Search Results - "Willemse, J A"

A neurologist's perspective on serum neurofilament light in the memory clinic: a prospective implementation study by Willemse, E A J, Scheltens, P, Teunissen, C E, Vijverberg, E G B

“…Neurofilament light in serum (sNfL) is a biomarker for axonal damage with elevated levels in many neurological disorders, including neurodegenerative…”
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Bioinformatics tools and data resources for assay development of fluid protein biomarkers by Waury, Katharina, Willemse, Eline A. J, Vanmechelen, Eugeen, Zetterberg, Henrik, Teunissen, Charlotte E, Abeln, Sanne

“…Fluid protein biomarkers are important tools in clinical research and health care to support diagnosis and to monitor patients. Especially within the field of…”
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A Method to Combine Neurofilament Light Measurements From Blood Serum and Plasma in Clinical and Population-Based Studies by Rübsamen, Nicole, Willemse, Eline A. J., Leppert, David, Wiendl, Heinz, Nauck, Matthias, Karch, André, Kuhle, Jens, Berger, Klaus

“…IntroductionNeurofilament light (NfL) can be detected in blood of healthy individuals and at elevated levels in those with different neurological diseases. We…”
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Social Touch in Human–Robot Interaction: Robot-Initiated Touches can Induce Positive Responses without Extensive Prior Bonding by Willemse, Christian J. A. M., van Erp, Jan B. F.

“…Social touch interactions can, depending on the type and strength of the dyadic social relationship, elicit a plethora of physiological, emotional, and…”
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Age‐ and disease‐specific reference values for neurofilament light presented in an online interactive support interface by Vermunt, Lisa, Otte, Marco, Verberk, Inge M. W., Killestein, Joep, Lemstra, Afina W., Flier, Wiesje M., Pijnenburg, Yolande A. L., Vijverberg, Everard G. B., Bouwman, Femke H., Gravesteijn, Gido, Berg, Wilma D. J., Scheltens, Philip, Harten, Argonde C., Willemse, Eline A. J., Teunissen, Charlotte E.

“…Interpretation of axonal damage biomarker Neurofilament Light chain (NfL) concentrations is difficult due to the lack of age‐specific and disease‐specific…”
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Preanalytical Stability of CSF Total and Oligomeric Alpha-Synuclein by Abdi, Ilham Y, Majbour, Nour K, Willemse, Eline A J, van de Berg, Wilma D J, Mollenhauer, Brit, Teunissen, Charlotte E, El-Agnaf, Omar M

“…: The role of cerebrospinal fluid (CSF) alpha-synuclein as a potential biomarker has been challenged mainly due to variable preanalytical measures between…”
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A Pragmatic, Data-Driven Method to Determine Cutoffs for CSF Biomarkers of Alzheimer Disease Based on Validation Against PET Imaging by Dumurgier, Julien, Sabia, Séverine, Zetterberg, Henrik, Teunissen, Charlotte E., Hanseeuw, Bernard, Orellana, Adelina, Schraen, Susanna, Gabelle, Audrey, Boada, Mercè, Lebouvier, Thibaud, Willemse, Eline A.J., Cognat, Emmanuel, Ruiz, Agustin, Hourregue, Claire, Lilamand, Matthieu, Bouaziz-Amar, Elodie, Laplanche, Jean-Louis, Lehmann, Sylvain, Pasquier, Florence, Scheltens, Philip, Blennow, Kaj, Singh-Manoux, Archana, Paquet, Claire

“…To elaborate a new algorithm to establish a standardized method to define cutoffs for CSF biomarkers of Alzheimer disease (AD) by validating the algorithm…”
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Comparing CSF amyloid‐beta biomarker ratios for two automated immunoassays, Elecsys and Lumipulse, with amyloid PET status by Willemse, Eline A. J., Tijms, Betty M., Berckel, Bart N. M., Le Bastard, Nathalie, Flier, Wiesje M., Scheltens, Philip, Teunissen, Charlotte E.

“…Introduction We evaluated for two novel automated biomarker assays how cerebrospinal fluid (CSF) amyloid beta (Aβ)1– 42‐ratios improved the concordance with…”
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Four subgroups based on tau levels in Alzheimer's disease observed in two independent cohorts by Duits, Flora H, Wesenhagen, Kirsten E J, Ekblad, Laura, Wolters, Emma, Willemse, Eline A J, Scheltens, Philip, van der Flier, Wiesje M, Teunissen, Charlotte E, Visser, Pieter Jelle, Tijms, Betty M

“…As Alzheimer's disease (AD) pathology presents decades before dementia manifests, unbiased biomarker cut-points may more closely reflect presence of pathology…”
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A multimodal marker for cognitive functioning in multiple sclerosis: the role of NfL, GFAP and conventional MRI in predicting cognitive functioning in a prospective clinical cohort by van Dam, Maureen, de Jong, Brigit A., Willemse, Eline A. J., Nauta, Ilse M., Huiskamp, Marijn, Klein, Martin, Moraal, Bastiaan, de Geus-Driessen, Sanne, Geurts, Jeroen J. G., Uitdehaag, Bernard M. J., Teunissen, Charlotte E., Hulst, Hanneke E.

“…Background Cognitive impairment in people with MS (PwMS) has primarily been investigated using conventional imaging markers or fluid biomarkers of…”
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Caregivers’ attitudes toward blood‐based biomarker testing for Alzheimer's disease by Bolsewig, Katharina, Blok, Hester, Willemse, Eline A. J., Zwaaftink, Rob B. M. Groot, Kooistra, Minke, Smets, Ellen M. A., Teunissen, Charlotte E., Visser, Leonie N. C.

“…INTRODUCTION We aimed to evaluate informal caregivers’ attitudes toward undergoing and future implementation of blood‐based biomarkers (BBBM) testing for…”
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Plasma NfL and GFAP as biomarkers of spinal cord degeneration in adrenoleukodystrophy by Ballegoij, Wouter J. C., Stadt, Stephanie I.W., Huffnagel, Irene C., Kemp, Stephan, Willemse, Eline A. J., Teunissen, Charlotte E., Engelen, Marc

“…Objective To explore the potential of neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) as biomarkers of spinal cord degeneration in…”
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Pre-analytical stability of novel cerebrospinal fluid biomarkers by Willemse, Eline A.J., Vermeiren, Yannick, Garcia-Ayllon, Maria-Salud, Bridel, Claire, De Deyn, Peter P., Engelborghs, Sebastiaan, van der Flier, Wiesje M., Jansen, Erwin E.W., Lopez-Font, Inmaculada B., Mendes, Vera, Manadas, Bruno, de Roeck, Naomi, Saez-Valero, Javier, Struys, Eduard A., Vanmechelen, Eugeen, Andreasson, Ulf, Teunissen, Charlotte E.

“…Stability of the cerebrospinal fluid (CSF) composition under different pre-analytical conditions is relevant for the diagnostic potential of biomarkers. Our…”
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A Cystatin C Cleavage ELISA Assay as a Quality Control Tool for Determining Sub-Optimal Storage Conditions of Cerebrospinal Fluid Samples in Alzheimer's Disease Research by Mommaerts, Kathleen, Willemse, Eline A J, Marchese, Monica, Larue, Catherine, van der Flier, Wiesje M, Betsou, Fay, Teunissen, Charlotte E

“…An N-terminal octapeptide cleavage of the cystatin C protein was discovered by mass spectrometry when cerebrospinal fluid (CSF) was stored at -20°C for 3…”
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Unbiased Approach to Counteract Upward Drift in Cerebrospinal Fluid Amyloid-β 1-42 Analysis Results by Tijms, Betty M, Willemse, Eline A J, Zwan, Marissa D, Mulder, Sandra D, Visser, Pieter Jelle, van Berckel, Bart N M, van der Flier, Wiesje M, Scheltens, Philip, Teunissen, Charlotte E

“…Low cerebrospinal fluid (CSF) amyloid-β 1-42 (Aβ 1-42) concentrations indicate amyloid plaque accumulation in the brain, a pathological hallmark of Alzheimer…”
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Assessing the Pre-Analytical Stability of Small-Molecule Metabolites in Cerebrospinal Fluid Using Direct-Infusion Metabolomics by Haijes, Hanneke A., Willemse, Eline A.J., Gerrits, Johan, van der Flier, Wiesje M., Teunissen, Charlotte E., Verhoeven-Duif, Nanda M., Jans, Judith J.M.

“…Metabolomics studies aiming to find biomarkers frequently make use of historical or multicenter cohorts. These samples often have different pre-analytical…”
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Hepatitis C in haemophilia patients in the Netherlands by Leebeek, FWG, Mauser-Bunschoten, EP, van der Meer, J, Willemse, JA

“…We have a well documented group of 1600 haemophilia patients in the Netherlands, not thousands. Thanks to large cohort studies in haemophilia patients in the…”
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Neurogranin as biomarker in CSF is non-specific to Alzheimer's disease dementia by Willemse, Eline A.J., Sieben, Anne, Somers, Charisse, Vermeiren, Yannick, De Roeck, Naomi, Timmers, Maarten, Van Broeckhoven, Christine, De Vil, Bart, Cras, Patrick, De Deyn, Peter P., Martin, Jean-Jacques, Teunissen, Charlotte E., Engelborghs, Sebastiaan, Bjerke, Maria

“…We aimed to evaluate the specificity of neurogranin (Ng) for Alzheimer's disease (AD) in a dementia cohort. Cerebrospinal fluid (CSF) Ng was measured (ELISA)…”
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Neurogranin as Cerebrospinal Fluid Biomarker for Alzheimer Disease: An Assay Comparison Study by Willemse, Eline A J, De Vos, Ann, Herries, Elizabeth M, Andreasson, Ulf, Engelborghs, Sebastiaan, van der Flier, Wiesje M, Scheltens, Philip, Crimmins, Dan, Ladenson, Jack H, Vanmechelen, Eugeen, Zetterberg, Henrik, Fagan, Anne M, Blennow, Kaj, Bjerke, Maria, Teunissen, Charlotte E

“…Neurogranin in cerebrospinal fluid (CSF) correlates with cognitive decline and is a potential novel biomarker for Alzheimer disease (AD) dementia. We…”
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Association of Plasma Amyloid, P-Tau, GFAP, and NfL With CSF, Clinical, and Cognitive Features in Patients With Dementia With Lewy Bodies by Bolsewig, Katharina, van Unnik, Annemartijn A J M, Blujdea, Elena R, Gonzalez, Maria C, Ashton, Nicholas J, Aarsland, Dag, Zetterberg, Henrik, Padovani, Alessandro, Bonanni, Laura, Mollenhauer, Brit, Schade, Sebastian, Vandenberghe, Rik, Poesen, Koen, Kramberger, Milica G, Paquet, Claire, Bousiges, Olivier, Cretin, Benjamin, Willemse, Eline A J, Teunissen, Charlotte E, Lemstra, Afina W

“…Plasma β-amyloid-1-42/1-40 (Aβ42/40), phosphorylated-tau (P-tau), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) have been widely…”
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