Search Results - "Wilkes, Jason J."

Loss-of-Function Mutation in Myostatin Reduces Tumor Necrosis Factor α Production and Protects Liver Against Obesity-Induced Insulin Resistance by WILKES, Jason J, LLOYD, David J, GEKAKIS, Nick

“…Loss-of-Function Mutation in Myostatin Reduces Tumor Necrosis Factor α Production and Protects Liver Against Obesity-Induced Insulin Resistance Jason J. Wilkes…”
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Chronic Endothelin-1 Treatment Leads to Insulin Resistance In Vivo by WILKES, Jason J, HEVENER, Andrea, OLEFSKY, Jerrold

“…Chronic Endothelin-1 Treatment Leads to Insulin Resistance In Vivo Jason J. Wilkes 1 , Andrea Hevener 2 and Jerrold Olefsky 3 1 Department of Medicine,…”
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Loss-of-Function Mutation in Myostatin Reduces Tumor Necrosis Factor [alpha] Production and Protects Liver Against Obesity-Induced Insulin Resistance by Wilkes, Jason J, Lloyd, David J, Gekakis, Nick

“…Insulin resistance develops in tandem with obesity. Ablating myostatin (Mstn) prevents obesity, so we investigated if Mstn deficiency could improve insulin…”
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Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities by Jurica, Elizabeth A., Wu, Ximao, Williams, Kristin N., Haque, Lauren E., Rampulla, Richard A., Mathur, Arvind, Zhou, Min, Cao, Gary, Cai, Hong, Wang, Tao, Liu, Heng, Xu, Carrie, Kunselman, Lori K., Antrilli, Thomas M., Hicks, Michael B., Sun, Qin, Dierks, Elizabeth A., Apedo, Atsu, Moore, Douglas B., Foster, Kimberly A., Cvijic, Mary Ellen, Panemangalore, Reshma, Khandelwal, Purnima, Wilkes, Jason J., Zinker, Bradley A., Robertson, Donald G., Janovitz, Evan B., Galella, Michael, Li, Yi-Xin, Li, Julia, Ramar, Thangeswaran, Jalagam, Prasada Rao, Jayaram, Ramya, Whaley, Jean M., Barrish, Joel C., Robl, Jeffrey A., Ewing, William R., Ellsworth, Bruce A.

“…[Display omitted] GPR40 AgoPAMs are highly effective antidiabetic agents that have a dual mechanism of action, stimulating both glucose-dependent insulin and…”
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Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists by Shi, Jun, Gu, Zhengxiang, Jurica, Elizabeth Anne, Wu, Ximao, Haque, Lauren E, Williams, Kristin N, Hernandez, Andres S, Hong, Zhenqiu, Gao, Qi, Dabros, Marta, Davulcu, Akin H, Mathur, Arvind, Rampulla, Richard A, Gupta, Arun Kumar, Jayaram, Ramya, Apedo, Atsu, Moore, Douglas B, Liu, Heng, Kunselman, Lori K, Brady, Edward J, Wilkes, Jason J, Zinker, Bradley A, Cai, Hong, Shu, Yue-Zhong, Sun, Qin, Dierks, Elizabeth A, Foster, Kimberly A, Xu, Carrie, Wang, Tao, Panemangalore, Reshma, Cvijic, Mary Ellen, Xie, Chunshan, Cao, Gary G, Zhou, Min, Krupinski, John, Whaley, Jean M, Robl, Jeffrey A, Ewing, William R, Ellsworth, Bruce Alan

“…G protein-coupled receptor 40 (GPR40) has become an attractive target for the treatment of diabetes since it was shown clinically to promote glucose-stimulated…”
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Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode by Jurica, Elizabeth A, Wu, Ximao, Williams, Kristin N, Hernandez, Andres S, Nirschl, David S, Rampulla, Richard A, Mathur, Arvind, Zhou, Min, Cao, Gary, Xie, Chunshan, Jacob, Biji, Cai, Hong, Wang, Tao, Murphy, Brian J, Liu, Heng, Xu, Carrie, Kunselman, Lori K, Hicks, Michael B, Sun, Qin, Schnur, Dora M, Sitkoff, Doree F, Dierks, Elizabeth A, Apedo, Atsu, Moore, Douglas B, Foster, Kimberly A, Cvijic, Mary Ellen, Panemangalore, Reshma, Flynn, Neil A, Maxwell, Brad D, Hong, Yang, Tian, Yuan, Wilkes, Jason J, Zinker, Bradley A, Whaley, Jean M, Barrish, Joel C, Robl, Jeffrey A, Ewing, William R, Ellsworth, Bruce A

“…A novel series of pyrrolidine-containing GPR40 agonists is described as a potential treatment for type 2 diabetes. The initial pyrrolidine hit was modified by…”
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Topiramate is an insulin-sensitizing compound in vivo with direct effects on adipocytes in female ZDF rats by Wilkes, Jason J, Nelson, Elizabeth, Osborne, Melville, Demarest, Keith T, Olefsky, Jerrold M

“…We have studied the in vivo and in vitro effects of Topiramate (TPM) in female Zucker diabetic fatty (ZDF) rats. After weight matching, drug treatment had a…”
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Topiramate treatment causes skeletal muscle insulin sensitization and increased Acrp30 secretion in high-fat-fed male Wistar rats by Wilkes, Jason J, Nguyen, M T Audrey, Bandyopadhyay, Gautam K, Nelson, Elizabeth, Olefsky, Jerrold M

“…We show that Topiramate (TPM) treatment normalizes whole body insulin sensitivity in high-fat diet (HFD)-fed male Wistar rats. Thus drug treatment markedly…”
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A modified high-fat diet induces insulin resistance in rat skeletal muscle but not adipocytes by Wilkes, J.J. (University of Waterloo, Ontario, Canada.), Bonen, A, Bell, R.C

“…We hypothesized that variation in dietary fatty acid composition in rats fed a high-fat diet had tissue-specific effects on glucose uptake sufficient to…”
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Reduced insulin-stimulated glucose transport in denervated muscle is associated with impaired Akt-alpha activation by Wilkes, J J, Bonen, A

“…Insulin signaling was examined in muscle made insulin resistant by short-term (24-h) denervation. Insulin-stimulated glucose transport in vitro was reduced by…”
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Chronic ethanol feeding in a high-fat diet decreases insulin-stimulated glucose transport in rat adipocytes by Wilkes, J.J, Deforrest, L.L, Nagy, L.E

“…Ethanol consumption has been associated with glucose intolerance and insulin resistance and is suggested to be an independent risk factor in the development of…”
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Chronic ethanol feeding impairs glucose tolerance but does not produce skeletal muscle insulin resistance in rat epitrochlearis muscle by Wilkes, J J, Nagy, L E

“…Herein, we have investigated whether male Wistar rats develop impaired glucose tolerance after ethanol feeding. Rats were fed a liquid diet providing 35%…”
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