Search Results - "Willberg, Christian B."

MAIT cells and viruses by Ussher, James E, Willberg, Christian B, Klenerman, Paul

“…Mucosal associated invariant T cells (MAIT cells) bear a T cell receptor (TCR) that specifically targets microbially derived metabolites. Functionally, they…”
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Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver by Jo, Juandy, Tan, Anthony T, Ussher, James E, Sandalova, Elena, Tang, Xin-Zi, Tan-Garcia, Alfonso, To, Natalie, Hong, Michelle, Chia, Adeline, Gill, Upkar S, Kennedy, Patrick T, Tan, Kai Chah, Lee, Kang Hoe, De Libero, Gennaro, Gehring, Adam J, Willberg, Christian B, Klenerman, Paul, Bertoletti, Antonio

“…The ability of innate immune cells to sense and respond to impending danger varies by anatomical location. The liver is considered tolerogenic but is still…”
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CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell Lineages by Fergusson, Joannah R., Smith, Kira E., Fleming, Vicki M., Rajoriya, Neil, Newell, Evan W., Simmons, Ruth, Marchi, Emanuele, Björkander, Sophia, Kang, Yu-Hoi, Swadling, Leo, Kurioka, Ayako, Sahgal, Natasha, Lockstone, Helen, Baban, Dilair, Freeman, Gordon J., Sverremark-Ekström, Eva, Davis, Mark M., Davenport, Miles P., Venturi, Vanessa, Ussher, James E., Willberg, Christian B., Klenerman, Paul

“…The C-type lectin CD161 is expressed by a large proportion of human T lymphocytes of all lineages, including a population known as mucosal-associated invariant…”
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MAIT cells: new guardians of the liver by Kurioka, Ayako, Walker, Lucy J, Klenerman, Paul, Willberg, Christian B

“…The liver is an important immunological organ that remains sterile and tolerogenic in homeostasis, despite continual exposure to non‐self food and…”
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Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection by Hoffmann, Matthias, Pantazis, Nikos, Martin, Genevieve E, Hickling, Stephen, Hurst, Jacob, Meyerowitz, Jodi, Willberg, Christian B, Robinson, Nicola, Brown, Helen, Fisher, Martin, Kinloch, Sabine, Babiker, Abdel, Weber, Jonathan, Nwokolo, Nneka, Fox, Julie, Fidler, Sarah, Phillips, Rodney, Frater, John

“…The rate at which HIV-1 infected individuals progress to AIDS is highly variable and impacted by T cell immunity. CD8 T cell inhibitory molecules are…”
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Macrophage Infection via Selective Capture of HIV-1-Infected CD4+ T Cells by Baxter, Amy E., Russell, Rebecca A., Duncan, Christopher J.A., Moore, Michael D., Willberg, Christian B., Pablos, Jose L., Finzi, Andrés, Kaufmann, Daniel E., Ochsenbauer, Christina, Kappes, John C., Groot, Fedde, Sattentau, Quentin J.

“…Macrophages contribute to HIV-1 pathogenesis by forming a viral reservoir and mediating neurological disorders. Cell-free HIV-1 infection of macrophages is…”
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Shared and Distinct Phenotypes and Functions of Human CD161++ Vα7.2+ T Cell Subsets by Kurioka, Ayako, Jahun, Aminu S, Hannaway, Rachel F, Walker, Lucy J, Fergusson, Joannah R, Sverremark-Ekström, Eva, Corbett, Alexandra J, Ussher, James E, Willberg, Christian B, Klenerman, Paul

“…Human mucosal-associated invariant T (MAIT) cells are an important T cell subset that are enriched in tissues and possess potent effector functions. Typically…”
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Mutant Prolactin Receptor and Familial Hyperprolactinemia by Newey, Paul J, Gorvin, Caroline M, Cleland, Stephen J, Willberg, Christian B, Bridge, Marcus, Azharuddin, Mohammed, Drummond, Russell S, van der Merwe, P. Anton, Klenerman, Paul, Bountra, Chas, Thakker, Rajesh V

“…The authors report cases of familial hyperprolactinemia due to a germline, loss-of-function mutation resulting in prolactin insensitivity. It appears to be…”
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Multi-functional Lectin-Like Transcript-1: a new player in human immune regulation by Llibre, Alba, Klenerman, Paul, Willberg, Christian B

“…Highlights • LLT1 and CD161 are lectin–like receptors encoded within the NKC • LLT1 regulates NK cells, the germinal centre reaction and bone metabolism •…”
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Epigenetic Features of HIV-Induced T-Cell Exhaustion Persist Despite Early Antiretroviral Therapy by Martin, Genevieve E, Sen, Debattama R, Pace, Matthew, Robinson, Nicola, Meyerowitz, Jodi, Adland, Emily, Thornhill, John P, Jones, Mathew, Ogbe, Ane, Parolini, Lucia, Olejniczak, Natalia, Zacharopoulou, Panagiota, Brown, Helen, Willberg, Christian B, Nwokolo, Nneka, Fox, Julie, Fidler, Sarah, Haining, W Nicholas, Frater, John

“…T cell dysfunction occurs early following HIV infection, impacting the emergence of non-AIDS morbidities and limiting curative efforts. ART initiated during…”
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CD32-Expressing CD4 T Cells Are Phenotypically Diverse and Can Contain Proviral HIV DNA by Martin, Genevieve E, Pace, Matthew, Thornhill, John P, Phetsouphanh, Chansavath, Meyerowitz, Jodi, Gossez, Morgane, Brown, Helen, Olejniczak, Natalia, Lwanga, Julianne, Ramjee, Gita, Kaleebu, Pontiano, Porter, Kholoud, Willberg, Christian B, Klenerman, Paul, Nwokolo, Nneka, Fox, Julie, Fidler, Sarah, Frater, John

“…Efforts to both characterize and eradicate the HIV reservoir have been limited by the rarity of latently infected cells and the absence of a specific denoting…”
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Correction: Rapid Progressing Allele HLA-B35 Px Restricted Anti-HIV-1 CD8+ T Cells Recognize Vestigial CTL Epitopes by Willberg, Christian B, Garrison, Keith E, Jones, R Brad, Meiklejohn, Duncan A, Spotts, Gerald, Liegler, Teri J, Ostrowski, Mario A, Karlsson, Annika C, Hecht, Frederick M, Nixon, Douglas F

“…[This corrects the article DOI: 10.1371/journal.pone.0010249.]…”
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Innate‐like CD8+ T‐cells and NK cells: converging functions and phenotypes by Kurioka, Ayako, Klenerman, Paul, Willberg, Christian B.

“…Summary New data in the worlds of both innate‐like CD8+ T‐cells and natural killer (NK) cells have, in parallel, clarified some of the phenotypes of these…”
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CD161++CD8+ T cells, including the MAIT cell subset, are specifically activated by IL‐12+IL‐18 in a TCR‐independent manner by Ussher, James E., Bilton, Matthew, Attwod, Emma, Shadwell, Jonathan, Richardson, Rachel, Lara, Catherine, Mettke, Elisabeth, Kurioka, Ayako, Hansen, Ted H., Klenerman, Paul, Willberg, Christian B.

“…CD161++CD8+ T cells represent a novel subset that is dominated in adult peripheral blood by mucosal‐associated invariant T (MAIT) cells, as defined by the…”
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MAIT cells are activated during human viral infections by van Wilgenburg, Bonnie, Scherwitzl, Iris, Hutchinson, Edward C., Leng, Tianqi, Kurioka, Ayako, Kulicke, Corinna, de Lara, Catherine, Cole, Suzanne, Vasanawathana, Sirijitt, Limpitikul, Wannee, Malasit, Prida, Young, Duncan, Denney, Laura, Moore, Michael D., Fabris, Paolo, Giordani, Maria Teresa, Oo, Ye Htun, Laidlaw, Stephen M., Dustin, Lynn B., Ho, Ling-Pei, Thompson, Fiona M., Ramamurthy, Narayan, Mongkolsapaya, Juthathip, Willberg, Christian B., Screaton, Gavin R., Klenerman, Paul

“…Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated…”
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Defining T Cell Subsets in Human Tonsils Using ChipCytometry by Hagel, Joachim P, Bennett, Kyle, Buffa, Francesca, Klenerman, Paul, Willberg, Christian B, Powell, Kate

“…ChipCytometry is a multiplex imaging method that can be used to analyze either cell suspensions or tissue sections. Images are acquired by iterative cycles of…”
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TLR signaling in human antigen‐presenting cells regulates MR1‐dependent activation of MAIT cells by Ussher, James E., Wilgenburg, Bonnie, Hannaway, Rachel F., Ruustal, Kerstin, Phalora, Prabhjeet, Kurioka, Ayako, Hansen, Ted H., Willberg, Christian B., Phillips, Rodney E., Klenerman, Paul

“…Mucosal‐associated invariant T (MAIT) cells are an abundant innate‐like T lymphocyte population that are enriched in liver and mucosal tissues. They are…”
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Immunodominance of HIV-1 specific CD8+ T-cell responses is related to disease progression rate in vertically infected adolescents by Sharp, Elizabeth R, Willberg, Christian B, Kuebler, Peter J, Abadi, Jacob, Fennelly, Glenn J, Dobroszycki, Joanna, Wiznia, Andrew A, Rosenberg, Michael G, Nixon, Douglas F

“…HIV-1 vertically infected children in the USA are living into adolescence and beyond with the widespread use of antiretroviral drugs. These patients exhibit…”
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Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection by Muenchhoff, Maximilian, Adland, Emily, Karimanzira, Owen, Crowther, Carol, Pace, Matthew, Csala, Anna, Leitman, Ellen, Moonsamy, Angeline, McGregor, Callum, Hurst, Jacob, Groll, Andreas, Mori, Masahiko, Sinmyee, Smruti, Thobakgale, Christina, Tudor-Williams, Gareth, Prendergast, Andrew J, Kloverpris, Henrik, Roider, Julia, Leslie, Alasdair, Shingadia, Delane, Brits, Thea, Daniels, Samantha, Frater, John, Willberg, Christian B, Walker, Bruce D, Ndung'u, Thumbi, Jooste, Pieter, Moore, Penny L, Morris, Lynn, Goulder, Philip

“…Disease-free infection in HIV-infected adults is associated with human leukocyte antigen-mediated suppression of viremia, whereas in the sooty mangabey and…”
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Association of differentiation state of CD4+ T cells and disease progression in HIV-1 perinatally infected children by Sharp, Elizabeth R, Willberg, Christian B, Kuebler, Peter J, Abadi, Jacob, Fennelly, Glenn J, Dobroszycki, Joanna, Wiznia, Andrew A, Rosenberg, Michael G, Nixon, Douglas F

“…In the USA, most HIV-1 infected children are on antiretroviral drug regimens, with many individuals surviving through adolescence and into adulthood. The…”
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