Search Results - "Willems, Rob"

Dissemination of cephalosporin resistance genes between Escherichia coli strains from farm animals and humans by specific plasmid lineages by de Been, Mark, Lanza, Val F, de Toro, María, Scharringa, Jelle, Dohmen, Wietske, Du, Yu, Hu, Juan, Lei, Ying, Li, Ning, Tooming-Klunderud, Ave, Heederik, Dick J J, Fluit, Ad C, Bonten, Marc J M, Willems, Rob J L, de la Cruz, Fernando, van Schaik, Willem

“…Third-generation cephalosporins are a class of β-lactam antibiotics that are often used for the treatment of human infections caused by Gram-negative bacteria,…”
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Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial by Reyman, Marta, van Houten, Marlies A., Watson, Rebecca L., Chu, Mei Ling J. N., Arp, Kayleigh, de Waal, Wouter J., Schiering, Irene, Plötz, Frans B., Willems, Rob J. L., van Schaik, Willem, Sanders, Elisabeth A. M., Bogaert, Debby

“…Broad-spectrum antibiotics for suspected early-onset neonatal sepsis (sEONS) may have pronounced effects on gut microbiome development and selection of…”
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Multidrug-Resistant Enterococcal Infections: New Compounds, Novel Antimicrobial Therapies? by van Harten, Roel M, Willems, Rob J.L, Martin, Nathaniel I, Hendrickx, Antoni P.A

“…Over the past two decades infections due to antibiotic-resistant bacteria have escalated world-wide, affecting patient morbidity, mortality, and health care…”
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Population biology of Gram-positive pathogens: high-risk clones for dissemination of antibiotic resistance by Willems, Rob J.L., Hanage, William P., Bessen, Debra E., Feil, Edward J.

“…Abstract Infections caused by multiresistant Gram-positive bacteria represent a major health burden in the community as well as in hospitalized patients…”
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Enterococcus faecium: from microbiological insights to practical recommendations for infection control and diagnostics by Zhou, Xuewei, Willems, Rob J L, Friedrich, Alexander W, Rossen, John W A, Bathoorn, Erik

“…Early in its evolution, Enterococcus faecium acquired traits that allowed it to become a successful nosocomial pathogen. E. faecium inherent tenacity to build…”
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Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era by Pöntinen, Anna K., Top, Janetta, Arredondo-Alonso, Sergio, Tonkin-Hill, Gerry, Freitas, Ana R., Novais, Carla, Gladstone, Rebecca A., Pesonen, Maiju, Meneses, Rodrigo, Pesonen, Henri, Lees, John A., Jamrozy, Dorota, Bentley, Stephen D., Lanza, Val F., Torres, Carmen, Peixe, Luisa, Coque, Teresa M., Parkhill, Julian, Schürch, Anita C., Willems, Rob J. L., Corander, Jukka

“…Enterococcus faecalis is a commensal and nosocomial pathogen, which is also ubiquitous in animals and insects, representing a classical generalist…”
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Core Genome Multilocus Sequence Typing Scheme for High- Resolution Typing of Enterococcus faecium by de Been, Mark, Pinholt, Mette, Top, Janetta, Bletz, Stefan, Mellmann, Alexander, van Schaik, Willem, Brouwer, Ellen, Rogers, Malbert, Kraat, Yvette, Bonten, Marc, Corander, Jukka, Westh, Henrik, Harmsen, Dag, Willems, Rob J L

“…Enterococcus faecium, a common inhabitant of the human gut, has emerged in the last 2 decades as an important multidrug-resistant nosocomial pathogen. Since…”
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Insertion sequence-driven diversification creates a globally dispersed emerging multiresistant subspecies of E. faecium by Leavis, Helen L, Willems, Rob J L, van Wamel, Willem J B, Schuren, Frank H, Caspers, Martien P M, Bonten, Marc J M

“…Enterococcus faecium, an ubiquous colonizer of humans and animals, has evolved in the last 15 years from an avirulent commensal to the third most frequently…”
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Limited influence of hospital wastewater on the microbiome and resistome of wastewater in a community sewerage system by Buelow, Elena, Bayjanov, Jumamurat R, Majoor, Eline, Willems, Rob Jl, Bonten, Marc Jm, Schmitt, Heike, van Schaik, Willem

“…Effluents from wastewater treatment plants (WWTPs) have been proposed to act as point sources of antibiotic-resistant bacteria (ARB) and antimicrobial…”
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Conditionally essential genes for survival during starvation in Enterococcus faecium E745 by de Maat, Vincent, Arredondo-Alonso, Sergio, Willems, Rob J L, van Schaik, Willem

“…The nosocomial pathogen Enterococcus faecium can survive for prolonged periods of time on surfaces in the absence of nutrients. This trait is thought to…”
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mlplasmids: a user-friendly tool to predict plasmid- and chromosome-derived sequences for single species by Arredondo-Alonso, Sergio, Rogers, Malbert R C, Braat, Johanna C, Verschuuren, Tess D, Top, Janetta, Corander, Jukka, Willems, Rob J L, Schürch, Anita C

“…Assembly of bacterial short-read whole-genome sequencing data frequently results in hundreds of contigs for which the origin, plasmid or chromosome, is…”
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Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium by Zhang, Xinglin, Paganelli, Fernanda L, Bierschenk, Damien, Kuipers, Annemarie, Bonten, Marc J M, Willems, Rob J L, van Schaik, Willem

“…Enterococcus faecium has become a nosocomial pathogen of major importance, causing infections that are difficult to treat owing to its multi-drug resistance…”
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Global Emergence and Dissemination of Enterococci as Nosocomial Pathogens: Attack of the Clones? by Guzman Prieto, Ana M, van Schaik, Willem, Rogers, Malbert R C, Coque, Teresa M, Baquero, Fernando, Corander, Jukka, Willems, Rob J L

“…Enterococci are Gram-positive bacteria that are found in plants, soil and as commensals of the gastrointestinal tract of humans, mammals, and insects. Despite…”
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The global dissemination of hospital clones of Enterococcus faecium by van Hal, Sebastiaan J, Willems, Rob J L, Gouliouris, Theodore, Ballard, Susan A, Coque, Teresa M, Hammerum, Anette M, Hegstad, Kristin, Westh, Hendrik T, Howden, Benjamin P, Malhotra-Kumar, Surbhi, Werner, Guido, Yanagihara, Katsunori, Earl, Ashlee M, Raven, Katherine E, Corander, Jukka, Bowden, Rory

“…The hospital-adapted A1 group of Enterococcus faecium remains an organism of significant concern in the context of drug-resistant hospital-associated…”
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AsrR is an oxidative stress sensing regulator modulating Enterococcus faecium opportunistic traits, antimicrobial resistance, and pathogenicity by Lebreton, François, van Schaik, Willem, Sanguinetti, Maurizio, Posteraro, Brunella, Torelli, Riccardo, Le Bras, Florian, Verneuil, Nicolas, Zhang, Xinglin, Giard, Jean-Christophe, Dhalluin, Anne, Willems, Rob J L, Leclercq, Roland, Cattoir, Vincent

“…Oxidative stress serves as an important host/environmental signal that triggers a wide range of responses in microorganisms. Here, we identified an oxidative…”
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Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island by van Schaik, Willem, Top, Janetta, Riley, David R, Boekhorst, Jos, Vrijenhoek, Joyce E P, Schapendonk, Claudia M E, Hendrickx, Antoni P A, Nijman, Isaäc J, Bonten, Marc J M, Tettelin, Hervé, Willems, Rob J L

“…The Gram-positive bacterium Enterococcus faecium is an important cause of nosocomial infections in immunocompromized patients. We present a…”
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Enterococcal Surface Protein Esp Is Important for Biofilm Formation of Enterococcus faecium E1162 by HEIKENS, Esther, BONTEN, Marc J. M, WILLEMS, Rob J. L

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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CRISPR-Cas9-mediated genome editing in vancomycin-resistant Enterococcus faecium by de Maat, Vincent, Stege, Paul B, Dedden, Mark, Hamer, Maud, van Pijkeren, Jan-Peter, Willems, Rob J L, van Schaik, Willem

“…ABSTRACT The Gram-positive bacterium Enterococcus faecium is becoming increasingly prevalent as a cause of hospital-acquired, antibiotic-resistant infections…”
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Extended-spectrum beta-lactamase (ESBL)-producing and non-ESBL-producing Escherichia coli isolates causing bacteremia in the Netherlands (2014 - 2016) differ in clonal distribution, antimicrobial resistance gene and virulence gene content by van Hout, Denise, Verschuuren, Tess D, Bruijning-Verhagen, Patricia C J, Bosch, Thijs, Schürch, Anita C, Willems, Rob J L, Bonten, Marc J M, Kluytmans, Jan A J W

“…Knowledge on the molecular epidemiology of Escherichia coli causing E. coli bacteremia (ECB) in the Netherlands is mostly based on extended-spectrum…”
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Pangenome-spanning epistasis and coselection analysis via de Bruijn graphs by Kuronen, Juri, Horsfield, Samuel T, Pöntinen, Anna K, Mallawaarachchi, Sudaraka, Arredondo-Alonso, Sergio, Thorpe, Harry, Gladstone, Rebecca A, Willems, Rob J L, Bentley, Stephen D, Croucher, Nicholas J, Pensar, Johan, Lees, John A, Tonkin-Hill, Gerry, Corander, Jukka

“…Studies of bacterial adaptation and evolution are hampered by the difficulty of measuring traits such as virulence, drug resistance, and transmissibility in…”
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