Search Results - "Willard Gallo, K."

The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014 by Salgado, R., Denkert, C., Demaria, S., Sirtaine, N., Klauschen, F., Pruneri, G., Wienert, S., Van den Eynden, G., Baehner, F.L., Penault-Llorca, F., Perez, E.A., Thompson, E.A., Symmans, W.F., Richardson, A.L., Brock, J., Criscitiello, C., Bailey, H., Ignatiadis, M., Floris, G., Sparano, J., Kos, Z., Nielsen, T., Rimm, D.L., Allison, K.H., Reis-Filho, J.S., Loibl, S., Sotiriou, C., Viale, G., Badve, S., Adams, S., Willard-Gallo, K., Loi, S.

“…Evidence is strengthening for the morphological evaluation of tumor infiltrating lymphocytes (TILs) in breast cancer. Herein, the concepts for TILs assessment…”
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Homologous Recombination Repair Deficiency and the Immune Response in Breast Cancer: A Literature Review by Pellegrino, B., Musolino, A., Llop-Guevara, A., Serra, V., De Silva, P., Hlavata, Z., Sangiolo, D., Willard-Gallo, K., Solinas, C.

“…The success of cancer immunotherapy with immune checkpoint blockade (ICB) has demonstrated the importance of targeting a preexisting immune response in a broad…”
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Characterization of human breast cancer tissues by infrared imaging by Verdonck, M, Denayer, A, Delvaux, B, Garaud, S, De Wind, R, Desmedt, C, Sotiriou, C, Willard-Gallo, K, Goormaghtigh, E

“…Fourier Transform InfraRed (FTIR) spectroscopy coupled to microscopy (IR imaging) has shown unique advantages in detecting morphological and molecular…”
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Clonal Th2 lymphocytes in patients with the idiopathic hypereosinophilic syndrome by Roufosse, F., Schandené, L., Sibille, C., Willard‐Gallo, K., Kennes, B., Efira, A., Goldman, M., Cogan, E.

“…Idiopathic hypereosinophilic syndrome (HES) and Gleich's syndrome are related disorders characterized by persistent or recurrent hypereosinophilia of unknown…”
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Clinical significance of CD73 in triple-negative breast cancer: multiplex analysis of a phase III clinical trial by Buisseret, L., Pommey, S., Allard, B., Garaud, S., Bergeron, M., Cousineau, I., Ameye, L., Bareche, Y., Paesmans, M., Crown, J.P.A., Di Leo, A., Loi, S., Piccart-Gebhart, M., Willard-Gallo, K., Sotiriou, C., Stagg, J.

“…CD73 is an ecto-enzyme that promotes tumor immune escape through the production of immunosuppressive extracellular adenosine in the tumor microenvironment…”
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Tumor-infiltrating lymphocytes in patients with HER2-positive breast cancer treated with neoadjuvant chemotherapy plus trastuzumab, lapatinib or their combination: A meta-analysis of randomized controlled trials by Solinas, C, Ceppi, M, Lambertini, M, Scartozzi, M, Buisseret, L, Garaud, S, Fumagalli, D, de Azambuja, E, Salgado, R, Sotiriou, C, Willard-Gallo, K, Ignatiadis, M

“…Highlights • This is a meta-analysis of neoadjuvant randomized studies investigating TIL in HER2-positive breast cancer. • High baseline TIL are associated…”
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HTLV-I infection of WE17/10 CD4+ cell line leads to progressive alteration of Ca2+ influx that eventually results in loss of CD7 expression and activation of an antiapoptotic pathway involving AKT and BAD which paves the way for malignant transformation by AKL, H, BADRAN, B. M, ZEIN, N. E, BEX, F, SOTIRIOU, C, WILLARD-GALLO, K. E, BURNY, A, MARTIAT, P

“…Adult T-cell leukemia/lymphoma (ATLL) is a malignancy slowly emerging from human T-cell leukemia virus type 1 (HTLV-I)-infected mature CD4(+) T-cells. To…”
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Label-free phenotyping of peripheral blood lymphocytes by infrared imaging by Verdonck, M, Garaud, S, Duvillier, H, Willard-Gallo, K, Goormaghtigh, E

“…It is now widely accepted that the immune microenvironment of tumors and more precisely Tumor Infiltrating Lymphocytes (TIL) play an important role in cancer…”
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Immune functions of follicular helper CD4+CXCR5+ T cells in human breast cancer by Langouo Fontsa, M., Noel, G., Garaud, S., de Wind, A., Van den Eynden, G., Boisson, A., Naveaux, C., Larsimont, D., Piccart, M., Willard-Gallo, K.

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The long and winding road to biomarkers for immunotherapy: a retrospective analysis of samples from patients with triple-negative breast cancer treated with pembrolizumab by Buisseret, L., Bareche, Y., Venet, D., Girard, E., Gombos, A., Emonts, P., Majjaj, S., Rouas, G., Serra, M., Debien, V., Agostinetto, E., Garaud, S., Willard-Gallo, K., Larsimont, D., Stagg, J., Rothé, F., Sotiriou, C.

“…Immune checkpoint blockade (ICB) in combination with chemotherapy improves outcome of patients with triple-negative breast cancer (TNBC) in metastatic and…”
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FOXP1, PD‐1 AND PD‐L1 ARE SIGNIFICANTLY UPREGULATED IN LYMPHOCYTES FROM CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS COMPARED TO AGE‐MATCHED HEALTHY DONORS by De Silva, P., Stamatopoulos, B., Dang Chi, V., Garaud, S., Francois, R., Thibaud, V., Solinas, C., Boisson, A., Duvillier, H., Rouas, R., Lewalle, P., Willard‐Gallo, K., Bron, D.

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The role of NPM, p14arf and MDM2 in precursors of bronchial squamous cell carcinoma by Mascaux, C, Bex, F, Martin, B, Burny, A, Haller, A, Paesmans, M, Willard-Gallo, K, Ninane, V, Sculier, J-P

“…Murine double minute clone 2 (MDM2), p14 alternate reading frame (p14arf), and nucleophosmin (NPM) regulate p53 activity. A total of 200 biopsies, including…”
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HTLV-I infection of WE17/10 CD4+ cell line leads to progressive alteration of Ca2+ influx that eventually results in loss of CD7 expression and activation of an antiapoptotic pathway involving AKT and BAD which paves the way for malignant transformation by Akl, H, Badran, B M, El Zein, N, Bex, F, Sotiriou, C, Willard-gallo, K E, Burny, A, Martiat, P

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Immune evasion before tumour invasion in early lung squamous carcinogenesis by Mascaux, Céline, Angelova, Mihaela, Vasaturo, Angela, Beane, Jennifer, Hijazi, Kahkeshan, Anthoine, Geraldine, Buttard, Bénédicte, Rothe, Françoise, Willard-Gallo, Karen, Haller, Annick, Ninane, Vincent, Burny, Arsène, Sculier, Jean-Paul, Spira, Avi, Galon, Jérôme

“…Early detection and treatment are critical for improving the outcome of patients with cancer 1 . Understanding the largely uncharted biology of carcinogenesis…”
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1192P Breast cancer induces a tolerogenic signalling pathway profile in CD4+ lymphocytes from a subset of primary breast cancer patients, characterized by increased JAK-STAT3 and TGFβpathway activity by Willard-Gallo, K., Wesseling-Rozendaal, Y., Van De Stolpe, A.

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HTLV-I infection of WE17/10 CD4 super(+) cell line leads to progressive alteration of Ca super(2+) influx that eventually results in loss of CD7 expression and activation of an antiapoptotic pathway involving AKT and BAD which paves the way for malignant transformation by Akl, H, Badran, B M, Zein, N E, Bex, F, Sotiriou, C, Willard-Gallo, KE, Burny, A, Martiat, P

“…Adult T-cell leukemia/lymphoma (ATLL) is a malignancy slowly emerging from human T-cell leukemia virus type 1 (HTLV-I)-infected mature CD4 super(+) T-cells. To…”
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Targeting PD-1 in cancer: Biological insights with a focus on breast cancer by Solinas, Cinzia, Aiello, Marco, De Silva, Pushpamali, Gu-Trantien, Chunyan, Migliori, Edoardo, Willard-Gallo, Karen

“…•PD-1 /PD-Ls pathway maintains self-tolerance and minimizes peripheral tissue damage.•PD-1 is expressed by a variety of immune cells in the tumor…”
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Modulation of CD3-gamma gene expression after HIV type 1 infection of the WE17/10 T cell line is progressive and occurs in concert with decreased production of viral p24 antigen by Willard-Gallo, K E, Delmelle-Wibaut, C, Segura-Zapata, I, Janssens, M, Willems, L, Kettmann, R

“…HIV-1 infection of WE17/10, an IL-2-dependent CD4+ human T cell line, abrogates T cell receptor (TCR)/CD3 expression due to a transcription level defect in the…”
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Synthesis of functional bovine leukemia virus (BLV) p34tax protein by recombinant baculoviruses by Chen, G, Willems, L, Portetelle, D, Willard-Gallo, K E, Burny, A, Gheysen, D, Kettmann, R

“…The bovine leukemia virus (BLV) p34tax (also called tat, p34, XLOR gene product) is a 34-kDa polypeptide encoded in the 3'-terminal region of the virus. This…”
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The dynamics between neo-adjuvant treatment and immune responses in human breast cancer by Thomas, N., Garaud, S., De Wind, A., Pabois, A., De Silva, P., Craciun, L., Boisson, A., Naveaux, C., Duvillier, H., Larsimont, D., Awada, A., Willard-Gallo, K.

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