Search Results - "Williams, James A"

Advancements in DNA vaccine vectors, non-mechanical delivery methods, and molecular adjuvants to increase immunogenicity by Suschak, John J., Williams, James A., Schmaljohn, Connie S.

“…A major advantage of DNA vaccination is the ability to induce both humoral and cellular immune responses. DNA vaccines are currently used in veterinary…”
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HIV-1 Neutralizing Antibodies with Limited Hypermutation from an Infant by Simonich, Cassandra A., Williams, Katherine L., Verkerke, Hans P., Williams, James A., Nduati, Ruth, Lee, Kelly K., Overbaugh, Julie

“…HIV-1 broadly neutralizing antibodies (bnAbs) develop in a subset of infected adults and exhibit high levels of somatic hypermutation (SHM) due to years of…”
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Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes by Cornell, Caitlin E., Black, Roy A., Xue, Mengjun, Litz, Helen E., Ramsay, Andrew, Gordon, Moshe, Mileant, Alexander, Cohen, Zachary R., Williams, James A., Lee, Kelly K., Drobny, Gary P., Keller, Sarah L.

“…The membranes of the first protocells on the early Earth were likely self-assembled from fatty acids. A major challenge in understanding how protocells could…”
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Improving cell and gene therapy safety and performance using next-generation Nanoplasmid vectors by Williams, James A., Paez, Patrick A.

“…The cell and gene therapy industry has employed the same plasmid technology for decades in vaccination, cell and gene therapy, and as a raw material in viral…”
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Improving DNA vaccine performance through vector design by Williams, James A

“…DNA vaccines are a rapidly deployed next generation vaccination platform for treatment of human and animal disease. DNA delivery devices, such as…”
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Vector Design for Improved DNA Vaccine Efficacy, Safety and Production by Williams, James A

“…DNA vaccination is a disruptive technology that offers the promise of a new rapidly deployed vaccination platform to treat human and animal disease with…”
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Development of a SimpleProbe real-Time PCR Assay for rapid detection and identification of the US novel urethrotropic clade of Neisseria meningitidis ST-11 (US_NmUC) by Toh, Evelyn, Williams, James A, Qadadri, Brahim, Ermel, Aaron, Nelson, David E

“…Urethritis, or inflammation of the urethra, is one of the most common reasons men seek clinical care. Sexually transmitted pathogens including Neisseria…”
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Neisseria meningitidis ST11 Complex Isolates Associated with Nongonococcal Urethritis, Indiana, USA, 2015-2016 by Toh, Evelyn, Gangaiah, Dharanesh, Batteiger, Byron E, Williams, James A, Arno, Janet N, Tai, Albert, Batteiger, Teresa A, Nelson, David E

“…At a clinic in Indianapolis, Indiana, USA, we observed an increase in Neisseria gonorrhoeae-negative men with suspected gonococcal urethritis who had urethral…”
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Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage by Simonich, Cassandra A., Doepker, Laura, Ralph, Duncan, Williams, James A., Dhar, Amrit, Yaffe, Zak, Gentles, Lauren, Small, Christopher T., Oliver, Brian, Vigdorovich, Vladimir, Mangala Prasad, Vidya, Nduati, Ruth, Sather, D. Noah, Lee, Kelly K., Matsen IV, Frederick A., Overbaugh, Julie

“…HIV-infected infants develop broadly neutralizing plasma responses with more rapid kinetics than adults, suggesting the ontogeny of infant responses could…”
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Improved antibiotic-free DNA vaccine vectors utilizing a novel RNA based plasmid selection system by Luke, Jeremy, Carnes, Aaron E, Hodgson, Clague P, Williams, James A

“…Abstract To ensure safety, regulatory agencies recommend elimination of antibiotic resistance markers from therapeutic and vaccine plasmid DNA vectors. Here,…”
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Performance of the cobas CT/NG Test Compared to the Aptima AC2 and Viper CTQ/GCQ Assays for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae by VAN DER POL, Barbara, LIESENFELD, Oliver, WILLIAMS, James A, TAYLOR, Stephanie N, LILLIS, Rebecca A, BODY, Barbara A, NYE, Mindy, EISENHUT, Carol, HOOK, Edward W

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Detection of Trichomonas vaginalis DNA by Use of Self-Obtained Vaginal Swabs with the BD ProbeTec Qx Assay on the BD Viper System by Van Der Pol, Barbara, Williams, James A, Taylor, Stephanie N, Cammarata, Catherine L, Rivers, Charles A, Body, Barbara A, Nye, Melinda, Fuller, Deanna, Schwebke, Jane R, Barnes, Mathilda, Gaydos, Charlotte A

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Nanoplasmid Vectors Co-expressing Innate Immune Agonists Enhance DNA Vaccines for Venezuelan Equine Encephalitis Virus and Ebola Virus by Suschak, John J., Dupuy, Lesley C., Shoemaker, Charles J., Six, Carolyn, Kwilas, Steven A., Spik, Kristin W., Williams, James A., Schmaljohn, Connie S.

“…DNA vaccines expressing codon-optimized Venezuelan equine encephalitis virus (VEEV) and Ebola virus (EBOV) glycoprotein genes provide protective immunity to…”
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Superinfection Drives HIV Neutralizing Antibody Responses from Several B Cell Lineages that Contribute to a Polyclonal Repertoire by Williams, Katherine L., Wang, Bingjie, Arenz, Dana, Williams, James A., Dingens, Adam S., Cortez, Valerie, Simonich, Cassandra A., Rainwater, Stephanie, Lehman, Dara A., Lee, Kelly K., Overbaugh, Julie

“…Eliciting broad and potent HIV-specific neutralizing antibody responses represents the holy grail of HIV vaccine efforts. Data from singly infected individuals…”
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Coexpressed RIG-I Agonist Enhances Humoral Immune Response to Influenza Virus DNA Vaccine by LUKE, Jeremy M, SIMON, Gregory G, SÖDERHOLM, Jonas, ERRETT, John S, AUGUST, J. Thomas, GALE, Michael, HODGSON, Clague P, WILLIAMS, James A

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Comparison of the Abbott m2000 RealTime CT Assay and the Cepheid GeneXpert CT/NG Assay to the Roche Amplicor CT Assay for Detection of Chlamydia trachomatis in Ocular Samples from Tanzania by Dize, Laura, West, Sheila, Williams, James A, Van Der Pol, Barbara, Quinn, Thomas C, Gaydos, Charlotte A

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Novel Non-integrating DNA Nano-S/MAR Vectors Restore Gene Function in Isogenic Patient-Derived Pancreatic Tumor Models by Bozza, Matthias, Green, Edward W., Espinet, Elisa, De Roia, Alice, Klein, Corinna, Vogel, Vanessa, Offringa, Rienk, Williams, James A., Sprick, Martin, Harbottle, Richard P.

“…We describe herein non-integrating minimally sized nano-S/MAR DNA vectors, which can be used to genetically modify dividing cells in place of integrating…”
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Enhanced neutralising antibody response to bovine viral diarrhoea virus (BVDV) induced by DNA vaccination in calves by R. El-Attar, Laila M, Thomas, Carole, Luke, Jeremy, A. Williams, James, Brownlie, Joe

“…Highlights • Co-expression of a RIG-I agonist with BVDV viral antigen could enhance DNA vaccine potency in cattle. • Integration of RIG-I agonist greatly…”
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Extensive Variation and Rapid Shift of the MG192 Sequence in Mycoplasma genitalium Strains from Patients with Chronic Infection by Ma, Liang, Mancuso, Miriam, Williams, James A, Van Der Pol, Barbara, Fortenberry, J Dennis, Jia, Qiuyao, Myers, Leann, Martin, David H

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Delivery of non-viral naked DNA vectors to liver in small weaned pigs by hydrodynamic retrograde intrabiliary injection by Chan, Tatjana, Grisch-Chan, Hiu Man, Schmierer, Philipp, Subotic, Ulrike, Rimann, Nicole, Scherer, Tanja, Hetzel, Udo, Bozza, Matthias, Harbottle, Richard, Williams, James A., Steblaj, Barbara, Ringer, Simone K., Häberle, Johannes, Sidler, Xaver, Thöny, Beat

“…Hepatic gene therapy by delivering non-integrating therapeutic vectors in newborns remains challenging due to the risk of dilution and loss of efficacy in the…”
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