Search Results - "Williams, Pete A."

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci by Choquet, Hélène, Paylakhi, Seyyedhassan, Kneeland, Stephen C., Thai, Khanh K., Hoffmann, Thomas J., Yin, Jie, Kvale, Mark N., Banda, Yambazi, Tolman, Nicholas G., Williams, Pete A., Schaefer, Catherine, Melles, Ronald B., Risch, Neil, John, Simon W. M., Nair, K. Saidas, Jorgenson, Eric

“…Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss, yet much of the genetic risk remains unaccounted for, especially in…”
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Glaucoma as a Metabolic Optic Neuropathy: Making the Case for Nicotinamide Treatment in Glaucoma by Williams, Pete A, Harder, Jeffrey M, John, Simon W.M

“…Mitochondrial dysfunction may be an important, if not essential, component of human glaucoma. Using transcriptomics followed by molecular and neurobiological…”
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Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction by Tribble, James R., Otmani, Amin, Sun, Shanshan, Ellis, Sevannah A., Cimaglia, Gloria, Vohra, Rupali, Jöe, Melissa, Lardner, Emma, Venkataraman, Abinaya P., Domínguez-Vicent, Alberto, Kokkali, Eirini, Rho, Seungsoo, Jóhannesson, Gauti, Burgess, Robert W., Fuerst, Peter G., Brautaset, Rune, Kolko, Miriam, Morgan, James E., Crowston, Jonathan G., Votruba, Marcela, Williams, Pete A.

“…Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for neuronal survival. Glaucoma is a common neurodegenerative disease in…”
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Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma by Williams, Pete A, Tribble, James R, Pepper, Keating W, Cross, Stephen D, Morgan, B Paul, Morgan, James E, John, Simon W M, Howell, Gareth R

“…Glaucoma is a complex, multifactorial disease characterised by the loss of retinal ganglion cells and their axons leading to a decrease in visual function. The…”
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Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS by Petrova, Veselina, Pearson, Craig S., Ching, Jared, Tribble, James R., Solano, Andrea G., Yang, Yunfei, Love, Fiona M., Watt, Robert J., Osborne, Andrew, Reid, Evan, Williams, Pete A., Martin, Keith R., Geller, Herbert M., Eva, Richard, Fawcett, James W.

“…Adult mammalian central nervous system axons have intrinsically poor regenerative capacity, so axonal injury has permanent consequences. One approach to…”
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Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma by Williams, Pete A, Howell, Gareth R, Barbay, Jessica M, Braine, Catherine E, Sousa, Gregory L, John, Simon W M, Morgan, James E

“…Glaucoma is a complex disease affecting an estimated 70 million people worldwide, characterised by the progressive degeneration of retinal ganglion cells and…”
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The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature by Hagström, Anna, Kal Omar, Ruba, Williams, Pete A, Stålhammar, Gustav

“…Uveal melanoma is a rare form of cancer with high mortality. The incidence of metastases is attributed to early seeding of micrometastases from the eye to…”
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Pyrroloquinoline quinone: a potential neuroprotective compound for neurodegenerative diseases targeting metabolism by Canovai, Alessio, Williams, Pete A

“…Pyrroloquinoline quinone is a quinone described as a cofactor for many bacterial dehydrogenases and is reported to exert an effect on metabolism in mammalian…”
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A serum protein signature at the time of Uveal Melanoma diagnosis predicts long-term patient survival by Herrspiegel, Christina, Plastino, Flavia, Lardner, Emma, Seregard, Stefan, Williams, Pete A, André, Helder, Stålhammar, Gustav

“…To develop a prognostic test based on a single blood sample obtained at the time of uveal melanoma diagnosis. 83 patients diagnosed with posterior uveal…”
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Nicotinamide and WLDS Act Together to Prevent Neurodegeneration in Glaucoma by Williams, Pete A., Harder, Jeffrey M., Foxworth, Nicole E., Cardozo, Brynn H., Cochran, Kelly E., John, Simon W. M.

“…Glaucoma is a complex neurodegenerative disease characterized by progressive visual dysfunction leading to vision loss. Retinal ganglion cells are the primary…”
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Author Correction: NMNAT2 is a druggable target to drive neuronal NAD production by Tribble, James R., Jöe, Melissa, Varricchio, Carmine, Otmani, Amin, Canovai, Alessio, Habchi, Baninia, Daskalakis, Evangelia, Chaleckis, Romanas, Loreto, Andrea, Gilley, Jonathan, Wheelock, Craig E., Jóhannesson, Gauti, Wong, Raymond C. B., Coleman, Michael P., Brancale, Andrea, Williams, Pete A.

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Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice by Harder, Jeffrey M, Williams, Pete A, Braine, Catherine E, Yang, Hongtian S, Thomas, Jocelyn M, Foxworth, Nicole E, John, Simon W M, Howell, Gareth R

“…The risk of glaucoma increases significantly with age and exposure to elevated intraocular pressure, two factors linked with neuroinflammation. The complement…”
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Potential Therapeutic Benefit of NAD + Supplementation for Glaucoma and Age-Related Macular Degeneration by Cimaglia, Gloria, Votruba, Marcela, Morgan, James E, André, Helder, Williams, Pete A

“…Glaucoma and age-related macular degeneration are leading causes of irreversible blindness worldwide with significant health and societal burdens. To date, no…”
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Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice by Tribble, James R, Harder, Jeffrey M, Williams, Pete A, John, Simon W M

“…Glaucoma is the leading cause of irreversible vision loss. Ocular hypertension is a major risk factor for glaucoma and recent work has demonstrated critical…”
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NMNAT2 is a druggable target to drive neuronal NAD production by Tribble, James R., Jöe, Melissa, Varricchio, Carmine, Otmani, Amin, Canovai, Alessio, Habchi, Baninia, Daskalakis, Evangelia, Chaleckis, Romanas, Loreto, Andrea, Gilley, Jonathan, Wheelock, Craig E., Jóhannesson, Gauti, Wong, Raymond C. B., Coleman, Michael P., Brancale, Andrea, Williams, Pete A.

“…Maintenance of NAD pools is critical for neuronal survival. The capacity to maintain NAD pools declines in neurodegenerative disease. We identify that low…”
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The prognostic implication of latitude in uveal melanoma: a nationwide observational cohort study of all patients born in Sweden between 1947 and 1989 by Stålhammar, Gustav, Williams, Pete A., Landelius, Tomas

“…Background The incidence of uveal melanoma increases with latitude. In this study, we examine the importance of latitude for uveal melanoma prognosis. Methods…”
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Glycolysis and glucose metabolism as a target for bioenergetic and neuronal protection in glaucoma by Williams, Pete A, Casson, Robert J

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Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma by Williams, Pete A, Braine, Catherine E, Kizhatil, Krishnakumar, Foxworth, Nicole E, Tolman, Nicholas G, Harder, Jeffrey M, Scott, Rebecca A, Sousa, Gregory L, Panitch, Alyssa, Howell, Gareth R, John, Simon W M

“…Glaucoma is characterized by the progressive dysfunction and loss of retinal ganglion cells. Recent work in animal models suggests that a critical…”
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A Miniature, Fiber-Coupled, Wireless, Deep-Brain Optogenetic Stimulator by Lee, Steven T., Williams, Pete A., Braine, Catherine E., Lin, Da-Ting, John, Simon W. M., Irazoqui, Pedro P.

“…Controlled, wireless neuromodulation using miniature implantable devices is a long-sought goal in neuroscience. It will allow many studies and treatments that…”
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Widespread retina and optic nerve neuroinflammation in enucleated eyes from glaucoma patients by Rutigliani, Carola, Tribble, James R, Hagström, Anna, Lardner, Emma, Jóhannesson, Gauti, Stålhammar, Gustav, Williams, Pete A

“…Neuroinflammation is recognized as a key component of neurodegenerative disease. In glaucoma, a common neurodegenerative disease and the leading cause of…”
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