Search Results - "Williams, Jan"

NLRP3 inflammasome inhibition attenuates sepsis-induced platelet activation and prevents multi-organ injury in cecal-ligation puncture by Cornelius, Denise C, Travis, Olivia K, Tramel, Robert W, Borges-Rodriguez, Marivee, Baik, Cedar H, Greer, Mallory, Giachelli, Chelsea A, Tardo, Geilda A, Williams, Jan M

“…Sepsis is characterized by organ dysfunction due to a dysregulated immune response to infection. Currently, no effective treatment for sepsis exists. Platelets…”
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Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial by Vermorken, Jan B, Dr, Stöhlmacher-Williams, Jan, MD, Davidenko, Irina, MD, Licitra, Lisa, MD, Winquist, Eric, MD, Villanueva, Cristian, MD, Foa, Paolo, MD, Rottey, Sylvie, MD, Skladowski, Krzysztof, MD, Tahara, Makoto, MD, Pai, Vasant R, MD, Faivre, Sandrine, MD, Blajman, Cesar R, MD, Forastiere, Arlene A, MD, Stein, Brian N, MBBS, Oliner, Kelly S, PhD, Pan, Zhiying, PhD, Bach, Bruce A, MD

“…Summary Background Previous trials have shown that anti-EGFR monoclonal antibodies can improve clinical outcomes of patients with recurrent or metastatic…”
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Effects of a new SGLT2 inhibitor, luseogliflozin, on diabetic nephropathy in T2DN rats by Kojima, Naoki, Williams, Jan M, Takahashi, Teisuke, Miyata, Noriyuki, Roman, Richard J

“…This study examined the effect of long-term control of hyperglycemia with a new sodium glucose cotransporter 2 inhibitor, luseogliflozin, given alone or in…”
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Efficacy of the irreversible ErbB family blocker afatinib in epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)-pretreated non-small-cell lung cancer patients with brain metastases or leptomeningeal disease by Hoffknecht, Petra, Tufman, Amanda, Wehler, Thomas, Pelzer, Theo, Wiewrodt, Rainer, Schütz, Martin, Serke, Monika, Stöhlmacher-Williams, Jan, Märten, Angela, Maria Huber, Rudolf, Dickgreber, Nicolas J

“…Afatinib is an effective first-line treatment in patients with epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC) and has shown…”
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AT1-AA (Angiotensin II Type 1 Receptor Agonistic Autoantibody) Blockade Prevents Preeclamptic Symptoms in Placental Ischemic Rats by Cunningham, Mark W, Castillo, Javier, Ibrahim, Tarek, Cornelius, Denise C, Campbell, Nathan, Amaral, Lorena, Vaka, Venkata Ramana, Usry, Nathan, Williams, Jan M, LaMarca, Babbette

“…Women with preeclampsia produce AT1-AA (agonistic autoantibodies to the angiotensin II type 1 receptor), which stimulate reactive oxygen species, inflammatory…”
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IL-33 supplementation improves uterine artery resistance and maternal hypertension in response to placental ischemia by Wang, Xi, Shields, Corbin, Tardo, Geilda, Peacock, Greg, Hester, Emily, Anderson, Marissa, Williams, Jan M, Cornelius, Denise C

“…Preeclampsia (PE), a leading cause of maternal/fetal morbidity and mortality, is a hypertensive pregnancy disorder with end-organ damage that manifests after…”
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20-Hydroxyeicosatetraeonic Acid: A New Target for the Treatment of Hypertension by Williams, Jan M, Murphy, Sydney, Burke, Marilyn, Roman, Richard J

“…Arachidonic acid is metabolized by enzymes of the CYP4A and 4F families to 20-hydroxyeicosatetraeonic acid (20-HETE), which plays an important role in the…”
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Agonistic Autoantibodies to the Angiotensin II Type 1 Receptor Enhance Angiotensin II–Induced Renal Vascular Sensitivity and Reduce Renal Function During Pregnancy by Cunningham, Mark W, Williams, Jan M, Amaral, Lorena, Usry, Nathan, Wallukat, Gerd, Dechend, Ralf, LaMarca, Babbette

“…Preeclamptic women produce agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA) and exhibit increased blood pressure (mean arterial…”
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Neutralizing MIP3 α Reduces Renal Immune Cell Infiltration and Progressive Renal Injury in Young Obese Dahl Salt-Sensitive Rats by Ekperikpe, Ubong S, Poudel, Bibek, Shields, Corbin A, Mandal, Sautan, Cornelius, Denise C, Williams, Jan M

“…Recently, we reported that the early progression of renal injury in obese Dahl salt-sensitive leptin receptor mutant (SS mutant) rats was associated with…”
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20-Hydroxyeicosatetraenoic acid contributes to the inhibition of K+ channel activity and vasoconstrictor response to angiotensin II in rat renal microvessels by Fan, Fan, Sun, Cheng-Wen, Maier, Kristopher G, Williams, Jan M, Pabbidi, Malikarjuna R, Didion, Sean P, Falck, John R, Zhuo, Jialong, Roman, Richard J

“…The present study examined whether 20-hydroxyeicosatetraenoic acid (HETE) contributes to the vasoconstrictor effect of angiotensin II (ANG II) in renal…”
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Synergistic Interaction of Hypertension and Diabetes in Promoting Kidney Injury and the Role of Endoplasmic Reticulum Stress by Wang, Zhen, do Carmo, Jussara M, Aberdein, Nicola, Zhou, Xinchun, Williams, Jan M, da Silva, Alexandre A, Hall, John E

“…Diabetes mellitus and hypertension are major risk factors for chronic kidney injury, together accounting for >70% of end-stage renal disease. In this study, we…”
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NLRP3 inhibition improves maternal hypertension, inflammation, and vascular dysfunction in response to placental ischemia by Wang, Xi, Travis, Olivia K, Shields, Corbin A, Tardo, G Ann, Giachelli, Chelsea, Nutter, Christopher W, Glenn, Hannah L, Cooper, Olive G, Davis, Tatiana, Thomas, Rashauna, Williams, Jan M, Cornelius, Denise C

“…Preeclampsia (PE) is a pregnancy-specific hypertensive disorder with end-organ damage that presents after 20 wk of gestation. PE pathophysiology often includes…”
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The Dahl salt-sensitive rat is a spontaneous model of superimposed preeclampsia by Gillis, Ellen E, Williams, Jan M, Garrett, Michael R, Mooney, Jennifer N, Sasser, Jennifer M

“…The mechanisms of the pathogenesis of preeclampsia, a leading cause of maternal morbidity and death worldwide, are poorly understood in part due to a lack of…”
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Chronic treatment with IL-25 increases renal M2 macrophages and reduces renal injury in obese Dahl salt-sensitive rats during the prepubescent stage by Poudel, Bibek, Ekperikpe, Ubong S, Mandal, Sautan, Wilson, Gregory E, Shields, Corbin A, Cornelius, Denise C, Williams, Jan M

“…Recently, we have reported that the early progression of proteinuria in the obese Dahl salt-sensitive (SS) leptin receptor mutant (SS mutant) strain was…”
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Treatment with rapamycin reduces progressive proteinuria while inducing hyperglycemia in obese Dahl salt‐sensitive leptin‐receptor mutant rats prior to puberty by Brown, Andrea K., Ekperikpe, Ubong S., Cornelius, Denise C., Williams, Jan M.

“…Prepubertal obesity (PPO) is now considered a risk factor for the development of proteinuria and renal injury in children. Recently, we observed the early…”
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Knockout of Dual-Specificity Protein Phosphatase 5 Protects Against Hypertension-Induced Renal Injury by Zhang, Chao, He, Xiaochen, Murphy, Sydney R, Zhang, Huawei, Wang, Shaoxun, Ge, Ying, Gao, Wenjun, Williams, Jan M, Geurts, Aron M, Roman, Richard J, Fan, Fan

“…Dual-specificity protein phosphatase 5 (DUSP5) is a member of the tyrosine-threonine phosphatase family with the ability to dephosphorylate and inactivate…”
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TFAP2E–DKK4 and Chemoresistance in Colorectal Cancer by Ebert, Matthias P.A, Tänzer, Marc, Balluff, Benjamin, Burgermeister, Elke, Kretzschmar, Antje Karen, Hughes, David J, Tetzner, Reimo, Lofton-Day, Catherine, Rosenberg, Robert, Reinacher-Schick, Anke C, Schulmann, Karsten, Tannapfel, Andrea, Hofheinz, Ralf, Röcken, Christoph, Keller, Gisela, Langer, Rupert, Specht, Katja, Porschen, Rainer, Stöhlmacher-Williams, Jan, Schuster, Tibor, Ströbel, Philipp, Schmid, Roland M

“…Patients whose tumors showed methylation and decreased expression of the gene TFAP2E were more than five times as likely as patients with normal TFAP2E gene…”
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Inhibition of Caspase 1 Reduces Blood Pressure, Cytotoxic NK Cells, and Inflammatory T-Helper 17 Cells in Placental Ischemic Rats by Shields, Corbin A, Tardo, Geilda A, Wang, Xi, Peacock, Gregory, Robbins, Marcus, Glenn, Hannah, Wilson, Rachel, Williams, Jan M, Cornelius, Denise C

“…Preeclampsia (PE) is characterized by maternal hypertension, fetal growth restriction (FGR), and increased inflammation and populations of cytotoxic NK cells…”
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Placental ischemia-stimulated T-helper 17 cells induce preeclampsia-associated cytolytic natural killer cells during pregnancy by Shields, Corbin A, McCalmon, Maggie, Ibrahim, Tarek, White, Dakota L, Williams, Jan M, LaMarca, Babbette, Cornelius, Denise C

“…Previous studies have demonstrated that T-helper 17 (T 17) cells and cytolytic natural killer (cNK) cells are increased in women with preeclampsia. In this…”
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IL‐33 Signaling Inhibition Leads to a Preeclampsia‐Like Phenotype in Pregnant Rats by Wang, Xi, Shields, Corbin A., Thompson, Deanna, McKay, Jie, Wilson, Rachel, Robbins, Marcus K., Glenn, Hannah, Fontenot, Molly, Williams, Jan M., Cornelius, Denise C.

“…ABSTRACT Problem Preeclampsia (PE) is a hypertensive pregnancy disorder that is a leading cause of maternal and fetal morbidity and mortality characterized by…”
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