Search Results - "Willenbrock, Frances"

TET2 Drives 5hmc Marking of GATA6 and Epigenetically Defines Pancreatic Ductal Adenocarcinoma Transcriptional Subtypes by Eyres, Michael, Lanfredini, Simone, Xu, Haonan, Burns, Adam, Blake, Andrew, Willenbrock, Frances, Goldin, Robert, Hughes, Daniel, Hughes, Sophie, Thapa, Asmita, Vavoulis, Dimitris, Hubert, Aline, D’Costa, Zenobia, Sabbagh, Ahmad, Abraham, Aswin G., Blancher, Christine, Jones, Stephanie, Verrill, Clare, Silva, Michael, Soonawalla, Zahir, Maughan, Timothy, Schuh, Anna, Mukherjee, Somnath, O’Neill, Eric

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by advanced disease stage at presentation, aggressive disease biology, and resistance to therapy,…”
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RAPTOR up-regulation contributes to resistance of renal cancer cells to PI3K-mTOR inhibition by Earwaker, Philip, Anderson, Caroline, Willenbrock, Frances, Harris, Adrian L, Protheroe, Andrew S, Macaulay, Valentine M

“…The outlook for patients with advanced renal cell cancer (RCC) has been improved by targeted agents including inhibitors of the PI3 kinase (PI3K)-AKT-mTOR…”
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Predicting Early Disease Recurrence of Pancreatic Cancer following Surgery: Determining the Role of NUDT15 as a Prognostic Biomarker by Hughes, Daniel Llwyd, Willenbrock, Frances, Soonawalla, Zahir, Mukherjee, Somnath, O'Neill, Eric

“…Surgical resection remains the only curative treatment strategy for Pancreatic Ductal Adenocarcinoma (PDAC). A proportion of patients succumb to early disease…”
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The Gαq/11 proteins contribute to T lymphocyte migration by promoting turnover of integrin LFA-1 through recycling by Svensson, Lena, Stanley, Paula, Willenbrock, Frances, Hogg, Nancy

“…The role of Gαi proteins coupled to chemokine receptors in directed migration of immune cells is well understood. In this study we show that the separate class…”
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Tissue inhibitors of matrix metalloendopeptidases by Murphy, G, Willenbrock, F

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The insider's guide to leukocyte integrin signalling and function by Hogg, Nancy, Patzak, Irene, Willenbrock, Frances

“…Key Points 'Inside-out' signalling causes integrins such as lymphocyte function-associated antigen 1 (LFA1; also known as αLβ2 integrin) to switch from a bent…”
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Structure-function relationships in the tissue inhibitors of metalloproteinases by Willenbrock, F, Murphy, G

“…The tissue inhibitors of metalloproteinases (TIMPs) are proteins that specifically inhibit the matrix metalloproteinases. They consist of two distinct…”
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The Specificity of TIMP-2 for Matrix Metalloproteinases Can Be Modified by Single Amino Acid Mutations by Butler, G S, Hutton, M, Wattam, B A, Williamson, R A, Knäuper, V, Willenbrock, F, Murphy, G

“…Residues 1–127 of human TIMP-2 (N-TIMP-2), comprising three of the disulfide-bonded loops of the TIMP-2 molecule, is a discrete protein domain that folds…”
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The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: A kinetic analysis of the inhibition of gelatinase A by Willenbrock, Frances, Crabbe, Thomas, Slocombe, Patrick M, Sutton, Chris W, Docherty, Andrew J. P, Cockett, Mark I, O'Shea, Mark, Brocklehurst, Keith, Phillips, Ian R, Murphy, Gillian

“…The cloning and expression of the full-length tissue inhibitor of metalloproteinase 2 (TIMP-2), delta 187-194TIMP-2, and delta 128-194TIMP-2 and the…”
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Precision therapy for pancreatic cancer; the role of patient derived cancer avatars by Hughes, Daniel, Willenbrock, Frances, Reddy, Srikanth, Udupa, Venkatesha, Silva, Michael, Soonawalla, Zahir, Mukherjee, Somnath, O’Neill, Eric

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53BP1‐mediated recruitment of RASSF1A to ribosomal DNA breaks promotes local ATM signaling by Tsaridou, Stavroula, Velimezi, Georgia, Willenbrock, Frances, Chatzifrangkeskou, Maria, Elsayed, Waheba, Panagopoulos, Andreas, Karamitros, Dimitris, Gorgoulis, Vassilis, Lygerou, Zoi, Roukos, Vassilis, O'Neill, Eric, Pefani, Dafni Eleftheria

“…DNA lesions occur across the genome and constitute a threat to cell viability; however, damage at specific genomic loci has a relatively greater impact on…”
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Abstract C42: Cell culture under perfusion conditions reduces cellular metabolic stress and mimics the in vivo physiologic environment in pancreatic cancer by Hughes, Daniel, Willenbrock, Frances, Soonawalla, Zahir, Reddy, Srikanth, Silva, Michael, Mukherjee, Somnath, O'Neill, Eric

“…Abstract Introduction: Tumor responsiveness to chemotherapy in PDAC varies significantly across patients, and some patients may succumb to very early recurrent…”
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Different Domain Interactions Are Involved in the Binding of Tissue Inhibitors of Metalloproteinases to Stromelysin-1 and Gelatinase A by Nguyen, Quang, Willenbrock, Frances, Cockett, Mark I, O'Shea, Mark, Docherty, Andrew J. P, Murphy, Gillian

“…The matrix metalloproteinases gelatinase A and stromelysin-1 have definable N-terminal (catalytic) and C-terminal domains. In order to analyze their…”
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Abstract 3593: Raptor upregulation contributes to maintenance of 4EBP1 phosphorylation and TORC kinase resistance in renal cancer cells by Earwaker, Philip, Willenbrock, Frances, Protheroe, Andrew, Macaulay, Valentine

“…Abstract Advanced renal cell cancer (RCC) is incurable, but recent advances in targeted treatment have improved the prognosis. Rapalogue inhibitors of the…”
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Dual-specificity protein phosphatase DUSP4 regulates response to MEK inhibition in BRAF wild-type melanoma by Gupta, Avinash, Towers, Christopher, Willenbrock, Frances, Brant, Roz, Hodgson, Darren Richard, Sharpe, Alan, Smith, Paul, Cutts, Anthony, Schuh, Anna, Asher, Ruth, Myers, Kevin, Love, Sharon, Collins, Linda, Wise, Adelyn, Middleton, Mark Roy, Macaulay, Valentine Moya

“…Background Aiming to improve treatment options for BRAF wild-type melanoma, we previously conducted the DOC-MEK study of docetaxel with MEK inhibitor (MEKi)…”
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Development of human pancreatic cancer avatars as a model for dynamic immune landscape profiling and personalized therapy by Hughes, Daniel, Evans, Alice, Go, Simei, Eyres, Michael, Pan, Liuliu, Mukherjee, Somnath, Soonawalla, Zahir, Willenbrock, Frances, O'Neill, Eric

“…Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer, a disease with dismal overall survival. Advances in treatment are…”
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Abstract B40: High circulating CCL5 is associated with poor prognosis in locally advanced pancreatic cancer (LAPC): Biomarker analysis from the randomized phase II SCALOP trial by Willenbrock, Frances, Cox, Catrin, Wilhelm-Benartzi, Charlotte, Abraham, Aswin, Owens, Robert, Sabbagh, Ahmad, Hurt, Chris, Maughan, Tim, O'Neill, Eric, Mukherjee, Somnath

“…Abstract Background: SCALOP recruited 114 patients with LAPC. Induction chemotherapy consisted of 3 cycles of gemcitabine and capecitabine (GEMCAP). Patients…”
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Abstract PR02: Loss of TET2 activity results in epigenetic instability and drives PDAC molecular subtypes by Eyres, Michael, Lanfredini, Simone, Willenbrock, Frances, Thapa, Asmita, Blake, Andrew, Burns, Adam, Sabbagh, Ahmad, Abraham, Aswin, Maughan, Timothy, Soonawalla, Zahir, Schuh, Anna, Mukhergee, Somnath, O'Neill, Eric

“…Abstract Background: mRNA datasets have defined two molecular subtypes of pancreatic ductal adenocarcinoma (PDAC), classical and squamous, with distinct…”
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Biochemical characterization of matrilysin. Activation conforms to the stepwise mechanisms proposed for other matrix metalloproteinases by Crabbe, Thomas, Willenbrock, Frances, Eaton, Di, Hynds, Peter, Carne, Alexander F, Murphy, Gillian, Docherty, Andrew J. P

“…The latent precursor of matrilysin (EC 3.4.24.23; punctuated metalloproteinase (PUMP) was purified from transfected mouse myeloma cell conditioned medium and…”
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Circulating biomarkers and outcomes from a randomised phase 2 trial of gemcitabine versus capecitabine-based chemoradiotherapy for pancreatic cancer by Willenbrock, Frances, Cox, Catrin M., Parkes, Eileen E., Wilhelm-Benartzi, Charlotte S., Abraham, Aswin G., Owens, Robert, Sabbagh, Ahmad, Jones, Christopher M., Hughes, Daniel L. I., Maughan, Tim, Hurt, Christopher N., O’Neill, Eric E., Mukherjee, Somnath

“…Background The Phase 2 SCALOP trial compared gemcitabine with capecitabine-based consolidation chemoradiotherapy (CRT) in locally advanced pancreatic cancer…”
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