Search Results - "William Paradee"

TFH cells depend on Tcf1-intrinsic HDAC activity to suppress CTLA4 and guard B-cell help function by Li, Fengyin, Zhao, Xin, Zhang, Yali, Shao, Peng, Ma, Xiaoke, Paradee, William J., Liu, Chengyu, Wang, Jianmin, Xue, Hai-Hui

“…Precise regulation of coinhibitory receptors is essential for maintaining immune tolerance without interfering with protective immunity, yet the mechanism…”
Get full text

Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells by Xing, Shaojun, Gai, Kexin, Li, Xiang, Shao, Peng, Zeng, Zhouhao, Zhao, Xudong, Zhao, Xin, Chen, Xia, Paradee, William J, Meyerholz, David K, Peng, Weiqun, Xue, Hai-Hui

“…Tcf1 and Lef1 have versatile functions in regulating T cell development and differentiation, but intrinsic requirements for these factors in regulatory T (T…”
Get full text

T FH cells depend on Tcf1-intrinsic HDAC activity to suppress CTLA4 and guard B-cell help function by Li, Fengyin, Zhao, Xin, Zhang, Yali, Shao, Peng, Ma, Xiaoke, Paradee, William J, Liu, Chengyu, Wang, Jianmin, Xue, Hai-Hui

“…Precise regulation of coinhibitory receptors is essential for maintaining immune tolerance without interfering with protective immunity, yet the mechanism…”
Get full text

Neuropeptide S (NPS) neurons: Parabrachial identity and novel distributions by Huang, Dake, Zhang, Richie, Gasparini, Silvia, McDonough, Miriam C., Paradee, William J., Geerling, Joel C.

“…Neuropeptide S (NPS) increases wakefulness. A small number of neurons in the brainstem express Nps. These neurons are located in or near the parabrachial…”
Get full text

Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 ( Rgs2 ) From Cells Expressing Agouti-Related Peptide or the ANG (Angiotensin) II Type 1A Receptor in Mice by Ritter, McKenzie L., Deng, Guorui, Reho, John J., Deng, Yue, Sapouckey, Sarah A., Opichka, Megan A., Balapattabi, Kirthikaa, Wackman, Kelsey K., Brozoski, Daniel T., Lu, Ko-Ting, Paradee, William J., Gibson-Corley, Katherine N., Cui, Huxing, Nakagawa, Pablo, Morselli, Lisa L., Sigmund, Curt D., Grobe, Justin L.

“…BACKGROUNDRGS (regulator of G protein signaling) family members catalyze the termination of G protein signaling cascades. Single nucleotide polymorphisms in…”
Get full text

Characterization of Mice Ubiquitously Overexpressing Human 15-Lipoxygenase-1: Effect of Diabetes on Peripheral Neuropathy and Treatment with Menhaden Oil by Coppey, Lawrence, Obrosov, Alexander, Shevalye, Hanna, Davidson, Eric, Paradee, William, Yorek, Mark A.

“…To rigorously explore the role of omega-3 polyunsaturated fatty acids (PUFA) in the treatment of diabetic peripheral neuropathy (DPN), we have created a…”
Get full text

High-throughput Screening of Mouse Knockout Lines Identifies True Lean and Obese Phenotypes by Brommage, Robert, Desai, Urvi, Revelli, Jean‐Pierre, Donoviel, Dorit B., Fontenot, Gregory K., DaCosta, Christopher M., Smith, Deon D., Kirkpatrick, Laura L., Coker, Kenneth J., Donoviel, Michael S., Eberhart, Derek E., Holt, Kathleen H., Kelly, Michael R., Paradee, William J., Philips, Anne V., Platt, Kenneth A., Suwanichkul, Adisak, Hansen, Gwenn M., Sands, Arthur T., Zambrowicz, Brian P., Powell, David R.

“…We developed a high‐throughput approach to knockout (KO) and phenotype mouse orthologs of the 5,000 potential drug targets in the human genome. As part of the…”
Get full text

Abstract 4147384: P66ShcK81-sumoylation mediates hyperlipidemia-induced endothelial dysfunction in mice by Uppulapu, Shravan Kumar, KUMAR, JITENDRA, Kumari, Sujata, Sharma, Kanika, Paradee, William, Yadav, Ravi Prakash, Kumar, Vikas, Kumar, Santosh

“…Abstract only Introduction: Hyperlipidemia promotes atherosclerosis, a leading cause of myocardial infarction and stroke. Atherosclerosis is commonly…”
Get full text

Impaired Female Reproductive Function in A Novel Estrogen Receptor Alpha Hypomorphic Mouse Model by Saito, Kenji, Rodeghiero, Samuel R., Dickey, Jacob E., Paradee, William J., Cui, Huxing

“…Abstract only…”
Get full text

Aphidicolin-Induced FRA3B Breakpoints Cluster in Two Distinct Regions by Wang, Liang, Paradee, William, Mullins, Chadwick, Shridhar, Ravi, Rosati, Rita, Wilke, Charles M., Glover, Thomas W., Smith, David I.

“…The common fragile site at chromosomal band 3p14.2 (FRA3B) is the most sensitive single site in the human genome to induced chromosomal lesions. This fragile…”
Get full text

Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (Rgs2) from Cells Expressing Agouti-Related Peptide or the Angiotensin II Type 1A Receptor in Mice by Ritter, McKenzie L., Deng, Guorui, Reho, John J., Deng, Yue, Sapouckey, Sarah A., Opichka, Megan A., Balapattabi, Kirthikaa, Wackman, Kelsey K., Brozoski, Daniel T., Lu, Ko-Ting, Paradee, William J., Gibson-Corley, Katherine N., Cui, Huxing, Nakagawa, Pablo, Morselli, Lisa L., Sigmund, Curt D., Grobe, Justin L.

Get full text

Control of Resting Metabolism by Regulator of G Protein Signaling‐2 (Rgs2) in AgRP Neurons by Deng, Guorui, Morselli, Lisa L, Sapouckey, Sarah A, Sebag, Julien A, Rahmouni, Kamal, Gibson‐Corley, Katherine N, Sigmund, Curt D, Cui, Huxing, Paradee, William J, Grobe, Justin L

“…Resting metabolic rate (RMR) normally accounts for ~70% of total energy expenditure, and obesity is associated with and maintained via suppression of RMR. We…”
Get full text

FRA3B Extends Over a Broad Region and Contains a Spontaneous HPV16 Integration Site: Direct Evidence for the Coincidence of Viral Integration Sites and Fragile Sites by Wilke, Charles M., Hall, Bryan K., Hoge, Ann, Paradee, William, Smith, David I., Glover, Thomas W.

“…The common fragile site at 3p14.2 (FRA3B) is the most sensitive site on normal human chromosomes for the formation of gaps and breaks when DNA replication is…”
Get full text

Deletion of the Gene Encoding the Ubiquitously Expressed Glucose-6-phosphatase Catalytic Subunit-related Protein (UGRP)/Glucose-6-phosphatase Catalytic Subunit-β Results in Lowered Plasma Cholesterol and Elevated Glucagon by Wang, Yingda, Oeser, James K., Yang, Chunmei, Sarkar, Suparna, Hackl, Seija I., Hasty, Alyssa H., McGuinness, Owen P., Paradee, William, Hutton, John C., Powell, David R., O'Brien, Richard M.

“…In liver, glucose-6-phosphatase catalyzes the hydrolysis of glucose-6-phosphate (G6P) to glucose and inorganic phosphate, the final step in the gluconeogenic…”
Get full text

Deletion of the Gene Encoding the Ubiquitously Expressed Glucose-6-phosphatase Catalytic Subunit-related Protein (UGRP)/Glucose-6-phosphatase Catalytic Subunit-β Results in Lowered Plasma Cholesterol and Elevated Glucagon by Yingda Wang, James K. Oeser, Chunmei Yang, Suparna Sarkar, Seija I. Hackl, Alyssa H. Hasty, Owen P. McGuinness, William Paradee, John C. Hutton, David R. Powell, Richard M. O'Brien

“…In liver, glucose-6-phosphatase catalyzes the hydrolysis of glucose-6-phosphate (G6P) to glucose and inorganic phosphate, the final step in the gluconeogenic…”
Get full text

Frequent breakpoints in the 3p14.2 fragile site, FRA3B, in pancreatic tumors by SHRIDHAR, R, SHRIDHAR, V, WANG, S, PARADEE, W, DUGAN, M, SARKAR, F, WILKE, C, GLOVER, T. W, VAITKEVICIUS, V. K, SMITH, D. I

“…FRA3B, at chromosomal band 3p14.2, is the most active common fragile site in the human genome. Homozygous deletions in the region of FRA3B have been observed…”
Get full text

Re-Examination of Factors Associated with Expansion of CGG Repeats Using a Single Nucleotide Polymorphism in FMR1 by Gunter, Chris, Paradee, William, Crawford, Dana C., Meadows, Kellen A., Newman, James, Kunst, Catherine B., Nelson, David L., Schwartz, Charles, Murray, Anna, Macpherson, James N., Sherman, Stephanie L., Warren, Stephen T.

“…In at least 98% of fragile X syndrome cases, the disease results from expansion of the CGG repeat in the 5′ end of FMR1. The use of microsatellite markers in…”
Get full text

A 350-kb Cosmid Contig in 3p14.2 That Crosses the t(3;8) Hereditary Renal Cell Carcinoma Translocation Breakpoint and 17 Aphidicolin-Induced FRA3B Breakpoints by Paradee, William, Wilke, Charles M., Wang, Liang, Shridhar, Ravi, Mullins, Chadwick M., Hoge, Ann, Glover, Thomas W., Smith, David I.

“…The constitutive fragile site at human chromosomal band 3p14.2, FRA3B, has been described as the most active common fragile site in the human genome. FRA3B is…”
Get full text

Frequent breakpoints in the region surrounding FRA3B in sporadic renal cell carcinomas by SHRIDHAR, V, WANG, L, PETROS, J, SMITH, D. I, ROSATI, R, PARADEE, W, SHRIDHAR, R, MULLINS, C, SAKR, W, GRIGNON, D, MILLER, O. J, SUN, Q. C

“…The constitutive fragile site at chromosomal band 3p14.2, FRA3B, is the most active common fragile site in the human genome. We have localized…”
Get full text

The FHIT gene is alternatively spliced in normal kidney and renal cell carcinoma by LUAN, X, SHI, G, ZOHOURI, M, PARADEE, W, SMITH, D. I, DECKER, H. J, CANNIZZARO, L. A

“…FHIT (Fragile Histidine Triad), a putative tumor suppressor gene, was cloned from fetal brain and colon cDNA libraries. Portions of this gene are deleted in…”
Get full text