Search Results - "Willemsen, Ellen C.L"

Farnesoid X Receptor Activation Promotes Hepatic Amino Acid Catabolism and Ammonium Clearance in Mice by Massafra, Vittoria, Milona, Alexandra, Vos, Harmjan R, Ramos, Rúben J.J, Gerrits, Johan, Willemsen, Ellen C.L, Ramos Pittol, José M, Ijssennagger, Noortje, Houweling, Martin, Prinsen, Hubertus C.M.T, Verhoeven-Duif, Nanda M, Burgering, Boudewijn M, van Mil, Saskia W.C

“…Background & Aims The nuclear receptor subfamily 1 group H member 4 (NR1H4 or farnesoid X receptor [FXR]) regulates bile acid synthesis, transport, and…”
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FXR Isoforms Control Different Metabolic Functions in Liver Cells via Binding to Specific DNA Motifs by Ramos Pittol, Jose Miguel, Milona, Alexandra, Morris, Imogen, Willemsen, Ellen C.L., van der Veen, Suzanne W., Kalkhoven, Eric, van Mil, Saskia W.C.

“…The nuclear receptor subfamily 1 group H member 4 (NR1H4, also called FXR) is a ligand-activated transcription factor that, upon binding of bile acids,…”
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Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology by Bijsmans, Ingrid T.G.W., Milona, Alexandra, Ijssennagger, Noortje, Willemsen, Ellen C.L., Ramos Pittol, José M., Jonker, Johan W., Lange, Katja, Hooiveld, Guido J.E.J., van Mil, Saskia W.C.

“…Nuclear receptors (NRs) are ligand-activated transcription factors regulating a large variety of processes involved in reproduction, development, and…”
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Ablation of liver Fxr results in an increased colonic mucus barrier in mice by Ijssennagger, Noortje, van Rooijen, Kristel S., Magnúsdóttir, Stefanía, Ramos Pittol, José M., Willemsen, Ellen C.L., de Zoete, Marcel R., Baars, Matthijs J.D., Stege, Paul B., Colliva, Carolina, Pellicciari, Roberto, Youssef, Sameh A., de Bruin, Alain, Vercoulen, Yvonne, Kuipers, Folkert, van Mil, Saskia W.C.

“…The interorgan crosstalk between the liver and the intestine has been the focus of intense research. Key in this crosstalk are bile acids, which are secreted…”
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Steroidogenic control of liver metabolism through a nuclear receptor-network by Milona, Alexandra, Massafra, Vittoria, Vos, Harmjan, Naik, Jyoti, Artigas, Natalia, Paterson, Helen A.B., Bijsmans, Ingrid T.G.W., Willemsen, Ellen C.L., Ramos Pittol, Jose M., Miguel-Aliaga, Irene, Bosma, Piter, Burgering, Boudewijn M.T., Williamson, Catherine, Vernia, Santiago, Dhillo, Waljit S., van Mil, Saskia W.C., Owen, Bryn M.

“…Coupling metabolic and reproductive pathways is essential for the survival of species. However, the functions of steroidogenic enzymes expressed in metabolic…”
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Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease by Gadaleta, Raffaella M, van Erpecum, Karel J, Oldenburg, Bas, Willemsen, Ellen C L, Renooij, Willem, Murzilli, Stefania, Klomp, Leo W J, Siersema, Peter D, Schipper, Marguerite E I, Danese, Silvio, Penna, Giuseppe, Laverny, Gilles, Adorini, Luciano, Moschetta, Antonio, van Mil, Saskia W C

“…Inflammatory bowel disease (IBD) is characterised by chronic intestinal inflammation, resulting from dysregulation of the mucosal immune system and compromised…”
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Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine by Gadaleta, Raffaella M., Oldenburg, Bas, Willemsen, Ellen C.L., Spit, Maureen, Murzilli, Stefania, Salvatore, Lorena, Klomp, Leo W.J., Siersema, Peter D., van Erpecum, Karel J., van Mil, Saskia W.C.

“…Hyperactivation of NF-κB is a key factor in the pathophysiology of inflammatory bowel disease (IBD). We previously showed that the bile salt nuclear Farnesoid…”
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Raised hepatic bile acid concentrations during pregnancy in mice are associated with reduced farnesoid X receptor function by Milona, Alexandra, Owen, Bryn M., Cobbold, Jeremy F. L., Willemsen, Ellen C. L., Cox, Isobel J., Boudjelal, Mohamed, Cairns, William, Schoonjans, Kristina, Taylor‐Robinson, Simon D., Klomp, Leo W. J., Parker, Malcolm G., White, Roger, van Mil, Saskia W. C., Williamson, Catherine

“…Pregnancy alters bile acid homeostasis and can unmask cholestatic disease in genetically predisposed but otherwise asymptomatic individuals. In this report, we…”
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