Search Results - "Wilkison, W. O."

Adipose-derived stromal cells--their utility and potential in bone formation by Halvorsen, Y.C, Wilkison, W.O, Gimble, J.M

“…Many organs contain connective tissue or stromal cells and these cells play important roles in growth, development and tissue repair. Subcutaneous adipose…”
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Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways by CLAFFEY, K. P, WILKISON, W. O, SPIEGELMAN, B. M

“…Vascular endothelial growth factor (VEGF) is an angiogenic polypeptide that has been isolated from a variety of tumorigenic and nontransformed cell lines…”
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Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor by Lu, Dongsi, Willard, Derril, Patel, Indravadan R, Kadwell, Sue, Overton, Laurie, Kost, Tom, Luther, Michael, Chen, Wenbiao, Woychik, Richard P, Wilkison, William O, Cone, Roger D

“…The genetic loci agouti and extension control the relative amounts of eumelanin (brown-black) and phaeomelanin (yellow-red) pigments in mammals: extension…”
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Role of the sulfonylurea receptor in regulating human adipocyte metabolism by Shi, H, Moustaid-Moussa, N, Wilkison, W.O, Zemel, M.B

“…ABSTRACTA regulatory role for intracellular Ca2+ ([Ca2+]i) in adipocyte lipogenesis, lipolysis and triglyceride accumulation has been demonstrated. Compounds…”
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Upregulation of adipocyte metabolism by agouti protein: possible paracrine actions in yellow mouse obesity by Jones, B.H, Kim, J.H, Zemel, M.B, Woychik, R.P, Michaud, E.J, Wilkison, W.O, Moustaid, N

“…Mutations leading to ectopic expression of the murine agouti gene (a) result in progressive obesity. To further characterize this model, we analyzed adipose…”
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Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes by Digby, J. E., Montague, C. T., Sewter, C. P., Sanders, L., Wilkison, W. O., O'Rahilly, S., Prins, J. B.

“…Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes. J E Digby , C T Montague , C P Sewter , L Sanders…”
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Randomized trial showing efficacy and safety of twice-daily remogliflozin etabonate for the treatment of type 2 diabetes by Sykes, A. P., O'Connor-Semmes, R., Dobbins, R., Dorey, D. J., Lorimer, J. D., Walker, S., Wilkison, W. O., Kler, L.

“…We compared the efficacy of twice‐daily doses of remogliflozin etabonate (RE) and once‐daily pioglitazone with placebo for reduction in glycated haemoglobin…”
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Agouti regulation of intracellular calcium: role of melanocortin receptors by Kim, J H, Kiefer, L L, Woychik, R P, Wilkison, W O, Truesdale, A, Ittoop, O, Willard, D, Nichols, J, Zemel, M B

“…Several dominant mutations at the murine agouti locus cause a syndrome of marked obesity and insulin resistance. We have recently reported that intracellular…”
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Randomized efficacy and safety trial of once-daily remogliflozin etabonate for the treatment of type 2 diabetes by Sykes, A. P., Kemp, G. L., Dobbins, R., O'Connor-Semmes, R., Almond, S. R., Wilkison, W. O., Walker, S., Kler, L.

“…The sodium‐dependent glucose transporter 2 (SGLT2) inhibitor remogliflozin etabonate (RE) was evaluated in a 12‐week, double‐blind, randomized, placebo‐ and…”
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Combined effects of insulin treatment and adipose tissue-specific agouti expression on the development of obesity by Mynatt, R.L, Miltenberger, R.J, Klebig, M.L, Zemel, M.B, Wilkinson, J.E, Wilkison, W.O, Woychik, R.P

“…The agouti gene product is a secreted protein that acts in a paracrine manner to regulate coat color in mammals. Several dominant mutations at the agouti locus…”
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Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK293 cells by MOUNTJOY, KATHLEEN G, KONG, PHILIP L, TAYLOR, JOHN A, WILLARD, DERRIL H, WILKISON, WILLIAM O

“…1 Research Centre for Developmental Medicine and Biology, Department of Paediatrics 2 School of Biological Sciences, University of Auckland, Auckland 1, New…”
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Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice by Zemel, M.B. (University of Tennessee, Knoxville, TN.), Kim, J.H, Woychik, R.P, Michaud, E.J, Kadwell, S.H, Patel, I.R, Wilkison, W.O

“…Several dominant mutations at the agouti locus in the mouse cause a syndrome of marked obesity, hyperinsulinemia, and insulin resistance. Although it is known…”
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An Agouti Mutation Lacking the Basic Domain Induces Yellow Pigmentation but Not Obesity in Transgenic Mice by Miltenberger, R. J., Mynatt, R. L., Bruce, B. D., Wilkison, W. O., Woychik, R. P., Michaud, E. J.

“…Chronic antagonism of melanocortin receptors by the paracrine-acting agouti gene product induces both yellow fur and a maturity-onset obesity syndrome in mice…”
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An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ) by Lehmann, Jürgen M., Moore, Linda B., Smith-Oliver, Tracey A., Wilkison, William O., Willson, Timothy M., Kliewer, Steven A.

“…Thiazolidinedione derivatives are antidiabetic agents that increase the insulin sensitivity of target tissues in animal models of non-insulin-dependent…”
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Effects of a potent melanocortin agonist on the diabetic/obese phenotype in yellow mice by ZEMEL, M. B, MOORE, J. W, JAMES, M, WILKISON, W. O, MOUSTAID, N, KIM, J. H, NICHOLS, J. S, BLANCHARD, S. G, PARKS, D. J, HARRIS, C, LEE, F. W, GRIZZLE, M

“…To test the hypothesis that a melanocortin agonist can reverse obesity and insulin resistance in mice overexpressing the agouti protein. EXPERIMENTAL MODEL:…”
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Control of the adipsin gene in adipocyte differentiation. Identification of distinct nuclear factors binding to single- and double-stranded DNA by WILKISON, W. O, HYE YEONG MIN, CLAFFEY, K. P, SATTERBERG, B. L, SPIEGELMAN, B. M

“…The mouse adipsin gene encodes a serine protease with complement factor D activity that is expressed during adipocyte differentiation and is deficient in…”
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Adipogenic potential of human adipose derived stromal cells from multiple donors is heterogeneous by Sen, Anindita, Lea-Currie, Y. Renee, Sujkowska, Danuta, Franklin, Dawn M., Wilkison, William O., Halvorsen, Yuan-Di C., Gimble, Jeffrey M.

“…The current study was done to assess if heterogeneity existed in the degree of adipogenesis in stromal cells (preadipocytes) from multiple donors. In addition…”
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Role of the agouti gene in obesity by Michaud, EJ, Mynatt, RL, Miltenberger, RJ, Klebig, ML, Wilkinson, JE, Zemel, MB, Wilkison, WO, Woychik, RP

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Biosynthesis of the vasoactive lipid monobutyrin. Central role of diacylglycerol by WILKISON, W. O, SPIEGELMAN, B. M

“…Monobutyrin (1-butyrylglycerol) is a simple lipid secreted by adipocytes that stimulates both angiogenesis and vasodilation of microvascular beds. While…”
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Thiazolidinediones and glucocorticoids synergistically induce differentiation of human adipose tissue stromal cells: Biochemical, cellular, and molecular analysis by Halvorsen, Yuan-Di C., Bond, Arden, Sen, Anindita, Franklin, Dawn M., Lea-Currie, Y.Renee, Sujkowski, Danuta, Ellis, P.Nicole, Wilkison, William O., Gimble, Jeffrey M.

“…While adipocyte differentiation has been studied extensively in murine cultures, the lack of a readily available preadipocyte model has hindered equivalent…”
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