Search Results - "Willemen, Hanneke"

Divergent roles of immune cells and their mediators in pain by Raoof, Ramin, Willemen, Hanneke L D M, Eijkelkamp, Niels

“…Abstract Chronic pain is a major debilitating condition that is difficult to treat. Although chronic pain may appear to be a disorder of the nervous system,…”
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MicroRNA-124 as a novel treatment for persistent hyperalgesia by Willemen, Hanneke L D M, Huo, Xiao-Jiao, Mao-Ying, Qi-Liang, Zijlstra, Jitske, Heijnen, Cobi J, Kavelaars, Annemieke

“…Chronic pain is often associated with microglia activation in the spinal cord. We recently showed that microglial levels of the kinase G protein-coupled…”
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Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain by van der Vlist, Michiel, Raoof, Ramin, Willemen, Hanneke L.D.M., Prado, Judith, Versteeg, Sabine, Martin Gil, Christian, Vos, Martijn, Lokhorst, Roeland E., Pasterkamp, R. Jeroen, Kojima, Toshiyuki, Karasuyama, Hajime, Khoury-Hanold, William, Meyaard, Linde, Eijkelkamp, Niels

“…The current paradigm is that inflammatory pain passively resolves following the cessation of inflammation. Yet, in a substantial proportion of patients with…”
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Pre-Existing High Glucocorticoid Receptor Number Predicting Development of Posttraumatic Stress Symptoms After Military Deployment by van Zuiden, Mirjam, Geuze, Elbert, Willemen, Hanneke L.D.M., Vermetten, Eric, Maas, Mirjam, Heijnen, Cobi J., Kavelaars, Annemieke

“…Objective:The development of posttraumatic stress disorder (PTSD) is influenced by preexisting vulnerability factors. The authors aimed at identifying a…”
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Mesenchymal Stem Cell Transplantation Attenuates Brain Injury After Neonatal Stroke by VELTHOVEN, Cindy T. J. Van, SHELDON, R. Ann, KAVELAARS, Annemieke, DERUGIN, Nikita, VEXLER, Zinaida S, WILLEMEN, Hanneke L. D. M, MAAS, Mirjam, HEIJNEN, Cobi J, FERRIERO, Donna M

“…Brain injury caused by stroke is a frequent cause of perinatal morbidity and mortality with limited therapeutic options. Mesenchymal stem cells (MSC) have been…”
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Glucocorticoid Receptor Pathway Components Predict Posttraumatic Stress Disorder Symptom Development: A Prospective Study by van Zuiden, Mirjam, Geuze, Elbert, Willemen, Hanneke L.D.M, Vermetten, Eric, Maas, Mirjam, Amarouchi, Karima, Kavelaars, Annemieke, Heijnen, Cobi J

“…Background Biological correlates of posttraumatic stress disorder (PTSD) have mostly been studied using cross-sectional or posttrauma prospective designs…”
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Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain by Wang, Huijing, Heijnen, Cobi J, van Velthoven, Cindy T J, Willemen, Hanneke L D M, Ishikawa, Yoshihiro, Zhang, Xinna, Sood, Anil K, Vroon, Anne, Eijkelkamp, Niels, Kavelaars, Annemieke

“…Chronic pain is a major clinical problem, yet the mechanisms underlying the transition from acute to chronic pain remain poorly understood. In mice, reduced…”
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Monocytes/Macrophages control resolution of transient inflammatory pain by Willemen, Hanneke L D M, Eijkelkamp, Niels, Garza Carbajal, Anibal, Wang, Huijing, Mack, Matthias, Zijlstra, Jitske, Heijnen, Cobi J, Kavelaars, Annemieke

“…Insights into mechanisms governing resolution of inflammatory pain are of great importance for many chronic pain-associated diseases. Here we investigate the…”
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The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes by Davydova, Erna, Shimazu, Tadahiro, Schuhmacher, Maren Kirstin, Jakobsson, Magnus E., Willemen, Hanneke L. D. M., Liu, Tongri, Moen, Anders, Ho, Angela Y. Y., Małecki, Jędrzej, Schroer, Lisa, Pinto, Rita, Suzuki, Takehiro, Grønsberg, Ida A., Sohtome, Yoshihiro, Akakabe, Mai, Weirich, Sara, Kikuchi, Masaki, Olsen, Jesper V., Dohmae, Naoshi, Umehara, Takashi, Sodeoka, Mikiko, Siino, Valentina, McDonough, Michael A., Eijkelkamp, Niels, Schofield, Christopher J., Jeltsch, Albert, Shinkai, Yoichi, Falnes, Pål Ø.

“…Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers…”
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Myostatin and CXCL11 promote nervous tissue macrophages to maintain osteoarthritis pain by Martin Gil, Christian, Raoof, Ramin, Versteeg, Sabine, Willemen, Hanneke L.D.M., Lafeber, Floris P.J.G., Mastbergen, Simon C., Eijkelkamp, Niels

“…•Dorsal Root Ganglia (DRG) macrophages maintain, but do not initiate osteoarthritis (OA) pain.•CXCL1, partially expressed in satellite glial cells, drives…”
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Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2 by Vila-Bedmar, Rocio, Cruces-Sande, Marta, Lucas, Elisa, Willemen, Hanneke L D M, Heijnen, Cobi J, Kavelaars, Annemieke, Mayor, Jr, Federico, Murga, Cristina

“…Insulin resistance is a common feature of obesity and predisposes individuals to various prevalent pathological conditions. G protein (heterotrimeric guanine…”
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IL4-10 Fusion Protein Is a Novel Drug to Treat Persistent Inflammatory Pain by Eijkelkamp, Niels, Steen-Louws, Cristine, Hartgring, Sarita A Y, Willemen, Hanneke L D M, Prado, Judith, Lafeber, Floris P J G, Heijnen, Cobi J, Hack, C E, van Roon, Joel A G, Kavelaars, Annemieke

“…Chronic pain is a major clinical problem that is difficult to treat and requires novel therapies. Although most pain therapies primarily target neurons,…”
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GRK2 levels in myeloid cells modulate adipose-liver crosstalk in high fat diet-induced obesity by Vila-Bedmar, Rocío, Cruces-Sande, Marta, Arcones, Alba C., Willemen, Hanneke L. D. M., Prieto, Patricia, Moreno-Indias, Isabel, Díaz-Rodríguez, Daniel, Francisco, Sara, Jaén, Rafael I., Gutiérrez-Repiso, Carolina, Heijnen, Cobi J., Boscá, Lisardo, Fresno, Manuel, Kavelaars, Annemieke, Mayor, Federico, Murga, Cristina

“…Macrophages are key effector cells in obesity-associated inflammation. G protein-coupled receptor kinase 2 (GRK2) is highly expressed in different immune cell…”
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Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration by Małecki, Jędrzej M., Willemen, Hanneke L.D.M., Pinto, Rita, Ho, Angela Y.Y., Moen, Anders, Eijkelkamp, Niels, Falnes, Pål Ø.

“…Lysine methylation is a common posttranslational modification of nuclear and cytoplasmic proteins but is also present in mitochondria. The human protein…”
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Therapeutic Potential of Genetically Modified Mesenchymal Stem Cells After Neonatal Hypoxic-Ischemic Brain Damage by van Velthoven, Cindy TJ, Braccioli, Luca, Willemen, Hanneke LDM, Kavelaars, Annemieke, Heijnen, Cobi J

“…Mesenchymal stem cells (MSCs) have been shown to improve outcomes after neonatal hypoxic-ischemic (HI) brain injury possibly by secretion of growth factors…”
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Identification of FAM173B as a protein methyltransferase promoting chronic pain by Willemen, Hanneke L D M, Kavelaars, Annemieke, Prado, Judith, Maas, Mirjam, Versteeg, Sabine, Nellissen, Lara J J, Tromp, Jeshua, Gonzalez Cano, Rafael, Zhou, Wenjun, Jakobsson, Magnus E, Małecki, Jędrzej, Posthuma, George, Habib, Abdella M, Heijnen, Cobi J, Falnes, Pål Ø, Eijkelkamp, Niels

“…Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide…”
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Mitochondria and sensory processing in inflammatory and neuropathic pain by Silva Santos Ribeiro, P, Willemen, Hanneke L D M, Eijkelkamp, Niels

“…Rheumatic diseases, such as osteoarthritis and rheumatoid arthritis, affect over 750 million people worldwide and contribute to approximately 40% of chronic…”
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Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase by Małecki, Jędrzej M., Willemen, Hanneke L.D.M., Pinto, Rita, Ho, Angela Y.Y., Moen, Anders, Kjønstad, Ingrid F., Burgering, Boudewijn M.T., Zwartkruis, Fried, Eijkelkamp, Niels, Falnes, Pål Ø.

“…Lysine methylation is an important post-translational modification that is also present on mitochondrial proteins, but the mitochondrial lysine-specific…”
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Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage by Nijboer, Cora H, Heijnen, Cobi J, Degos, Vincent, Willemen, Hanneke L.D.M, Gressens, Pierre, Kavelaars, Annemieke

“…Abstract G protein-coupled receptor (GPCR) kinase 2 (GRK2) regulates cellular signaling via desensitization of GPCRs and by direct interaction with…”
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GRK2: A Novel Cell-Specific Regulator of Severity and Duration of Inflammatory Pain by Eijkelkamp, Niels, Heijnen, Cobi J, Willemen, Hanneke L. D. M, Deumens, Ronald, Joosten, Elbert A. J, Kleibeuker, Wendy, den Hartog, Ilona J. M, van Velthoven, Cindy T. J, Nijboer, Cora, Nassar, Mohammed A, Dorn, Gerald W., II, Wood, John N, Kavelaars, Annemieke

“…Chronic pain associated with inflammation is a common clinical problem, and the underlying mechanisms have only begun to be unraveled. GRK2 regulates cellular…”
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