Search Results - "Williams, Adele P."

EZH2 inhibition decreases neuroblastoma proliferation and in vivo tumor growth by Bownes, Laura V, Williams, Adele P, Marayati, Raoud, Stafman, Laura L, Markert, Hooper, Quinn, Colin H, Wadhwani, Nikita, Aye, Jamie M, Stewart, Jerry E, Yoon, Karina J, Mroczek-Musulman, Elizabeth, Beierle, Elizabeth A

“…Investigation of the mechanisms responsible for aggressive neuroblastoma and its poor prognosis is critical to identify novel therapeutic targets and improve…”
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PP2A activation alone and in combination with cisplatin decreases cell growth and tumor formation in human HuH6 hepatoblastoma cells by Stafman, Laura L, Williams, Adele P, Marayati, Raoud, Aye, Jamie M, Stewart, Jerry E, Mroczek-Musulman, Elizabeth, Beierle, Elizabeth A

“…Despite an increase in incidence, treatments for hepatoblastoma remain virtually unchanged for the past 20 years, emphasizing the need for novel therapeutics…”
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Focal Adhesion Kinase Inhibition Contributes to Tumor Cell Survival and Motility in Neuroblastoma Patient-Derived Xenografts by Stafman, Laura L., Williams, Adele P., Marayati, Raoud, Aye, Jamie M., Markert, Hooper R., Garner, Evan F., Quinn, Colin H., Lallani, Shoeb B., Stewart, Jerry E., Yoon, Karina J., Whelan, Kimberly, Beierle, Elizabeth A.

“…Patient-derived xenografts (PDXs) provide an opportunity to evaluate the effects of therapies in an environment that more closely resembles the human condition…”
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PIM kinases mediate resistance to cisplatin chemotherapy in hepatoblastoma by Marayati, Raoud, Stafman, Laura L., Williams, Adele P., Bownes, Laura V., Quinn, Colin H., Aye, Jamie M., Stewart, Jerry E., Yoon, Karina J., Anderson, Joshua C., Willey, Christopher D., Beierle, Elizabeth A.

“…Despite increasing incidence, treatment for hepatoblastoma has not changed significantly over the past 20 years. Chemotherapeutic strategies continue to rely…”
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FTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts by Garner, Evan F., Williams, Adele P., Stafman, Laura L., Aye, Jamie M., Mroczek-Musulman, Elizabeth, Moore, Blake P., Stewart, Jerry E., Friedman, Gregory K., Beierle, Elizabeth A.

“…Group 3 tumors account for 28% of medulloblastomas and have the worst prognosis. FTY720, an immunosuppressant currently approved for treatment of multiple…”
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Preclinical evidence for employing MEK inhibition in NRAS mutated pediatric gastroenteropancreatic neuroendocrine-like tumors by Quinn, Colin H., Beierle, Andee M., Williams, Adele P., Marayati, Raoud, Bownes, Laura V., Market, Hooper R., Erwin, Michael E., Aye, Jamie M., Stewart, Jerry E., Mroczek-Musulman, Elizabeth, Yoon, Karina J., Beierle, Elizabeth A.

“…•Targetable NRAS mutation were identified in pediatric neuroendocrine-like tumors.•Primary and metastatic PDX cells harbor phenotypic and genetic…”
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Targeting PIM Kinases Affects Maintenance of CD133 Tumor Cell Population in Hepatoblastoma by Stafman, Laura L., Williams, Adele P., Garner, Evan F., Aye, Jamie M., Stewart, Jerry E., Yoon, Karina J., Whelan, Kimberly, Beierle, Elizabeth A.

“…Hepatoblastoma is the most common primary liver tumor in children, but treatment has not changed significantly in the past 20 years. We have previously…”
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Downregulation of PDGFRß Signaling Overcomes Crizotinib Resistance in a TYRO3 and ALK Mutated Neuroendocrine-Like Tumor by Quinn, Colin H., Beierle, Andee M., Williams, Adele P., Marayati, Raoud, Bownes, Laura V., Markert, Hooper R., Aye, Jamie M., Stewart, Jerry E., Mroczek-Musulman, Elizabeth, Crossman, David K., Yoon, Karina J., Beierle, Elizabeth A.

“…•Rare, high grade neuroendocrine-like pediatric tumor has TYRO3 and ALK mutations.•Crizotinib downregulates STAT3 and ERK1/2 signaling in tumor.•In vivo…”
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9-cis-UAB30, a novel rexinoid agonist, decreases tumorigenicity and cancer cell stemness of human neuroblastoma patient-derived xenografts by Marayati, Raoud, Bownes, Laura V., Stafman, Laura L., Williams, Adele P., Quinn, Colin H., Atigadda, Venkatram, Aye, Jamie M., Stewart, Jerry E., Yoon, Karina J., Beierle, Elizabeth A.

“…Retinoic acid (RA) therapy has been utilized as maintenance therapy for high-risk neuroblastoma, but over half of patients treated with RA relapse…”
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Investigation of PP2A and Its Endogenous Inhibitors in Neuroblastoma Cell Survival and Tumor Growth by Williams, Adele P., Garner, Evan F., Waters, Alicia M., Stafman, Laura L., Aye, Jamie M., Markert, Hooper, Stewart, Jerry E., Beierle, Elizabeth A.

“…High-risk neuroblastoma continues to carry a poor prognosis. Nearly 50% of these tumors relapse following extensive treatment regimens. Protein phosphatase 2A…”
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A pediatric case of xanthogranulomatous pyelonephritis in the setting of Covid-19 and multi-system inflammatory syndrome (MIS-C) by Julson, Janet R., Sibat Noor, MD, Williams, Adele P., Wicker, Jason, Beierle, Elizabeth A.

“…Xanthogranulmatous pyelonephritis is a rare, chronic inflammatory pathology of the kidney. It most commonly arises in middle-aged females, but there are case…”
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UAB30, A Novel Rexinoid Agonist, Decreases Stemness In Group 3 Medulloblastoma Human Cell Line Xenografts by Williams, Adele P., Garner, Evan F., Stafman, Laura L., Aye, Jamie M., Quinn, Colin H., Marayati, Raoud, Stewart, Jerry E., Atigadda, Venkatram R., Mroczek-Musulman, Elizabeth, Moore, Blake P., Beierle, Elizabeth A., Friedman, Gregory K.

“…PURPOSE: In spite of advances in therapy for some subtypes, group 3 medulloblastoma continues to portend a poor prognosis. A subpopulation of medulloblastoma…”
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Pentalogy of Cantrell by Williams, Adele P., Marayati, Raoud, Beierle, Elizabeth A.

“…Pentalogy of Cantrell is a constellation of five congenital defects that pose a unique challenge for surgeons. Defects of the heart, pericardium, diaphragm,…”
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CRISPR/Cas9-mediated knockout of PIM3 suppresses tumorigenesis and cancer cell stemness in human hepatoblastoma cells by Marayati, Raoud, Stafman, Laura L., Williams, Adele P., Bownes, Laura V., Quinn, Colin H., Markert, Hooper R., Easlick, Juliet L., Stewart, Jerry E., Crossman, David K., Mroczek-Musulman, Elizabeth, Beierle, Elizabeth A.

“…Hepatoblastoma remains one of the most difficult childhood tumors to treat and is alarmingly understudied. We previously demonstrated that Proviral Insertion…”
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Novel retinoic acid derivative induces differentiation and growth arrest in neuroblastoma by Marayati, Raoud, Williams, Adele P., Bownes, Laura V., Quinn, Colin H., Stewart, Jerry E., Mroczek-Musulman, Elizabeth, Atigadda, Venkatram R., Beierle, Elizabeth A.

“…Retinoic acid (RA) is a differentiating agent utilized as maintenance therapy for high-risk neuroblastoma (NB), but associated toxicities limit its use. We…”
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Corruption of neuroblastoma patient derived xenografts with human T cell lymphoma by Williams, Adele P., Stewart, Jerry E., Stafman, Laura L., Aye, Jamie M., Mroczek-Musulman, Elizabeth, Ren, Changchun, Yoon, Karina, Whelan, Kimberly, Beierle, Elizabeth A.

“…Patient derived xenografts (PDXs) provide a unique opportunity for investigators to study tumor cell activity, response to therapeutics, and resistance…”
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Metastatic human hepatoblastoma cells exhibit enhanced tumorigenicity, invasiveness and a stem cell-like phenotype by Marayati, Raoud, Julson, Janet R., Bownes, Laura V., Quinn, Colin H., Hutchins, Sara C., Williams, Adele P., Markert, Hooper R., Beierle, Andee M., Stewart, Jerry E., Hjelmeland, Anita B., Mroczek-Musulman, Elizabeth, Beierle, Elizabeth A.

“…Metastatic hepatoblastoma continues to pose a significant treatment challenge, primarily because the precise mechanisms involved in metastasis are not fully…”
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Novel second-generation rexinoid induces growth arrest and reduces cancer cell stemness in human neuroblastoma patient-derived xenografts by Marayati, Raoud, Bownes, Laura V., Quinn, Colin H., Wadhwani, Nikita, Williams, Adele P., Markert, Hooper R., Atigadda, Venkatram, Aye, Jamie M., Stewart, Jerry E., Yoon, Karina J., Beierle, Elizabeth A.

“…The poor therapeutic efficacy seen with current treatments for neuroblastoma may be attributed to stem cell-like cancer cells (SCLCCs), a subpopulation of…”
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The presence of PIM3 increases hepatoblastoma tumorigenesis and tumor initiating cell phenotype and is associated with decreased patient survival by Stafman, Laura L, Waldrop, Mary G, Williams, Adele P, Aye, Jamie M, Stewart, Jerry E, Mroczek-Musulman, Elizabeth, Yoon, Karina J, Whelan, Kimberly, Beierle, Elizabeth A

“…Hepatoblastoma is the most common primary liver cancer of childhood and has few prognostic indicators. We have previously shown that Proviral Integration site…”
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UAB30, a novel RXR agonist, decreases tumorigenesis and leptomeningeal disease in group 3 medulloblastoma patient-derived xenografts by Garner, Evan F., Stafman, Laura L., Williams, Adele P., Aye, Jamie M., Goolsby, Caroline, Atigadda, Venkatram R., Moore, Blake P., Nan, Li, Stewart, Jerry E., Hjelmeland, Anita B., Friedman, Gregory K., Beierle, Elizabeth A.

“…Background Group 3 tumors account for approximately 25–30% of medulloblastomas and have the worst prognosis. UAB30 is a novel synthetic rexinoid shown to have…”
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