Search Results - "Wilhelm, S."

Microfluidic Assembly of Monodisperse Vesosomes as Artificial Cell Models by Deng, Nan-Nan, Yelleswarapu, Maaruthy, Zheng, Lifei, Huck, Wilhelm T. S

“…Vesosomes are nested liposomal structures with high potential as advanced drug delivery vehicles, bioreactors and artificial cells. However, to date no method…”
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Monodisperse Uni- and Multicompartment Liposomes by Deng, Nan-Nan, Yelleswarapu, Maaruthy, Huck, Wilhelm T. S

“…Liposomes are self-assembled phospholipid vesicles with great potential in fields ranging from targeted drug delivery to artificial cells. The formation of…”
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3D microniches reveal the importance of cell size and shape by Bao, Min, Xie, Jing, Piruska, Aigars, Huck, Wilhelm T. S.

“…Geometrical cues have been shown to alter gene expression and differentiation on 2D substrates. However, little is known about how geometrical cues affect cell…”
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Poised epigenetic states and acquired drug resistance in cancer by Brown, Robert, Curry, Edward, Magnani, Luca, Wilhelm-Benartzi, Charlotte S., Borley, Jane

“…Brown et al . argue that epigenetic heterogeneity leads to therapeutic resistance, such that bivalently marked gene promoters result in epigenetically poised…”
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Microfluidic Formation of Monodisperse Coacervate Organelles in Liposomes by Deng, Nan‐Nan, Huck, Wilhelm T. S.

“…Coacervates have been widely studied as model compartments in protocell research. Complex coacervates composed of disordered proteins and RNA have also been…”
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25th Anniversary Article: Designer Hydrogels for Cell Cultures: A Materials Selection Guide by Thiele, Julian, Ma, Yujie, Bruekers, Stéphanie M. C., Ma, Shaohua, Huck, Wilhelm T. S.

“…Cell culturing, whether for tissue engineering or cell biology studies, always involves placing cells in a non‐natural environment and no material currently…”
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Microdroplets in Microfluidics: An Evolving Platform for Discoveries in Chemistry and Biology by Theberge, Ashleigh B, Courtois, Fabienne, Schaerli, Yolanda, Fischlechner, Martin, Abell, Chris, Hollfelder, Florian, Huck, Wilhelm T.S

“…Microdroplets in microfluidics offer a great number of opportunities in chemical and biological research. They provide a compartment in which species or…”
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Emerging applications of stimuli-responsive polymer materials by Luzinov, Igor, Minko, Sergiy, Stuart, Martien A. Cohen, Huck, Wilhelm T. S, Genzer, Jan, Müller, Marcus, Ober, Christopher, Stamm, Manfred, Sukhorukov, Gleb B, Szleifer, Igal, Tsukruk, Vladimir V, Urban, Marek, Winnik, Françoise, Zauscher, Stefan

“…Stimuli-responsive polymers can be engineered, in both film and colloid forms, to respond to a variety of inputs, from temperature to pH. The inherent…”
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Electrochemically Mediated Atom Transfer Radical Polymerization on Nonconducting Substrates: Controlled Brush Growth through Catalyst Diffusion by Li, Bin, Yu, Bo, Huck, Wilhelm T. S, Liu, Weimin, Zhou, Feng

“…Surface initiated atom transfer radical polymerization (SI-ATRP) was triggered after diffusion of a CuI/L activator generated at a working electrode. A stable…”
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Ultrarapid Generation of Femtoliter Microfluidic Droplets for Single-Molecule-Counting Immunoassays by Shim, Jung-uk, Ranasinghe, Rohan T, Smith, Clive A, Ibrahim, Shehu M, Hollfelder, Florian, Huck, Wilhelm T. S, Klenerman, David, Abell, Chris

“…We report a microfluidic droplet-based approach enabling the measurement of chemical reactions of individual enzyme molecules and its application to a…”
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Effect of Polymer Brush Architecture on Antibiofouling Properties by Gunkel, Gesine, Weinhart, Marie, Becherer, Tobias, Haag, Rainer, Huck, Wilhelm T. S.

“…Polymer brushes show great promise in next-generation antibiofouling surfaces. Here, we have studied the influence of polymer brush architecture on protein…”
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The nanotechnology of life-inspired systems by Grzybowski, Bartosz A., Huck, Wilhelm T. S.

“…Living matter should inspire the design of future nanosystems. For some decades now, nanotechnology has been touted as the 'next big thing' with potential…”
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Macromolecularly Crowded Protocells from Reversibly Shrinking Monodisperse Liposomes by Deng, Nan-Nan, Vibhute, Mahesh A, Zheng, Lifei, Zhao, Hui, Yelleswarapu, Maaruthy, Huck, Wilhelm T. S

“…The compartmentalization of cell-free gene expression systems in liposomes provides an attractive route to the formation of protocells, but these models do not…”
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Dynamic Environmental Conditions Affect the Composition of a Model Prebiotic Reaction Network by van Duppen, Peer, Daines, Elena, Robinson, William E., Huck, Wilhelm T. S.

“…Prebiotic environments are dynamic, containing a range of periodic and aperiodic variations in reaction conditions. However, the impact of the temporal…”
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Comparison of ixekizumab with ustekinumab in moderate‐to‐severe psoriasis: 24‐week results from IXORA‐S, a phase III study by Reich, K., Pinter, A., Lacour, J.P., Ferrandiz, C., Micali, G., French, L.E., Lomaga, M., Dutronc, Y., Henneges, C., Wilhelm, S., Hartz, S., Paul, C.

“…Summary Background It has been shown that the interleukin (IL)‐23/IL‐17 axis is critical in the pathogenesis of psoriasis. Objectives To present the primary…”
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Cooperative Adsorption of Lipoprotein Phospholipids, Triglycerides, and Cholesteryl Esters Are a Key Factor in Nonspecific Adsorption from Blood Plasma to Antifouling Polymer Surfaces by Gunkel, Gesine, Huck, Wilhelm T. S

“…Nonspecific protein adsorption is a central challenge for the use of polymeric materials in biological media. While the quantity of adsorbed protein can be…”
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Collagen Gels with Different Fibrillar Microarchitectures Elicit Different Cellular Responses by Xie, Jing, Bao, Min, Bruekers, Stéphanie M. C, Huck, Wilhelm T. S

“…The extracellular matrix consists of a complex mixture of fibrillar proteins, in which the architecture and mechanical properties of the protein fibrils vary…”
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Programmable chemical reaction networks: emulating regulatory functions in living cells using a bottom-up approach by van Roekel, Hendrik W H, Rosier, Bas J H M, Meijer, Lenny H H, Hilbers, Peter A J, Markvoort, Albert J, Huck, Wilhelm T S, de Greef, Tom F A

“…Living cells are able to produce a wide variety of biological responses when subjected to biochemical stimuli. It has become apparent that these biological…”
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Environmental conditions drive self-organization of reaction pathways in a prebiotic reaction network by Robinson, William E., Daines, Elena, van Duppen, Peer, de Jong, Thijs, Huck, Wilhelm T. S.

“…The evolution of life from the prebiotic environment required a gradual process of chemical evolution towards greater molecular complexity. Elaborate…”
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Reversible Photoswitchable Inhibitors Generate Ultrasensitivity in Out-of-Equilibrium Enzymatic Reactions by Teders, Michael, Pogodaev, Aleksandr A, Bojanov, Glenn, Huck, Wilhelm T. S

“…Ultrasensitivity is a ubiquitous emergent property of biochemical reaction networks. The design and construction of synthetic reaction networks exhibiting…”
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