Search Results - "Williams, Noelle"

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15 by Ting, Han, Goralski, Maria, Gaskill, Nicholas, Capota, Emanuela, Kim, Jiwoong, Ting, Tabitha C., Xie, Yang, Williams, Noelle S., Nijhawan, Deepak

“…Indisulam is an aryl sulfonamide drug with selective anticancer activity. Its mechanism of action and the basis for its selectivity have so far been unknown…”
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Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells by Lafita-Navarro, M Carmen, Venkateswaran, Niranjan, Kilgore, Jessica A, Kanji, Suman, Han, Jungsoo, Barnes, Spencer, Williams, Noelle S, Buszczak, Michael, Burma, Sandeep, Conacci-Sorrell, Maralice

“…Glioblastoma is the most common and aggressive type of cancer in the brain; its poor prognosis is often marked by reoccurrence due to resistance to the…”
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Targeted inhibitors of P-glycoprotein increase chemotherapeutic-induced mortality of multidrug resistant tumor cells by Nanayakkara, Amila K., Follit, Courtney A., Chen, Gang, Williams, Noelle S., Vogel, Pia D., Wise, John G.

“…Overexpression of ATP-binding cassette (ABC) transporters is often linked to multidrug resistance (MDR) in cancer chemotherapies. P-glycoprotein (P-gp) is one…”
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MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer by Venkateswaran, Niranjan, Lafita-Navarro, M Carmen, Hao, Yi-Heng, Kilgore, Jessica A, Perez-Castro, Lizbeth, Braverman, Jonathan, Borenstein-Auerbach, Nofit, Kim, Min, Lesner, Nicholas P, Mishra, Prashant, Brabletz, Thomas, Shay, Jerry W, DeBerardinis, Ralph J, Williams, Noelle S, Yilmaz, Omer H, Conacci-Sorrell, Maralice

“…Tumors display increased uptake and processing of nutrients to fulfill the demands of rapidly proliferating cancer cells. Seminal studies have shown that the…”
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Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer by Lum, Lawrence, Chen, Baozhi, Dodge, Michael E, Tang, Wei, Lu, Jianming, Ma, Zhiqiang, Fan, Chih-Wei, Wei, Shuguang, Hao, Wayne, Kilgore, Jessica, Williams, Noelle S, Roth, Michael G, Amatruda, James F, Chen, Chuo

“…The pervasive influence of secreted Wnt signaling proteins in tissue homeostasis and tumorigenesis has galvanized efforts to identify small molecules that…”
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A mass balance approach for calculation of recovery and binding enables the use of ultrafiltration as a rapid method for measurement of plasma protein binding for even highly lipophilic compounds by Wang, Changguang, Williams, Noelle S.

“…Correlation of mean %PPB in mouse plasma of 27 compounds determined by ultrafiltration versus rapid equilibrium dialysis. %PPB was determined by mass balance…”
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Utilizing Digital Health to Collect Electronic Patient-Reported Outcomes in Prostate Cancer: Single-Arm Pilot Trial by Tran, Christine, Dicker, Adam, Leiby, Benjamin, Gressen, Eric, Williams, Noelle, Jim, Heather

“…Measuring patient-reported outcomes (PROs) requires an individual's perspective on their symptoms, functional status, and quality of life. Digital health…”
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NQO1-dependent, Tumor-selective Radiosensitization of Non-small Cell Lung Cancers by Motea, Edward A, Huang, Xiumei, Singh, Naveen, Kilgore, Jessica A, Williams, Noelle S, Xie, Xian-Jin, Gerber, David E, Beg, Muhammad S, Bey, Erik A, Boothman, David A

“…Development of tumor-specific therapies for the treatment of recalcitrant non-small cell lung cancers (NSCLC) is urgently needed. Here, we investigated the…”
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Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study by McCarthy, James S, Prof, Lotharius, Julie, PhD, Rückle, Thomas, PhD, Chalon, Stephan, MD, Phillips, Margaret A, Prof, Elliott, Suzanne, PhD, Sekuloski, Silvana, PhD, Griffin, Paul, MD, Ng, Caroline L, PhD, Fidock, David A, Prof, Marquart, Louise, PhD, Williams, Noelle S, PhD, Gobeau, Nathalie, PhD, Bebrevska, Lidiya, PhD, Rosario, Maria, PhD, Marsh, Kennan, PhD, Möhrle, Jörg J, Dr

“…Summary Background DSM265 is a novel antimalarial that inhibits plasmodial dihydroorotate dehydrogenase, an enzyme essential for pyrimidine biosynthesis. We…”
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A trimethoprim derivative impedes antibiotic resistance evolution by Manna, Madhu Sudan, Tamer, Yusuf Talha, Gaszek, Ilona, Poulides, Nicole, Ahmed, Ayesha, Wang, Xiaoyu, Toprak, Furkan C. R., Woodard, DaNae R., Koh, Andrew Y., Williams, Noelle S., Borek, Dominika, Atilgan, Ali Rana, Hulleman, John D., Atilgan, Canan, Tambar, Uttam, Toprak, Erdal

“…The antibiotic trimethoprim (TMP) is used to treat a variety of Escherichia coli infections, but its efficacy is limited by the rapid emergence of…”
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Reducing acetylated tau is neuroprotective in brain injury by Shin, Min-Kyoo, Vázquez-Rosa, Edwin, Koh, Yeojung, Dhar, Matasha, Chaubey, Kalyani, Cintrón-Pérez, Coral J., Barker, Sarah, Miller, Emiko, Franke, Kathryn, Noterman, Maria F., Seth, Divya, Allen, Rachael S., Motz, Cara T., Rao, Sriganesh Ramachandra, Skelton, Lara A., Pardue, Machelle T., Fliesler, Steven J., Wang, Chao, Tracy, Tara E., Gan, Li, Liebl, Daniel J., Savarraj, Jude P.J., Torres, Glenda L., Ahnstedt, Hilda, McCullough, Louise D., Kitagawa, Ryan S., Choi, H. Alex, Zhang, Pengyue, Hou, Yuan, Chiang, Chien-Wei, Li, Lang, Ortiz, Francisco, Kilgore, Jessica A., Williams, Noelle S., Whitehair, Victoria C., Gefen, Tamar, Flanagan, Margaret E., Stamler, Jonathan S., Jain, Mukesh K., Kraus, Allison, Cheng, Feixiong, Reynolds, James D., Pieper, Andrew A.

“…Traumatic brain injury (TBI) is the largest non-genetic, non-aging related risk factor for Alzheimer’s disease (AD). We report here that TBI induces tau…”
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Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors by Huang, Xiumei, Motea, Edward A., Moore, Zachary R., Yao, Jun, Dong, Ying, Chakrabarti, Gaurab, Kilgore, Jessica A., Silvers, Molly A., Patidar, Praveen L., Cholka, Agnieszka, Fattah, Farjana, Cha, Yoonjeong, Anderson, Glenda G., Kusko, Rebecca, Peyton, Michael, Yan, Jingsheng, Xie, Xian-Jin, Sarode, Venetia, Williams, Noelle S., Minna, John D., Beg, Muhammad, Gerber, David E., Bey, Erik A., Boothman, David A.

“…Therapeutic drugs that block DNA repair, including poly(ADP-ribose) polymerase (PARP) inhibitors, fail due to lack of tumor-selectivity. When PARP inhibitors…”
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Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy by Ma, Xinpeng, Huang, Xiumei, Moore, Zachary, Huang, Gang, Kilgore, Jessica A., Wang, Yiguang, Hammer, Suntrea, Williams, Noelle S., Boothman, David A., Gao, Jinming

“…Lung cancer is one of the most lethal forms of cancer and current chemotherapeutic strategies lack broad specificity and efficacy. Recently, β-lapachone…”
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A male-derived nonribosomal peptide pheromone controls female schistosome development by Chen, Rui, Wang, Jipeng, Gradinaru, Irina, Vu, Hieu S., Geboers, Sophie, Naidoo, Jacinth, Ready, Joseph M., Williams, Noelle S., DeBerardinis, Ralph J., Ross, Elliott M., Collins, James J.

“…Schistosomes cause morbidity and death throughout the developing world due to the massive numbers of eggs female worms deposit into the blood of their host…”
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An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris by Iyer, Kali R., Camara, Kaddy, Daniel-Ivad, Martin, Trilles, Richard, Pimentel-Elardo, Sheila M., Fossen, Jen L., Marchillo, Karen, Liu, Zhongle, Singh, Shakti, Muñoz, José F., Kim, Sang Hu, Porco, John A., Cuomo, Christina A., Williams, Noelle S., Ibrahim, Ashraf S., Edwards, John E., Andes, David R., Nodwell, Justin R., Brown, Lauren E., Whitesell, Luke, Robbins, Nicole, Cowen, Leah E.

“…Candida auris is an emerging fungal pathogen that exhibits resistance to multiple drugs, including the most commonly prescribed antifungal, fluconazole. Here,…”
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Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK‐925 and ARN‐776 in narcoleptic orexin/tTA; TetO‐DTA mice by Sun, Yu, Ranjan, Alok, Tisdale, Ryan, Ma, Shun‐Chieh, Park, Sunmee, Haire, Meghan, Heu, Jasmine, Morairty, Stephen R., Wang, Xiaoyu, Rosenbaum, Daniel M., Williams, Noelle S., De Brabander, Jef K., Kilduff, Thomas S.

“…Summary The sleep disorder narcolepsy, a hypocretin deficiency disorder thought to be due to degeneration of hypothalamic hypocretin/orexin neurons, is…”
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Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer by Zhang, Lu, Theodoropoulos, Panayotis C, Eskiocak, Ugur, Wang, Wentian, Moon, Young-Ah, Posner, Bruce, Williams, Noelle S, Wright, Woodring E, Kim, Sang Bum, Nijhawan, Deepak, De Brabander, Jef K, Shay, Jerry W

“…Mutations in the adenomatous polyposis coli (APC) gene are common in colorectal cancer (CRC), and more than 90% of those mutations generate stable truncated…”
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Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency by Tesla, Rachel, Guhl, Charlotte, Werthmann, Gordon C., Dixon, Danielle, Cenik, Basar, Addepalli, Yesu, Liang, Jue, Fass, Daniel M., Rosenthal, Zachary, Haggarty, Stephen J., Williams, Noelle S., Posner, Bruce A., Ready, Joseph M., Herz, Joachim

“…Heterozygous loss-of-function mutations in the GRN gene are a major cause of hereditary frontotemporal dementia. The mechanisms linking frontotemporal dementia…”
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Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist by Moon, Jesung, Zhou, Huanyu, Zhang, Li-shu, Tan, Wei, Liu, Ying, Zhang, Shanrong, Morlock, Lorraine K., Bao, Xiaoping, Palecek, Sean P., Feng, Jian Q., Williams, Noelle S., Amatruda, James F., Olson, Eric N., Bassel-Duby, Rhonda, Lum, Lawrence

“…The secreted Wnt signaling molecules are essential to the coordination of cell-fate decision making in multicellular organisms. In adult animals, the secreted…”
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Longer heating duration increases localized doxorubicin deposition and therapeutic index in Vx2 tumors using MR-HIFU mild hyperthermia and thermosensitive liposomal doxorubicin by Bing, Chenchen, Patel, Pratik, Staruch, Robert M., Shaikh, Sumbul, Nofiele, Joris, Wodzak Staruch, Michelle, Szczepanski, Debra, Williams, Noelle S., Laetsch, Theodore, Chopra, Rajiv

“…Thermosensitive liposomal doxorubicin (LTSL-Dox) combined with mild hyperthermia enhances the localized delivery of doxorubicin (Dox) within a heated region…”
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