Search Results - "William, M"

Drug Transport across the Blood–Brain Barrier by Pardridge, William M

“…The blood–brain barrier (BBB) prevents the brain uptake of most pharmaceuticals. This property arises from the epithelial-like tight junctions within the brain…”
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Acetaminophen (APAP) hepatotoxicity—Isn’t it time for APAP to go away? by Lee, William M.

“…Acetaminophen (APAP) is the most commonly used drug for the treatment of pain and fever around the world. At the same time, APAP can cause dose-related…”
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Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles by Aumiller, William M., Keating, Christine D.

“…Biological cells are highly organized, with numerous subcellular compartments. Phosphorylation has been hypothesized as a means to control the…”
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Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain by Pardridge, William M

“…Alzheimer's disease (AD) and treatment of the brain in aging require the development of new biologic drugs, such as recombinant proteins or gene therapies…”
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The phagocyte NOX2 NADPH oxidase in microbial killing and cell signaling by Nauseef, William M

“…•Phagocyte NOX2 NADPH oxidase generates oxidants.•Optimal antimicrobial action in phagosomes depends on oxidants.•Precise mechanisms of oxidant-dependent…”
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SAUR Proteins as Effectors of Hormonal and Environmental Signals in Plant Growth by Ren, Hong, Gray, William M.

“…The plant hormone auxin regulates numerous aspects of plant growth and development. Early auxin response genes mediate its genomic effects on plant growth and…”
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CSF, blood-brain barrier, and brain drug delivery by Pardridge, William M

“…There are 2 misconceptions about the cerebrospinal fluid (CSF), the blood-brain barrier (BBB), and brain drug delivery, which date back to the discovery of a…”
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Integrated analysis of multimodal single-cell data by Hao, Yuhan, Hao, Stephanie, Andersen-Nissen, Erica, Mauck, William M., Zheng, Shiwei, Butler, Andrew, Lee, Maddie J., Wilk, Aaron J., Darby, Charlotte, Zager, Michael, Hoffman, Paul, Stoeckius, Marlon, Papalexi, Efthymia, Mimitou, Eleni P., Jain, Jaison, Srivastava, Avi, Stuart, Tim, Fleming, Lamar M., Yeung, Bertrand, Rogers, Angela J., McElrath, Juliana M., Blish, Catherine A., Gottardo, Raphael, Smibert, Peter, Satija, Rahul

“…The simultaneous measurement of multiple modalities represents an exciting frontier for single-cell genomics and necessitates computational methods that can…”
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The global burden of neurological disorders by Carroll, William M

“…Because the resources and the ability of health-care systems facing this increasing demand vary by nation and the neurological diseases GBD provides the most…”
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Antimicrobial Resistance in Neisseria gonorrhoeae in the 21st Century: Past, Evolution, and Future by UNEMO, Magnus, SHAFER, William M

“…Neisseria gonorrhoeae is evolving into a superbug with resistance to previously and currently recommended antimicrobials for treatment of gonorrhea, which is a…”
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Addressing Health-Related Misinformation on Social Media by Chou, Wen-Ying Sylvia, Oh, April, Klein, William M. P

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Comprehensive Integration of Single-Cell Data by Stuart, Tim, Butler, Andrew, Hoffman, Paul, Hafemeister, Christoph, Papalexi, Efthymia, Mauck, William M., Hao, Yuhan, Stoeckius, Marlon, Smibert, Peter, Satija, Rahul

“…Single-cell transcriptomics has transformed our ability to characterize cell states, but deep biological understanding requires more than a taxonomic listing…”
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Self-Assembly of Biomolecular Condensates with Shared Components by Jacobs, William M.

“…Biomolecular condensates self-assemble when proteins and nucleic acids spontaneously demix to form droplets within the crowded intracellular milieu. This…”
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Treatment of Alzheimer's Disease and Blood-Brain Barrier Drug Delivery by Pardridge, William M

“…Despite the enormity of the societal and health burdens caused by Alzheimer's disease (AD), there have been no FDA approvals for new therapeutics for AD since…”
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Chronic pain: an update on burden, best practices, and new advances by Cohen, Steven P, Vase, Lene, Hooten, William M

“…Chronic pain exerts an enormous personal and economic burden, affecting more than 30% of people worldwide according to some studies. Unlike acute pain, which…”
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A Historical Review of Brain Drug Delivery by Pardridge, William M

“…The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914, that a drug for syphilis, salvarsan, did not enter the brain,…”
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Neutrophils at work by Nauseef, William M, Borregaard, Niels

“…Neutrophils are classically known for their role as efficient phagocytes. Nauseef and Borregaard discuss other aspects of their biology, including trafficking,…”
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Cerebral Blood Flow Autoregulation and Dysautoregulation by Armstead, William M., PhD

“…This article provides a review of cerebral autoregulation, particularly as it relates to the clinician scientist experienced in neuroscience in anesthesia and…”
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Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers by Okugawa, Yoshinaga, Grady, William M, Goel, Ajay

“…Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the fundamental processes driving the initiation and progression of CRC is the…”
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Cellular senescence in development, regeneration and disease by Rhinn, Muriel, Ritschka, Birgit, Keyes, William M.

“…ABSTRACT Cellular senescence is a state comprising an essentially irreversible proliferative arrest combined with phenotypic changes and pronounced secretory…”
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