Search Results - "Williams, Mark T. S."

Cancer Treatment: An Overview of Pulsed Electric Field Utilization and Generation by Alshahat, Mahmoud A, Elgenedy, Mohamed A, Aboushady, Ahmed A, Williams, Mark T. S

“…Patients diagnosed with cancer receive different types of treatments based on the type and the level of the tumour. An emerging treatment that differs from…”
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IL-10R inhibition reprograms tumor-associated macrophages and reverses drug resistance in multiple myeloma by Sun, Jennifer, Corradini, Stefan, Azab, Feda, Shokeen, Monica, Muz, Barbara, Miari, Katerina E., Maksimos, Mina, Diedrich, Camila, Asare, Obed, Alhallak, Kinan, Park, Chaelee, Lubben, Berit, Chen, Yixuan, Adebayo, Ola, Bash, Hannah, Kelley, Sarah, Fiala, Mark, Bender, Diane E., Zhou, Haibin, Wang, Shaomeng, Vij, Ravi, Williams, Mark T. S., Azab, Abdel Kareem

“…Multiple myeloma (MM) is the cancer of plasma cells within the bone marrow and remains incurable. Tumor-associated macrophages (TAMs) within the tumor…”
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The ability to cross the blood–cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts by Williams, Mark T.S., Yousafzai, Yasar M., Elder, Alex, Rehe, Klaus, Bomken, Simon, Frishman-Levy, Liron, Tavor, Sigal, Sinclair, Paul, Dormon, Katie, Masic, Dino, Perry, Tracey, Weston, Victoria J., Kearns, Pamela, Blair, Helen, Russell, Lisa J., Heidenreich, Olaf, Irving, Julie A.E., Izraeli, Shai, Vormoor, Josef, Graham, Gerard J., Halsey, Christina

“…Prevention of central nervous system (CNS) relapse is critical for cure of childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Despite this,…”
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Macrophages in Acute Myeloid Leukaemia: Significant Players in Therapy Resistance and Patient Outcomes by Miari, Katerina E., Guzman, Monica L., Wheadon, Helen, Williams, Mark T. S.

“…Acute Myeloid Leukaemia (AML) is a commonly occurring severe haematological malignancy, with most patients exhibiting sub-optimal clinical outcomes. Therapy…”
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Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia by Williams, Mark T.S., Yousafzai, Yasar, Cox, Charlotte, Blair, Allison, Carmody, Ruaidhrí, Sai, Shuji, Chapman, Karen E., McAndrew, Rachel, Thomas, Angela, Spence, Alison, Gibson, Brenda, Graham, Gerard J., Halsey, Christina

“…Genome-wide association studies have consistently implicated the interleukin-15 (IL-15) gene in acute lymphoblastic leukemia (ALL) biology, including…”
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Deletion of TSPO Causes Dysregulation of Cholesterol Metabolism in Mouse Retina by Farhan, Fahad, Almarhoun, Mohammad, Wong, Aileen, Findlay, Amy S, Bartholomew, Chris, Williams, Mark T S, Hurd, Toby W, Shu, Xinhua

“…Cholesterol dysregulation has been implicated in age-related macular degeneration (AMD), the most common cause of visual impairment in the elderly. The 18 KDa…”
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Stromal bone marrow fibroblasts and mesenchymal stem cells support acute myeloid leukaemia cells and promote therapy resistance by Miari, Katerina E., Williams, Mark T. S.

“…The bone marrow (BM) is the primary site of adult haematopoiesis, where stromal elements (e.g. fibroblasts and mesenchymal stem cells [MSCs]) work in concert…”
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Cancer microenvironment and pharmacological interventions by Williams, Mark T. S., Guzman, Monica L.

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Multiple myeloma: therapeutic delivery of antibodies and aptamers by Pujol-Navarro, Neret, Al Qaraghuli, Mohammed M, Kubiak-Ossowska, Karina, Alsaadi, Manal M, Horne, Gillian A, Soutar, Richard L, Paspali, Elpiniki, Ferro, Valerie A, Williams, Mark Ts, Mulheran, Paul A

“…Multiple myeloma is the second most common hematological malignancy in adults, accounting for 2% of all cancer-related deaths in the UK. Current…”
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Targeting 3D chromosomal architecture at the RANK loci to suppress myeloma-driven osteoclastogenesis by Thümmler, Katja, Williams, Mark TS, Kitson, Susan, Sood, Shatakshi, Akbar, Moeed, Cole, John J, Hunter, Ewan, Soutar, Richard, Goodyear, Carl S

“…Bone disease represents a major cause of morbidity and mortality in Multiple Myeloma (MM); primarily driven by osteoclasts whose differentiation is dependent…”
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Central Nervous System Involvement in a Xenograft Model of Pre-B Acute Lymphoblastic Leukaemia Is Associated with Dysfunctional CXCR4 Expression and Upregulation of the Neurotropic Chemokine Receptors CCR6 and CX3CR1 by Halsey, Christina, Williams, Mark TS, Yousafzai, Yasar, Rehe, Klaus, Heidenreich, Olaf, Vormoor, Josef, Gibson, Brenda, Graham, Gerard

“…Abstract 3449 Despite huge advances in the treatment of paediatric acute lymphoblastic leukaemia (ALL) challenges remain. Disease in the central nervous system…”
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An Analysis Of Mechanisms Of Central Nervous System Infiltration In Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice by Yousafzai, Yasar M, Williams, Mark TS, Rehe, Klaus, Le Brocq, Michelle, Bomken, Simon, Sinclair, Paul B, Dormon, Katie, Masic, Dino, Archer, Leanne, Watt, Jennifer, Perry, Tracey A, Weston, Victoria J, Kearns, Pamela R, Blair, Helen, Lisa, Russel, Heidenreich, Olaf, Irving, Julie, Vormoor, Josef, Gibson, Brenda, Graham, Gerard J, Halsey, Christina

“…Despite great advances in the treatment of paediatric acute lymphoblastic leukaemia (ALL), disease in the central nervous system (CNS) continues to pose…”
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Targeting 3D chromosomal architecture at the RANK loci to suppress myeloma-driven osteoclastogenesis by Thümmler, Katja, Williams, Mark TS, Kitson, Susan, Sood, Shatakshi, Akbar, Moeed, Cole, John J, Hunter, Ewan, Soutar, Richard, Goodyear, Carl S

“…Bone disease represents a major cause of morbidity and mortality in Multiple Myeloma (MM); primarily driven by osteoclasts whose differentiation is dependent…”
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