Search Results - "Williams, Glynn"

A Scalable Metal‐, Azide‐, and Halogen‐Free Method for the Preparation of Triazoles by Clark, Peter R., Williams, Glynn D., Hayes, Jerome F., Tomkinson, Nicholas C. O.

“…A scalable metal‐, azide‐, and halogen‐free method for the synthesis of substituted 1,2,3‐triazoles has been developed. The reaction proceeds through a…”
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Development of a Large-Scale Copper(I)/TEMPO-Catalyzed Aerobic Alcohol Oxidation for the Synthesis of LSD1 Inhibitor GSK2879552 by Ochen, Augustine, Whitten, Robert, Aylott, Helen E, Ruffell, Katie, Williams, Glynn D, Slater, Fiona, Roberts, Andrew, Evans, Paul, Steves, Janelle E, Sanganee, Mahesh J

“…An improved process to an aldehyde en route to an LSD1 inhibitor was developed using an aerobic oxidation with a CuI and TEMPO (2,2,6,6-tetramethylpiperdine…”
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Organic Solvent Nanofiltration (OSN): A New Technology Platform for Liquid-Phase Oligonucleotide Synthesis (LPOS) by Kim, Jeong F, Gaffney, Piers R. J, Valtcheva, Irina B, Williams, Glynn, Buswell, Andrew M, Anson, Mike S, Livingston, Andrew G

“…Organic solvent nanofiltration (OSN) technology is a membrane process for molecular separation in harsh organic media. However, despite having well-documented…”
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Process Safety in the Pharmaceutical Industry: A Selection of Illustrative Case Studies by Dunn, Anna L, Payne, Andrew, Clark, Peter R, McKay, Christopher, Williams, Glynn D, Wheelhouse, Katherine, Arendt, Kevin, Dixon, Frank, Shilcrat, Susan

“…Awareness of best safety practices in the industrial sector will allow students in chemistry and chemical engineering programs to apply these approaches to…”
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Multigram Synthesis of Tetrasubsituted Dihydrobenzofuran GSK973 Enabled by High-Throughput Experimentation and a Claisen Rearrangement in Flow by Alder, Catherine M, Gray, Matthew, Huff, Chelsea A, Manning, Calvin O, Preston, Alex, Rushworth, Philip, Shuster, Leanna E, Watson, Robert J, Wheelhouse, Katherine M. P, Williams, Glynn D, Demont, Emmanuel H

“…This article describes two routes toward the synthesis of cis or trans C2,3,5,7-tetrasubstituted dihydrobenzofurans as potent and selective bromodomain and…”
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Correction to “Multigram Synthesis of Tetrasubstituted Dihydrobenzofuran GSK973 Enabled by High-Throughput Experimentation and a Claisen Rearrangement in Flow” by Alder, Catherine M, Gray, Matthew, Huff, Chelsea A, Manning, Calvin O, Preston, Alex, Rushworth, Philip, Shuster, Leanna E, Watson, Robert J, Wheelhouse, Katherine M. P, Williams, Glynn D, Demont, Emmanuel H

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Liquid-Phase Synthesis of 2′-Methyl-RNA on a Homostar Support through Organic-Solvent Nanofiltration by Gaffney, Piers R. J., Kim, Jeong F., Valtcheva, Irina B., Williams, Glynn D., Anson, Mike S., Buswell, Andrew M., Livingston, Andrew G.

“…Due to the discovery of RNAi, oligonucleotides (oligos) have re‐emerged as a major pharmaceutical target that may soon be required in ton quantities. However,…”
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A One-Pot Process for the Enantioselective Synthesis of Amines via Reductive Amination under Transfer Hydrogenation Conditions by Williams, Glynn D, Pike, Richard A, Wade, Charles E, Wills, Martin

“…Cyclic amines may be prepared via a sequence of deprotection followed by intramolecular reductive amination of t-Boc-protected amino ketones under asymmetric…”
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Knowledge and attitudes of anesthesia providers about noncardiac surgery in adults with congenital heart disease by Maxwell, Bryan G, Williams, Glynn D, Ramamoorthy, Chandra

“…To examine the knowledge and attitudes of anesthesia providers in relation to the care of adult congenital heart disease (ACHD) patients presenting for…”
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A Scalable Metal‐, Azide‐, and Halogen‐Free Method for the Preparation of Triazoles by Clark, Peter R., Williams, Glynn D., Hayes, Jerome F., Tomkinson, Nicholas C. O.

“…A scalable metal‐, azide‐, and halogen‐free method for the synthesis of substituted 1,2,3‐triazoles has been developed. The reaction proceeds through a…”
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An azide and acetylene free synthesis of 1-substituted 1,2,3-triazoles by Patterson, Sarah J.M., Clark, Peter R., Williams, Glynn D., Tomkinson, Nicholas C.O.

“…[Display omitted] •An azide and acetylene-free synthesis of 1-substituted 1,2,3-triazoles is presented.•2,2-Dimethoxyacetaldehyde as the carbon-precursor of…”
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Evaluation of Sponge Metal Catalysts in a Trickle Bed Reactor for the Continuous Hydrogenation of an Aliphatic Nitro Intermediate by Carangio, Antonella, Edwards, Lee J., Fernandez-Puertas, Eneritz, Hayes, Jerome F., Kucharski, Maciej M., Rutherford, Graham W., Wheelhouse, Katherine M. P., Williams, Glynn D.

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Multigram Synthesis of Tetrasubstituted Dihydrobenzofuran GSK973 Enabled by High-Throughput Experimentation and a Claisen Rearrangement in Flow by Alder, Catherine M., Gray, Matthew, Huff, Chelsea A., Manning, Calvin O., Preston, Alex, Rushworth, Philip, Shuster, Leanna E., Watson, Robert J., Wheelhouse, Katherine M. P., Williams, Glynn D., Demont, Emmanuel H.

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Selective Continuous Flow Iodination Guided by Direct Spectroscopic Observation of Equilibrating Aryl Lithium Regioisomers by Dunn, Anna L, Leitch, David C, Journet, Michel, Martin, Michael, Tabet, Elie A, Curtis, Neil R, Williams, Glynn, Goss, Charles, Shaw, Tony, O’Hare, Bernie, Wade, Charles, Toczko, Matthew A, Liu, Peng

“…The iodination of 4-fluoro-2-(trifluoromethyl)­benzonitrile via C–H lithiation and subsequent treatment with iodine under continuous flow conditions is…”
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Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides by Dysko, Anna, Baker, Ysobel R, McClorey, Graham, Wood, Matthew J. A, Fenner, Sabine, Williams, Glynn, El-Sagheer, Afaf, Brown, Tom

“…Oligonucleotides are rapidly emerging as powerful therapeutics for hard to treat diseases. Short single-stranded oligonucleotides can base pair with target RNA…”
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Radioactive waste management in the UAE: Proposal for an inventory management system by Al Nuaimi, Abdulla Hashim, Williams, Laurence Glynn

“…The United Arab Emirates (UAE) is currently heavily reliant on the burning of fossil-fuels to generate most of its electric power needs. Owing to the newly set…”
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An optimised synthetic approach to a chiral derivatising agent and the utilisation of a dimerisation reaction in the synthesis of a novel C2-symmetric diphosphine ligand by Williams, Glynn D., Wade, Charles E., Clarkson, Guy J., Wills, Martin

“…We report an optimised synthetic approach to the chiral derivatising agent (5 R)-methyl-1-(chloromethyl)-2-pyrrolidinone. In addition, the observation of an…”
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The use of lung scanning in the diagnosis of pulmonary embolism by Glynn-Williams, B

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Compounds Containing Bromide by Glynn-Williams, W. I.

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CHANGES IN PULMONARY FUNCTION AFTER MODIFIED VENO-VENOUS ULTRAFILTRATION FOLLOWING CARDIOPULMONARY BYPASS IN INFANTS by Thiagarajan, Ravi, Keenan, Heather, Stephens, Kenton, Williams, Glynn, Ramamoorthy, Chandra, Lupinetti, F. Mark

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