Search Results - "William A. Frazier"

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer by Halle, Annett, Khoury, Joseph El, Lacy-Hulbert, Adam, Stewart, Cameron R, Frazier, William A, Rayner, Katey J, Boyer, Laurent, Moore, Kathryn J, van Gils, Janine M, Zhong, Ruiqin, Stuart, Lynda M, Deng, Jiusheng, Golenbock, Douglas T, Wilkinson, Kim

“…The molecular mechanisms behind recognition of altered self remain unclear. Moore and co-workers show that oxidized low-density lipoprotein (LDL) and β-amyloid…”
Get full text

Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy by Liu, Katherine E, Frazier, William A

“…BNIP3 is a dual function protein, able to activate autophagy and induce cell death. Upon expression of BNIP3, which is upregulated by hypoxia, the protein…”
Get full text

Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis by Murphy, Kenneth M, Kohyama, Masako, Ise, Wataru, Edelson, Brian T, Wilker, Peter R, Hildner, Kai, Mejia, Carlo, Frazier, William A, Murphy, Theresa L

“…Tissue macrophages comprise a heterogeneous group of cell types differing in location, surface markers and function. Red pulp macrophages are a distinct…”
Get full text

Antibody mediated therapy targeting CD47 inhibits tumor progression of hepatocellular carcinoma by Xiao, Zhenyu, Chung, Haniee, Banan, Babak, Manning, Pamela T, Ott, Katherine C, Lin, Shin, Capoccia, Benjamin J, Subramanian, Vijay, Hiebsch, Ronald R, Upadhya, Gundumi A, Mohanakumar, Thalachallour, Frazier, William A, Lin, Yiing, Chapman, William C

“…Highlights • First time demonstrating that CD47 blockade has anti-tumor effects against HCC. • In vitro CD47 blockade results in increase in phagocytosis of…”
Get full text

CD47 Is Necessary for Inhibition of Nitric Oxide-stimulated Vascular Cell Responses by Thrombospondin-1 by Isenberg, Jeff S., Ridnour, Lisa A., Dimitry, Julie, Frazier, William A., Wink, David A., Roberts, David D.

“…CD36 is necessary for inhibition of some angiogenic responses by the matricellular glycoprotein thrombospondin-1 and is therefore assumed to be the receptor…”
Get full text

Differential Interactions of Thrombospondin-1, -2, and -4 with CD47 and Effects on cGMP Signaling and Ischemic Injury Responses by Isenberg, Jeff S., Annis, Douglas S., Pendrak, Michael L., Ptaszynska, Malgorzata, Frazier, William A., Mosher, Deane F., Roberts, David D.

“…Thrombospondin-1 regulates nitric oxide (NO) signaling in vascular cells via CD47. Because CD47 binding motifs are conserved in the C-terminal signature…”
Get full text

Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling by Isenberg, Jeff S., Romeo, Martin J., Yu, Christine, Yu, Christine K., Nghiem, Khauh, Monsale, Jude, Rick, Margaret E., Wink, David A., Frazier, William A., Roberts, David D.

“…Platelet α-granules constitute the major rapidly releasable reservoir of thrombospondin-1 in higher animals. Although some fragments and peptides derived from…”
Get full text

Inhibitory signaling through signal regulatory protein-α is not sufficient to explain the antitumor activities of CD47 antibodies by David R. Soto-Pantoja, Thomas W. Miller, William A. Frazier, David D. Roberts

Get full text

Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia by Olsson, Mattias, Bruhns, Pierre, Frazier, William A., Ravetch, Jeffrey V., Oldenborg, Per-Arne

“…Interaction between target cell CD47 and the inhibitory macrophage receptor signal regulatory protein α (SIRPα) counteracts macrophage phagocytosis of…”
Get full text

Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress by Isenberg, Jeff S., Qin, Yan, Maxhimer, Justin B., Sipes, John M., Despres, Daryl, Schnermann, Jurgen, Frazier, William A., Roberts, David D.

“…Nitric oxide (NO) locally regulates vascular resistance and blood pressure by modulating blood vessel tone. Thrombospondin-1 signaling via its receptor CD47…”
Get full text

CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A by PARTHA PRATIM MANNA, FRAZIER, William A

“…Thrombospondins (TSPs) have been implicated as antitumor and antimetastasis factors in breast cancer. Although this effect has been attributed to the…”
Get full text

CD47 Regulates Bone Mass and Tumor Metastasis to Bone by ULUCKAN, Özge, BECKER, Stephanie N, HONGJU DENG, WEI ZOU, PRIOR, Julie L, PIWNICA-WORMS, David, FRAZIER, William A, WEILBAECHER, Katherine N

“…CD47, also called integrin-associated protein, plays a critical role in the innate immune response and is an atypical member of the immunoglobulin superfamily…”
Get full text

CD47 blockade triggers T cell–mediated destruction of immunogenic tumors by Liu, Xiaojuan, Pu, Yang, Cron, Kyle, Deng, Liufu, Kline, Justin, Frazier, William A, Xu, Hairong, Peng, Hua, Fu, Yang-Xin, Xu, Meng Michelle

“…Although previous work indicated that the antitumor effects of anti-CD47 require macrophage phagocytosis of tumor cells, new work done in immunocompetent mice…”
Get full text

Treatment of liver ischemia–reperfusion injury by limiting thrombospondin-1/CD47 signaling by Isenberg, Jeff S., MD, Maxhimer, Justin B., MD, Powers, Perlita, Tsokos, Maria, MD, Frazier, William A., PhD, Roberts, David D., PhD

“…Background Ischemia–reperfusion (I/R) injury remains a primary complication of transplant surgery, accounting for about 80% of liver transplant failures, and…”
Get full text

Imaging of CD47 Expression in Xenograft and Allograft Tumor Models by Zheleznyak, Alexander, Ikotun, Oluwatayo F., Dimitry, Julie, Frazier, William A., Lapi, Suzanne E.

“…CD47 functions as a marker of “self” by inhibiting phagocytosis of autologous cells. CD47 has been shown to be overexpressed by various tumor types as a means…”
Get full text

Deficit of CD47 Results in a Defect of Marginal Zone Dendritic Cells, Blunted Immune Response to Particulate Antigen and Impairment of Skin Dendritic Cell Migration by Hagnerud, Sven, Manna, Partha Pratim, Cella, Marina, Stenberg, Asa, Frazier, William A, Colonna, Marco, Oldenborg, Per-Arne

“…CD47 is a ubiquitously expressed cell surface glycoprotein that associates with integrins and regulates chemotaxis, migration, and activation of leukocytes…”
Get full text

CD47 Augments Fas/CD95-mediated Apoptosis by Manna, Partha P, Dimitry, Julie, Oldenborg, Per-Arne, Frazier, William A

“…Fas (CD95) mediates apoptosis of many cell types, but the susceptibility of cells to killing by Fas ligand and anti-Fas antibodies is highly variable. Jurkat T…”
Get full text

Development of AO-176, a Next-Generation Humanized Anti-CD47 Antibody with Novel Anticancer Properties and Negligible Red Blood Cell Binding by Puro, Robyn J, Bouchlaka, Myriam N, Hiebsch, Ronald R, Capoccia, Benjamin J, Donio, Michael J, Manning, Pamela T, Frazier, William A, Karr, Robert W, Pereira, Daniel S

“…Inhibitors of adaptive immune checkpoints have shown promise as cancer treatments. CD47 is an innate immune checkpoint receptor broadly expressed on normal…”
Get full text

CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions by Azcutia, Veronica, Routledge, Matthew, Williams, Marcie R, Newton, Gail, Frazier, William A, Manica, Andrè, Croce, Kevin J, Parkos, Charles A, Schmider, Angela B, Turman, Melissa V, Soberman, Roy J, Luscinskas, Francis W

“…CD47 plays an important but incompletely understood role in the innate and adaptive immune responses. CD47, also called integrin-associated protein, has been…”
Get full text

Antibody blockade of thrombospondin accelerates reendothelialization and reduces neointima formation in balloon-injured rat carotid artery by DONGHUI CHEN, ASAHARA, T, KRASINSKI, K, WITZENBICHLER, B, JIHONG YANG, MAGNER, M, KEARNEY, M, FRAZIER, W. A, ISNER, J. M, ANDRES, V

“…Remodeling of the extracellular matrix plays an important role during the pathogenesis of atherosclerosis and restenosis. The matrix glycoprotein…”
Get full text