Search Results - "Willer, J."

METAL: fast and efficient meta-analysis of genomewide association scans by Willer, Cristen J., Li, Yun, Abecasis, Gonçalo R.

“…METAL provides a computationally efficient tool for meta-analysis of genome-wide association scans, which is a commonly used approach for improving power…”
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Polygenic Risk Scores for Cardiovascular Disease: A Scientific Statement From the American Heart Association by O’Sullivan, Jack W., Raghavan, Sridharan, Marquez-Luna, Carla, Luzum, Jasmine A., Damrauer, Scott M., Ashley, Euan A., O’Donnell, Christopher J., Willer, Cristen J., Natarajan, Pradeep

“…Cardiovascular disease is the leading contributor to years lost due to disability or premature death among adults. Current efforts focus on risk prediction and…”
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Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies by Zhou, Wei, Nielsen, Jonas B., Fritsche, Lars G., Dey, Rounak, Gabrielsen, Maiken E., Wolford, Brooke N., LeFaive, Jonathon, VandeHaar, Peter, Gagliano, Sarah A., Gifford, Aliya, Bastarache, Lisa A., Wei, Wei-Qi, Denny, Joshua C., Lin, Maoxuan, Hveem, Kristian, Kang, Hyun Min, Abecasis, Goncalo R., Willer, Cristen J., Lee, Seunggeun

“…In genome-wide association studies (GWAS) for thousands of phenotypes in large biobanks, most binary traits have substantially fewer cases than controls. Both…”
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Genetic variation across the human olfactory receptor repertoire alters odor perception by Trimmer, C., Keller, A., Murphy, N. R., Snyder, L. L., Willer, J. R., Nagai, M. H., Katsanis, N., Vosshall, L. B., Matsunami, H., Mainland, J. D.

“…Humans use a family of more than 400 olfactory receptors (ORs) to detect odors, but there is currently no model that can predict olfactory perception from…”
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MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes by Li, Yun, Willer, Cristen J., Ding, Jun, Scheet, Paul, Abecasis, Gonçalo R.

“…Genome‐wide association studies (GWAS) can identify common alleles that contribute to complex disease susceptibility. Despite the large number of SNPs assessed…”
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Unravelling the genetic architecture of human complex traits through whole genome sequencing by Bocher, Ozvan, Willer, Cristen J., Zeggini, Eleftheria

“…Whole genome sequencing has enabled new insights into the genetic architecture of complex traits, especially through access to low-frequency and rare…”
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Exploring and visualizing large-scale genetic associations by using PheWeb by Gagliano Taliun, Sarah A., VandeHaar, Peter, Boughton, Andrew P., Welch, Ryan P., Taliun, Daniel, Schmidt, Ellen M., Zhou, Wei, Nielsen, Jonas B., Willer, Cristen J., Lee, Seunggeun, Fritsche, Lars G., Boehnke, Michael, Abecasis, Gonçalo R.

“…The ability of investigators to explore their own data by alternating between these two view types, is an increasingly common feature of large-scale…”
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LocusZoom: regional visualization of genome-wide association scan results by Pruim, Randall J., Welch, Ryan P., Sanna, Serena, Teslovich, Tanya M., Chines, Peter S., Gliedt, Terry P., Boehnke, Michael, Abecasis, Gonçalo R., Willer, Cristen J.

“…Genome-wide association studies (GWAS) have revealed hundreds of loci associated with common human genetic diseases and traits. We have developed a web-based…”
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Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals by Stanzick, Kira J., Li, Yong, Schlosser, Pascal, Gorski, Mathias, Wuttke, Matthias, Thomas, Laurent F., Rasheed, Humaira, Rowan, Bryce X., Graham, Sarah E., Vanderweff, Brett R., Patil, Snehal B., Robinson-Cohen, Cassiane, Gaziano, John M., O’Donnell, Christopher J., Willer, Cristen J., Hallan, Stein, Åsvold, Bjørn Olav, Gessner, Andre, Hung, Adriana M., Pattaro, Cristian, Köttgen, Anna, Stark, Klaus J., Heid, Iris M., Winkler, Thomas W.

“…Genes underneath signals from genome-wide association studies (GWAS) for kidney function are promising targets for functional studies, but prioritizing…”
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The emerging landscape of health research based on biobanks linked to electronic health records: Existing resources, statistical challenges, and potential opportunities by Beesley, Lauren J., Salvatore, Maxwell, Fritsche, Lars G., Pandit, Anita, Rao, Arvind, Brummett, Chad, Willer, Cristen J., Lisabeth, Lynda D., Mukherjee, Bhramar

“…Biobanks linked to electronic health records provide rich resources for health‐related research. With improvements in administrative and informatics…”
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GREGOR: evaluating global enrichment of trait-associated variants in epigenomic features using a systematic, data-driven approach by Schmidt, Ellen M, Zhang, Ji, Zhou, Wei, Chen, Jin, Mohlke, Karen L, Chen, Y Eugene, Willer, Cristen J

“…The majority of variation identified by genome wide association studies falls in non-coding genomic regions and is hypothesized to impact regulatory elements…”
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Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections by Guo, Dong-chuan, Grove, Megan L., Prakash, Siddharth K., Eriksson, Per, Hostetler, Ellen M., LeMaire, Scott A., Body, Simon C., Shalhub, Sherene, Estrera, Anthony L., Safi, Hazim J., Regalado, Ellen S., Zhou, Wei, Mathis, Michael R., Eagle, Kim A., Yang, Bo, Willer, Cristen J., Boerwinkle, Eric, Milewicz, Dianna M.

“…Acute aortic dissections are a preventable cause of sudden death if individuals at risk are identified and surgically repaired in a non-emergency setting…”
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Genome-scale CRISPR screening for modifiers of cellular LDL uptake by Emmer, Brian T, Sherman, Emily J, Lascuna, Paul J, Graham, Sarah E, Willer, Cristen J, Ginsburg, David

“…Hypercholesterolemia is a causal and modifiable risk factor for atherosclerotic cardiovascular disease. A critical pathway regulating cholesterol homeostasis…”
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Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis by Graham, Sarah E., Nielsen, Jonas B., Zawistowski, Matthew, Zhou, Wei, Fritsche, Lars G., Gabrielsen, Maiken E., Skogholt, Anne Heidi, Surakka, Ida, Hornsby, Whitney E., Fermin, Damian, Larach, Daniel B., Kheterpal, Sachin, Brummett, Chad M., Lee, Seunggeun, Kang, Hyun Min, Abecasis, Goncalo R., Romundstad, Solfrid, Hallan, Stein, Sampson, Matthew G., Hveem, Kristian, Willer, Cristen J.

“…Chronic kidney disease (CKD) is a growing health burden currently affecting 10–15% of adults worldwide. Estimated glomerular filtration rate (eGFR) as a marker…”
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Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits by Choudhury, Ananyo, Brandenburg, Jean-Tristan, Chikowore, Tinashe, Sengupta, Dhriti, Boua, Palwende Romuald, Crowther, Nigel J., Agongo, Godfred, Asiki, Gershim, Gómez-Olivé, F. Xavier, Kisiangani, Isaac, Maimela, Eric, Masemola-Maphutha, Matshane, Micklesfield, Lisa K., Nonterah, Engelbert A., Norris, Shane A., Sorgho, Hermann, Tinto, Halidou, Tollman, Stephen, Graham, Sarah E., Willer, Cristen J., Hazelhurst, Scott, Ramsay, Michèle

“…Genetic associations for lipid traits have identified hundreds of variants with clear differences across European, Asian and African studies. Based on a…”
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Timing of birth and risk of multiple sclerosis: population based study by Willer, Cristen J, Dyment, David A, Sadovnick, A Dessa, Rothwell, Peter M, Murray, T Jock, Ebers, George C

“…Abstract Objectives To determine if risk of multiple sclerosis (MS) is associated with month of birth in countries in the northern hemisphere and if factors…”
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Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production by Guo, Yanhong, Fan, Yanbo, Zhang, Jifeng, Lomberk, Gwen A, Zhou, Zhou, Sun, Lijie, Mathison, Angela J, Garcia-Barrio, Minerva T, Zhang, Ji, Zeng, Lixia, Li, Lei, Pennathur, Subramaniam, Willer, Cristen J, Rader, Daniel J, Urrutia, Raul, Chen, Y Eugene

“…Recent genome-wide association studies have revealed that variations near the gene locus encoding the transcription factor Krüppel-like factor 14 (KLF14) are…”
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The Power of Meta-Analysis in Genome-Wide Association Studies by Panagiotou, Orestis A, Willer, Cristen J, Hirschhorn, Joel N, Ioannidis, John P.A

“…Meta-analysis of multiple genome-wide association (GWA) studies has become common practice over the past few years. The main advantage of this technique is the…”
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Exposure and risk factors for COVID-19 and the impact of staying home on Michigan residents by Wu, Kuan-Han H, Hornsby, Whitney E, Klunder, Bethany, Krause, Amelia, Driscoll, Anisa, Kulka, John, Bickett-Hickok, Ryan, Fellows, Austin, Graham, Sarah, Kaleba, Erin O, Hayek, Salim S, Shi, Xu, Sutton, Nadia R, Douville, Nicholas, Mukherjee, Bhramar, Jamerson, Kenneth, Brummett, Chad M, Willer, Cristen J

“…COVID-19 has had a substantial impact on clinical care and lifestyles globally. The State of Michigan reports over 80,000 positive COVID-19 tests between March…”
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Genetic associations with temporal shifts in obesity and severe obesity during the obesity epidemic in Norway: A longitudinal population-based cohort (the HUNT Study) by Brandkvist, Maria, Bjørngaard, Johan Håkon, Ødegård, Rønnaug Astri, Brumpton, Ben, Smith, George Davey, Åsvold, Bjørn Olav, Sund, Erik R, Kvaløy, Kirsti, Willer, Cristen J, Vie, Gunnhild Åberge

“…Obesity has tripled worldwide since 1975 as environments are becoming more obesogenic. Our study investigates how changes in population weight and obesity over…”
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