Search Results - "Wilkinson, Richard D"

Dating Primate Divergences through an Integrated Analysis of Palaeontological and Molecular Data by Wilkinson, Richard D., Steiper, Michael E., Soligo, Christophe, Martin, Robert D., Yang, Ziheng, Tavaré, Simon

“…Estimation of divergence times is usually done using either the fossil record or sequence data from modern species. We provide an integrated analysis of…”
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Calibrating cardiac electrophysiology models using latent Gaussian processes on atrial manifolds by Coveney, Sam, Roney, Caroline H., Corrado, Cesare, Wilkinson, Richard D., Oakley, Jeremy E., Niederer, Steven A., Clayton, Richard H.

“…Models of electrical excitation and recovery in the heart have become increasingly detailed, but have yet to be used routinely in the clinical setting to guide…”
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Bayesian Calibration of Electrophysiology Models Using Restitution Curve Emulators by Coveney, Sam, Corrado, Cesare, Oakley, Jeremy E, Wilkinson, Richard D, Niederer, Steven A, Clayton, Richard H

“…Calibration of cardiac electrophysiology models is a fundamental aspect of model personalization for predicting the outcomes of cardiac therapies, simulation…”
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A bioavailable cathepsin S nitrile inhibitor abrogates tumor development by Wilkinson, Richard D A, Young, Andrew, Burden, Roberta E, Williams, Rich, Scott, Christopher J

“…Cathepsin S has been implicated in a variety of malignancies with genetic ablation studies demonstrating a key role in tumor invasion and neo-angiogenesis…”
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PALEO-PGEM v1.0: a statistical emulator of Pliocene–Pleistocene climate by Holden, Philip B, Edwards, Neil R, Rangel, Thiago F, Pereira, Elisa B, Tran, Giang T, Wilkinson, Richard D

“…We describe the development of the “Paleoclimate PLASIM-GENIE (Planet Simulator–Grid-Enabled Integrated Earth system model) emulator” PALEO-PGEM and its…”
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Corrigendum: Bayesian Calibration of Electrophysiology Models Using Restitution Curve Emulators by Coveney, Sam, Corrado, Cesare, Oakley, Jeremy E., Wilkinson, Richard D., Niederer, Steven A., Clayton, Richard H.

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Estimating primate divergence times by using conditioned birth-and-death processes by Wilkinson, Richard D., Tavaré, Simon

“…The fossil record provides a lower bound on the primate divergence time of 54.8 million years ago, but does not provide an explicit estimate for the divergence…”
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Cathepsin S: therapeutic, diagnostic, and prognostic potential by Wilkinson, Richard D A, Williams, Rich, Scott, Christopher J, Burden, Roberta E

“…Cathepsin S is a member of the cysteine cathepsin protease family. It is a lysosomal protease which can promote degradation of damaged or unwanted proteins in…”
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Considering discrepancy when calibrating a mechanistic electrophysiology model by Lei, Chon Lok, Ghosh, Sanmitra, Whittaker, Dominic G, Aboelkassem, Yasser, Beattie, Kylie A, Cantwell, Chris D, Delhaas, Tammo, Houston, Charles, Novaes, Gustavo Montes, Panfilov, Alexander V, Pathmanathan, Pras, Riabiz, Marina, Dos Santos, Rodrigo Weber, Walmsley, John, Worden, Keith, Mirams, Gary R, Wilkinson, Richard D

“…Uncertainty quantification (UQ) is a vital step in using mathematical models and simulations to take decisions. The field of cardiac simulation has begun to…”
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The Emergence of Lobsters: Phylogenetic Relationships, Morphological Evolution and Divergence Time Comparisons of an Ancient Group (Decapoda: Achelata, Astacidea, Glypheidea, Polychelida) by Bracken-Grissom, Heather D., Ahyong, Shane T., Wilkinson, Richard D., Feldmann, Rodney M., Schweitzer, Carrie E., Breinholt, Jesse W., Bendall, Matthew, Palero, Ferran, Chan, Tin-yam, Felder, Darryl L., Robles, Rafael, Chu, Ka-Hou, Tsang, Ling-Ming, Kim, Dohyup, Martin, Joel W., Crandall, Keith A.

“…Lobsters are a ubiquitous and economically important group of decapod crustaceans that include the infraorders Polychelida, Glypheidea, Astacidea and Achelata…”
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Bayesian model selection for the glacial-interglacial cycle by Carson, Jake, Crucifix, Michel, Preston, Simon, Wilkinson, Richard D.

“…A prevailing viewpoint in paleoclimate science is that a single paleoclimate record contains insufficient information to discriminate between typical competing…”
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Oxidation modulates LINGO2-induced inactivation of large conductance, Ca2+-activated potassium channels by Dudem, Srikanth, Boon, Pei Xin, Mullins, Nicholas, McClafferty, Heather, Shipston, Michael J., Wilkinson, Richard D.A., Lobb, Ian, Sergeant, Gerard P., Thornbury, Keith D., Tikhonova, Irina G., Hollywood, Mark A.

“…Ca2+ and voltage-activated K+ (BK) channels are ubiquitous ion channels that can be modulated by accessory proteins, including β, γ, and LINGO1 BK subunits. In…”
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Gaussian process manifold interpolation for probabilistic atrial activation maps and uncertain conduction velocity by Coveney, Sam, Corrado, Cesare, Roney, Caroline H, O'Hare, Daniel, Williams, Steven E, O'Neill, Mark D, Niederer, Steven A, Clayton, Richard H, Oakley, Jeremy E, Wilkinson, Richard D

“…In patients with atrial fibrillation, local activation time (LAT) maps are routinely used for characterizing patient pathophysiology. The gradient of LAT maps…”
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Cell to whole organ global sensitivity analysis on a four-chamber heart electromechanics model using Gaussian processes emulators by Strocchi, Marina, Longobardi, Stefano, Augustin, Christoph M, Gsell, Matthias A F, Petras, Argyrios, Rinaldi, Christopher A, Vigmond, Edward J, Plank, Gernot, Oates, Chris J, Wilkinson, Richard D, Niederer, Steven A

“…Cardiac pump function arises from a series of highly orchestrated events across multiple scales. Computational electromechanics can encode these events in…”
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Probabilistic Interpolation of Uncertain Local Activation Times on Human Atrial Manifolds by Coveney, Sam, Clayton, Richard H., Corrado, Cesare, Roney, Caroline H., Wilkinson, Richard D., Oakley, Jeremy E., Lindgren, Finn, Williams, Steven E., O'Neill, Mark D., Niederer, Steven A.

“…Objective: Local activation time (LAT) mapping of the atria is important for targeted treatment of atrial arrhythmias, but current methods do not interpolate…”
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Reconstructing the Antarctic ice-sheet shape at the Last Glacial Maximum using ice-core data by Turner, Fiona E, Buck, Caitlin E, Jones, Julie M, Sime, Louise C, Vallet, Irene Malmierca, Wilkinson, Richard D

“…Abstract The Antarctic ice sheet (AIS) is the Earth’s largest store of frozen water; understanding how it changed in the past allows us to improve projections…”
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Quantifying the impact of shape uncertainty on predicted arrhythmias by Corrado, Cesare, Roney, Caroline H., Razeghi, Orod, Lemus, Josè Alonso Solís, Coveney, Sam, Sim, Iain, Williams, Steven E., O’Neill, Mark D., Wilkinson, Richard D., Clayton, Richard H., Niederer, Steven A.

“…Personalised computer models are increasingly used to diagnose cardiac arrhythmias and tailor treatment. Patient-specific models of the left atrium are often…”
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Detecting non-binomial sex allocation when developmental mortality operates by Wilkinson, Richard D., Kapranas, Apostolos, Hardy, Ian C.W.

“…Optimal sex allocation theory is one of the most intricately developed areas of evolutionary ecology. Under a range of conditions, particularly under…”
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Emulation and interpretation of high-dimensional climate model outputs by Holden, Philip B., Edwards, Neil R., Garthwaite, Paul H., Wilkinson, Richard D.

“…Running complex computer models can be expensive in computer time, while learning about the relationships between input and output variables can be difficult…”
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CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner by Wilkinson, Richard D A, Magorrian, Sinead M, Williams, Rich, Young, Andrew, Small, Donna M, Scott, Christopher J, Burden, Roberta E

“…Cathepsins S (CatS) has been implicated in numerous tumourigenic processes and here we document for the first time its involvement in CCL2 regulation within…”
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