Search Results - "Willems, Rob Jl"

Comparative genomic analysis reveals significant enrichment of mobile genetic elements and genes encoding surface structure-proteins in hospital-associated clonal complex 2 Enterococcus faecalis by Solheim, Margrete, Brekke, Mari C, Snipen, Lars G, Willems, Rob J L, Nes, Ingolf F, Brede, Dag A

“…Enterococci rank among the leading causes of nosocomial infections. The failure to identify pathogen-specific genes in Enterococcus faecalis has led to a…”
Get full text

Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island by van Schaik, Willem, Top, Janetta, Riley, David R, Boekhorst, Jos, Vrijenhoek, Joyce E P, Schapendonk, Claudia M E, Hendrickx, Antoni P A, Nijman, Isaäc J, Bonten, Marc J M, Tettelin, Hervé, Willems, Rob J L

“…The Gram-positive bacterium Enterococcus faecium is an important cause of nosocomial infections in immunocompromized patients. We present a…”
Get full text

Identification of high-risk enterococcal clonal complexes: global dispersion and antibiotic resistance by Leavis, Helen L, Bonten, Marc JM, Willems, Rob JL

“…Vancomycin-resistant Enterococcus faecium spread dramatically in hospital settings in the USA in the 1990s and reached endemicity at the turn of the century…”
Get full text

Dynamics of ampicillin-resistant Enterococcus faecium clones colonizing hospitalized patients: data from a prospective observational study by Weisser, Maja, Oostdijk, Evelien A, Willems, Rob J L, Bonten, Marc J M, Frei, Reno, Elzi, Luigia, Halter, Jörg, Widmer, Andreas F, Top, Janetta

“…Little is known about the dynamics of colonizing Enterococcus faecium clones during hospitalization, invasive infection and after discharge. In a prospective…”
Get full text

Enterococcal surface protein Esp is not essential for cell adhesion and intestinal colonization of Enterococcus faecium in mice by Heikens, Esther, Leendertse, Masja, Wijnands, Lucas M, van Luit-Asbroek, Miranda, Bonten, Marc J M, van der Poll, Tom, Willems, Rob J L

“…Enterococcus faecium has globally emerged as a cause of hospital-acquired infections with high colonization rates in hospitalized patients. The enterococcal…”
Get full text

New methods to analyse microarray data that partially lack a reference signal by Carpaij, Neeltje, Fluit, Ad C, Lindsay, Jodi A, Bonten, Marc Jm, Willems, Rob Jl

“…Microarray-based Comparative Genomic Hybridisation (CGH) has been used to assess genetic variability between bacterial strains. Crucial for interpretation of…”
Get full text

Limited influence of hospital wastewater on the microbiome and resistome of wastewater in a community sewerage system by Buelow, Elena, Bayjanov, Jumamurat R, Majoor, Eline, Willems, Rob Jl, Bonten, Marc Jm, Schmitt, Heike, van Schaik, Willem

“…Effluents from wastewater treatment plants (WWTPs) have been proposed to act as point sources of antibiotic-resistant bacteria (ARB) and antimicrobial…”
Get full text

Multidrug-Resistant Enterococcal Infections: New Compounds, Novel Antimicrobial Therapies? by van Harten, Roel M, Willems, Rob J.L, Martin, Nathaniel I, Hendrickx, Antoni P.A

“…Over the past two decades infections due to antibiotic-resistant bacteria have escalated world-wide, affecting patient morbidity, mortality, and health care…”
Get full text

Transition of Enterococcus faecium from commensal organism to nosocomial pathogen by Willems, Rob Jl, van Schaik, Willem

“…The Gram-positive species Enterococcus faecium has long been thought of as a harmless commensal of the mammalian GI tract. In the last two decades, however, E…”
Get more information

Population biology of Gram-positive pathogens: high-risk clones for dissemination of antibiotic resistance by Willems, Rob J.L., Hanage, William P., Bessen, Debra E., Feil, Edward J.

“…Abstract Infections caused by multiresistant Gram-positive bacteria represent a major health burden in the community as well as in hospitalized patients…”
Get full text

Pangenome-spanning epistasis and coselection analysis via de Bruijn graphs by Kuronen, Juri, Horsfield, Samuel T, Pöntinen, Anna K, Mallawaarachchi, Sudaraka, Arredondo-Alonso, Sergio, Thorpe, Harry, Gladstone, Rebecca A, Willems, Rob J L, Bentley, Stephen D, Croucher, Nicholas J, Pensar, Johan, Lees, John A, Tonkin-Hill, Gerry, Corander, Jukka

“…Studies of bacterial adaptation and evolution are hampered by the difficulty of measuring traits such as virulence, drug resistance, and transmissibility in…”
Get full text

Enterococcal Surface Protein Esp Is Important for Biofilm Formation of Enterococcus faecium E1162 by HEIKENS, Esther, BONTEN, Marc J. M, WILLEMS, Rob J. L

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The Two-Component System ChtRS Contributes to Chlorhexidine Tolerance in Enterococcus faecium by Guzmán Prieto, Ana M, Wijngaarden, Jessica, Braat, Johanna C, Rogers, Malbert R C, Majoor, Eline, Brouwer, Ellen C, Zhang, Xinglin, Bayjanov, Jumamurat R, Bonten, Marc J M, Willems, Rob J L, van Schaik, Willem

“…is one of the primary causes of nosocomial infections. Disinfectants are commonly used to prevent infections with multidrug-resistant in hospitals. Worryingly,…”
Get full text

Multilocus Sequence Typing Scheme for Enterococcus faecalis Reveals Hospital-Adapted Genetic Complexes in a Background of High Rates of Recombination by Ruiz-Garbajosa, Patricia, Bonten, Marc J.M, Robinson, D. Ashley, Top, Janetta, Nallapareddy, Sreedhar R, Torres, Carmen, Coque, Teresa M, Cantón, Rafael, Baquero, Fernando, Murray, Barbara E, Campo, Rosa del, Willems, Rob J.L

“…A multilocus sequence typing (MLST) scheme based on seven housekeeping genes was used to investigate the epidemiology and population structure of Enterococcus…”
Get full text

Insight into antimicrobial susceptibility and population structure of contemporary human Enterococcus faecalis isolates from Europe by Kuch, Alicja, Willems, Rob J. L., Werner, Guido, Coque, Teresa M., Hammerum, Anette M., Sundsfjord, Arnfinn, Klare, Ingo, Ruiz-Garbajosa, Patricia, Simonsen, Gunnar S., van Luit-Asbroek, Miranda, Hryniewicz, Waleria, Sadowy, Ewa

“…Objectives To investigate antimicrobial susceptibility and clonal relatedness of Enterococcus faecalis human isolates recovered recently (2006-09) in six…”
Get full text

Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium by Zhang, Xinglin, Paganelli, Fernanda L, Bierschenk, Damien, Kuipers, Annemarie, Bonten, Marc J M, Willems, Rob J L, van Schaik, Willem

“…Enterococcus faecium has become a nosocomial pathogen of major importance, causing infections that are difficult to treat owing to its multi-drug resistance…”
Get full text

AsrR is an oxidative stress sensing regulator modulating Enterococcus faecium opportunistic traits, antimicrobial resistance, and pathogenicity by Lebreton, François, van Schaik, Willem, Sanguinetti, Maurizio, Posteraro, Brunella, Torelli, Riccardo, Le Bras, Florian, Verneuil, Nicolas, Zhang, Xinglin, Giard, Jean-Christophe, Dhalluin, Anne, Willems, Rob J L, Leclercq, Roland, Cattoir, Vincent

“…Oxidative stress serves as an important host/environmental signal that triggers a wide range of responses in microorganisms. Here, we identified an oxidative…”
Get full text

The impact of host metapopulation structure on the population genetics of colonizing bacteria by Numminen, Elina, Gutmann, Michael, Shubin, Mikhail, Marttinen, Pekka, Méric, Guillaume, van Schaik, Willem, Coque, Teresa M., Baquero, Fernando, Willems, Rob J.L., Sheppard, Samuel K., Feil, Edward J., Hanage, William P., Corander, Jukka

“…Many key bacterial pathogens are frequently carried asymptomatically, and the emergence and spread of these opportunistic pathogens can be driven, or…”
Get full text

A genomic virulence reference map of Enterococcus faecalis reveals an important contribution of phage03-like elements in nosocomial genetic lineages to pathogenicity in a Caenorhabditis elegans infection model by La Rosa, Sabina Leanti, Snipen, Lars-Gustav, Murray, Barbara E, Willems, Rob J L, Gilmore, Michael S, Diep, Dzung B, Nes, Ingolf F, Brede, Dag Anders

“…In the present study, the commensal and pathogenic host-microbe interaction of Enterococcus faecalis was explored using a Caenorhabditis elegans model system…”
Get full text

The cell wall architecture of Enterococcus faecium: from resistance to pathogenesis by Hendrickx, Antoni P A, van Schaik, Willem, Willems, Rob J L

“…The cell wall of Gram-positive bacteria functions as a surface organelle that continuously interacts with its environment through a plethora of cell…”
Get more information