Search Results - "Willebrords, Joost"

Inhibitors of connexin and pannexin channels as potential therapeutics by Willebrords, Joost, Maes, Michaël, Crespo Yanguas, Sara, Vinken, Mathieu

“…While gap junctions support the exchange of a number of molecules between neighboring cells, connexin hemichannels provide communication between the cytosol…”
Get full text

Pannexin1 as mediator of inflammation and cell death by Crespo Yanguas, Sara, Willebrords, Joost, Johnstone, Scott R., Maes, Michaël, Decrock, Elke, De Bock, Marijke, Leybaert, Luc, Cogliati, Bruno, Vinken, Mathieu

“…Pannexins form channels at the plasma membrane surface that establish a pathway for communication between the cytosol of individual cells and their…”
Get full text

Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice by Willebrords, Joost, Cogliati, Bruno, Pereira, Isabel Veloso Alves, da Silva, Tereza Cristina, Crespo Yanguas, Sara, Maes, Michaël, Govoni, Veronica Mollica, Lima, Andressa, Felisbino, Daniele Aparecida, Decrock, Elke, Nogueira, Marina Sayuri, de Castro, Inar Alves, Leclercq, Isabelle, Leybaert, Luc, Rodrigues, Robim Marcelino, Vinken, Mathieu

“…While gap junctions mediate intercellular communication and support liver homeostasis, connexin hemichannels are preferentially opened by pathological stimuli,…”
Get full text

Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease by Willebrords, Joost, Maes, Michaël, Pereira, Isabel Veloso Alves, da Silva, Tereza Cristina, Govoni, Veronica Mollica, Lopes, Valéria Veras, Crespo Yanguas, Sara, Shestopalov, Valery I., Nogueira, Marina Sayuri, de Castro, Inar Alves, Farhood, Anwar, Mannaerts, Inge, van Grunsven, Leo, Akakpo, Jephte, Lebofsky, Margitta, Jaeschke, Hartmut, Cogliati, Bruno, Vinken, Mathieu

“…Pannexins are transmembrane proteins that form communication channels connecting the cytosol of an individual cell with its extracellular environment. A number…”
Get full text

TAT-Gap19 and Carbenoxolone Alleviate Liver Fibrosis in Mice by Crespo Yanguas, Sara, da Silva, Tereza C, Pereira, Isabel V A, Willebrords, Joost, Maes, Michaël, Sayuri Nogueira, Marina, Alves de Castro, Inar, Leclercq, Isabelle, Romualdo, Guilherme R, Barbisan, Luís F, Leybaert, Luc, Cogliati, Bruno, Vinken, Mathieu

“…Although a plethora of signaling pathways are known to drive the activation of hepatic stellate cells in liver fibrosis, the involvement of connexin-based…”
Get full text

Experimental models of liver fibrosis by Crespo Yanguas, Sara, Cogliati, Bruno, Willebrords, Joost, Maes, Michaël, Colle, Isabelle, van den Bossche, Bert, de Oliveira, Claudia Pinto Marques Souza, Andraus, Wellington, Alves, Venâncio Avancini, Leclercq, Isabelle, Vinken, Mathieu

“…Hepatic fibrosis is a wound healing response to insults and as such affects the entire world population. In industrialized countries, the main causes of liver…”
Get full text

Connexins and their channels in inflammation by Willebrords, Joost, Crespo Yanguas, Sara, Maes, Michaël, Decrock, Elke, Wang, Nan, Leybaert, Luc, Kwak, Brenda R, Green, Colin R, Cogliati, Bruno, Vinken, Mathieu

“…Inflammation may be caused by a variety of factors and is a hallmark of a plethora of acute and chronic diseases. The purpose of inflammation is to eliminate…”
Get more information

Roles of connexins and pannexins in digestive homeostasis by Maes, Michaël, Cogliati, Bruno, Crespo Yanguas, Sara, Willebrords, Joost, Vinken, Mathieu

“…Connexin proteins are abundantly present in the digestive system. They primarily form gap junctions, which control the intercellular exchange of critical…”
Get full text

Connexin and pannexin signaling in gastrointestinal and liver disease by Maes, Michaël, Crespo Yanguas, Sara, Willebrords, Joost, Cogliati, Bruno, Vinken, Mathieu

“…Gap junctions, which mediate intercellular communication, are key players in digestive homeostasis. They are also frequently involved in gastrointestinal and…”
Get full text

Connexin hemichannel inhibition reduces acetaminophen-induced liver injury in mice by Maes, Michaël, Crespo Yanguas, Sara, Willebrords, Joost, Weemhoff, James L., da Silva, Tereza Cristina, Decrock, Elke, Lebofsky, Margitta, Pereira, Isabel Veloso Alves, Leybaert, Luc, Farhood, Anwar, Jaeschke, Hartmut, Cogliati, Bruno, Vinken, Mathieu

“…•Inhibition of connexin hemichannels by connexin mimetic peptides.•No effects of connexin mimetic peptides on gap junctions.•Cx32 hemichannel inhibition…”
Get full text

Analysis of Liver Connexin Expression Using Reverse Transcription Quantitative Real-Time Polymerase Chain Reaction by Maes, Michaël, Willebrords, Joost, Crespo Yanguas, Sara, Cogliati, Bruno, Vinken, Mathieu

“…Although connexin production is mainly regulated at the protein level, altered connexin gene expression has been identified as the underlying mechanism of…”
Get more information

Detection of Connexins in Liver Cells Using Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis and Immunoblot Analysis by Willebrords, Joost, Maes, Michaël, Yanguas, Sara Crespo, Cogliati, Bruno, Vinken, Mathieu

“…Since connexin expression is partly regulated at the protein level, immunoblot analysis represents a frequently addressed technique in the connexin research…”
Get more information

Involvement of connexin43 in acetaminophen-induced liver injury by Maes, Michaël, McGill, Mitchell R., da Silva, Tereza Cristina, Abels, Chloé, Lebofsky, Margitta, Maria Monteiro de Araújo, Cintia, Tiburcio, Taynã, Veloso Alves Pereira, Isabel, Willebrords, Joost, Crespo Yanguas, Sara, Farhood, Anwar, Beschin, Alain, Van Ginderachter, Jo A., Zaidan Dagli, Maria Lucia, Jaeschke, Hartmut, Cogliati, Bruno, Vinken, Mathieu

“…Being goalkeepers of liver homeostasis, gap junctions are also involved in hepatotoxicity. However, their role in this process is ambiguous, as gap junctions…”
Get full text

Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity by Maes, Michaël, McGill, Mitchell R., da Silva, Tereza Cristina, Abels, Chloé, Lebofsky, Margitta, Weemhoff, James L., Tiburcio, Taynã, Veloso Alves Pereira, Isabel, Willebrords, Joost, Crespo Yanguas, Sara, Farhood, Anwar, Beschin, Alain, Van Ginderachter, Jo A., Penuela, Silvia, Jaeschke, Hartmut, Cogliati, Bruno, Vinken, Mathieu

“…Pannexins constitute a relatively new family of transmembrane proteins that form channels linking the cytoplasmic compartment with the extracellular…”
Get full text

Immunohisto- and Cytochemistry Analysis of Connexins by Cogliati, Bruno, Maes, Michaël, Pereira, Isabel Veloso Alves, Willebrords, Joost, Da Silva, Tereza Cristina, Crespo Yanguas, Sara, Vinken, Mathieu

“…Immunohistochemistry (IHC) is a ubiquitous used technique to identify and analyze protein expression in the context of tissue and cell morphology. In the…”
Get more information

Connexin32 deficiency is associated with liver injury, inflammation and oxidative stress in experimental non‐alcoholic steatohepatitis by Tiburcio, Taynã Cristina, Willebrords, Joost, Silva, Tereza Cristina, Pereira, Isabel Veloso Alves, Nogueira, Marina Sayuri, Crespo Yanguas, Sara, Maes, Michaël, Silva, Elisangela dos Anjos, Dagli, Maria Lucia Zaidan, Castro, Inar Alves, Oliveira, Cláudia Pinto, Vinken, Mathieu, Cogliati, Bruno

“…Summary Non‐alcoholic steatohepatitis is a highly prevalent liver pathology featured by hepatocellular fat deposition and inflammation. Connexin32, which is…”
Get full text

Genetic ablation of pannexin1 counteracts liver fibrosis in a chemical, but not in a surgical mouse model by Crespo Yanguas, Sara, da Silva, Tereza C., Pereira, Isabel V. A., Maes, Michaël, Willebrords, Joost, Shestopalov, Valery I., Goes, Bruna M., Sayuri Nogueira, Marina, Alves de Castro, Inar, Romualdo, Guilherme R., Barbisan, Luís F., Gijbels, Eva, Vinken, Mathieu, Cogliati, Bruno

“…Liver fibrosis is the final common pathway for almost all causes of chronic liver injury. This chronic disease is characterized by excessive deposition of…”
Get full text

Measurement of Apoptotic and Necrotic Cell Death in Primary Hepatocyte Cultures by Maes, Michaël, Vanhaecke, Tamara, Cogliati, Bruno, Yanguas, Sara Crespo, Willebrords, Joost, Rogiers, Vera, Vinken, Mathieu

“…Hepatotoxicity, including drug-induced liver injury, is frequently accompanied by cell death. The latter is typically driven by apoptosis or necrosis, which…”
Get more information

Connexins, Pannexins, and Their Channels in Fibroproliferative Diseases by Cogliati, Bruno, Mennecier, Gregory, Willebrords, Joost, Da Silva, Tereza Cristina, Maes, Michaël, Pereira, Isabel Veloso Alves, Crespo Yanguas, Sara, Hernandez-Blazquez, Francisco Javier, Dagli, Maria Lúcia Zaidan, Vinken, Mathieu

“…Cellular and molecular mechanisms of wound healing, tissue repair, and fibrogenesis are established in different organs and are essential for the maintenance…”
Get full text

Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research by Willebrords, Joost, Pereira, Isabel Veloso Alves, Maes, Michaël, Crespo Yanguas, Sara, Colle, Isabelle, Van Den Bossche, Bert, Da Silva, Tereza Cristina, de Oliveira, Cláudia Pinto Marques Souza, Andraus, Wellington, Alves, Venâncio Avancini, Cogliati, Bruno, Vinken, Mathieu

“…Non-alcoholic fatty liver disease encompasses a spectrum of liver diseases, including simple steatosis, steatohepatitis, liver fibrosis and cirrhosis and…”
Get full text