Search Results - "Williams, Benfeard"

High-speed atomic force microscopy reveals structural dynamics of α-synuclein monomers and dimers by Zhang, Yuliang, Hashemi, Mohtadin, Lv, Zhengjian, Williams, Benfeard, Popov, Konstantin I, Dokholyan, Nikolay V, Lyubchenko, Yuri L

“…α-Synuclein (α-syn) is the major component of the intraneuronal inclusions called Lewy bodies, which are the pathological hallmark of Parkinson's disease…”
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ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations by Williams, 2nd, Benfeard, Convertino, Marino, Das, Jhuma, Dokholyan, Nikolay V

“…The increased risk of developing Alzheimer's disease (AD) is associated with the APOE gene, which encodes for three variants of Apolipoprotein E, namely E2,…”
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RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme by Miao, Zhichao, Adamiak, Ryszard W, Antczak, Maciej, Batey, Robert T, Becka, Alexander J, Biesiada, Marcin, Boniecki, Michał J, Bujnicki, Janusz M, Chen, Shi-Jie, Cheng, Clarence Yu, Chou, Fang-Chieh, Ferré-D'Amaré, Adrian R, Das, Rhiju, Dawson, Wayne K, Ding, Feng, Dokholyan, Nikolay V, Dunin-Horkawicz, Stanisław, Geniesse, Caleb, Kappel, Kalli, Kladwang, Wipapat, Krokhotin, Andrey, Łach, Grzegorz E, Major, François, Mann, Thomas H, Magnus, Marcin, Pachulska-Wieczorek, Katarzyna, Patel, Dinshaw J, Piccirilli, Joseph A, Popenda, Mariusz, Purzycka, Katarzyna J, Ren, Aiming, Rice, Greggory M, Santalucia, Jr, John, Sarzynska, Joanna, Szachniuk, Marta, Tandon, Arpit, Trausch, Jeremiah J, Tian, Siqi, Wang, Jian, Weeks, Kevin M, Williams, 2nd, Benfeard, Xiao, Yi, Xu, Xiaojun, Zhang, Dong, Zok, Tomasz, Westhof, Eric

“…RNA-Puzzles is a collective experiment in blind 3D RNA structure prediction. We report here a third round of RNA-Puzzles. Five puzzles, 4, 8, 12, 13, 14, all…”
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ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations: e1004359 by II, Benfeard Williams, Convertino, Marino, Das, Jhuma, Dokholyan, Nikolay V

“…The increased risk of developing Alzheimer's disease (AD) is associated with the APOE gene, which encodes for three variants of Apolipoprotein E, namely E2,…”
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Structure modeling of RNA using sparse NMR constraints by Williams, 2nd, Benfeard, Zhao, Bo, Tandon, Arpit, Ding, Feng, Weeks, Kevin M, Zhang, Qi, Dokholyan, Nikolay V

“…RNAs fold into distinct molecular conformations that are often essential for their functions. Accurate structure modeling of complex RNA motifs, including…”
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Molecular Mechanisms of the R61T Mutation in Apolipoprotein E4: A Dynamic Rescue by Williams, Benfeard, Convertino, Marino, Das, Jhuma, Dokholyan, Nikolay V.

“…The apolipoprotein E4 (ApoE4) gene is the strongest genetic risk factor for Alzheimer’s disease (AD). With respect to the other common isoforms of this protein…”
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An excited state underlies gene regulation of a transcriptional riboswitch by Zhao, Bo, Guffy, Sharon L, Williams, Benfeard, Zhang, Qi

“…The use of chemical exchange saturation transfer NMR reveals a previously hidden excited conformational state of the fluoride riboswitch, providing a model in…”
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Comparative Visualization of the RNA Suboptimal Conformational Ensemble In Vivo by Woods, Chanin T., Lackey, Lela, Williams, Benfeard, Dokholyan, Nikolay V., Gotz, David, Laederach, Alain

“…When a ribonucleic acid (RNA) molecule folds, it often does not adopt a single, well-defined conformation. The folding energy landscape of an RNA is highly…”
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Limits in accuracy and a strategy of RNA structure prediction using experimental information by Wang, Jian, Williams, Benfeard, Chirasani, Venkata R, Krokhotin, Andrey, Das, Rajeshree, Dokholyan, Nikolay V

“…RNA structural complexity and flexibility present a challenge for computational modeling efforts. Experimental information and bioinformatics data can be used…”
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P2‐068: Rational Design of APOE4 Mutants as a Tool for Cellular Studies in Alzheimer’s Disease by Williams, Benfeard, Convertino, Marino, Das, Jhuma, Dokholyan, Nikolay V.

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RATIONAL DESIGN OF APOE4 MUTANTS AS A TOOL FOR CELLULAR STUDIES IN ALZHEIMER’S DISEASE by Williams, Benfeard, Convertino, Marino, Das, Jhuma, Dokholyan, Nikolay V

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The Structure of Apolipoprotein E Isoforms and their Role in Alzheimer's Disease by Williams, Benfeard L

“…Alzheimer’s disease (AD) is a chronic, incurable neurodegenerative disorder. AD is the most common form of dementia. The strongest genetic risk factor for AD…”
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