Search Results - "Wilhelmsson, L Marcus"

Synthesis and Photophysical Characterization of a pH‐Sensitive Quadracyclic Uridine (qU) Analogue by Le, Hoang‐Ngoan, Kuchlyan, Jagannath, Baladi, Tom, Albinsson, Bo, Dahlén, Anders, Wilhelmsson, L. Marcus

“…Fluorescent base analogues (FBAs) have become useful tools for applications in biophysical chemistry, chemical biology, live‐cell imaging, and RNA…”
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Advances in Quantitative FRET-Based Methods for Studying Nucleic Acids by Preus, Søren, Wilhelmsson, L. Marcus

“…Förster resonance energy transfer (FRET) is a powerful tool for monitoring molecular distances and interactions at the nanoscale level. The strong dependence…”
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Exploring the conformational dynamics of the SARS-CoV-2 SL4 hairpin by combining optical tweezers and base analogues by Sundar Rajan, Vinoth, Wypijewska Del Nogal, Anna, Levin, Sune, Wilhelmsson, L Marcus, Westerlund, Fredrik

“…The parasitic nature of the SARS-CoV-2 virus demands selective packaging of its RNA genome (gRNA) from the abundance of other nucleic acids present in infected…”
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Metabolic RNA labeling in non-engineered cells following spontaneous uptake of fluorescent nucleoside phosphate analogues by Pfeiffer, Pauline, Nilsson, Jesper R, Gallud, Audrey, Baladi, Tom, Le, Hoang-Ngoan, Bood, Mattias, Lemurell, Malin, Dahlén, Anders, Grøtli, Morten, Esbjörner, Elin K, Wilhelmsson, L Marcus

“…RNA and its building blocks play central roles in biology and have become increasingly important as therapeutic agents and targets. Hence, probing and…”
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Fluorescent base analogues in gapmers enable stealth labeling of antisense oligonucleotide therapeutics by Nilsson, Jesper R., Baladi, Tom, Gallud, Audrey, Baždarević, Dženita, Lemurell, Malin, Esbjörner, Elin K., Wilhelmsson, L. Marcus, Dahlén, Anders

“…To expand the antisense oligonucleotide (ASO) fluorescence labeling toolbox beyond covalent conjugation of external dyes ( e.g. ATTO-, Alexa Fluor-, or cyanine…”
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Flexibility and Preorganization of Fluorescent Nucleobase-Pyrene Conjugates Control DNA and RNA Recognition by Ban, Željka, Matić, Josipa, Žinić, Biserka, Füchtbauer, Anders Foller, Wilhelmsson, L Marcus, Piantanida, Ivo

“…We synthesized a new amino acid-fluorescent nucleobase derivative (qAN1-AA) and from it two new fluorescent nucleobase-fluorophore (pyrene) conjugates, whereby…”
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Complex Conformational Dynamics of the Heart Failure-Associated Pre-miRNA-377 Hairpin Revealed by Single-Molecule Optical Tweezers by Wypijewska del Nogal, Anna, Sundar Rajan, Vinoth, Westerlund, Fredrik, Wilhelmsson, L. Marcus

“…Pre-miRNA-377 is a hairpin-shaped regulatory RNA associated with heart failure. Here, we use single-molecule optical tweezers to unzip pre-miRNA-377 and study…”
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Mammalian transcription factor A is a core component of the mitochondrial transcription machinery by Shi, Yonghong, Dierckx, Anke, Wanrooij, Paulina H, Wanrooij, Sjoerd, Larsson, Nils-Göran, Wilhelmsson, L. Marcus, Falkenberg, Maria, Gustafsson, Claes M

“…Transcription factor A (TFAM) functions as a DNA packaging factor in mammalian mitochondria. TFAM also binds sequence-specifically to sites immediately…”
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HnRNPK maintains single strand RNA through controlling double-strand RNA in mammalian cells by Mahale, Sagar, Setia, Meenakshi, Prajapati, Bharat, Subhash, Santhilal, Yadav, Mukesh Pratap, Thankaswamy Kosalai, Subazini, Deshpande, Ananya, Kuchlyan, Jagannath, Di Marco, Mirco, Westerlund, Fredrik, Wilhelmsson, L. Marcus, Kanduri, Chandrasekhar, Kanduri, Meena

“…Although antisense transcription is a widespread event in the mammalian genome, double-stranded RNA (dsRNA) formation between sense and antisense transcripts…”
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Interbase-FRET binding assay for pre-microRNAs by Bood, Mattias, del Nogal, Anna Wypijewska, Nilsson, Jesper R., Edfeldt, Fredrik, Dahlén, Anders, Lemurell, Malin, Wilhelmsson, L. Marcus, Grøtli, Morten

“…The aberrant expression of microRNAs (miRs) has been linked to several human diseases. A promising approach for targeting these anomalies is the use of…”
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Template-Directed Oligonucleotide Strand Ligation, Covalent Intramolecular DNA Circularization and Catenation Using Click Chemistry by Kumar, Ravindra, El-Sagheer, Afaf, Tumpane, John, Lincoln, Per, Wilhelmsson, L. Marcus, Brown, Tom

“…The copper-catalyzed azide−alkyne cycloaddition reaction has been used for the template-mediated chemical ligation of two oligonucleotide strands, one with a…”
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Interbase FRET in RNA: from A to Z by Füchtbauer, Anders F, Wranne, Moa S, Bood, Mattias, Weis, Erik, Pfeiffer, Pauline, Nilsson, Jesper R, Dahlén, Anders, Grøtli, Morten, Wilhelmsson, L Marcus

“…Abstract Interbase FRET can reveal highly detailed information about distance, orientation and dynamics in nucleic acids, complementing the existing structure…”
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Getting DNA and RNA out of the dark with 2CNqA: a bright adenine analogue and interbase FRET donor by Wypijewska del Nogal, Anna, Füchtbauer, Anders F, Bood, Mattias, Nilsson, Jesper R, Wranne, Moa S, Sarangamath, Sangamesh, Pfeiffer, Pauline, Rajan, Vinoth Sundar, El-Sagheer, Afaf H, Dahlén, Anders, Brown, Tom, Grøtli, Morten, Wilhelmsson, L Marcus

“…Abstract With the central role of nucleic acids there is a need for development of fluorophores that facilitate the visualization of processes involving…”
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Fluorescent nucleobase analogues for base-base FRET in nucleic acids: synthesis, photophysics and applications by Bood, Mattias, Sarangamath, Sangamesh, Wranne, Moa S, Grøtli, Morten, Wilhelmsson, L Marcus

“…Förster resonance energy transfer (FRET) between a donor nucleobase analogue and an acceptor nucleobase analogue, base-base FRET, works as a spectroscopic…”
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Fluorescent RNA cytosine analogue – an internal probe for detailed structure and dynamics investigations by Füchtbauer, Anders Foller, Preus, Søren, Börjesson, Karl, McPhee, Scott A., Lilley, David M. J., Wilhelmsson, L. Marcus

“…The bright fluorescent cytosine analogue tC O stands out among fluorescent bases due to its virtually unquenched fluorescence emission in duplex DNA. However,…”
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FRETmatrix: a general methodology for the simulation and analysis of FRET in nucleic acids by Preus, Søren, Kilså, Kristine, Miannay, Francois-Alexandre, Albinsson, Bo, Wilhelmsson, L Marcus

“…Förster resonance energy transfer (FRET) is a technique commonly used to unravel the structure and conformational changes of biomolecules being vital for all…”
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Characterization and use of an unprecedentedly bright and structurally non-perturbing fluorescent DNA base analogue by Sandin, Peter, Börjesson, Karl, Li, Hong, Mårtensson, Jerker, Brown, Tom, Wilhelmsson, L. Marcus, Albinsson, Bo

“…This article presents the first evidence that the DNA base analogue 1,3-diaza-2-oxophenoxazine, tCO, is highly fluorescent, both as free nucleoside and…”
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Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue by Bood, Mattias, Füchtbauer, Anders F, Wranne, Moa S, Ro, Jong Jin, Sarangamath, Sangamesh, El-Sagheer, Afaf H, Rupert, Déborah L M, Fisher, Rachel S, Magennis, Steven W, Jones, Anita C, Höök, Fredrik, Brown, Tom, Kim, Byeang Hyean, Dahlén, Anders, Wilhelmsson, L Marcus, Grøtli, Morten

“…Emissive base analogs are powerful tools for probing nucleic acids at the molecular level. Herein we describe the development and thorough characterization of…”
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Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue by Lawson, Christopher P., Füchtbauer, Anders F., Wranne, Moa S., Giraud, Tristan, Floyd, Thomas, Dumat, Blaise, Andersen, Nicolai K., H. El-Sagheer, Afaf, Brown, Tom, Gradén, Henrik, Wilhelmsson, L. Marcus, Grøtli, Morten

“…Fluorescent base analogues (FBAs) have emerged as a powerful class of molecular reporters of location and environment for nucleic acids. In our overall mission…”
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Development of bright fluorescent quadracyclic adenine analogues: TDDFT-calculation supported rational design by Foller Larsen, Anders, Dumat, Blaise, Wranne, Moa S., Lawson, Christopher P., Preus, Søren, Bood, Mattias, Gradén, Henrik, Marcus Wilhelmsson, L., Grøtli, Morten

“…Fluorescent base analogues (FBAs) comprise a family of increasingly important molecules for the investigation of nucleic acid structure and dynamics. We…”
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