
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