Search Results - "Williams, David B"

Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulum by Williams, David B

“…Calnexin and calreticulin are related proteins that comprise an ER chaperone system that ensures the proper folding and quality control of newly synthesized…”
Get full text

Participation of lectin chaperones and thiol oxidoreductases in protein folding within the endoplasmic reticulum by Rutkevich, Lori A, Williams, David B

“…Protein folding within the endoplasmic reticulum occurs in conjunction with a complex array of molecular chaperones and folding catalysts that assist the…”
Get full text

Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease by Bradford, Emily M, Ryu, Stacy H, Singh, Ajay Pal, Lee, Goo, Goretsky, Tatiana, Sinh, Preetika, Williams, David B, Cloud, Amber L, Gounaris, Elias, Patel, Vihang, Lamping, Olivia F, Lynch, Evan B, Moyer, Mary Pat, De Plaen, Isabelle G, Shealy, David J, Yang, Guang-Yu, Barrett, Terrence A

“…TNF plays an integral role in inflammatory bowel disease (IBD), as evidenced by the dramatic therapeutic responses in Crohn's disease (CD) patients induced by…”
Get full text

Vitamin K epoxide reductase contributes to protein disulfide formation and redox homeostasis within the endoplasmic reticulum by Rutkevich, Lori A, Williams, David B

“…The transfer of oxidizing equivalents from the endoplasmic reticulum (ER) oxidoreductin (Ero1) oxidase to protein disulfide isomerase is an important pathway…”
Get full text

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death by Panaretakis, Theocharis, Kepp, Oliver, Brockmeier, Ulf, Tesniere, Antoine, Bjorklund, Ann-Charlotte, Chapman, Daniel C, Durchschlag, Michael, Joza, Nicholas, Pierron, Gérard, van Endert, Peter, Yuan, Junying, Zitvogel, Laurence, Madeo, Frank, Williams, David B, Kroemer, Guido

“…Dying tumour cells can elicit a potent anticancer immune response by exposing the calreticulin (CRT)/ERp57 complex on the cell surface before the cells…”
Get full text

Structural Basis of Carbohydrate Recognition by Calreticulin by Kozlov, Guennadi, Pocanschi, Cosmin L., Rosenauer, Angelika, Bastos-Aristizabal, Sara, Gorelik, Alexei, Williams, David B., Gehring, Kalle

“…The calnexin cycle is a process by which glycosylated proteins are subjected to folding cycles in the endoplasmic reticulum lumen via binding to the membrane…”
Get full text

The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis by Kim, Seok-Jo, Cheresh, Paul, Jablonski, Renea P, Williams, David B, Kamp, David W

“…Convincing evidence has emerged demonstrating that impairment of mitochondrial function is critically important in regulating alveolar epithelial cell (AEC)…”
Get full text

Spherically complete models of Hensel minimal valued fields by Bradley‐Williams, David B., Halupczok, Immanuel

“…We prove that Hensel minimal expansions of finitely ramified Henselian valued fields admit spherically complete immediate elementary extensions. More…”
Get full text

Functional relationship between protein disulfide isomerase family members during the oxidative folding of human secretory proteins by Rutkevich, Lori A, Cohen-Doyle, Myrna F, Brockmeier, Ulf, Williams, David B

“…To examine the relationship between protein disulfide isomerase family members within the mammalian endoplasmic reticulum, PDI, ERp57, ERp72, and P5 were…”
Get full text

Contributions of the Lectin and Polypeptide Binding Sites of Calreticulin to Its Chaperone Functions in Vitro and in Cells by Lum, Ronnie, Ahmad, Samar, Hong, Seo Jung, Chapman, Daniel C., Kozlov, Guennadi, Williams, David B.

“…Calreticulin is a lectin chaperone of the endoplasmic reticulum that interacts with newly synthesized glycoproteins by binding to Glc1Man9GlcNAc2…”
Get full text

Cyclophilin C Participates in the US2-Mediated Degradation of Major Histocompatibility Complex Class I Molecules by Chapman, Daniel C, Stocki, Pawel, Williams, David B

“…Human cytomegalovirus uses a variety of mechanisms to evade immune recognition through major histocompatibility complex class I molecules. One mechanism…”
Get full text

Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice by Cheresh, Paul, Morales-Nebreda, Luisa, Kim, Seok-Jo, Yeldandi, Anjana, Williams, David B, Cheng, Yuan, Mutlu, Gökhan M, Budinger, G R Scott, Ridge, Karen, Schumacker, Paul T, Bohr, Vilhelm A, Kamp, David W

“…Asbestos causes asbestosis and malignancies by mechanisms that are not fully established. Alveolar epithelial cell (AEC) injury and repair are crucial…”
Get full text

Structural and Functional Relationships between the Lectin and Arm Domains of Calreticulin by Pocanschi, Cosmin L., Kozlov, Guennadi, Brockmeier, Ulf, Brockmeier, Achim, Williams, David B., Gehring, Kalle

“…Calreticulin and calnexin are key components in maintaining the quality control of glycoprotein folding within the endoplasmic reticulum. Although their lectin…”
Get full text

The Chronus Quantum software package by Williams‐Young, David B., Petrone, Alessio, Sun, Shichao, Stetina, Torin F., Lestrange, Patrick, Hoyer, Chad E., Nascimento, Daniel R., Koulias, Lauren, Wildman, Andrew, Kasper, Joseph, Goings, Joshua J., Ding, Feizhi, DePrince, A. Eugene, Valeev, Edward F., Li, Xiaosong

“…The Chronus Quantum (ChronusQ) software package is an open source (under the GNU General Public License v2) software infrastructure which targets the solution…”
Get full text

ER quality control in the biogenesis of MHC class I molecules by Chapman, Daniel C., Williams, David B.

“…Class I molecules of the major histocompatibility complex play a vital role in cellular immunity, reporting on the presence of viral or tumor-associated…”
Get full text

Functions of ERp57 in the Folding and Assembly of Major Histocompatibility Complex Class I Molecules by Zhang, Yinan, Baig, Ehtesham, Williams, David B.

“…ERp57 is a thiol oxidoreductase of the endoplasmic reticulum that appears to be recruited to substrates indirectly through its association with the molecular…”
Get full text

Approximate Green’s Function Coupled Cluster Method Employing Effective Dimension Reduction by Peng, Bo, Van Beeumen, Roel, Williams-Young, David B, Kowalski, Karol, Yang, Chao

“…The Green’s function coupled cluster (GFCC) method, originally proposed in the early 1990s, is a powerful many-body tool for computing and analyzing the…”
Get full text

Distinct Contributions of the Lectin and Arm Domains of Calnexin to Its Molecular Chaperone Function by Brockmeier, Achim, Brockmeier, Ulf, Williams, David B.

“…Calnexin is a Ca2+-binding transmembrane chaperone of the endoplasmic reticulum that recognizes Glc1Man5–9GlcNAc2 oligosaccharides on folding glycoproteins as…”
Get full text

Review of screening for pancreatic cancer in high risk individuals by Stoita, Alina, Penman, Ian D, Williams, David B

“…Pancreatic cancer is difficult to diagnose at an early stage and is associated with a very poor survival.Ten percent of pancreatic cancers result from genetic…”
Get full text

Significant detection of new germline pathogenic variants in Australian Pancreatic Cancer Screening Program participants by Murali, Krithika, Dwarte, Tanya M, Nikfarjam, Mehrdad, Tucker, Katherine M, Vaughan, Rhys B, Efthymiou, Marios, Collins, Allison, Spigelman, Allan D, Salmon, Lucinda, Johns, Amber L, Williams, David B, Delatycki, Martin B, John, Thomas, Stoita, Alina

“…Abstract Background The Australian Pancreatic Cancer Screening Program (APCSP) offers endoscopic ultrasound surveillance for individuals at increased risk of…”
Get full text