Search Results - "Wilkins, Sarah E"

Structure–function relationships of human JmjC oxygenases—demethylases versus hydroxylases by Markolovic, Suzana, Leissing, Thomas M, Chowdhury, Rasheduzzaman, Wilkins, Sarah E, Lu, Xin, Schofield, Christopher J

“…•Human JmjC domain-containing proteins belong to the 2OG oxygenase superfamily.•JmjC catalysis enables formation of stable alcohols or demethylation of…”
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JMJD5 is a human arginyl C-3 hydroxylase by Wilkins, Sarah E., Islam, Md. Saiful, Gannon, Joan M., Markolovic, Suzana, Hopkinson, Richard J., Ge, Wei, Schofield, Christopher J., Chowdhury, Rasheduzzaman

“…Oxygenase-catalysed post-translational modifications of basic protein residues, including lysyl hydroxylations and N ε -methyl lysyl demethylations, have…”
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Targeting Protein-Protein Interactions in the HIF System by Wilkins, Sarah E., Abboud, Martine I., Hancock, Rebecca L., Schofield, Christopher J.

“…Animals respond to chronic hypoxia by increasing the levels of a transcription factor known as the hypoxia‐inducible factor (HIF). HIF upregulates multiple…”
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Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications by Hsu, Kuo-Feng, Wilkins, Sarah E., Hopkinson, Richard J., Sekirnik, Rok, Flashman, Emily, Kawamura, Akane, McCullagh, James S.O., Walport, Louise J., Schofield, Christopher J.

“…Post-translational modifications (PTMs) to the tails of the core histone proteins are critically involved in epigenetic regulation. Hypoxia affects histone…”
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The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases by Roatsch, Martin, Hoffmann, Inga, Abboud, Martine I, Hancock, Rebecca L, Tarhonskaya, Hanna, Hsu, Kuo-Feng, Wilkins, Sarah E, Yeh, Tzu-Lan, Lippl, Kerstin, Serrer, Kerstin, Moneke, Isabelle, Ahrens, Theresa D, Robaa, Dina, Wenzler, Sandra, Barthes, Nicolas P. F, Franz, Henriette, Sippl, Wolfgang, Lassmann, Silke, Diederichs, Sven, Schleicher, Erik, Schofield, Christopher J, Kawamura, Akane, Schüle, Roland, Jung, Manfred

“…Fe­(II)- and 2-oxoglutarate (2OG)-dependent JumonjiC domain-containing histone demethylases (JmjC KDMs) are “epigenetic eraser” enzymes involved in the…”
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Publisher Correction: JMJD5 is a human arginyl C-3 hydroxylase by Wilkins, Sarah E., Islam, Md. Saiful, Gannon, Joan M., Markolovic, Suzana, Hopkinson, Richard J., Ge, Wei, Schofield, Christopher J., Chowdhury, Rasheduzzaman

“…The originally published version of this Article contained an error in the spelling of the author Md. Saiful Islam, which was incorrectly given as Saiful…”
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Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases by Markolovic, Suzana, Wilkins, Sarah E., Schofield, Christopher J.

“…The post-translational hydroxylation of prolyl and lysyl residues, as catalyzed by 2-oxoglutarate (2OG)-dependent oxygenases, was first identified in collagen…”
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PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia by Banh, Robert S., Iorio, Caterina, Marcotte, Richard, Xu, Yang, Cojocari, Dan, Rahman, Anas Abdel, Pawling, Judy, Zhang, Wei, Sinha, Ankit, Rose, Christopher M., Isasa, Marta, Zhang, Shuang, Wu, Ronald, Virtanen, Carl, Hitomi, Toshiaki, Habu, Toshiyuki, Sidhu, Sachdev S., Koizumi, Akio, Wilkins, Sarah E., Kislinger, Thomas, Gygi, Steven P., Schofield, Christopher J., Dennis, James W., Wouters, Bradly G., Neel, Benjamin G.

“…Tumours exist in a hypoxic microenvironment and must limit excessive oxygen consumption. Hypoxia-inducible factor (HIF) controls mitochondrial oxygen…”
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Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability by Makena, Anne, Brem, Jürgen, Pfeffer, Inga, Geffen, Rebecca E J, Wilkins, Sarah E, Tarhonskaya, Hanna, Flashman, Emily, Phee, Lynette M, Wareham, David W, Schofield, Christopher J

“…Metallo-β-lactamase (MBL)-based resistance is a threat to the use of most β-lactam antibiotics. Multiple variants of the New Delhi MBL (NDM) have recently been…”
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The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases by Markolovic, Suzana, Zhuang, Qinqin, Wilkins, Sarah E., Eaton, Charlotte D., Abboud, Martine I., Katz, Maximiliano J., McNeil, Helen E., Leśniak, Robert K., Hall, Charlotte, Struwe, Weston B., Konietzny, Rebecca, Davis, Simon, Yang, Ming, Ge, Wei, Benesch, Justin L. P., Kessler, Benedikt M., Ratcliffe, Peter J., Cockman, Matthew E., Fischer, Roman, Wappner, Pablo, Chowdhury, Rasheduzzaman, Coleman, Mathew L., Schofield, Christopher J.

“…Biochemical, structural and cellular studies reveal Jumonji-C (JmjC) domain-containing 7 (JMJD7) to be a 2-oxoglutarate (2OG)-dependent oxygenase that…”
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Optimal Translational Termination Requires C4 Lysyl Hydroxylation of eRF1 by Feng, Tianshu, Yamamoto, Atsushi, Wilkins, Sarah E., Sokolova, Elizaveta, Yates, Luke A., Münzel, Martin, Singh, Pooja, Hopkinson, Richard J., Fischer, Roman, Cockman, Matthew E., Shelley, Jake, Trudgian, David C., Schödel, Johannes, McCullagh, James S.O., Ge, Wei, Kessler, Benedikt M., Gilbert, Robert J., Frolova, Ludmila Y., Alkalaeva, Elena, Ratcliffe, Peter J., Schofield, Christopher J., Coleman, Mathew L.

“…Efficient stop codon recognition and peptidyl-tRNA hydrolysis are essential in order to terminate translational elongation and maintain protein sequence…”
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An essential role for dNTP homeostasis following CDK-induced replication stress by Pai, Chen-Chun, Hsu, Kuo-Feng, Durley, Samuel C, Keszthelyi, Andrea, Kearsey, Stephen E, Rallis, Charalampos, Folkes, Lisa K, Deegan, Rachel, Wilkins, Sarah E, Pfister, Sophia X, De León, Nagore, Schofield, Christopher J, Bähler, Jürg, Carr, Antony M, Humphrey, Timothy C

“…Replication stress is a common feature of cancer cells, and thus a potentially important therapeutic target. Here, we show that cyclin-dependent kinase…”
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Ankyrin Repeat Proteins of Orf Virus Influence the Cellular Hypoxia Response Pathway by Chen, Da-Yuan, Fabrizio, Jacqueline-Alba, Wilkins, Sarah E, Dave, Keyur A, Gorman, Jeffrey J, Gleadle, Jonathan M, Fleming, Stephen B, Peet, Daniel J, Mercer, Andrew A

“…Hypoxia-inducible factor (HIF) is a transcriptional activator with a central role in regulating cellular responses to hypoxia. It is also emerging as a major…”
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Factor Inhibiting HIF (FIH) Recognizes Distinct Molecular Features within Hypoxia-inducible Factor-α (HIF-α) versus Ankyrin Repeat Substrates by Wilkins, Sarah E., Karttunen, Sarah, Hampton-Smith, Rachel J., Murchland, Iain, Chapman-Smith, Anne, Peet, Daniel J.

“…Factor Inhibiting HIF (FIH) catalyzes the β-hydroxylation of asparagine residues in HIF-α transcription factors as well as ankyrin repeat domain (ARD) proteins…”
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YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase by Sekirnik, Rok, Wilkins, Sarah E., Bush, Jacob, Tarhonskaya, Hanna, Münzel, Martin, Hussein, Aayan, Flashman, Emily, Mohammed, Shabaz, McDonough, Michael A., Loenarz, Christoph, Schofield, Christopher J.

“…YcfD from Escherichia coli is a homologue of the human ribosomal oxygenases NO66 and MINA53, which catalyse histidyl-hydroxylation of the 60S subunit and…”
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Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases by Markolovic, Suzana, Zhuang, Qinqin, Wilkins, Sarah E., Eaton, Charlotte D., Abboud, Martine I., Katz, Maximiliano J., McNeil, Helen E., Leśniak, Robert K., Hall, Charlotte, Struwe, Weston B., Konietzny, Rebecca, Davis, Simon, Yang, Ming, Ge, Wei, Benesch, Justin L. P., Kessler, Benedikt M., Ratcliffe, Peter J., Cockman, Matthew E., Fischer, Roman, Wappner, Pablo, Chowdhury, Rasheduzzaman, Coleman, Mathew L., Schofield, Christopher J.

“…In the version of this article initially published, authors Sarah E. Wilkins, Charlotte D. Eaton, Martine I. Abboud and Maximiliano J. Katz were incorrectly…”
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Decreased Self-Appraisal Accuracy on Cognitive Tests of Executive Functioning Is a Predictor of Decline in Mild Cognitive Impairment by Scherling, Carole S, Wilkins, Sarah E, Zakrezewski, Jessica, Kramer, Joel H, Miller, Bruce L, Weiner, Michael W, Rosen, Howard J

“…Mild cognitive impairment (MCI) in older individuals is associated with increased risk of progression to dementia. The factors predicting progression are not…”
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An Examination of Types of Stigma and Burnout Among Mental Health Care Providers Working With Serious Mental Illness: A Mediational Model and Relations to Quality of Care by Wilkins, Sarah E

“…Limited literature focuses on the demands/stressors experienced by mental health providers (MHPs) who treat clients with a serious mental illness (SMI), and…”
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Differences in hydroxylation and binding of Notch and HIF-1α demonstrate substrate selectivity for factor inhibiting HIF-1 (FIH-1) by Wilkins, Sarah E., Hyvärinen, Jaana, Chicher, Johana, Gorman, Jeffrey J., Peet, Daniel J., Bilton, Rebecca L., Koivunen, Peppi

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Biochemical characterization of New Delhi metallo-[Beta]-lactamase variants reveals differences in protein stability by Makena, Anne, Brem, Jürgen, Pfeffer, Inga, Geffen, Rebecca E J, Wilkins, Sarah E, Tarhonskaya, Hanna, Flashman, Emily, Phee, Lynette M, Wareham, David W, Schofield, Christopher J

“…Metallo-β-lactamase (MBL)-based resistance is a threat to the use of most ...-lactam antibiotics. Multiple variants of the New Delhi MBL (NDM) have recently…”
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