Search Results - "Wilkinson, K D"

The ubiquitin pathway in Parkinson's disease by Leroy, Elisabeth, Boyer, Rebecca, Auburger, Georg, Leube, Barbara, Ulm, Gudrun, Mezey, Eva, Harta, Gyongyi, Brownstein, Michael J, Jonnalagada, Sobhanadditya, Chernova, Tanya, Dehejia, Anindya, Lavedan, Christian, Gasser, Thomas, Steinbach, Peter J, Wilkinson, Keith D, Polymeropoulos, Mihael H

“…Mutations of the α-synuclein gene, have been identified in some familial forms of Parkinson's disease, and α-synuclein protein has been shown to accumulate in…”
Get full text

BAP1 : a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression by JENSEN, D. E, PROCTOR, M, MINNA, J, BORODOVSKY, A, SCHULTZ, D. C, WILKINSON, K. D, MAUL, G. G, BARLEV, N, BERGER, S. L, PRENDERGAST, G. C, RAUSCHER, F. J, MARQUIS, S. T, GARDNER, H. P, HA, S. I, CHODOSH, L. A, ISHOV, A. M, TOMMERUP, N, VISSING, H, SEKIDO, Y

“…We have identified a novel protein, BAP1, which binds to the RING finger domain of the Breast/Ovarian Cancer Susceptibility Gene product, BRCA1. BAP1 is a…”
Get full text

Ubiquitin-dependent signaling: the role of ubiquitination in the response of cells to their environment by Wilkinson, K D

“…The response of a cell to its external environment requires rapid and significant alteration of protein amount, localization and/or function. This regulation…”
Get more information

FMR1 Protein: Conserved RNP Family Domains and Selective RNA Binding by Ashley, Claude T., Wilkinson, Keith D., Reines, Daniel, Warren, Stephen T.

“…Fragile X syndrome is the result of transcriptional suppression of the gene FMR1 as a result of a trinucleotide repeat expansion mutation. The normal function…”
Get full text

Purified Recombinant Fmrp Exhibits Selective RNA Binding as an Intrinsic Property of the Fragile X Mental Retardation Protein by Brown, V, Small, K, Lakkis, L, Feng, Y, Gunter, C, Wilkinson, K D, Warren, S T

“…Fragile X syndrome is caused by the transcriptional silencing of the FMR1 gene due to a trinucleotide repeat expansion. The encoded protein, Fmrp, has been…”
Get full text

Roles of ubiquitinylation in proteolysis and cellular regulation by WILKINSON, K. D

“…Most eukaryotic organisms respond to starvation, nutrient deprivation, and/or stress by increasing the rates of intracellular proteolysis. The amino acids…”
Get full text

Ubiquitination and deubiquitination: Targeting of proteins for degradation by the proteasome by Wilkinson, Keith D.

“…The post-translational modification of proteins by covalent attachment of ubiquitin targets these proteins for degradation by the proteasome. An astounding…”
Get full text

Nonhydrolyzable Diubiquitin Analogues Are Inhibitors of Ubiquitin Conjugation and Deconjugation by Yin, Luming, Krantz, Bryan, Russell, Nathaniel S, Deshpande, Seema, Wilkinson, Keith D

“…A series of nonhydrolyzable ubiquitin dimer analogues has been synthesized and evaluated as inhibitors of ubiquitin-dependent processes. Dimer analogues were…”
Get full text

Regulation of ubiquitin‐dependent processes by deubiquitinating enzymes by Wilkinson, Keith D.

“…An astounding number of important regulatory and structural proteins are subject to modification by the attachment of ubiquitin or ubiquitin‐like proteins…”
Get full text

The Neuron-Specific Protein PGP 9.5 is a Ubiquitin Carboxyl-Terminal Hydrolase by Wilkinson, Keith D., Lee, Keunmyoung, Deshpande, Seema, Duerksen-Hughes, Penelope, Boss, Jeremy M., Pohl, Jan

“…A complementary DNA (cDNA) for ubiquitin carboxyl-terminal hydrolase isozyme L3 was cloned from human B cells. The cDNA encodes a protein of 230 amino acids…”
Get full text

Comparisons of neuronal (PGP 9.5) and non-neuronal ubiquitin C-terminal hydrolases by Wilkinson, K D, Deshpande, S, Larsen, C N

Get more information

Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases by Lowe, J, McDermott, H, Landon, M, Mayer, R J, Wilkinson, K D

“…The recent discovery that brain PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase suggests that the role of this protein should be studied in relation to…”
Get more information

Microarray Identification of FMRP-Associated Brain mRNAs and Altered mRNA Translational Profiles in Fragile X Syndrome by Brown, Victoria, Jin, Peng, Ceman, Stephanie, Darnell, Jennifer C., O'Donnell, William T., Tenenbaum, Scott A., Jin, Xiaokui, Feng, Yue, Wilkinson, Keith D., Keene, Jack D., Darnell, Robert B., Warren, Stephen T.

“…Fragile X syndrome results from the absence of the RNA binding FMR protein. Here, mRNA was coimmunoprecipitated with the FMRP ribonucleoprotein complex and…”
Get full text

A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14 by Borodovsky, Anna, Kessler, Benedikt M., Casagrande, Rocco, Overkleeft, Herman S., Wilkinson, Keith D., Ploegh, Hidde L.

“…A C‐terminally modified ubiquitin (Ub) derivative, ubiquitin vinyl sulfone (UbVS), was synthesized as an active site‐directed probe that irreversibly modifies…”
Get full text

The fragile X mental retardation protein inhibits translation via interacting with mRNA by Li, Z, Zhang, Y, Ku, L, Wilkinson, K D, Warren, S T, Feng, Y

“…Fragile X syndrome is a frequent form of inherited mental retardation caused by functional loss of the fragile X mental retardation protein, FMRP. The function…”
Get full text

Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function by Olzmann, James A., Brown, Keith, Wilkinson, Keith D., Rees, Howard D., Huai, Qing, Ke, Hengming, Levey, Allan I., Li, Lian, Chin, Lih-Shen

“…Mutations in DJ-1, a protein of unknown function, were recently identified as the cause for an autosomal recessive, early onset form of familial Parkinson's…”
Get full text

Specific and Covalent Targeting of Conjugating and Deconjugating Enzymes of Ubiquitin-Like Proteins by Hemelaar, Joris, Borodovsky, Anna, Kessler, Benedikt M., Reverter, David, Cook, Julie, Kolli, Nagamallesawari, Gan-Erdene, Tudev, Wilkinson, Keith D., Gill, Grace, Lima, Christopher D., Ploegh, Hidde L., Ovaa, Huib

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells by CESHI CHEN, XIAODONG SUN, QIMEI RAN, WILKINSON, Keith D, MURPHY, T. J, SIMONS, Jonathan W, DONG, Jin-Tang

“…Ubiquitin-mediated proteolysis plays a central role in controlling intracellular levels of essential regulatory molecules such as p53, cyclins, myc, BRCA1,…”
Get full text

DEN1 Is a Dual Function Protease Capable of Processing the C Terminus of Nedd8 and Deconjugating Hyper-neddylated CUL1 by Wu, Kenneth, Yamoah, Kosj, Dolios, Georgia, Gan-Erdene, Tudeviin, Tan, Peilin, Chen, Angus, Lee, Chee-gun, Wei, Ning, Wilkinson, Keith D., Wang, Rong, Pan, Zhen-Qiang

“…Nedd8 activates ubiquitination by increasing the efficiency of polyubiquitin chain assembly through its covalent conjugation to cullin molecules. Here we…”
Get full text

Comparison of the three-dimensional structures of human, yeast, and oat ubiquitin by Vijay-Kumar, S., Bugg, C.E., Wilkinson, K.D., Vierstra, R.D., Hatfield, P.M., Cook, W.J.

“…The crystal structure of human ubiquitin has been solved by x-ray diffraction methods and refined by standard procedures to a conventional crystallographic R…”
Get full text