Search Results - "Wille, Timo"

Organophosphorus compounds and oximes: a critical review by Worek, Franz, Thiermann, Horst, Wille, Timo

“…Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population. Treatment of OP poisoning is an ongoing challenge and burden for…”
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Organophosphorus pesticides exhibit compound specific effects in rat precision-cut lung slices (PCLS): mechanisms involved in airway response, cytotoxicity, inflammatory activation and antioxidative defense by Tigges, Jonas, Worek, Franz, Thiermann, Horst, Wille, Timo

“…Organophosphorus compound pesticides (OP) are widely used in pest control and might be misused for terrorist attacks. Although acetylcholinesterase (AChE)…”
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Local sympathetic denervation attenuates myocardial inflammation and improves cardiac function after myocardial infarction in mice by Ziegler, Karin A, Ahles, Andrea, Wille, Timo, Kerler, Julia, Ramanujam, Deepak, Engelhardt, Stefan

“…Abstract Aims Cardiac inflammation has been suggested to be regulated by the sympathetic nervous system (SNS). However, due to the lack of methodology to…”
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In Vitro Interaction of Organophosphono- and Organophosphorothioates with Human Acetylcholinesterase by Worek, Franz, Thiermann, Horst, Koller, Marianne, Wille, Timo

“…The implementation of the Chemical Weapons Convention (CWC) in 1997 was a milestone in the prohibition of chemical warfare agents (CWA). Yet, the repeated use…”
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Post-VX exposure treatment of rats with engineered phosphotriesterases by Stigler, Lisa, Köhler, Anja, Koller, Marianne, Job, Laura, Escher, Benjamin, Potschka, Heidrun, Thiermann, Horst, Skerra, Arne, Worek, Franz, Wille, Timo

“…The biologically stable and highly toxic organophosphorus nerve agent (OP) VX poses a major health threat. Standard medical therapy, consisting of reactivators…”
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Public health and medical preparedness for mass casualties from the deliberate release of synthetic opioids by Cibulsky, Susan M, Wille, Timo, Funk, Renée, Sokolowski, Danny, Gagnon, Christine, Lafontaine, Marc, Brevett, Carol, Jabbour, Rabih, Cox, Jessica, Russell, David R, Jett, David A, Thomas, Jerry D, Nelson, Lewis S

“…The large amounts of opioids and the emergence of increasingly potent illicitly manufactured synthetic opioids circulating in the unregulated drug supply in…”
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Chromenones as Multineurotargeting Inhibitors of Human Enzymes by Lemke, Carina, Christmann, Joscha, Yin, Jiafei, Alonso, José M, Serrano, Estefanía, Chioua, Mourad, Ismaili, Lhassane, Martínez-Grau, María Angeles, Beadle, Christopher D, Vetman, Tatiana, Dato, Florian M, Bartz, Ulrike, Elsinghorst, Paul W, Pietsch, Markus, Müller, Christa E, Iriepa, Isabel, Wille, Timo, Marco-Contelles, José, Gütschow, Michael

“…The complex nature of multifactorial diseases, such as Morbus Alzheimer, has produced a strong need to design multitarget-directed ligands to address the…”
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Oximes in organophosphate poisoning: 60 years of hope and despair by Worek, Franz, Thiermann, Horst, Wille, Timo

“…The high number of annual fatalities following suicidal poisoning by organophosphorus (OP) pesticides and the recent homicidal use of the chemical warfare…”
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Toxicology of organophosphorus compounds in view of an increasing terrorist threat by Worek, Franz, Wille, Timo, Koller, Marianne, Thiermann, Horst

“…The implementation of the Chemical Weapon Convention (CWC), prohibiting the development, production, storage and use of chemical weapons by 192 nations and the…”
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Catalytic bioscavengers in nerve agent poisoning: A promising approach? by Worek, Franz, Thiermann, Horst, Wille, Timo

“…•Catalytic bioscavengers are considered promising for treatment of nerve agent poisoning.•Recent in vitro and in vivo data support the bioscavenger…”
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AChE reactivation in precision-cut lung slices following organophosphorus compound poisoning by Gölitz, Fee, Herbert, Julia, Worek, Franz, Wille, Timo

“…Precision-cut lung slices (PCLS) are a suitable model for analyzing the acetylcholinesterase (AChE) activity and subsequent effects after exposure to…”
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The suitability of a polydimethylsiloxane-based (PDMS) microfluidic two compartment system for the toxicokinetic analysis of organophosphorus compounds by Amend, Niko, Koller, Marianne, Schmitt, Christian, Worek, Franz, Wille, Timo

“…Organ-on-a-chip platforms are an emerging technology in experimental and regulatory toxicology (species-specific differences, ethical considerations). They…”
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A pharmacologically pre-contracted smooth muscle bowel model for the study of highly-potent opioid receptor agonists and antagonists by Amend, Niko, Thiermann, Horst, Worek, Franz, Wille, Timo

“…Isolated organ models are a versatile tool for pharmacological and toxicological research. Small bowel has been used to assess the inhibition of smooth muscle…”
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Diagnostics and treatment of nerve agent poisoning—current status and future developments by Amend, Niko, Niessen, Karin V., Seeger, Thomas, Wille, Timo, Worek, Franz, Thiermann, Horst

“…Although 193 states have committed to the Chemical Weapons Convention and 98% of the declared chemical weapons stockpiles have been destroyed so far, nerve…”
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The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study by Worek, Franz, Thiermann, Horst, Wille, Timo

“…•We determined the in vitro kinetic interactions of human and guinea pig AChE, soman, HI-6 and MMB-4.•In a static assay, HI-6 retarded the inhibition of human…”
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Release of protein-bound nerve agents by excess fluoride from whole blood: GC-MS/MS method development, validation, and application to a real-life denatured blood sample by Koller, Marianne, Thiermann, Horst, Worek, Franz, Wille, Timo

“…•Nerve agent regeneration from whole blood successfully complements fluoride-induced regeneration methods for plasma and tissues while sample preparation is…”
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Evidence of nerve agent VX exposure in rat plasma by detection of albumin-adducts in vitro and in vivo by Kranawetvogl, Tamara, Kranawetvogl, Andreas, Scheidegger, Lisa, Wille, Timo, Steinritz, Dirk, Worek, Franz, Thiermann, Horst, John, Harald

“…VX is a highly toxic organophosphorus nerve agent that reacts with a variety of endogenous proteins such as serum albumin under formation of adducts that can…”
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Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning by Herbert, Julia, Thiermann, Horst, Worek, Franz, Wille, Timo

“…•ACh induced spontaneously reversible airway contractions in non-poisoned PCLS.•In OP poisoned PCLS, ACh-induced airway contractions were…”
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Human HepaRG liver spheroids: cold storage protocol and study on pyridinium oxime-induced hepatotoxicity in vitro by Horn, Gabriele, Kranawetvogl, Tamara, John, Harald, Weigel, Carlotta, Rauen, Ursula, Worek, Franz, Wille, Timo

“…Oximes play an essential role in the therapy of organophosphorus compound (OP) poisoning by reactivating inhibited acetylcholinesterase. Impairment of liver…”
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Optimization of long-term cold storage of rat precision-cut lung slices with a tissue preservation solution by Tigges, Jonas, Eggerbauer, Florian, Worek, Franz, Thiermann, Horst, Rauen, Ursula, Wille, Timo

“…Precision-cut lung slices (PCLS) are used as ex vivo model of the lung to fill the gap between in vitro and in vivo experiments. To allow optimal utilization…”
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