Search Results - "William E. Van Nostrand"

Reduced Levels of Cerebrospinal Fluid/Plasma Aβ40 as an Early Biomarker for Cerebral Amyloid Angiopathy in RTg-DI Rats by Zhu, Xiaoyue, Xu, Feng, Hoos, Michael D, Lee, Hedok, Benveniste, Helene, Nostrand, William E Van

“…The accumulation of fibrillar amyloid β-protein (Aβ) in blood vessels of the brain, the condition known as cerebral amyloid angiopathy (CAA), is a common small…”
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Mechanism of Nucleated Conformational Conversion of Aβ42 by Fu, Ziao, Aucoin, Darryl, Davis, Judianne, Van Nostrand, William E, Smith, Steven O

“…Soluble oligomers and protofibrils of the Aβ42 peptide are neurotoxic intermediates in the conversion of monomeric Aβ42 into the amyloid fibrils associated…”
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Capping of Aβ42 Oligomers by Small Molecule Inhibitors by Fu, Ziao, Aucoin, Darryl, Ahmed, Mahiuddin, Ziliox, Martine, Van Nostrand, William E, Smith, Steven O

“…Aβ42 peptides associate into soluble oligomers and protofibrils in the process of forming the amyloid fibrils associated with Alzheimer’s disease. The…”
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Author Correction: Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure by Xu, Feng, Fu, Ziao, Dass, Sharmila, Kotarba, AnnMarie E., Davis, Judianne, Smith, Steven O., Van Nostrand, William E.

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Age-Dependent Neurovascular Dysfunction and Damage in a Mouse Model of Cerebral Amyloid Angiopathy by Park, Laibaik, Koizumi, Kenzo, El Jamal, Sleiman, Zhou, Ping, Previti, Mary Lou, Van Nostrand, William E, Carlson, George, Iadecola, Costantino

“…BACKGROUND AND PURPOSE—Accumulation of amyloid-β in cerebral blood vessels occurs in familial and sporadic forms of cerebral amyloid angiopathy and is a…”
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Anti-Parallel β-Hairpin Structure in Soluble Aβ Oligomers of Aβ40-Dutch and Aβ40-Iowa by Fu, Ziao, Van Nostrand, William E, Smith, Steven O

“…The amyloid-β (Aβ) peptides are associated with two prominent diseases in the brain, Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). Aβ42 is…”
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Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy by Zhu, Xiaoyue, Hatfield, Joshua, Sullivan, Joseph K, Xu, Feng, Van Nostrand, William E

“…Cerebral amyloid angiopathy (CAA) is a common cerebral small vessel disease of the aged and a prominent comorbidity of Alzheimer's disease (AD). CAA can…”
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Longitudinal markers of cerebral amyloid angiopathy and related inflammation in rTg-DI rats by Schrader, Joseph M., Xu, Feng, Agostinucci, Kevin J., DaSilva, Nicholas A., Van Nostrand, William E.

“…Cerebral amyloid angiopathy (CAA) is a prevalent vascular dementia and common comorbidity of Alzheimer’s disease (AD). While it is known that vascular…”
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The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer’s disease by Boon, Baayla D. C., Bulk, Marjolein, Jonker, Allert J., Morrema, Tjado H. J., van den Berg, Emma, Popovic, Marko, Walter, Jochen, Kumar, Sathish, van der Lee, Sven J., Holstege, Henne, Zhu, Xiaoyue, Van Nostrand, William E., Natté, Remco, van der Weerd, Louise, Bouwman, Femke H., van de Berg, Wilma D. J., Rozemuller, Annemieke J. M., Hoozemans, Jeroen J. M.

“…Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) deposits, which come in myriad morphologies with varying clinical relevance. Previously, we…”
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Animal models of cerebral amyloid angiopathy by Jäkel, Lieke, Van Nostrand, William E, Nicoll, James A R, Werring, David J, Verbeek, Marcel M

“…Cerebral amyloid angiopathy (CAA), due to vascular amyloid β (Aβ) deposition, is a risk factor for intracerebral haemorrhage and dementia. CAA can occur in…”
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Longitudinal Cognitive Decline in a Novel Rodent Model of Cerebral Amyloid Angiopathy Type-1 by Popescu, Dominique L, Van Nostrand, William E, Robinson, John K

“…Cerebral amyloid angiopathy (CAA) is a small vessel disease characterized by β-amyloid (Aβ) accumulation in and around the cerebral blood vessels and…”
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Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-β by Park, Laibaik, Wang, Gang, Zhou, Ping, Zhou, Joan, Pitstick, Rose, Previti, Mary Lou, Younkin, Linda, Younkin, Steven G., Van Nostrand, William E., Cho, Sunghee, Anrather, Josef, Carlson, George A., Iadecola, Costantino, Südhof, Thomas C.

“…Increasing evidence indicates that cerebrovascular dysfunction plays a pathogenic role in Alzheimer's dementia (AD). Amyloid-β (Aβ), a peptide central to the…”
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Environmental Enrichment: Disentangling the Influence of Novelty, Social, and Physical Activity on Cerebral Amyloid Angiopathy in a Transgenic Mouse Model by Robison, Lisa S, Francis, Nikita, Popescu, Dominique L, Anderson, Maria E, Hatfield, Joshua, Xu, Feng, Anderson, Brenda J, Van Nostrand, William E, Robinson, John K

“…Cerebral amyloid angiopathy (CAA) is the deposition of amyloid protein in the cerebral vasculature, a common feature in both aging and Alzheimer's disease…”
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Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure by Xu, Feng, Fu, Ziao, Dass, Sharmila, Kotarba, AnnMarie E., Davis, Judianne, Smith, Steven O., Van Nostrand, William E.

“…Cerebrovascular accumulation of amyloid β-protein (Aβ), a condition known as cerebral amyloid angiopathy (CAA), is a common pathological feature of patients…”
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Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD by Colton, Carol A, Mott, Ryan T, Sharpe, Hayley, Xu, Qing, Van Nostrand, William E, Vitek, Michael P

“…Microglia are associated with neuritic plaques in Alzheimer disease (AD) and serve as a primary component of the innate immune response in the brain. Neuritic…”
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Progression of Amyloid Pathology to Alzheimer's Disease Pathology in an Amyloid Precursor Protein Transgenic Mouse Model by Removal of Nitric Oxide Synthase 2 by Wilcock, Donna M, Lewis, Matthew R, Van Nostrand, William E, Davis, Judianne, Previti, Mary Lou, Gharkholonarehe, Nastaran, Vitek, Michael P, Colton, Carol A

“…Alzheimer's disease (AD) is characterized by three primary pathologies in the brain: amyloid plaques, neurofibrillary tangles, and neuron loss. Mouse models…”
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Minocycline Reduces Microglial Activation and Improves Behavioral Deficits in a Transgenic Model of Cerebral Microvascular Amyloid by Fan, Rong, Xu, Feng, Previti, Mary Lou, Davis, Judianne, Grande, Alicia M, Robinson, John K, Van Nostrand, William E

“…Cerebral microvascular amyloid beta protein (Abeta) deposition and associated neuroinflammation is increasingly recognized as an important component leading to…”
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Impact of Non-pharmacological Chronic Hypertension on a Transgenic Rat Model of Cerebral Amyloid Angiopathy by Stanisavljevic, Aleksandra, Schrader, Joseph M, Zhu, Xiaoyue, Mattar, Jennifer M, Hanks, Ashley, Xu, Feng, Majchrzak, Mark, Robinson, John K, Van Nostrand, William E

“…Cerebral amyloid angiopathy (CAA), a common comorbidity of Alzheimer's disease (AD), is a cerebral small vessel disease (CSVD) characterized by deposition of…”
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Long-term voluntary wheel running does not alter vascular amyloid burden but reduces neuroinflammation in the Tg-SwDI mouse model of cerebral amyloid angiopathy by Robison, Lisa S, Popescu, Dominique L, Anderson, Maria E, Francis, Nikita, Hatfield, Joshua, Sullivan, Joseph K, Beigelman, Steven I, Xu, Feng, Anderson, Brenda J, Van Nostrand, William E, Robinson, John K

“…Cardiovascular exercise (CVE) has been shown to be protective against cognitive decline in aging and the risk for dementias, including Alzheimer's Disease…”
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Brain and Circulating Levels of Aβ1―40 Differentially Contribute to Vasomotor Dysfunction in the Mouse Brain by PARK, Laibaik, PING ZHOU, KOIZUMI, Kenzo, EL JAMAL, Sleiman, PREVITI, Mary Lou, VAN NOSTRAND, William E, CARLSON, George, IADECOLA, Costantino

“…Amyloid-β (Aβ), a peptide that accumulates in the brain and circulates in the blood of patients with Alzheimer disease, alters the regulation of cerebral blood…”
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