Search Results - "William St. Clair, E."

Efficacy of Remission-Induction Regimens for ANCA-Associated Vasculitis by Specks, Ulrich, Merkel, Peter A, Seo, Philip, Spiera, Robert, Langford, Carol A, Hoffman, Gary S, Kallenberg, Cees G.M, St. Clair, E. William, Fessler, Barri J, Ding, Linna, Viviano, Lisa, Tchao, Nadia K, Phippard, Deborah J, Asare, Adam L, Lim, Noha, Ikle, David, Jepson, Brett, Brunetta, Paul, Allen, Nancy B, Fervenza, Fernando C, Geetha, Duvuru, Keogh, Karina, Kissin, Eugene Y, Monach, Paul A, Peikert, Tobias, Stegeman, Coen, Ytterberg, Steven R, Mueller, Mark, Sejismundo, Lourdes P, Mieras, Kathleen, Stone, John H

“…This study of ANCA-associated vasculitis compared a single course of rituximab with conventional immunosuppression with cyclophosphamide followed by…”
Get full text

Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type by Unizony, Sebastian, Villarreal, Miguel, Miloslavsky, Eli M, Lu, Na, Merkel, Peter A, Spiera, Robert, Seo, Philip, Langford, Carol A, Hoffman, Gary S, Kallenberg, Cg M, St Clair, E William, Ikle, David, Tchao, Nadia K, Ding, Linna, Brunetta, Paul, Choi, Hyon K, Monach, Paul A, Fervenza, Fernando, Stone, John H, Specks, Ulrich

“…To evaluate whether the classification of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) according to ANCA type…”
Get more information

Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis by Stone, John H, Merkel, Peter A, Spiera, Robert, Seo, Philip, Langford, Carol A, Hoffman, Gary S, Kallenberg, Cees G.M, St. Clair, E. William, Turkiewicz, Anthony, Tchao, Nadia K, Webber, Lisa, Ding, Linna, Sejismundo, Lourdes P, Mieras, Kathleen, Weitzenkamp, David, Ikle, David, Seyfert-Margolis, Vicki, Mueller, Mark, Brunetta, Paul, Allen, Nancy B, Fervenza, Fernando C, Geetha, Duvuru, Keogh, Karina A, Kissin, Eugene Y, Monach, Paul A, Peikert, Tobias, Stegeman, Coen, Ytterberg, Steven R, Specks, Ulrich

“…This multicenter, randomized, double-blind, double-dummy, noninferiority trial compared rituximab with cyclophosphamide for remission induction in…”
Get full text

A pilot risk model for the prediction of rapid radiographic progression in rheumatoid arthritis by Vastesaeger, Nathan, Xu, Stephen, Aletaha, Daniel, St Clair, E. William, Smolen, Josef S.

“…Objectives. Identifying patients with RA at high risk of rapid radiographic progression (RRP) is critical for making appropriate treatment decisions. We…”
Get full text

Unique Sjögren’s syndrome patient subsets defined by molecular features by James, Judith A, Guthridge, Joel M, Chen, Hua, Lu, Rufei, Bourn, Rebecka L, Bean, Krista, Munroe, Melissa E, Smith, Miles, Chakravarty, Eliza, Baer, Alan N, Noaiseh, Ghaith, Parke, Ann, Boyle, Karen, Keyes-Elstein, Lynette, Coca, Andreea, Utset, Tammy, Genovese, Mark C, Pascual, Virginia, Utz, Paul J, Holers, V. Michael, Deane, Kevin D, Sivils, Kathy L, Aberle, Teresa, Wallace, Daniel J, McNamara, James, Franchimont, Nathalie, St. Clair, E. William

“…Abstract Objective To address heterogeneity complicating primary SS (pSS) clinical trials, research and care by characterizing and clustering patients by their…”
Get full text

Clinical and Molecular Findings After Autologous Stem Cell Transplantation or Cyclophosphamide for Scleroderma: Handling Missing Longitudinal Data by Keyes‐Elstein, Lynette, Pinckney, Ashley, Goldmuntz, Ellen, Welch, Beverly, Franks, Jennifer M., Martyanov, Viktor, Wood, Tammara A., Crofford, Leslie, Mayes, Maureen, McSweeney, Peter, Nash, Richard, Georges, George, Csuka, M. E., Simms, Robert, Furst, Daniel, Khanna, Dinesh, Clair, E. William St, Whitfield, Michael L., Sullivan, Keith M.

“…Objective Among individuals with systemic sclerosis (SSc) randomized to cyclophosphamide (CYC) (n = 34) or hematopoietic stem cell transplantation (HSCT)…”
Get full text

Serum proteins reflecting inflammation, injury and repair as biomarkers of disease activity in ANCA-associated vasculitis by Monach, Paul A, Warner, Roscoe L, Tomasson, Gunnar, Specks, Ulrich, Stone, John H, Ding, Linna, Fervenza, Fernando C, Fessler, Barri J, Hoffman, Gary S, Iklé, David, Kallenberg, Cees G M, Krischer, Jeffrey, Langford, Carol A, Mueller, Mark, Seo, Philip, St Clair, E William, Spiera, Robert, Tchao, Nadia, Ytterberg, Steven R, Johnson, Kent J, Merkel, Peter A

“…To identify circulating proteins that distinguish between active anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and remission in a…”
Get more information

Autoreactive Plasmablasts After B Cell Depletion With Rituximab and Relapses in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis by Berti, Alvise, Hillion, Sophie, Konig, Maximilian F., Moura, Marta Casal, Hummel, Amber M., Carmona, Eva, Peikert, Tobias, Fervenza, Fernando C., Kallenberg, Cees G.M., Langford, Carol A., Merkel, Peter A., Monach, Paul A., Seo, Philip, Spiera, Robert F., Brunetta, Paul, St. Clair, E. William, Harris, Kristina M., Stone, John H., Grandi, Guido, Pers, Jacques‐Olivier, Specks, Ulrich, Cornec, Divi

“…Objective Autoreactive B cells are responsible for antineutrophil cytoplasmic antibody (ANCA) production in ANCA‐associated vasculitis (AAV). Rituximab (RTX)…”
Get full text

Antiproteinase 3 antineutrophil cytoplasmic antibodies and disease activity in wegener granulomatosis by FINKIELMAN, Javier D, MERKEL, Peter A, HUMMEL, Amber M, VISS, Margaret A, PEIKERT, Tobias, STONE, John H, SPECKS, Ulrich, SCHROEDER, Darrell, HOFFMAN, Gary S, SPIERA, Robert, CLAIR, E. William St, DAVIS, John C, MCCUNE, W. Joseph, LEARS, Andrea K, YTTERBERG, Steven R

“…The utility of antineutrophil cytoplasmic antibody (ANCA) levels to guide the management of patients with Wegener granulomatosis remains controversial. To…”
Get full text

B cell–directed therapies for autoimmune disease and correlates of disease response and relapse by Levesque, Marc C., MD, PhD, St. Clair, E. William, MD

“…Recent advances have led to the development of mAbs that effectively deplete B cells in human beings and target pathways essential for B-cell development. B…”
Get full text

Approaches to Establishing Tolerance in Immune Mediated Diseases by Huffaker, Michelle F, Sanda, Srinath, Chandran, Sindhu, Chung, Sharon A, St Clair, E William, Nepom, Gerald T, Smilek, Dawn E

“…The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic…”
Get full text

Clinical Utility of Serial Measurements of Antineutrophil Cytoplasmic Antibodies Targeting Proteinase 3 in ANCA-Associated Vasculitis by Thompson, Gwen E, Fussner, Lynn A, Hummel, Amber M, Schroeder, Darrell R, Silva, Francisco, Snyder, Melissa R, Langford, Carol A, Merkel, Peter A, Monach, Paul A, Seo, Philip, Spiera, Robert F, St Clair, E William, Stone, John H, Specks, Ulrich

“…The utility of ANCA testing as an indicator of disease activity in ANCA-associated vasculitis (AAV) remains controversial. This study aimed to determine the…”
Get full text

Gastric Antral Vascular Ectasia and Its Clinical Correlates in Patients with Early Diffuse Systemic Sclerosis in the SCOT Trial by HUNG, Emily W, MAYES, Maureen D, MINEISHI, Shin, PHILLIPS, Kristine, SEIBOLD, James R, BREDESON, Christopher, CSUKA, Mary Ellen, NASH, Richard A, WENER, Mark H, SIMMS, Robert, BALLEN, Karen, LECLERCQ, Sharon, SHARIF, Roozbeh, STOREK, Jan, GOLDMUNTZ, Ellen, WELCH, Beverly, KEYES-ELSTEIN, Lynette, CASTINA, Sharon, CROFFORD, Leslie J, MCSWEENEY, Peter, SULLIVAN, Keith M, ASSASSI, Shervin, MACHICAO, Victor I, HOSING, Chitra, CLAIR, E. William St, FURST, Daniel E, KHANNA, Dinesh, FORMAN, Stephen

“…To describe the prevalence and clinical correlates of endoscopic gastric antral vascular ectasia (GAVE; "watermelon stomach") in early diffuse systemic…”
Get full text

Adipose depots, not disease-related factors, account for skeletal muscle insulin sensitivity in established and treated rheumatoid arthritis by AbouAssi, Hiba, Tune, K Noelle, Gilmore, Brian, Bateman, Lori A, McDaniel, Gary, Muehlbauer, Michael, Huebner, Janet L, Hoenig, Helen M, Kraus, Virginia B, St Clair, E William, Kraus, William E, Huffman, Kim M

“…In prior reports, individuals with rheumatoid arthritis (RA) exhibited increased insulin resistance. However, those studies were limited by either suboptimal…”
Get full text

Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren's syndrome [version 1; peer review: 2 approved] by Leverenz, David L, St. Clair, E. William

“…Primary Sjögren's syndrome is a chronic autoimmune disease characterized by salivary and lacrimal gland dysfunction, leading to substantial morbidity and…”
Get full text

Using Mass Spectrometry to Quantify Rituximab and Perform Individualized Immunoglobulin Phenotyping in ANCA-Associated Vasculitis by Mills, John R, Cornec, Divi, Dasari, Surendra, Ladwig, Paula M, Hummel, Amber M, Cheu, Melissa, Murray, David L, Willrich, Maria A, Snyder, Melissa R, Hoffman, Gary S, Kallenberg, Cees G. M, Langford, Carol A, Merkel, Peter A, Monach, Paul A, Seo, Philip, Spiera, Robert F, St. Clair, E. William, Stone, John H, Specks, Ulrich, Barnidge, David R

“…Therapeutic monoclonal immunoglobulins (mAbs) are used to treat patients with a wide range of disorders including autoimmune diseases. As pharmaceutical…”
Get full text

Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis by Lipsky, Peter E, van der Heijde, Desiree M.F.M, St. Clair, E. William, Furst, Daniel E, Breedveld, Ferdinand C, Kalden, Joachim R, Smolen, Josef S, Weisman, Michael, Emery, Paul, Feldmann, Marc, Harriman, Gregory R, Maini, Ravinder N

“…Tumor necrosis factor α (TNF-α) has a central role in the pathogenesis of rheumatoid arthritis, 1 – 3 as demonstrated by the clinical benefit of…”
Get full text

Serum Biomarkers of Disease Activity in Longitudinal Assessment of Patients with ANCA‐Associated Vasculitis by Monach, Paul A., Warner, Roscoe L., Lew, Robert, Tómasson, Gunnar, Specks, Ulrich, Stone, John H., Fervenza, Fernando C., Hoffman, Gary S., Kallenberg, Cees G. M., Langford, Carol A., Seo, Philip, St. Clair, E. William, Spiera, Robert, Johnson, Kent J., Merkel, Peter A.

“…Objective Improved biomarkers of current disease activity and prediction of relapse are needed in antineutrophil cytoplasmic antibody–associated vasculitis…”
Get full text

Challenges in the pursuit of immune tolerance by Nepom, Gerald T., St. Clair, E. William, Turka, Laurence A.

“…Strategies for inducing immune tolerance are fundamentally similar across a spectrum of immune‐mediated disorders, including allergic disease, autoimmunity,…”
Get full text

IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis by Kelley, James M., Monach, Paul A., Ji, Chuanyi, Zhou, Yebin, Wu, Jianming, Tanaka, Sumiaki, Mahr, Alfred D., Johnson, Sharleen, McAlear, Carol, Cuthbertson, David, Carette, Simon, Davis, John C., Dellaripa, Paul F., Hoffman, Gary S., Khalidi, Nader, Langford, Carol A., Seo, Phillip, St. Clair, E. William, Specks, Ulrich, Stone, John H., Spiera, Robert F., Ytterberg, Steven R., Merkel, Peter A., Edberg, Jeffrey C., Kimberly, Robert P.

“…Granulomatosis with polyangiitis (Wegener's) is a rare autoimmune neutrophil-mediated vasculitis that can cause renal disease and mucosal manifestations…”
Get full text