Search Results - "Wilke, Carol A."

New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis by Sun, Lei, Louie, Marisa C, Vannella, Kevin M, Wilke, Carol A, LeVine, Ann Marie, Moore, Bethany B, Shanley, Thomas P

“…IL-10 is most commonly recognized as an anti-inflammatory cytokine possessing immunosuppressive effects necessary for regulated resolution of proinflammation…”
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An Essential Role for Fibronectin Extra Type III Domain A in Pulmonary Fibrosis by Muro, Andres F, Moretti, Federico A, Moore, Bethany B, Yan, Mei, Atrasz, Rachelle G, Wilke, Carol A, Flaherty, Kevin R, Martinez, Fernando J, Tsui, Jessica L, Sheppard, Dean, Baralle, Francisco E, Toews, Galen B, White, Eric S

“…Tissue fibrosis is considered a dysregulated wound-healing response. Fibronectin containing extra type III domain A (EDA) is implicated in the regulation of…”
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The Role of CCL12 in the Recruitment of Fibrocytes and Lung Fibrosis by Moore, Bethany B, Murray, Lynne, Das, Anuk, Wilke, Carol A, Herrygers, Amy B, Toews, Galen B

“…We have previously shown that mice that are genetically deficient in the CCR2 gene (CCR2-/- mice) are protected from fluorescein isothiocyanate (FITC)-induced…”
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Natural Secretory Immunoglobulins Promote Enteric Viral Infections by Turula, Holly, Bragazzi Cunha, Juliana, Mainou, Bernardo A, Ramakrishnan, Sadeesh K, Wilke, Carol A, Gonzalez-Hernandez, Mariam B, Pry, Alexandra, Fava, Julianne, Bassis, Christine M, Edelman, Jacob, Shah, Yatrik M, Corthesy, Blaise, Moore, Bethany B, Wobus, Christiane E

“…Noroviruses are enteric pathogens causing significant morbidity, mortality, and economic losses worldwide. Secretory immunoglobulins (sIg) are a first line of…”
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Influenza-induced immune suppression to methicillin-resistant Staphylococcus aureus is mediated by TLR9 by Martínez-Colón, Giovanny J, Warheit-Niemi, Helen, Gurczynski, Stephen J, Taylor, Quincy M, Wilke, Carol A, Podsiad, Amy B, Crespo, Joel, Bhan, Urvashi, Moore, Bethany B

“…Bacterial lung infections, particularly with methicillin-resistant Staphylococcus aureus (MRSA), increase mortality following influenza infection, but the…”
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Prostaglandin E2 Production and T Cell Function in Mouse Adenovirus Type 1 Infection following Allogeneic Bone Marrow Transplantation by McCarthy, Mary K, Procario, Megan C, Wilke, Carol A, Moore, Bethany B, Weinberg, Jason B

“…Adenovirus infections are important complications of bone marrow transplantation (BMT). We demonstrate delayed clearance of mouse adenovirus type 1 (MAV-1)…”
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Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway by White, Eric S., Sagana, Rommel L., Booth, Adam J., Yan, Mei, Cornett, Ashley M., Bloomheart, Christopher A., Tsui, Jessica L., Wilke, Carol A., Moore, Bethany B., Ritzenthaler, Jeffrey D., Roman, Jesse, Muro, Andrés F.

“…Fibronectin (FN), a ubiquitous glycoprotein that plays critical roles in physiologic and pathologic conditions, undergoes alternative splicing which…”
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CD8+ T Cell Response to Gammaherpesvirus Infection Mediates Inflammation and Fibrosis in Interferon Gamma Receptor-Deficient Mice by O'Flaherty, Brigid M, Matar, Caline G, Wakeman, Brian S, Garcia, AnaPatricia, Wilke, Carol A, Courtney, Cynthia L, Moore, Bethany B, Speck, Samuel H

“…Idiopathic pulmonary fibrosis (IPF), one of the most severe interstitial lung diseases, is a progressive fibrotic disorder of unknown etiology. However, there…”
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Bleomycin-Induced E Prostanoid Receptor Changes Alter Fibroblast Responses to Prostaglandin E2 by Moore, Bethany B, Ballinger, Megan N, White, Eric S, Green, Maranne E, Herrygers, Amy B, Wilke, Carol A, Toews, Galen B, Peters-Golden, Marc

“…Although PGE(2) is a potent inhibitor of fibroblast function, PGE(2) levels are paradoxically elevated in murine lungs undergoing fibrotic responses. Pulmonary…”
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Protection from Pulmonary Fibrosis in the Absence of CCR2 Signaling by Moore, Bethany B, Paine, Robert, III, Christensen, Paul J, Moore, Thomas A, Sitterding, Stephanie, Ngan, Rose, Wilke, Carol A, Kuziel, William A, Toews, Galen B

“…Pulmonary fibrosis can be modeled in animals by intratracheal instillation of FITC, which results in acute lung injury, inflammation, and extracellular matrix…”
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Cysteinyl Leukotrienes Are Autocrine and Paracrine Regulators of Fibrocyte Function by Vannella, Kevin M, McMillan, Tracy R, Charbeneau, Ryan P, Wilke, Carol A, Thomas, Peedikayil E, Toews, Galen B, Peters-Golden, Marc, Moore, Bethany B

“…Pulmonary fibrosis is characterized by the accumulation of fibroblasts and myofibroblasts. These cells may accumulate from three potential sources: the…”
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IL‐17A deficiency mitigates bleomycin‐induced complement activation during lung fibrosis by Cipolla, Ellyse, Fisher, Amanda J., Gu, Hongmei, Mickler, Elizabeth A., Agarwal, Manisha, Wilke, Carol A., Kim, Kevin K., Moore, Bethany B., Vittal, Ragini

“…ABSTRACT Interleukin 17A (IL‐17A) and complement (C′) activation have each been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). We have…”
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Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis by Naik, Payal K, Bozyk, Paul D, Bentley, J Kelley, Popova, Antonia P, Birch, Carolyn M, Wilke, Carol A, Fry, Christopher D, White, Eric S, Sisson, Thomas H, Tayob, Nabihah, Carnemolla, Barbara, Orecchia, Paola, Flaherty, Kevin R, Hershenson, Marc B, Murray, Susan, Martinez, Fernando J, Moore, Bethany B

“…Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease without effective therapeutics. Periostin has been reported to be elevated in IPF…”
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GM-CSF Regulates Bleomycin-Induced Pulmonary Fibrosis Via a Prostaglandin-Dependent Mechanism by Moore, Bethany B, Coffey, Michael J, Christensen, Paul, Sitterding, Stephanie, Ngan, Rose, Wilke, Carol A, McDonald, Rod, Phare, Susan M, Peters-Golden, Marc, Paine, Robert, III, Toews, Galen B

“…To characterize the role of GM-CSF in pulmonary fibrosis, we have studied bleomycin-induced fibrosis in wild-type mice vs mice with a targeted deletion of the…”
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Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx by Vittal, Ragini, Walker, Natalie M, McLinden, A Patrick, Braeuer, Russell R, Ke, Fang, Fattahi, Fatemeh, Combs, Michael P, Misumi, Keizo, Aoki, Yoshiro, Wheeler, David S, Wilke, Carol A, Huang, Steven K, Moore, Bethany B, Cao, Pengxiu, Lama, Vibha N

“…Idiopathic pulmonary fibrosis (IPF) is marked by unremitting matrix deposition and architectural distortion. Multiple profibrotic pathways contribute to the…”
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Lung Dysbiosis, Inflammation, and Injury in Hematopoietic Cell Transplantation by O'Dwyer, David N, Zhou, Xiaofeng, Wilke, Carol A, Xia, Meng, Falkowski, Nicole R, Norman, Katy C, Arnold, Kelly B, Huffnagle, Gary B, Murray, Susan, Erb-Downward, John R, Yanik, Gregory A, Moore, Bethany B, Dickson, Robert P

“…Hematopoietic cell transplant (HCT) is a common treatment for hematological neoplasms and autoimmune disorders. Among HCT recipients, pulmonary complications…”
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First-Onset Herpesviral Infection and Lung Injury in Allogeneic Hematopoietic Cell Transplantation by Zhou, Xiaofeng, O'Dwyer, David N, Xia, Meng, Miller, Holly K, Chan, Paul R, Trulik, Kelsey, Chadwick, Mathew M, Hoffman, Timothy C, Bulte, Camille, Sekerak, Kevin, Wilke, Carol A, Patel, Swapneel J, Yokoyama, Wayne M, Murray, Susan, Yanik, Gregory A, Moore, Bethany B

“…"Noninfectious" pulmonary complications are significant causes of morbidity and mortality after allogeneic hematopoietic cell transplant. Early-onset viral…”
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Loss of myeloid-specific protein phosphatase 2A enhances lung injury and fibrosis and results in IL-10-dependent sensitization of epithelial cell apoptosis by Sun, Lei, Hult, Elissa M, Cornell, Timothy T, Kim, Kevin K, Shanley, Thomas P, Wilke, Carol A, Agarwal, Manisha, Gurczynski, Stephen J, Moore, Bethany B, Dahmer, Mary K

“…Protein phosphatase 2A (PP2A), a ubiquitously expressed Ser/Thr phosphatase is an important regulator of cytokine signaling and cell function. We previously…”
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Modulating lung immune cells by pulmonary delivery of antigen-specific nanoparticles to treat autoimmune disease by Saito, Eiji, Gurczynski, Stephen J, Kramer, Kevin R, Wilke, Carol A, Miller, Stephen D, Moore, Bethany B, Shea, Lonnie D

“…Antigen-specific particles can treat autoimmunity, and pulmonary delivery may provide for easier delivery than intravenous or subcutaneous routes. The lung is…”
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Loss of CCR2 signaling alters leukocyte recruitment and exacerbates γ-herpesvirus-induced pneumonitis and fibrosis following bone marrow transplantation by Gurczynski, Stephen J, Procario, Megan C, O'Dwyer, David N, Wilke, Carol A, Moore, Bethany B

“…CCR2-expressing leukocytes are required for the progression of fibrosis in models of induced lung injury as well as models of bone marrow transplant…”
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