Search Results - "Wilkinson, David J."

Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes by Baker, Jonathan, Falconer, Adrian M D, Wilkinson, David J, Europe-Finner, G Nicholas, Litherland, Gary J, Rowan, Andrew D

“…Many catabolic stimuli, including interleukin-1 (IL-1) in combination with oncostatin M (OSM), promote cartilage breakdown via the induction of…”
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Isolation of Enteric Nervous System Progenitor Cells from the Aganglionic Gut of Patients with Hirschsprung's Disease by Wilkinson, David J, Bethell, George S, Shukla, Rajeev, Kenny, Simon E, Edgar, David H

“…Enteric nervous system progenitor cells isolated from postnatal human gut and cultured as neurospheres can then be transplanted into aganglionic gut to restore…”
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Recent advances in understanding the regulation of metalloproteinases [version 1; peer review: 2 approved] by Young, David A, Barter, Matt J, Wilkinson, David J

“…Metalloproteinases remain important players in arthritic disease, in part because members of this large enzymatic family, namely matrix metalloproteinase-1…”
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Jonathan GE Hinkle, Alkaform, and Dental Anesthesia Apparatus: A New Discovery, and Perhaps the First Practitioner of Conscious Sedation? by Wilkinson, David J

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Serpins in cartilage and osteoarthritis: what do we know? by Wilkinson, David J

“…Serpins (serine proteinase inhibitors) are an ancient superfamily of structurally similar proteins, the majority of which use an elegant suicide inhibition…”
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Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to MMP1 expression in human chondrocytes by Macdonald, Christopher D, Falconer, Adrian M D, Chan, Chun Ming, Wilkinson, David J, Skelton, Andrew, Reynard, Louise, Litherland, Gary J, Europe-Finner, G Nicholas, Rowan, Andrew D

“…Irreversible cartilage collagen breakdown by the collagenolytic matrix metalloproteinases (MMPs)-1 and MMP-13 represents a key event in pathologies associated…”
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Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis by Litherland, Gary J., Hui, Wang, Elias, Martina S., Wilkinson, David J., Watson, Sharon, Huesa, Carmen, Young, David A., Rowan, Andrew D.

“…Objective To assess the role of glycogen synthase kinase 3 (GSK‐3) as a regulator of cartilage destruction in human tissue and a murine model of osteoarthritis…”
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The serine proteinase HtrA1 is ubiquitous and abundant in osteoarthritic joints, but what is it doing? by Wilkinson, David J.

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Regulation of progenitor cell proliferation and neuronal differentiation in enteric nervous system neurospheres by Theocharatos, Sokratis, Wilkinson, David J, Darling, Sarah, Wilm, Bettina, Kenny, Simon E, Edgar, David

“…Enteric nervous system (ENS) progenitor cells isolated from mouse and human bowel can be cultured in vitro as neurospheres which are aggregates of the…”
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Minipig and Human Metabolism of Aldehyde Oxidase Substrates: In Vitro–In Vivo Comparisons by Wilkinson, David J., Southall, Rosalind L., Li, Mingguang, Wright, Lisa M., Corfield, Lindsay J., Heeley, Thomas A., Bratby, Benjamin, Mannu, Ranbir, Johnson, Sarah L., Shaw, Victoria, Friett, Holly L., Blakeburn, Louise A., Kendrick, John S., Otteneder, Michael B.

“…The importance of aldehyde oxidase (AOX) is becoming increasingly recognized in the prediction of human pharmacokinetic parameters from animal data. The…”
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An anaesthetist who missed a golden opportunity by Wilkinson, David J

“…Richard Gordon (1921–2017) was a prolific writer of both humorous fiction and historical reviews. He trained in medicine at St Bartholomew’s Hospital (Barts)…”
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Katharine Georgina Lloyd-Williams, CBE (1896-1973): an inspirational anaesthesia role model by Wilkinson, David J

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The Guthrie Boulder: A Forgotten Monument to Anesthesia in Chicago by Wilkinson, David J., Reilly, Felicia

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The Guthrie Boulder: A Forgotten Monument to Anesthesia in Chicago by Wilkinson, David J, Reilly, Felicia

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A non-obstetric exposure to chloroform for Queen Victoria by Wilkinson, David J

“…The administration of chloroform by John Snow to Queen Victoria to provide analgesia for the delivery of her children was a pivotal moment in the development…”
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Balancing quality and equity of access in specialist neonatal surgery: implications of the GIRFT report by Lansdale, Nick, Goldacre, Raph, Wilkinson, David J, Bower, Peter

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Laparoscopic hernia repair in children: does recreating the open operation improve outcomes? A systematic review by Goneidy, Ayman, Verhoef, Christian, Lansdale, Nick, Peters, Robert T., Wilkinson, David J.

“…Purpose The use of laparoscopy for paediatric inguinal hernia repairs has increased significantly over the past 2 decades. However, there is significant…”
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Future therapies for Hirschsprung's disease by Wilkinson, David J., MBChB, BMedSci (Hons), MRCS (Eng), Edgar, David H., MA, DPhil, Kenny, Simon E., BSc, ChB (Hons), MD, FRCS (Paed), FAAP

“…The current management of Hirschsprung's disease (HSCR) is still associated with significant long-term morbidities despite on-going refinements in surgical…”
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Endoscopic vs laparoscopic paediatric gastrostomies: Time to change our practice? by Koh, Claudia, Nicoara, Cezar Doru, Lansdale, Nick, Peters, Robert T, Wilkinson, David J

“…•Large comparative study of percutaneous vs laparoscopic gastrostomy techniques.•Laparoscopic balloon gastrostomies have lower major complication…”
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Laparoscopic inguinal herniotomy: Recreating the open operation optimises outcomes by Ducey, Jonathan, Peters, Robert T, Wilkinson, David J, Verhoef, Christian, Lansdale, Nick

“…•Laparoscopic inguinal herniorrhaphy is associated with higher recurrence rates compared to open herniotomy.•Our laparoscopic herniotomy (LIH) cohort shows low…”
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