Search Results - "Wilkinson, S E"

Neonatal Lipopolysaccharide Exposure Delays Puberty and Alters Hypothalamic Kiss1 and Kiss1r mRNA Expression in the Female Rat by Knox, A. M. I., Li, X. F., Kinsey-Jones, J. S., Wilkinson, E. S., Wu, X. Q., Cheng, Y.S., Milligan, S. R., Lightman, S. L., O'Byrne, K. T.

“…Immunological challenge experienced in early life can have long‐term programming effects on the hypothalamic‐pituitary‐adrenal axis that permanently influence…”
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Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C by WILKINSON, S. E, PARKER, P. J, NIXON, J. S

“…The protein kinase C (PKC) family of isoenzymes is believed to mediate a wide range of signal-transduction pathways in many different cell types. A series of…”
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Experimental Jetlag Disrupts Circadian Clock Genes But Improves Performance in Racehorses After Light-Dependent Rapid Resetting of Neuroendocrine Systems and the Rest-Activity Cycle by Tortonese, D. J., Preedy, D. F., Hesketh, S. A., Webb, H. N., Wilkinson, E. S., Allen, W. R., Fuller, C. J., Townsend, J., Short, R. V.

“…Abrupt alterations in the 24‐h light : dark cycle, such as those resulting from transmeridian air travel, disrupt circadian biological rhythms in humans with…”
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Down-Regulation of Hypothalamic Kisspeptin and its Receptor, Kiss1r, mRNA Expression is Associated with Stress-Induced Suppression of Luteinising Hormone Secretion in the Female Rat by Kinsey-Jones, J. S., Li, X. F., Knox, A. M. I., Wilkinson, E. S., Zhu, X. L., Chaudhary, A. A., Milligan, S. R., Lightman, S. L., O'Byrne, K. T.

“…Identification of kisspeptin (Kiss1) and its G protein‐coupled receptor 54 (Kiss1r) as an essential component of the hypothalamic‐pituitary‐gonadal (HPG) axis…”
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Protein kinase C: is its pivotal role in cellular activation over-stated? by Wilkinson, S E, Hallam, T J

“…Evidence has emerged over the past decade to suggest that protein kinase C (PKC) is a widespread family of kinases responsible for many diverse and critical…”
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Ro 09-2210 Exhibits Potent Anti-proliferative Effects on Activated T Cells by Selectively Blocking MKK Activity by Williams, D. H, Wilkinson, S. E, Purton, T, Lamont, A, Flotow, H, Murray, E. J

“…By using high throughput screening of microbial broths, we have identified a compound, designated Ro 09-2210, which is able to block anti-CD3 induced…”
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T-cell signal transduction and the role of protein kinase C by Wilkinson, S. E, Nixon, J. S

“…The T lymphocyte has a vital part to play in maintaining the host response to bacterial and viral infection and also appears to play a key pathological role in…”
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Potent selective inhibitors of protein kinase C by Davis, Peter D., Hill, Christopher H., Keech, Elizabeth, Lawton, Geoffrey, Nixon, John S., Sedgwick, Anthony D., Wadsworth, Julie, Westmacott, Donald, Wilkinson, Sandra E.

“…A series of potent, selective inhibitors of protein kinase C has been derived from the structural lead provided by the microbial broth products, staurosporine…”
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The effect of new potent selective inhibitors of protein kinase C on the neutrophil respiratory burst by Twomey, B, Muid, R E, Nixon, J S, Sedgwick, A D, Wilkinson, S E, Dale, M M

“…New potent inhibitors of protein kinase C were found to inhibit protein kinase C isolated from rat brain and human neutrophils, with a large degree of…”
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Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation by Birchall, A M, Bishop, J, Bradshaw, D, Cline, A, Coffey, J, Elliott, L H, Gibson, V M, Greenham, A, Hallam, T J, Harris, W

“…Several lines of circumstantial evidence support the assumption that protein kinase C (PKC) activation together with elevated levels of cytosolic Ca++ are…”
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A role for the medial preoptic area in CGRP-induced suppression of pulsatile LH secretion in the female rat by Li, X F, Kinsey-Jones, J S, Bowe, J E, Wilkinson, E S, Brain, S D, Lightman, S L, O'Byrne, K T

“…Calcitonin gene-related peptide (CGRP) is involved in a variety of stress responses and plays a pivotal role in stress-induced suppression of the GnRH pulse…”
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Accelerated schedule of hepatitis B vaccination in high-risk youth by Wilkinson, S E, Morath, M, Bennett, D L, Burgess, M A, Isaacs, D

“…To perform a feasibility and immunogenicity study of an accelerated schedule of hepatitis B immunization for high-risk youth. High-risk adolescents attending a…”
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K252a is a potent and selective inhibitor of phosphorylase kinase by Elliott, L H, Wilkinson, S E, Sedgwick, A D, Hill, C H, Lawton, G, Davis, P D, Nixon, J S

“…The inhibition of phosphorylase kinase by a number of protein kinase inhibitors was examined. Both K252a and staurosporine are potent inhibitors of…”
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Phosphorylation of SLP-76 by the ZAP-70 Protein-tyrosine Kinase Is Required for T-cell Receptor Function by Wardenburg, Juliane Bubeck, Fu, Chong, Jackman, Janet K., Flotow, Horst, Wilkinson, Sandra E., Williams, David H., Johnson, Robin, Kong, Guanghui, Chan, Andrew C., Findell, Paul R.

“…Two families of tyrosine kinases, the Src and Syk families, are required for T-cell receptor activation. While the Src kinases are responsible for…”
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A novel conformationally restricted protein kinase C inhibitor, Ro 31-8425, inhibits human neutrophil superoxide generation by soluble, particulate and post-receptor stimuli by Muid, Robert E., Dale, M.Maureen, Davis, Peter D., Elliott, Lucy H., Hill, Christopher H., Kumar, Hari, Lawton, Geoffrey, Twomey, Breda M., Wadsworth, Julie, Wilkinson, Sandra E., Nixon, John S.

“…A novel, bis-indolylmaleimide, Ro 31-8425, bearing a conformationally restricted side chain, inhibits protein kinase C isolated from rat brain and human…”
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Potent collagenase inhibitors prevent interleukin-1-induced cartilage degradation in vitro by Nixon, J S, Bottomley, K M, Broadhurst, M J, Brown, P A, Johnson, W H, Lawton, G, Marley, J, Sedgwick, A D, Wilkinson, S E

“…The matrix metalloproteinases (MMPs) collagenase, gelatinase and stromelysin, contribute to the destruction of articular cartilage which occurs during…”
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Modulation of cellular processes by H7, a non-selective inhibitor of protein kinases by Nixon, J S, Wilkinson, S E, Davis, P D, Sedgwick, A D, Wadsworth, J, Westmacott, D

“…H7 has been described as a potent inhibitor of protein kinase C (PKC) and has been widely used to investigate the regulatory role of this enzyme in intact cell…”
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Inhibitors of protein kinase C. 1. 2,3-bisarylmaleimides by Davis, Peter D, Hill, Christopher H, Lawton, Geoffrey, Nixon, John S, Wilkinson, Sandra E, Hurst, Steven A, Keech, Elizabeth, Turner, Susan E

“…The design and synthesis of a series of novel inhibitors of protein kinase C (PKC) is described. These 2,3-bisarylmaleimides were derived from the structural…”
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Myocardial strain and strain rate in Kawasaki disease by McCandless, Rachel T, Minich, L LuAnn, Wilkinson, Stephen E, McFadden, Molly L, Tani, Lloyd Y, Menon, Shaji C

“…We sought to determine whether velocity vector imaging (VVI)-derived left ventricular (LV) myocardial deformation indices could detect subtle myocardial…”
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Protein kinase C. Measurement of translocation, activation, and role in cellular responses by Wilkinson, S E, Hallam, T J

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