Search Results - "Willberg, Christian"

Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver by Jo, Juandy, Tan, Anthony T, Ussher, James E, Sandalova, Elena, Tang, Xin-Zi, Tan-Garcia, Alfonso, To, Natalie, Hong, Michelle, Chia, Adeline, Gill, Upkar S, Kennedy, Patrick T, Tan, Kai Chah, Lee, Kang Hoe, De Libero, Gennaro, Gehring, Adam J, Willberg, Christian B, Klenerman, Paul, Bertoletti, Antonio

“…The ability of innate immune cells to sense and respond to impending danger varies by anatomical location. The liver is considered tolerogenic but is still…”
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Manufacturing-Induced Imperfections in Composite Parts Manufactured via Automated Fiber Placement by Falk Heinecke, Christian Willberg

“…The automated fiber placement process (AFP) enables the manufacturing of large and geometrical complex fiber composite structures with high quality at low…”
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MAIT cells and viruses by Ussher, James E, Willberg, Christian B, Klenerman, Paul

“…Mucosal associated invariant T cells (MAIT cells) bear a T cell receptor (TCR) that specifically targets microbially derived metabolites. Functionally, they…”
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Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection by Hoffmann, Matthias, Pantazis, Nikos, Martin, Genevieve E, Hickling, Stephen, Hurst, Jacob, Meyerowitz, Jodi, Willberg, Christian B, Robinson, Nicola, Brown, Helen, Fisher, Martin, Kinloch, Sabine, Babiker, Abdel, Weber, Jonathan, Nwokolo, Nneka, Fox, Julie, Fidler, Sarah, Phillips, Rodney, Frater, John

“…The rate at which HIV-1 infected individuals progress to AIDS is highly variable and impacted by T cell immunity. CD8 T cell inhibitory molecules are…”
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Innate‐like CD8+ T‐cells and NK cells: converging functions and phenotypes by Kurioka, Ayako, Klenerman, Paul, Willberg, Christian B.

“…Summary New data in the worlds of both innate‐like CD8+ T‐cells and natural killer (NK) cells have, in parallel, clarified some of the phenotypes of these…”
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CD161++CD8+ T cells, including the MAIT cell subset, are specifically activated by IL‐12+IL‐18 in a TCR‐independent manner by Ussher, James E., Bilton, Matthew, Attwod, Emma, Shadwell, Jonathan, Richardson, Rachel, Lara, Catherine, Mettke, Elisabeth, Kurioka, Ayako, Hansen, Ted H., Klenerman, Paul, Willberg, Christian B.

“…CD161++CD8+ T cells represent a novel subset that is dominated in adult peripheral blood by mucosal‐associated invariant T (MAIT) cells, as defined by the…”
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CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell Lineages by Fergusson, Joannah R., Smith, Kira E., Fleming, Vicki M., Rajoriya, Neil, Newell, Evan W., Simmons, Ruth, Marchi, Emanuele, Björkander, Sophia, Kang, Yu-Hoi, Swadling, Leo, Kurioka, Ayako, Sahgal, Natasha, Lockstone, Helen, Baban, Dilair, Freeman, Gordon J., Sverremark-Ekström, Eva, Davis, Mark M., Davenport, Miles P., Venturi, Vanessa, Ussher, James E., Willberg, Christian B., Klenerman, Paul

“…The C-type lectin CD161 is expressed by a large proportion of human T lymphocytes of all lineages, including a population known as mucosal-associated invariant…”
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MAIT cells: new guardians of the liver by Kurioka, Ayako, Walker, Lucy J, Klenerman, Paul, Willberg, Christian B

“…The liver is an important immunological organ that remains sterile and tolerogenic in homeostasis, despite continual exposure to non‐self food and…”
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Macrophage Infection via Selective Capture of HIV-1-Infected CD4+ T Cells by Baxter, Amy E., Russell, Rebecca A., Duncan, Christopher J.A., Moore, Michael D., Willberg, Christian B., Pablos, Jose L., Finzi, Andrés, Kaufmann, Daniel E., Ochsenbauer, Christina, Kappes, John C., Groot, Fedde, Sattentau, Quentin J.

“…Macrophages contribute to HIV-1 pathogenesis by forming a viral reservoir and mediating neurological disorders. Cell-free HIV-1 infection of macrophages is…”
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Defining T Cell Subsets in Human Tonsils Using ChipCytometry by Hagel, Joachim P, Bennett, Kyle, Buffa, Francesca, Klenerman, Paul, Willberg, Christian B, Powell, Kate

“…ChipCytometry is a multiplex imaging method that can be used to analyze either cell suspensions or tissue sections. Images are acquired by iterative cycles of…”
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Shared and Distinct Phenotypes and Functions of Human CD161++ Vα7.2+ T Cell Subsets by Kurioka, Ayako, Jahun, Aminu S, Hannaway, Rachel F, Walker, Lucy J, Fergusson, Joannah R, Sverremark-Ekström, Eva, Corbett, Alexandra J, Ussher, James E, Willberg, Christian B, Klenerman, Paul

“…Human mucosal-associated invariant T (MAIT) cells are an important T cell subset that are enriched in tissues and possess potent effector functions. Typically…”
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TLR signaling in human antigen‐presenting cells regulates MR1‐dependent activation of MAIT cells by Ussher, James E., Wilgenburg, Bonnie, Hannaway, Rachel F., Ruustal, Kerstin, Phalora, Prabhjeet, Kurioka, Ayako, Hansen, Ted H., Willberg, Christian B., Phillips, Rodney E., Klenerman, Paul

“…Mucosal‐associated invariant T (MAIT) cells are an abundant innate‐like T lymphocyte population that are enriched in liver and mucosal tissues. They are…”
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Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection by Muenchhoff, Maximilian, Adland, Emily, Karimanzira, Owen, Crowther, Carol, Pace, Matthew, Csala, Anna, Leitman, Ellen, Moonsamy, Angeline, McGregor, Callum, Hurst, Jacob, Groll, Andreas, Mori, Masahiko, Sinmyee, Smruti, Thobakgale, Christina, Tudor-Williams, Gareth, Prendergast, Andrew J, Kloverpris, Henrik, Roider, Julia, Leslie, Alasdair, Shingadia, Delane, Brits, Thea, Daniels, Samantha, Frater, John, Willberg, Christian B, Walker, Bruce D, Ndung'u, Thumbi, Jooste, Pieter, Moore, Penny L, Morris, Lynn, Goulder, Philip

“…Disease-free infection in HIV-infected adults is associated with human leukocyte antigen-mediated suppression of viremia, whereas in the sooty mangabey and…”
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Mutant Prolactin Receptor and Familial Hyperprolactinemia by Newey, Paul J, Gorvin, Caroline M, Cleland, Stephen J, Willberg, Christian B, Bridge, Marcus, Azharuddin, Mohammed, Drummond, Russell S, van der Merwe, P. Anton, Klenerman, Paul, Bountra, Chas, Thakker, Rajesh V

“…The authors report cases of familial hyperprolactinemia due to a germline, loss-of-function mutation resulting in prolactin insensitivity. It appears to be…”
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Human T cell responses to Japanese encephalitis virus in health and disease by Turtle, Lance, Bali, Tanushka, Buxton, Gemma, Chib, Savita, Chan, Sajesh, Soni, Mohammed, Hussain, Mohammed, Isenman, Heather, Fadnis, Prachi, Venkataswamy, Manjunatha M, Satishkumar, Vishali, Lewthwaite, Penny, Kurioka, Ayako, Krishna, Srinivasa, Shankar, M Veera, Ahmed, Riyaz, Begum, Ashia, Ravi, Vasanthapuram, Desai, Anita, Yoksan, Sutee, Fernandez, Stefan, Willberg, Christian B, Kloverpris, Henrik N, Conlon, Christopher, Klenerman, Paul, Satchidanandam, Vijaya, Solomon, Tom

“…Japanese encephalitis (JE) virus (JEV) is an important cause of encephalitis in children of South and Southeast Asia. However, the majority of individuals…”
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Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection by Zilber, Eva, Martin, Genevieve E, Willberg, Christian B, Fox, Julie, Nwokolo, Nneka, Fidler, Sarah, Frater, John

“…Soluble forms of the coinhibitory receptors programmed death 1 (PD-1) and Tim-3 exist, but their relationship with T-cell surface expression remains unclear…”
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Multi-functional Lectin-Like Transcript-1: a new player in human immune regulation by Llibre, Alba, Klenerman, Paul, Willberg, Christian B

“…Highlights • LLT1 and CD161 are lectin–like receptors encoded within the NKC • LLT1 regulates NK cells, the germinal centre reaction and bone metabolism •…”
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Validation of a 20 m Wind Turbine Blade Model by Willberg, Christian, Ravi, Rakesh, Rieke, Johannes, Heinecke, Falk

“…In the projects Smartblades and Smartblades 2 a full-scale 20 m rotor blade for the NREL CART3 wind turbine was designed, built and tested. The rotor blade was…”
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Levels of Human Immunodeficiency Virus DNA Are Determined Before ART Initiation and Linked to CD8 T-Cell Activation and Memory Expansion by Martin, Genevieve E, Pace, Matthew, Shearer, Freya M, Zilber, Eva, Hurst, Jacob, Meyerowitz, Jodi, Thornhill, John P, Lwanga, Julianne, Brown, Helen, Robinson, Nicola, Hopkins, Emily, Olejniczak, Natalia, Nwokolo, Nneka, Fox, Julie, Fidler, Sarah, Willberg, Christian B, Frater, John

“…Abstract Initiation of antiretroviral therapy (ART) in early compared with chronic human immunodeficiency virus (HIV) infection is associated with a smaller…”
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PeriLab — Peridynamic Laboratory by Willberg, Christian, Hesse, Jan-Timo, Pernatii, Anna

“…This paper introduces PeriLab, a modern Peridynamics solver developed in the Julia programming language. Emphasizing easy installation, usability, and…”
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