Search Results - "Williams, Adrian C"

Chitosan-based mucoadhesive tablets for oral delivery of ibuprofen by Sogias, Ioannis A., Williams, Adrian C., Khutoryanskiy, Vitaliy V.

“…Chitosan and its half-acetylated derivative have been compared as excipients in mucoadhesive tablets containing ibuprofen. Initially the powder formulations…”
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Serotonin Syndrome: Pathophysiology, Clinical Features, Management, and Potential Future Directions by Scotton, William J, Hill, Lisa J, Williams, Adrian C, Barnes, Nicholas M

“…Serotonin syndrome (SS) (also referred to as serotonin toxicity) is a potentially life-threatening drug-induced toxidrome associated with increased…”
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POZylation: a new approach to enhance nanoparticle diffusion through mucosal barriers by Mansfield, Edward D H, Sillence, Katy, Hole, Patrick, Williams, Adrian C, Khutoryanskiy, Vitaliy V

“…The increasing use of nanoparticles in the pharmaceutical industry is generating concomitant interest in developing nanomaterials that can rapidly penetrate…”
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On the Role of Specific Interactions in the Diffusion of Nanoparticles in Aqueous Polymer Solutions by Mun, Ellina A, Hannell, Claire, Rogers, Sarah E, Hole, Patrick, Williams, Adrian C, Khutoryanskiy, Vitaliy V

“…Understanding nanoparticle diffusion within non-Newtonian biological and synthetic fluids is essential in designing novel formulations (e.g., nanomedicines for…”
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Controlling the Size of Thiolated Organosilica Nanoparticles by Al Mahrooqi, Jamila H, Mun, Ellina A, Williams, Adrian C, Khutoryanskiy, Vitaliy V

“…Nanoparticle characteristics, including their size, are governed by the reagents employed and the reaction parameters. Here, we systemically vary the catalyst,…”
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Common microRNA regulated pathways in Alzheimer’s and Parkinson’s disease by Awuson-David, Betina, Williams, Adrian C., Wright, Benjamin, Hill, Lisa J., Di Pietro, Valentina

“…MicroRNAs (miRNAs) are small non-coding RNAs involved in gene regulation. Recently, miRNA dysregulation has been found in neurodegenerative diseases such as…”
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Synthesis and Evaluation of Poly(3-hydroxypropyl Ethylene-imine) and Its Blends with Chitosan Forming Novel Elastic Films for Delivery of Haloperidol by Soradech, Sitthiphong, Kengkwasingh, Pattarawadee, Williams, Adrian C, Khutoryanskiy, Vitaliy V

“…This study aimed to develop novel elastic films based on chitosan and poly(3-hydroxypropyl ethyleneimine) or P3HPEI for the rapid delivery of haloperidol…”
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Nicotinamide restricts neural precursor proliferation to enhance catecholaminergic neuronal subtype differentiation from mouse embryonic stem cells by Griffin, Síle M, Pickard, Mark R, Hawkins, Clive P, Williams, Adrian C, Fricker, Rosemary A

“…Emerging evidence indicates that a strong relationship exists between brain regenerative therapies and nutrition. Early life nutrition plays an important role…”
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Deep Brain Stimulation for Parkinson's Disease with Early Motor Complications: A UK Cost-Effectiveness Analysis by Fundament, Tomasz, Eldridge, Paul R, Green, Alexander L, Whone, Alan L, Taylor, Rod S, Williams, Adrian C, Schuepbach, W M Michael

“…Parkinson's disease (PD) is a debilitating illness associated with considerable impairment of quality of life and substantial costs to health care systems…”
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A Novel Polymer Insect Repellent Conjugate for Extended Release and Decreased Skin Permeation of Para-Menthane-3,8-Diol by Shah, Sayyed I, Khutoryanskiy, Vitaliy V, Williams, Adrian C

“…We developed a novel polymer insect repellent conjugate for extended release and decreased skin permeation of the volatile insect repellent p-menthane-3,8-diol…”
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Nicotinamide alone accelerates the conversion of mouse embryonic stem cells into mature neuronal populations by Griffin, Síle M, Pickard, Mark R, Orme, Rowan P, Hawkins, Clive P, Williams, Adrian C, Fricker, Rosemary A

“…Vitamin B3 has been shown to play an important role during embryogenesis. Specifically, there is growing evidence that nicotinamide, the biologically active…”
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Effect of acyl chain length on transfection efficiency and toxicity of polyethylenimine by Aravindan, Latha, Bicknell, Katrina A., Brooks, Gavin, Khutoryanskiy, Vitaliy V., Williams, Adrian C.

“…Polyethylenimine (PEI) is an efficient nonviral gene delivery vector because of its high buffering capacity and DNA condensation ability. In our study, the…”
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Mutual Effects of Hydrogen Bonding and Polymer Hydrophobicity on Ibuprofen Crystal Inhibition in Solid Dispersions with Poly(N-vinyl pyrrolidone) and Poly(2-oxazolines) by Shan, Xiaoning, Moghul, Maryam A., Williams, Adrian C., Khutoryanskiy, Vitaliy V.

“…Poly(N-vinyl pyrrolidone) (PVP), poly(2-methyl-2-oxazoline) (PMOZ), poly(2-ethyl-2-oxazoline) (PEOZ), poly(2-n-propyl-2-oxazoline) (PnPOZ), and…”
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Can drug-bearing liposomes penetrate intact skin? by Maghraby, Gamal M.M. El, Williams, Adrian C., Barry, Brian W.

“…Using liposomes to deliver drugs to and through human skin is controversial, as their function varies with type and composition. Thus they may act as drug…”
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Bradykinesia Is Driven by Cumulative Beta Power During Continuous Movement and Alleviated by Gabaergic Modulation in Parkinson's Disease by Prokic, Emma J, Stanford, Ian M, Woodhall, Gavin L, Williams, Adrian C, Hall, Stephen D

“…Spontaneous and "event-related" motor cortex oscillations in the beta (15-30 Hz) frequency range are well-established phenomena. However, the precise…”
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Side chain variations radically alter the diffusion of poly(2-alkyl-2-oxazoline) functionalised nanoparticles through a mucosal barrier by Mansfield, Edward D H, de la Rosa, Victor R, Kowalczyk, Radoslaw M, Grillo, Isabelle, Hoogenboom, Richard, Sillence, Katy, Hole, Patrick, Williams, Adrian C, Khutoryanskiy, Vitaliy V

“…Functionalised nanomaterials are gaining popularity for use as drug delivery vehicles and, in particular, mucus penetrating nanoparticles may improve drug…”
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Meat and Nicotinamide: A Causal Role in Human Evolution, History, and Demographics by Williams, Adrian C, Hill, Lisa J

“…Hunting for meat was a critical step in all animal and human evolution. A key brain-trophic element in meat is vitamin B3 /nicotinamide. The supply of meat and…”
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Penetration enhancers by Williams, Adrian C., Barry, Brian W.

“…One long-standing approach for improving transdermal drug delivery uses penetration enhancers (also called sorption promoters or accelerants) which penetrate…”
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A Comparison of Thiolated and Disulfide-Crosslinked Polyethylenimine for Nonviral Gene Delivery by Aravindan, Latha, Bicknell, Katrina A., Brooks, Gavin, Khutoryanskiy, Vitaliy V., Williams, Adrian C.

“…Branched polyethylenimine (25 kDa) is thiolated and compared with redox‐sensitive crosslinked derivatives. Both polymers thiol contents are assessed; the…”
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Human skin explant model for the investigation of topical therapeutics by Neil, Jessica E., Brown, Marc B., Williams, Adrian C.

“…The development of in vitro and ex vivo models to mimic human illness is important not only for scientific understanding and investigating therapeutic…”
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